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Protein

Chemotaxis protein CheY homolog

Gene

cheY

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY seems to regulate the clockwise (CW) rotation (By similarity).By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumBy similarity1
Metal bindingi8MagnesiumBy similarity1
Metal bindingi53MagnesiumBy similarity1
Metal bindingi55Magnesium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Chemotaxis, Flagellar rotation, Two-component regulatory system

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP1067-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis protein CheY homolog
Gene namesi
Name:cheY
Ordered Locus Names:HP_1067
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810501 – 124Chemotaxis protein CheY homologAdd BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP71403.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HP_0392O251533EBI-6409045,EBI-6410665

Protein-protein interaction databases

DIPiDIP-3256N.
IntActiP71403. 4 interactors.
MINTiMINT-160671.
STRINGi85962.HP1067.

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Helixi10 – 22Combined sources13
Beta strandi28 – 33Combined sources6
Helixi34 – 43Combined sources10
Beta strandi49 – 52Combined sources4
Beta strandi57 – 59Combined sources3
Helixi61 – 69Combined sources9
Beta strandi74 – 76Combined sources3
Beta strandi79 – 84Combined sources6
Helixi88 – 97Combined sources10
Beta strandi101 – 105Combined sources5
Helixi109 – 120Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GWGX-ray1.80A1-124[»]
3H1EX-ray2.40A1-124[»]
3H1FX-ray2.20A1-124[»]
3H1GX-ray1.70A1-124[»]
ProteinModelPortaliP71403.
SMRiP71403.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP71403.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 120Response regulatoryPROSITE-ProRule annotationAdd BLAST119

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108VYJ. Bacteria.
COG0784. LUCA.
KOiK03413.
OMAiTNTHEAD.

Family and domain databases

InterProiIPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P71403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLVVDDSS TMRRIIKNTL SRLGYEDVLE AEHGVEAWEK LDANADTKVL
60 70 80 90 100
ITDWNMPEMN GLDLVKKVRS DSRFKEIPII MITTEGGKAE VITALKAGVN
110 120
NYIVKPFTPQ VLKEKLEVVL GTND
Length:124
Mass (Da):13,915
Last modified:November 1, 1997 - v2
Checksum:iF2B40BC0C04FCBFA
GO

Sequence cautioni

The sequence CAA57487 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti122T → A in strain: NCTC 11637 and NCTC 11638. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81897 Genomic DNA. Translation: CAA57487.1. Different initiation.
U97567 Genomic DNA. Translation: AAB66375.1.
AE000511 Genomic DNA. Translation: AAD08113.1.
AF021090 Genomic DNA. Translation: AAD01682.1.
PIRiC64653.
RefSeqiNP_207858.1. NC_000915.1.
WP_000772151.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08113; AAD08113; HP_1067.
GeneIDi899603.
KEGGiheo:C694_05515.
hpy:HP1067.
PATRICi20593473. VBIHelPyl33062_1116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81897 Genomic DNA. Translation: CAA57487.1. Different initiation.
U97567 Genomic DNA. Translation: AAB66375.1.
AE000511 Genomic DNA. Translation: AAD08113.1.
AF021090 Genomic DNA. Translation: AAD01682.1.
PIRiC64653.
RefSeqiNP_207858.1. NC_000915.1.
WP_000772151.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GWGX-ray1.80A1-124[»]
3H1EX-ray2.40A1-124[»]
3H1FX-ray2.20A1-124[»]
3H1GX-ray1.70A1-124[»]
ProteinModelPortaliP71403.
SMRiP71403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3256N.
IntActiP71403. 4 interactors.
MINTiMINT-160671.
STRINGi85962.HP1067.

Proteomic databases

PaxDbiP71403.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08113; AAD08113; HP_1067.
GeneIDi899603.
KEGGiheo:C694_05515.
hpy:HP1067.
PATRICi20593473. VBIHelPyl33062_1116.

Phylogenomic databases

eggNOGiENOG4108VYJ. Bacteria.
COG0784. LUCA.
KOiK03413.
OMAiTNTHEAD.

Enzyme and pathway databases

BioCyciHPY:HP1067-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP71403.

Family and domain databases

InterProiIPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHEY_HELPY
AccessioniPrimary (citable) accession number: P71403
Secondary accession number(s): O07677
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.