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Protein

Chemotaxis protein CheY homolog

Gene

cheY

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY seems to regulate the clockwise (CW) rotation (By similarity).By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumBy similarity1
Metal bindingi8MagnesiumBy similarity1
Metal bindingi53MagnesiumBy similarity1
Metal bindingi55Magnesium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processChemotaxis, Flagellar rotation, Two-component regulatory system
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP1067-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis protein CheY homolog
Gene namesi
Name:cheY
Ordered Locus Names:HP_1067
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810501 – 124Chemotaxis protein CheY homologAdd BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP71403

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HP_0392O251533EBI-6409045,EBI-6410665

Protein-protein interaction databases

DIPiDIP-3256N
IntActiP71403 4 interactors.
MINTiP71403
STRINGi85962.HP1067

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Helixi10 – 22Combined sources13
Beta strandi28 – 33Combined sources6
Helixi34 – 43Combined sources10
Beta strandi49 – 52Combined sources4
Beta strandi57 – 59Combined sources3
Helixi61 – 69Combined sources9
Beta strandi74 – 76Combined sources3
Beta strandi79 – 84Combined sources6
Helixi88 – 97Combined sources10
Beta strandi101 – 105Combined sources5
Helixi109 – 120Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GWGX-ray1.80A1-124[»]
3H1EX-ray2.40A1-124[»]
3H1FX-ray2.20A1-124[»]
3H1GX-ray1.70A1-124[»]
ProteinModelPortaliP71403
SMRiP71403
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP71403

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 120Response regulatoryPROSITE-ProRule annotationAdd BLAST119

Phylogenomic databases

eggNOGiENOG4108VYJ Bacteria
COG0784 LUCA
KOiK03413
OMAiPFQAPKV

Family and domain databases

CDDicd00156 REC, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF00072 Response_reg, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

P71403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLVVDDSS TMRRIIKNTL SRLGYEDVLE AEHGVEAWEK LDANADTKVL
60 70 80 90 100
ITDWNMPEMN GLDLVKKVRS DSRFKEIPII MITTEGGKAE VITALKAGVN
110 120
NYIVKPFTPQ VLKEKLEVVL GTND
Length:124
Mass (Da):13,915
Last modified:November 1, 1997 - v2
Checksum:iF2B40BC0C04FCBFA
GO

Sequence cautioni

The sequence CAA57487 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti122T → A in strain: NCTC 11637 and NCTC 11638. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81897 Genomic DNA Translation: CAA57487.1 Different initiation.
U97567 Genomic DNA Translation: AAB66375.1
AE000511 Genomic DNA Translation: AAD08113.1
AF021090 Genomic DNA Translation: AAD01682.1
PIRiC64653
RefSeqiNP_207858.1, NC_000915.1
WP_000772151.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08113; AAD08113; HP_1067
GeneIDi899603
KEGGiheo:C694_05515
hpy:HP1067
PATRICifig|85962.47.peg.1146

Similar proteinsi

Entry informationi

Entry nameiCHEY_HELPY
AccessioniPrimary (citable) accession number: P71403
Secondary accession number(s): O07677
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome