P71381 (TRPG_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component II
EC=4.1.3.27

Alternative name(s):
Glutamine amido-transferase

Gene names

Name:	trpG
Ordered Locus Names:	HI_1388

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Anthranilate synthase component II		PRO_0000056878
Regions
	Domain	3 – 193	191	Glutamine amidotransferase type-1
Sites
	Active site	84	1	By similarity
	Active site	170	1	By similarity
	Active site	172	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P71381 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 53FF77844D568B51	FASTA	193	21,509
	10 20 30 40 50 60 MANILFLDNF DSFTYNLVDQ FRVLGHNVTI YRNDCDLEKL VETALNTPDT ILALSPGPGT 70 80 90 100 110 120 PSEAGILLPL IERLKNQVPI IGVCLGHQAL IQAFGGKVVH AGEVLHGKVS RISHDNEAMF 130 140 150 160 170 180 KDLANPMPVA RYHSLMGQDL PKEFIVNAEY NGIIMAIRHR DLPICAFQFH PESILTVQGS 190 QLLQQSIEWL LNR

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC23034.1.
PIR	D64121.
RefSeq	NP_439540.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P71381.
SMR	P71381. Positions 2-193.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950293.
GenomeReviews	Gene locus HI_1388 in contig L42023_GR.
KEGG	hin:HI1388.
NMPDR	fig|71421.1.peg.1324.
PATRIC	20191469. VBIHaeInf48452_1445.
TIGR	HI_1388.
Phylogenomic databases
HOGENOM	HBG292341.
OMA	NIVMAIR.
PhylomeDB	P71381.
ProtClustDB	PRK05670.
Enzyme and pathway databases
BioCyc	HINF71421:HI_1388-MONOMER.
Family and domain databases
InterPro	IPR017926. GATASE_1. IPR006221. TrpG_papA. [Graphical view]
KO	K01658.
Pfam	PF00117. GATase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00566. TrpG_papA. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPG_HAEIN

Accession

Primary (citable) accession number: P71381

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program