P71366 (T3MH_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative type III restriction-modification system HindVIP enzyme mod
Short name=M.HindVIP
EC=2.1.1.72

Alternative name(s):
HindVIP methyltransferase

Gene names

Ordered Locus Names:

HI_1056

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	629 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.
Subunit structure	Contains two different subunits: res and mod. Mod is a homotetramer By similarity.
Sequence similarities	Belongs to the N(4)/N(6)-methyltransferase family.

Ontologies

Keywords
Biological process	Restriction system
Ligand	DNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA methylation on adenine Inferred from electronic annotation. Source: GOC DNA restriction-modification system Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW N-methyltransferase activity Inferred from electronic annotation. Source: InterPro site-specific DNA-methyltransferase (adenine-specific) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 629	629	Putative type III restriction-modification system HindVIP enzyme mod		PRO_0000088033

Sequences

	Sequence		Length	Mass (Da)
	P71366 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 93ADAD909DB41E84	FASTA	629	71,845
	10 20 30 40 50 60 MAGKAPKKAK KFILNAIIVS QSVSQSVSQS VSQSVSQSVS QSVSQSVSQS VSQSVSQSVS 70 80 90 100 110 120 QLYTKLTRKR QEIFFNQTLA FDEIDRLFDA KAFSKFSRYT ADGKQAVGEI KRHSDGTPAE 130 140 150 160 170 180 NLIIKGNNLI ALHSLAKQFK GKVKLIYIDP PYNTGNDGFK YNDKFNHSTW LTFMKNRLEI 190 200 210 220 230 240 AKTLLADDGV IFVQCDDIEQ AYLKILMDDI FDRDNFLNIV TVKTKIGGVS GSSEGKSLKD 250 260 270 280 290 300 STEFINVFSK NRERLFLNPV YQKTEVNEFI KNYEDSGKSW KYTQVLIDLG EKILLEEKDG 310 320 330 340 350 360 FKYYHYPNAQ MTSIVKFSQD QNLSKEIIYT EYSHKVYRTT NAQSSIRSKI IEDLYSIKNG 370 380 390 400 410 420 IVSIEYIPQK GKNAGNLIEV FYNASNKDMF MFLSDMLIKE KNKYFYLQKV NTLWDDIQYN 430 440 450 460 470 480 NLNKEGGYID FKNGKKPEAL LRRIIDMTTK EGDIVLDYHL GSGTTAAVAH KMNRQYIGIE 490 500 510 520 530 540 QMDYIETLAV ERLKKVIDGE QGGISKAVNW QGGGEFVYAE LAPFNETAKQ QILACEDSDD 550 560 570 580 590 600 IKTLFEDLCE RYFLKYNVSV KEFSQIIEEP EFQSLPLDEQ KQMVLEMLDL NQMYVSLSEM 610 620 DDEQFAGCLN DDDKALSRAF YQAEKKDGE

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22721.1.
PIR	C64180.
RefSeq	NP_439215.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P71366.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI1056.
Protein family/group databases
REBASE	3701. M.HindVI.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22721; AAC22721; HI_1056.
GeneID	950036.
KEGG	hin:HI1056.
PATRIC	20190777. VBIHaeInf48452_1101.
Phylogenomic databases
eggNOG	COG2189.
OMA	QAVGEIK.
Family and domain databases
InterPro	IPR002295. D21N6_MeTrfase. IPR002941. DNA_methylase_N4/N6. IPR002052. DNA_methylase_N6_adenine_CS. IPR001091. RM_Methylase. [Graphical view]
Pfam	PF01555. N6_N4_Mtase. 1 hit. [Graphical view]
PIRSF	PIRSF015855. TypeIII_Mtase_mKpnI. 1 hit.
PRINTS	PR00508. S21N4MTFRASE.
PROSITE	PS00092. N6_MTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

T3MH_HAEIN

Accession

Primary (citable) accession number: P71366

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program