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Protein

Putative type III restriction-modification system HindVIP enzyme mod

Gene

HI_1056

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

DNA-binding, S-adenosyl-L-methionine

Protein family/group databases

REBASEi3701. M.HindVI.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type III restriction-modification system HindVIP enzyme mod (EC:2.1.1.72)
Short name:
M.HindVIP
Alternative name(s):
HindVIP methyltransferase
Gene namesi
Ordered Locus Names:HI_1056
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 629629Putative type III restriction-modification system HindVIP enzyme modPRO_0000088033Add
BLAST

Interactioni

Subunit structurei

Contains two different subunits: res and mod. Mod is a homotetramer (By similarity).By similarity

Protein-protein interaction databases

STRINGi71421.HI1056.

Structurei

3D structure databases

ProteinModelPortaliP71366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Phylogenomic databases

eggNOGiCOG2189.
KOiK07316.
OMAiIHSEEFQ.
OrthoDBiEOG65F8SN.
PhylomeDBiP71366.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR002295. D21N6_MeTrfase.
IPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PIRSFiPIRSF015855. TypeIII_Mtase_mKpnI. 1 hit.
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P71366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKAPKKAK KFILNAIIVS QSVSQSVSQS VSQSVSQSVS QSVSQSVSQS
60 70 80 90 100
VSQSVSQSVS QLYTKLTRKR QEIFFNQTLA FDEIDRLFDA KAFSKFSRYT
110 120 130 140 150
ADGKQAVGEI KRHSDGTPAE NLIIKGNNLI ALHSLAKQFK GKVKLIYIDP
160 170 180 190 200
PYNTGNDGFK YNDKFNHSTW LTFMKNRLEI AKTLLADDGV IFVQCDDIEQ
210 220 230 240 250
AYLKILMDDI FDRDNFLNIV TVKTKIGGVS GSSEGKSLKD STEFINVFSK
260 270 280 290 300
NRERLFLNPV YQKTEVNEFI KNYEDSGKSW KYTQVLIDLG EKILLEEKDG
310 320 330 340 350
FKYYHYPNAQ MTSIVKFSQD QNLSKEIIYT EYSHKVYRTT NAQSSIRSKI
360 370 380 390 400
IEDLYSIKNG IVSIEYIPQK GKNAGNLIEV FYNASNKDMF MFLSDMLIKE
410 420 430 440 450
KNKYFYLQKV NTLWDDIQYN NLNKEGGYID FKNGKKPEAL LRRIIDMTTK
460 470 480 490 500
EGDIVLDYHL GSGTTAAVAH KMNRQYIGIE QMDYIETLAV ERLKKVIDGE
510 520 530 540 550
QGGISKAVNW QGGGEFVYAE LAPFNETAKQ QILACEDSDD IKTLFEDLCE
560 570 580 590 600
RYFLKYNVSV KEFSQIIEEP EFQSLPLDEQ KQMVLEMLDL NQMYVSLSEM
610 620
DDEQFAGCLN DDDKALSRAF YQAEKKDGE
Length:629
Mass (Da):71,845
Last modified:February 1, 1997 - v1
Checksum:i93ADAD909DB41E84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22721.1.
PIRiC64180.
RefSeqiNP_439215.1. NC_000907.1.
WP_010869119.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22721; AAC22721; HI_1056.
GeneIDi950036.
KEGGihin:HI1056.
PATRICi20190777. VBIHaeInf48452_1101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22721.1.
PIRiC64180.
RefSeqiNP_439215.1. NC_000907.1.
WP_010869119.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP71366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1056.

Protein family/group databases

REBASEi3701. M.HindVI.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22721; AAC22721; HI_1056.
GeneIDi950036.
KEGGihin:HI1056.
PATRICi20190777. VBIHaeInf48452_1101.

Phylogenomic databases

eggNOGiCOG2189.
KOiK07316.
OMAiIHSEEFQ.
OrthoDBiEOG65F8SN.
PhylomeDBiP71366.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR002295. D21N6_MeTrfase.
IPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PIRSFiPIRSF015855. TypeIII_Mtase_mKpnI. 1 hit.
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiT3MH_HAEIN
AccessioniPrimary (citable) accession number: P71366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: April 1, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.