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P71366

- T3MH_HAEIN

UniProt

P71366 - T3MH_HAEIN

Protein

Putative type III restriction-modification system HindVIP enzyme mod

Gene

HI_1056

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    DNA-binding, S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3701. M.HindVI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative type III restriction-modification system HindVIP enzyme mod (EC:2.1.1.72)
    Short name:
    M.HindVIP
    Alternative name(s):
    HindVIP methyltransferase
    Gene namesi
    Ordered Locus Names:HI_1056
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 629629Putative type III restriction-modification system HindVIP enzyme modPRO_0000088033Add
    BLAST

    Interactioni

    Subunit structurei

    Contains two different subunits: res and mod. Mod is a homotetramer By similarity.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI1056.

    Structurei

    3D structure databases

    ProteinModelPortaliP71366.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG2189.
    OMAiIHSEEFQ.
    OrthoDBiEOG65F8SN.
    PhylomeDBiP71366.

    Family and domain databases

    Gene3Di3.40.50.150. 2 hits.
    InterProiIPR002295. D21N6_MeTrfase.
    IPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01555. N6_N4_Mtase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015855. TypeIII_Mtase_mKpnI. 1 hit.
    PRINTSiPR00508. S21N4MTFRASE.
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P71366-1 [UniParc]FASTAAdd to Basket

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    MAGKAPKKAK KFILNAIIVS QSVSQSVSQS VSQSVSQSVS QSVSQSVSQS    50
    VSQSVSQSVS QLYTKLTRKR QEIFFNQTLA FDEIDRLFDA KAFSKFSRYT 100
    ADGKQAVGEI KRHSDGTPAE NLIIKGNNLI ALHSLAKQFK GKVKLIYIDP 150
    PYNTGNDGFK YNDKFNHSTW LTFMKNRLEI AKTLLADDGV IFVQCDDIEQ 200
    AYLKILMDDI FDRDNFLNIV TVKTKIGGVS GSSEGKSLKD STEFINVFSK 250
    NRERLFLNPV YQKTEVNEFI KNYEDSGKSW KYTQVLIDLG EKILLEEKDG 300
    FKYYHYPNAQ MTSIVKFSQD QNLSKEIIYT EYSHKVYRTT NAQSSIRSKI 350
    IEDLYSIKNG IVSIEYIPQK GKNAGNLIEV FYNASNKDMF MFLSDMLIKE 400
    KNKYFYLQKV NTLWDDIQYN NLNKEGGYID FKNGKKPEAL LRRIIDMTTK 450
    EGDIVLDYHL GSGTTAAVAH KMNRQYIGIE QMDYIETLAV ERLKKVIDGE 500
    QGGISKAVNW QGGGEFVYAE LAPFNETAKQ QILACEDSDD IKTLFEDLCE 550
    RYFLKYNVSV KEFSQIIEEP EFQSLPLDEQ KQMVLEMLDL NQMYVSLSEM 600
    DDEQFAGCLN DDDKALSRAF YQAEKKDGE 629
    Length:629
    Mass (Da):71,845
    Last modified:February 1, 1997 - v1
    Checksum:i93ADAD909DB41E84
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22721.1.
    PIRiC64180.
    RefSeqiNP_439215.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22721; AAC22721; HI_1056.
    GeneIDi950036.
    KEGGihin:HI1056.
    PATRICi20190777. VBIHaeInf48452_1101.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22721.1 .
    PIRi C64180.
    RefSeqi NP_439215.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P71366.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1056.

    Protein family/group databases

    REBASEi 3701. M.HindVI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22721 ; AAC22721 ; HI_1056 .
    GeneIDi 950036.
    KEGGi hin:HI1056.
    PATRICi 20190777. VBIHaeInf48452_1101.

    Phylogenomic databases

    eggNOGi COG2189.
    OMAi IHSEEFQ.
    OrthoDBi EOG65F8SN.
    PhylomeDBi P71366.

    Family and domain databases

    Gene3Di 3.40.50.150. 2 hits.
    InterProi IPR002295. D21N6_MeTrfase.
    IPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01555. N6_N4_Mtase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015855. TypeIII_Mtase_mKpnI. 1 hit.
    PRINTSi PR00508. S21N4MTFRASE.
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiT3MH_HAEIN
    AccessioniPrimary (citable) accession number: P71366
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3