ID TRKA_HAEIN Reviewed; 458 AA. AC P71354; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 27-MAR-2024, entry version 132. DE RecName: Full=Trk system potassium uptake protein TrkA; DE Short=K(+)-uptake protein TrkA; GN Name=trkA; OrderedLocusNames=HI_0625; OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales; OC Pasteurellaceae; Haemophilus. OX NCBI_TaxID=71421; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd; RX PubMed=7542800; DOI=10.1126/science.7542800; RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.; RT "Whole-genome random sequencing and assembly of Haemophilus influenzae RT Rd."; RL Science 269:496-512(1995). CC -!- FUNCTION: Part of a potassium transport system. {ECO:0000250}. CC -!- DOMAIN: The RCK N-terminal domain binds NAD and possibly other CC effectors. This is expected to cause a conformation change that CC regulates potassium transport (By similarity). {ECO:0000250}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L42023; AAC22285.1; -; Genomic_DNA. DR RefSeq; NP_438785.1; NC_000907.1. DR AlphaFoldDB; P71354; -. DR SMR; P71354; -. DR STRING; 71421.HI_0625; -. DR EnsemblBacteria; AAC22285; AAC22285; HI_0625. DR KEGG; hin:HI_0625; -. DR PATRIC; fig|71421.8.peg.651; -. DR eggNOG; COG0569; Bacteria. DR HOGENOM; CLU_046525_0_2_6; -. DR OrthoDB; 9775180at2; -. DR PhylomeDB; P71354; -. DR BioCyc; HINF71421:G1GJ1-652-MONOMER; -. DR Proteomes; UP000000579; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:InterPro. DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro. DR GO; GO:0006813; P:potassium ion transport; IBA:GO_Central. DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2. DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2. DR InterPro; IPR006036; K_uptake_TrkA. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR InterPro; IPR006037; RCK_C. DR InterPro; IPR036721; RCK_C_sf. DR InterPro; IPR003148; RCK_N. DR PANTHER; PTHR43833; POTASSIUM CHANNEL PROTEIN 2-RELATED-RELATED; 1. DR PANTHER; PTHR43833:SF5; TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKA; 1. DR Pfam; PF02080; TrkA_C; 2. DR Pfam; PF02254; TrkA_N; 2. DR PRINTS; PR00335; KUPTAKETRKA. DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2. DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2. DR PROSITE; PS51202; RCK_C; 2. DR PROSITE; PS51201; RCK_N; 2. PE 3: Inferred from homology; KW Ion transport; NAD; Potassium; Potassium transport; Reference proteome; KW Repeat; Transport. FT CHAIN 1..458 FT /note="Trk system potassium uptake protein TrkA" FT /id="PRO_0000148715" FT DOMAIN 2..131 FT /note="RCK N-terminal 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00543" FT DOMAIN 143..227 FT /note="RCK C-terminal 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00544" FT DOMAIN 234..356 FT /note="RCK N-terminal 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00543" FT DOMAIN 368..453 FT /note="RCK C-terminal 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00544" FT BINDING 7..11 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /ligand_label="1" FT /ligand_note="ligand shared between dimeric partners" FT /note="in other chain" FT /evidence="ECO:0000250" FT BINDING 30 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /ligand_label="1" FT /ligand_note="ligand shared between dimeric partners" FT /note="in other chain" FT /evidence="ECO:0000250" FT BINDING 73..74 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /ligand_label="1" FT /ligand_note="ligand shared between dimeric partners" FT /note="in other chain" FT /evidence="ECO:0000250" FT BINDING 98 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /ligand_label="1" FT /ligand_note="ligand shared between dimeric partners" FT /evidence="ECO:0000250" FT BINDING 234..262 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /ligand_label="2" FT /evidence="ECO:0000255" SQ SEQUENCE 458 AA; 50174 MW; E1FAB66AA1A221DA CRC64; MKIIILGAGQ VGTTLAENLV SEDNDITLVD NESPQLQTLQ EKHDLRVVQG SPSSPKVLRD AGAADADLMV AVTASDEINM VACQMGYTLF NTPTRIARIR NSEYLREKDK LFNNENIPID HLISPENLVT DEITRLIAYP GALQVAHFAN NRISIVVVKA YYGGALVGYA LSAFREHMPH IDCRIMSILR NGKPIRPQGS TIVEAGDEIT FICATEHIKA IMGELQRLEK PYKRVMIVGG GNVAFGVAKR LENSCTVKLI ERDSNRAQAL AEKLPKTLVF NGDASDQNLL FEEHIESVDV FLSLSSDDEA NIMSALLAKR LGAKKAMVLI QRIAYINLIQ GGTIDIAVSP QQVTISALLG HVRKGDVKNV ATLRHGIAEA IEIVAHGNVN TSNIVGRKIG ELRLPMGIII GALLRGNDVI IARRQVIIEE GDHIVIYLSD KKNVPEIEKL FQPSAFFI //