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P71354

- TRKA_HAEIN

UniProt

P71354 - TRKA_HAEIN

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Protein
Trk system potassium uptake protein TrkA
Gene
trkA, HI_0625
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Part of a potassium transport system By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301NAD 1 By similarity
Binding sitei98 – 981NAD 1; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 115NAD 1 By similarity
Nucleotide bindingi73 – 742NAD 1 By similarity
Nucleotide bindingi234 – 26229NAD 2 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. potassium ion transmembrane transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    NAD, Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trk system potassium uptake protein TrkA
    Short name:
    K(+)-uptake protein TrkA
    Gene namesi
    Name:trkA
    Ordered Locus Names:HI_0625
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: InterPro
    Complete GO annotation...

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 458458Trk system potassium uptake protein TrkA
    PRO_0000148715Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0625.

    Structurei

    3D structure databases

    ProteinModelPortaliP71354.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 131130RCK N-terminal 1
    Add
    BLAST
    Domaini143 – 22785RCK C-terminal 1
    Add
    BLAST
    Domaini234 – 356123RCK N-terminal 2
    Add
    BLAST
    Domaini368 – 45386RCK C-terminal 2
    Add
    BLAST

    Domaini

    The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport By similarity.

    Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0569.
    KOiK03499.
    OMAiSEDNDIT.
    OrthoDBiEOG6ZH2G8.
    PhylomeDBiP71354.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR006036. K_uptake_TrkA.
    IPR016040. NAD(P)-bd_dom.
    IPR006037. RCK_C.
    IPR003148. RCK_N.
    [Graphical view]
    PfamiPF02080. TrkA_C. 2 hits.
    PF02254. TrkA_N. 2 hits.
    [Graphical view]
    PRINTSiPR00335. KUPTAKETRKA.
    SUPFAMiSSF116726. SSF116726. 2 hits.
    PROSITEiPS51202. RCK_C. 2 hits.
    PS51201. RCK_N. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P71354-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIIILGAGQ VGTTLAENLV SEDNDITLVD NESPQLQTLQ EKHDLRVVQG    50
    SPSSPKVLRD AGAADADLMV AVTASDEINM VACQMGYTLF NTPTRIARIR 100
    NSEYLREKDK LFNNENIPID HLISPENLVT DEITRLIAYP GALQVAHFAN 150
    NRISIVVVKA YYGGALVGYA LSAFREHMPH IDCRIMSILR NGKPIRPQGS 200
    TIVEAGDEIT FICATEHIKA IMGELQRLEK PYKRVMIVGG GNVAFGVAKR 250
    LENSCTVKLI ERDSNRAQAL AEKLPKTLVF NGDASDQNLL FEEHIESVDV 300
    FLSLSSDDEA NIMSALLAKR LGAKKAMVLI QRIAYINLIQ GGTIDIAVSP 350
    QQVTISALLG HVRKGDVKNV ATLRHGIAEA IEIVAHGNVN TSNIVGRKIG 400
    ELRLPMGIII GALLRGNDVI IARRQVIIEE GDHIVIYLSD KKNVPEIEKL 450
    FQPSAFFI 458
    Length:458
    Mass (Da):50,174
    Last modified:February 1, 1997 - v1
    Checksum:iE1FAB66AA1A221DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22285.1.
    RefSeqiNP_438785.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22285; AAC22285; HI_0625.
    GeneIDi949682.
    KEGGihin:HI0625.
    PATRICi20189845. VBIHaeInf48452_0651.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22285.1 .
    RefSeqi NP_438785.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P71354.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0625.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22285 ; AAC22285 ; HI_0625 .
    GeneIDi 949682.
    KEGGi hin:HI0625.
    PATRICi 20189845. VBIHaeInf48452_0651.

    Phylogenomic databases

    eggNOGi COG0569.
    KOi K03499.
    OMAi SEDNDIT.
    OrthoDBi EOG6ZH2G8.
    PhylomeDBi P71354.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR006036. K_uptake_TrkA.
    IPR016040. NAD(P)-bd_dom.
    IPR006037. RCK_C.
    IPR003148. RCK_N.
    [Graphical view ]
    Pfami PF02080. TrkA_C. 2 hits.
    PF02254. TrkA_N. 2 hits.
    [Graphical view ]
    PRINTSi PR00335. KUPTAKETRKA.
    SUPFAMi SSF116726. SSF116726. 2 hits.
    PROSITEi PS51202. RCK_C. 2 hits.
    PS51201. RCK_N. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiTRKA_HAEIN
    AccessioniPrimary (citable) accession number: P71354
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 1, 1997
    Last modified: July 9, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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