P71354 (TRKA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trk system potassium uptake protein TrkA
Short name=K(+)-uptake protein TrkA

Gene names

Name:	trkA
Ordered Locus Names:	HI_0625

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of a potassium transport system By similarity.
Sequence similarities	Contains 2 RCK C-terminal domains. Contains 2 RCK N-terminal domains.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Domain	Repeat
Ligand	NAD Potassium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	potassium ion transmembrane transport Inferred from electronic annotation. Source: GOC
Cellular_component	plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro potassium ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Trk system potassium uptake protein TrkA		PRO_0000148715
Regions
	Domain	2 – 131	130	RCK N-terminal 1
	Domain	143 – 227	85	RCK C-terminal 1
	Domain	234 – 356	123	RCK N-terminal 2
	Domain	368 – 453	86	RCK C-terminal 2
	Nucleotide binding	2 – 31	30	NAD Potential
	Nucleotide binding	234 – 262	29	NAD Potential

Sequences

	Sequence		Length	Mass (Da)
	P71354 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: E1FAB66AA1A221DA	FASTA	458	50,174
	10 20 30 40 50 60 MKIIILGAGQ VGTTLAENLV SEDNDITLVD NESPQLQTLQ EKHDLRVVQG SPSSPKVLRD 70 80 90 100 110 120 AGAADADLMV AVTASDEINM VACQMGYTLF NTPTRIARIR NSEYLREKDK LFNNENIPID 130 140 150 160 170 180 HLISPENLVT DEITRLIAYP GALQVAHFAN NRISIVVVKA YYGGALVGYA LSAFREHMPH 190 200 210 220 230 240 IDCRIMSILR NGKPIRPQGS TIVEAGDEIT FICATEHIKA IMGELQRLEK PYKRVMIVGG 250 260 270 280 290 300 GNVAFGVAKR LENSCTVKLI ERDSNRAQAL AEKLPKTLVF NGDASDQNLL FEEHIESVDV 310 320 330 340 350 360 FLSLSSDDEA NIMSALLAKR LGAKKAMVLI QRIAYINLIQ GGTIDIAVSP QQVTISALLG 370 380 390 400 410 420 HVRKGDVKNV ATLRHGIAEA IEIVAHGNVN TSNIVGRKIG ELRLPMGIII GALLRGNDVI 430 440 450 IARRQVIIEE GDHIVIYLSD KKNVPEIEKL FQPSAFFI

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22285.1.
RefSeq	NP_438785.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P71354.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0625.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22285; AAC22285; HI_0625.
GeneID	949682.
KEGG	hin:HI0625.
PATRIC	20189845. VBIHaeInf48452_0651.
Phylogenomic databases
eggNOG	COG0569.
KO	K03499.
OMA	SEDNDIT.
ProtClustDB	PRK09496.
Family and domain databases
Gene3D	3.40.50.720. 2 hits.
InterPro	IPR006036. K_uptake_TrkA. IPR016040. NAD(P)-bd_dom. IPR006037. RCK_C. IPR003148. RCK_N. [Graphical view]
Pfam	PF02080. TrkA_C. 2 hits. PF02254. TrkA_N. 2 hits. [Graphical view]
PRINTS	PR00335. KUPTAKETRKA.
PROSITE	PS51202. RCK_C. 2 hits. PS51201. RCK_N. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRKA_HAEIN

Accession

Primary (citable) accession number: P71354

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program