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P71354 (TRKA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trk system potassium uptake protein TrkA

Short name=K(+)-uptake protein TrkA
Gene names
Name:trkA
Ordered Locus Names:HI_0625
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of a potassium transport system By similarity.

Domain

The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport By similarity.

Sequence similarities

Contains 2 RCK C-terminal domains.

Contains 2 RCK N-terminal domains.

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   DomainRepeat
   LigandNAD
Potassium
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionpotassium ion transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458Trk system potassium uptake protein TrkA
PRO_0000148715

Regions

Domain2 – 131130RCK N-terminal 1
Domain143 – 22785RCK C-terminal 1
Domain234 – 356123RCK N-terminal 2
Domain368 – 45386RCK C-terminal 2
Nucleotide binding7 – 115NAD 1 By similarity
Nucleotide binding73 – 742NAD 1 By similarity
Nucleotide binding234 – 26229NAD 2 Potential

Sites

Binding site301NAD 1 By similarity
Binding site981NAD 1; shared with dimeric partner By similarity

Sequences

Sequence LengthMass (Da)Tools
P71354 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: E1FAB66AA1A221DA

FASTA45850,174
        10         20         30         40         50         60 
MKIIILGAGQ VGTTLAENLV SEDNDITLVD NESPQLQTLQ EKHDLRVVQG SPSSPKVLRD 

        70         80         90        100        110        120 
AGAADADLMV AVTASDEINM VACQMGYTLF NTPTRIARIR NSEYLREKDK LFNNENIPID 

       130        140        150        160        170        180 
HLISPENLVT DEITRLIAYP GALQVAHFAN NRISIVVVKA YYGGALVGYA LSAFREHMPH 

       190        200        210        220        230        240 
IDCRIMSILR NGKPIRPQGS TIVEAGDEIT FICATEHIKA IMGELQRLEK PYKRVMIVGG 

       250        260        270        280        290        300 
GNVAFGVAKR LENSCTVKLI ERDSNRAQAL AEKLPKTLVF NGDASDQNLL FEEHIESVDV 

       310        320        330        340        350        360 
FLSLSSDDEA NIMSALLAKR LGAKKAMVLI QRIAYINLIQ GGTIDIAVSP QQVTISALLG 

       370        380        390        400        410        420 
HVRKGDVKNV ATLRHGIAEA IEIVAHGNVN TSNIVGRKIG ELRLPMGIII GALLRGNDVI 

       430        440        450 
IARRQVIIEE GDHIVIYLSD KKNVPEIEKL FQPSAFFI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22285.1.
RefSeqNP_438785.1. NC_000907.1.

3D structure databases

ProteinModelPortalP71354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0625.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22285; AAC22285; HI_0625.
GeneID949682.
KEGGhin:HI0625.
PATRIC20189845. VBIHaeInf48452_0651.

Phylogenomic databases

eggNOGCOG0569.
KOK03499.
OMASEDNDIT.
OrthoDBEOG6ZH2G8.
PhylomeDBP71354.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR006036. K_uptake_TrkA.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamPF02080. TrkA_C. 2 hits.
PF02254. TrkA_N. 2 hits.
[Graphical view]
PRINTSPR00335. KUPTAKETRKA.
SUPFAMSSF116726. SSF116726. 2 hits.
PROSITEPS51202. RCK_C. 2 hits.
PS51201. RCK_N. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRKA_HAEIN
AccessionPrimary (citable) accession number: P71354
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names