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Protein

Trk system potassium uptake protein TrkA

Gene

trkA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of a potassium transport system.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301NAD 1By similarity
Binding sitei98 – 981NAD 1; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 115NAD 1By similarity
Nucleotide bindingi73 – 742NAD 1By similarity
Nucleotide bindingi234 – 26229NAD 2Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. potassium ion transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

NAD, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Trk system potassium uptake protein TrkA
Short name:
K(+)-uptake protein TrkA
Gene namesi
Name:trkA
Ordered Locus Names:HI_0625
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Trk system potassium uptake protein TrkAPRO_0000148715Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0625.

Structurei

3D structure databases

ProteinModelPortaliP71354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 131130RCK N-terminal 1PROSITE-ProRule annotationAdd
BLAST
Domaini143 – 22785RCK C-terminal 1PROSITE-ProRule annotationAdd
BLAST
Domaini234 – 356123RCK N-terminal 2PROSITE-ProRule annotationAdd
BLAST
Domaini368 – 45386RCK C-terminal 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport (By similarity).By similarity

Sequence similaritiesi

Contains 2 RCK C-terminal domains.PROSITE-ProRule annotation
Contains 2 RCK N-terminal domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0569.
KOiK03499.
OMAiIACQVAY.
OrthoDBiEOG6ZH2G8.
PhylomeDBiP71354.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006036. K_uptake_TrkA.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF02080. TrkA_C. 2 hits.
PF02254. TrkA_N. 2 hits.
[Graphical view]
PRINTSiPR00335. KUPTAKETRKA.
SUPFAMiSSF116726. SSF116726. 2 hits.
PROSITEiPS51202. RCK_C. 2 hits.
PS51201. RCK_N. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P71354-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIIILGAGQ VGTTLAENLV SEDNDITLVD NESPQLQTLQ EKHDLRVVQG
60 70 80 90 100
SPSSPKVLRD AGAADADLMV AVTASDEINM VACQMGYTLF NTPTRIARIR
110 120 130 140 150
NSEYLREKDK LFNNENIPID HLISPENLVT DEITRLIAYP GALQVAHFAN
160 170 180 190 200
NRISIVVVKA YYGGALVGYA LSAFREHMPH IDCRIMSILR NGKPIRPQGS
210 220 230 240 250
TIVEAGDEIT FICATEHIKA IMGELQRLEK PYKRVMIVGG GNVAFGVAKR
260 270 280 290 300
LENSCTVKLI ERDSNRAQAL AEKLPKTLVF NGDASDQNLL FEEHIESVDV
310 320 330 340 350
FLSLSSDDEA NIMSALLAKR LGAKKAMVLI QRIAYINLIQ GGTIDIAVSP
360 370 380 390 400
QQVTISALLG HVRKGDVKNV ATLRHGIAEA IEIVAHGNVN TSNIVGRKIG
410 420 430 440 450
ELRLPMGIII GALLRGNDVI IARRQVIIEE GDHIVIYLSD KKNVPEIEKL

FQPSAFFI
Length:458
Mass (Da):50,174
Last modified:February 1, 1997 - v1
Checksum:iE1FAB66AA1A221DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22285.1.
RefSeqiNP_438785.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22285; AAC22285; HI_0625.
GeneIDi949682.
KEGGihin:HI0625.
PATRICi20189845. VBIHaeInf48452_0651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22285.1.
RefSeqiNP_438785.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP71354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0625.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22285; AAC22285; HI_0625.
GeneIDi949682.
KEGGihin:HI0625.
PATRICi20189845. VBIHaeInf48452_0651.

Phylogenomic databases

eggNOGiCOG0569.
KOiK03499.
OMAiIACQVAY.
OrthoDBiEOG6ZH2G8.
PhylomeDBiP71354.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006036. K_uptake_TrkA.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF02080. TrkA_C. 2 hits.
PF02254. TrkA_N. 2 hits.
[Graphical view]
PRINTSiPR00335. KUPTAKETRKA.
SUPFAMiSSF116726. SSF116726. 2 hits.
PROSITEiPS51202. RCK_C. 2 hits.
PS51201. RCK_N. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiTRKA_HAEIN
AccessioniPrimary (citable) accession number: P71354
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.