P71349 (SDHL_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-serine dehydratase
Short name=SDH
EC=4.3.1.17

Alternative name(s):
L-serine deaminase
Short name=L-SD

Gene names

Name:	sdaA
Ordered Locus Names:	HI_0288

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-serine = pyruvate + NH3.
Cofactor	Binds 1 4Fe-4S cluster Probable.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Sequence similarities	Belongs to the iron-sulfur dependent L-serine dehydratase family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW L-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	L-serine dehydratase		PRO_0000171906

Sequences

	Sequence		Length	Mass (Da)
	P71349 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 11002A51736DD386	FASTA	455	49,538
	10 20 30 40 50 60 MISVFDMFKV GIGPSSSHTV GPMKAGKQFI DDLIKRNQFE QTTEIHVDVY GSLSMTGRGH 70 80 90 100 110 120 STDIAIIMGL AGYLPHNVDI DMISGFIEKV KQTALLPINV GQKIVKFDFE NNLIFHRTFL 130 140 150 160 170 180 KLHENGMTIT ALDENRTELY RQTYYSIGGG FIVDEAHFGK EEKNTVQVPY PYKNAEDILK 190 200 210 220 230 240 HCSDNGLMLS TVMLENEIAL NGKEAVSAHL ENVWKTMQAC IEHGIHTEGI LPGPLRVPRR 250 260 270 280 290 300 AASLYRALQA NTNLSNDPMR VIDWVNMFAL AVNEENAAGG RVVTAPTNGA CGIIPAVLAY 310 320 330 340 350 360 YEKFISPLTP EIIERYLLAA GMIGSLYKMN ASISGAEVGC QGEVGVACSM AAAGLAEILG 370 380 390 400 410 420 GNPLQVCIAA EIAMEHNLGL TCDPVGGQVQ VPCIERNAIA SVKAINASRM ALRRTTNPRV 430 440 450 TLDKVIETMY ETGKDMNAKY RETSQGGLAV KIVCN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21953.1.
RefSeq	NP_438455.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P71349.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	949415.
GenomeReviews	Gene locus HI_0288 in contig L42023_GR.
KEGG	hin:HI0288.
NMPDR	fig|71421.1.peg.270.
PATRIC	20189115. VBIHaeInf48452_0304.
TIGR	HI_0288.
Phylogenomic databases
HOGENOM	HBG304565.
OMA	KNEIAMH.
ProtClustDB	CLSK789299.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0288-MONOMER.
Family and domain databases
InterPro	IPR004644. Fe-S_L-Ser_mono. IPR005130. Ser_deHydtase-like_asu. IPR005131. Ser_deHydtase_bsu. [Graphical view]
KO	K01752.
Pfam	PF03313. SDH_alpha. 1 hit. PF03315. SDH_beta. 1 hit. [Graphical view]
TIGRFAMs	TIGR00720. Sda_mono. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SDHL_HAEIN

Accession

Primary (citable) accession number: P71349

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program