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Protein

Glutamate-pyruvate aminotransferase AlaA

Gene

alaA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of alanine.By similarity

Catalytic activityi

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411Substrate; via amide nitrogenBy similarity
Binding sitei179 – 1791SubstrateBy similarity
Binding sitei378 – 3781SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-pyruvate aminotransferase AlaA (EC:2.6.1.2)
Gene namesi
Name:alaA
Ordered Locus Names:HI_0286
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Glutamate-pyruvate aminotransferase AlaAPRO_0000123869Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei240 – 2401N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiP71348.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi71421.HI0286.

Structurei

3D structure databases

ProteinModelPortaliP71348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
KOiK14260.
OMAiQRNRTWE.
OrthoDBiEOG6X9MJ6.
PhylomeDBiP71348.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

P71348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFPKSDKL EHVCYDIRGP VHKEALRLEE EGNKILKLNI GNPAPFGFEA
60 70 80 90 100
PDEILVDVLR NLPSAQGYCD SKGLYSARKA IVQYYQSKGI LGATVNDVYI
110 120 130 140 150
GNGVSELITM AMQALLNDGD EVLVPMPDYP LWTAAVTLSG GKAVHYLCDE
160 170 180 190 200
DANWFPTIDD IKAKVNAKTK AIVIINPNNP TGAVYSKELL QEIVEIARQN
210 220 230 240 250
NLIIFADEIY DKILYDGAVH HHIAALAPDL LTVTLNGLSK AYRVAGFRQG
260 270 280 290 300
WMILNGPKHN AKGYIEGLDM LASMRLCANV PMQHAIQTAL GGYQSINEFI
310 320 330 340 350
LPGGRLLEQR NKAYDLITQI PGITCVKPMG AMYMFPKIDV KKFNIHSDEK
360 370 380 390 400
MVLDLLRQEK VLLVHGKGFN WHSPDHFRIV TLPYVNQLEE AITKLARFLS

DYRQ
Length:404
Mass (Da):45,160
Last modified:February 1, 1997 - v1
Checksum:i7F2C3E24CC69FB46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21948.1.
RefSeqiNP_438453.1. NC_000907.1.
WP_005694022.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21948; AAC21948; HI_0286.
GeneIDi949411.
KEGGihin:HI0286.
PATRICi20189111. VBIHaeInf48452_0302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21948.1.
RefSeqiNP_438453.1. NC_000907.1.
WP_005694022.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP71348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0286.

Proteomic databases

PRIDEiP71348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21948; AAC21948; HI_0286.
GeneIDi949411.
KEGGihin:HI0286.
PATRICi20189111. VBIHaeInf48452_0302.

Phylogenomic databases

eggNOGiCOG0436.
KOiK14260.
OMAiQRNRTWE.
OrthoDBiEOG6X9MJ6.
PhylomeDBiP71348.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiALAA_HAEIN
AccessioniPrimary (citable) accession number: P71348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.