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P71348

- ALAA_HAEIN

UniProt

P71348 - ALAA_HAEIN

Protein

Glutamate-pyruvate aminotransferase AlaA

Gene

alaA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of alanine.By similarity

    Catalytic activityi

    L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411Substrate; via amide nitrogenBy similarity
    Binding sitei179 – 1791SubstrateBy similarity
    Binding sitei378 – 3781SubstrateBy similarity

    GO - Molecular functioni

    1. L-alanine:2-oxoglutarate aminotransferase activity Source: UniProtKB
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-pyruvate aminotransferase AlaA (EC:2.6.1.2)
    Gene namesi
    Name:alaA
    Ordered Locus Names:HI_0286
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Glutamate-pyruvate aminotransferase AlaAPRO_0000123869Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei240 – 2401N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiP71348.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI0286.

    Structurei

    3D structure databases

    ProteinModelPortaliP71348.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0436.
    KOiK14260.
    OMAiYQARDMR.
    OrthoDBiEOG6X9MJ6.
    PhylomeDBiP71348.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P71348-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLFPKSDKL EHVCYDIRGP VHKEALRLEE EGNKILKLNI GNPAPFGFEA    50
    PDEILVDVLR NLPSAQGYCD SKGLYSARKA IVQYYQSKGI LGATVNDVYI 100
    GNGVSELITM AMQALLNDGD EVLVPMPDYP LWTAAVTLSG GKAVHYLCDE 150
    DANWFPTIDD IKAKVNAKTK AIVIINPNNP TGAVYSKELL QEIVEIARQN 200
    NLIIFADEIY DKILYDGAVH HHIAALAPDL LTVTLNGLSK AYRVAGFRQG 250
    WMILNGPKHN AKGYIEGLDM LASMRLCANV PMQHAIQTAL GGYQSINEFI 300
    LPGGRLLEQR NKAYDLITQI PGITCVKPMG AMYMFPKIDV KKFNIHSDEK 350
    MVLDLLRQEK VLLVHGKGFN WHSPDHFRIV TLPYVNQLEE AITKLARFLS 400
    DYRQ 404
    Length:404
    Mass (Da):45,160
    Last modified:February 1, 1997 - v1
    Checksum:i7F2C3E24CC69FB46
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21948.1.
    RefSeqiNP_438453.1. NC_000907.1.
    WP_005694022.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21948; AAC21948; HI_0286.
    GeneIDi949411.
    KEGGihin:HI0286.
    PATRICi20189111. VBIHaeInf48452_0302.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21948.1 .
    RefSeqi NP_438453.1. NC_000907.1.
    WP_005694022.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P71348.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0286.

    Proteomic databases

    PRIDEi P71348.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21948 ; AAC21948 ; HI_0286 .
    GeneIDi 949411.
    KEGGi hin:HI0286.
    PATRICi 20189111. VBIHaeInf48452_0302.

    Phylogenomic databases

    eggNOGi COG0436.
    KOi K14260.
    OMAi YQARDMR.
    OrthoDBi EOG6X9MJ6.
    PhylomeDBi P71348.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiALAA_HAEIN
    AccessioniPrimary (citable) accession number: P71348
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3