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Protein

Glutamate-pyruvate aminotransferase AlaA

Gene

alaA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of alanine.By similarity

Catalytic activityi

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41Substrate; via amide nitrogenBy similarity1
Binding sitei179SubstrateBy similarity1
Binding sitei378SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-304-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-pyruvate aminotransferase AlaA (EC:2.6.1.2)
Gene namesi
Name:alaA
Ordered Locus Names:HI_0286
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238691 – 404Glutamate-pyruvate aminotransferase AlaAAdd BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei240N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiP71348

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi71421.HI0286

Structurei

3D structure databases

ProteinModelPortaliP71348
SMRiP71348
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHM Bacteria
COG0436 LUCA
KOiK14260
OMAiAPGTEWV
PhylomeDBiP71348

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

P71348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFPKSDKL EHVCYDIRGP VHKEALRLEE EGNKILKLNI GNPAPFGFEA
60 70 80 90 100
PDEILVDVLR NLPSAQGYCD SKGLYSARKA IVQYYQSKGI LGATVNDVYI
110 120 130 140 150
GNGVSELITM AMQALLNDGD EVLVPMPDYP LWTAAVTLSG GKAVHYLCDE
160 170 180 190 200
DANWFPTIDD IKAKVNAKTK AIVIINPNNP TGAVYSKELL QEIVEIARQN
210 220 230 240 250
NLIIFADEIY DKILYDGAVH HHIAALAPDL LTVTLNGLSK AYRVAGFRQG
260 270 280 290 300
WMILNGPKHN AKGYIEGLDM LASMRLCANV PMQHAIQTAL GGYQSINEFI
310 320 330 340 350
LPGGRLLEQR NKAYDLITQI PGITCVKPMG AMYMFPKIDV KKFNIHSDEK
360 370 380 390 400
MVLDLLRQEK VLLVHGKGFN WHSPDHFRIV TLPYVNQLEE AITKLARFLS

DYRQ
Length:404
Mass (Da):45,160
Last modified:February 1, 1997 - v1
Checksum:i7F2C3E24CC69FB46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC21948.1
RefSeqiNP_438453.1, NC_000907.1
WP_005694022.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC21948; AAC21948; HI_0286
GeneIDi949411
KEGGihin:HI0286
PATRICifig|71421.8.peg.302

Similar proteinsi

Entry informationi

Entry nameiALAA_HAEIN
AccessioniPrimary (citable) accession number: P71348
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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