ID NQRE_HAEIN Reviewed; 198 AA. AC P71342; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 27-MAR-2024, entry version 129. DE RecName: Full=Na(+)-translocating NADH-quinone reductase subunit E {ECO:0000255|HAMAP-Rule:MF_00429}; DE Short=Na(+)-NQR subunit E {ECO:0000255|HAMAP-Rule:MF_00429}; DE Short=Na(+)-translocating NQR subunit E {ECO:0000255|HAMAP-Rule:MF_00429}; DE EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00429}; DE AltName: Full=NQR complex subunit E {ECO:0000255|HAMAP-Rule:MF_00429}; DE AltName: Full=NQR-1 subunit E {ECO:0000255|HAMAP-Rule:MF_00429}; GN Name=nqrE {ECO:0000255|HAMAP-Rule:MF_00429}; GN OrderedLocusNames=HI_0170; OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales; OC Pasteurellaceae; Haemophilus. OX NCBI_TaxID=71421; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd; RX PubMed=7542800; DOI=10.1126/science.7542800; RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.; RT "Whole-genome random sequencing and assembly of Haemophilus influenzae RT Rd."; RL Science 269:496-512(1995). RN [2] RP IDENTIFICATION AS NQR SYSTEM. RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd; RX PubMed=8601449; DOI=10.1016/0014-5793(96)00114-7; RA Hayashi M., Nakayama Y., Unemoto T.; RT "Existence of Na+-translocating NADH-quinone reductase in Haemophilus RT influenzae."; RL FEBS Lett. 381:174-176(1996). CC -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to CC ubiquinol by two successive reactions, coupled with the transport of CC Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are CC probably involved in the second step, the conversion of ubisemiquinone CC to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00429}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n CC Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540, CC ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP- CC Rule:MF_00429}; CC -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and CC NqrF. {ECO:0000255|HAMAP-Rule:MF_00429}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP- CC Rule:MF_00429}; Multi-pass membrane protein {ECO:0000255|HAMAP- CC Rule:MF_00429}. CC -!- SIMILARITY: Belongs to the NqrDE/RnfAE family. {ECO:0000255|HAMAP- CC Rule:MF_00429}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L42023; AAC21840.1; -; Genomic_DNA. DR RefSeq; NP_438338.1; NC_000907.1. DR AlphaFoldDB; P71342; -. DR SMR; P71342; -. DR STRING; 71421.HI_0170; -. DR EnsemblBacteria; AAC21840; AAC21840; HI_0170. DR KEGG; hin:HI_0170; -. DR PATRIC; fig|71421.8.peg.174; -. DR eggNOG; COG2209; Bacteria. DR HOGENOM; CLU_095255_0_0_6; -. DR OrthoDB; 9803631at2; -. DR PhylomeDB; P71342; -. DR BioCyc; HINF71421:G1GJ1-180-MONOMER; -. DR Proteomes; UP000000579; Chromosome. DR GO; GO:0009276; C:Gram-negative-bacterium-type cell wall; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule. DR GO; GO:0022904; P:respiratory electron transport chain; IEA:InterPro. DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule. DR HAMAP; MF_00429; NqrE; 1. DR InterPro; IPR003667; NqrDE/RnfAE. DR InterPro; IPR010967; NqrE. DR NCBIfam; TIGR01940; nqrE; 1. DR PANTHER; PTHR30335; INTEGRAL MEMBRANE PROTEIN OF SOXR-REDUCING COMPLEX; 1. DR PANTHER; PTHR30335:SF1; NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT E; 1. DR Pfam; PF02508; Rnf-Nqr; 1. DR PIRSF; PIRSF006102; NQR_DE; 1. PE 3: Inferred from homology; KW Cell inner membrane; Cell membrane; Ion transport; Membrane; NAD; KW Reference proteome; Sodium; Sodium transport; Translocase; Transmembrane; KW Transmembrane helix; Transport; Ubiquinone. FT CHAIN 1..198 FT /note="Na(+)-translocating NADH-quinone reductase subunit FT E" FT /id="PRO_0000214252" FT TRANSMEM 11..31 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00429" FT TRANSMEM 35..55 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00429" FT TRANSMEM 77..97 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00429" FT TRANSMEM 110..130 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00429" FT TRANSMEM 140..160 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00429" FT TRANSMEM 176..196 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00429" SQ SEQUENCE 198 AA; 21306 MW; 29C6544D4BF71BDE CRC64; MEHYISLFVK AVFIENMALS FFLGMCTFLA VSKKVSPAFG LGIAVTFVLG IAVPVNQLIY ANVLKENALI EGVDLSFLNF ITFIGVIAGL VQILEMVLDK FMPSLYNALG IFLPLIAVNC AIFGGVSFMV QRDYNFPESI VYGFGSGLGW MLAIVALAGL TEKMKYADIP AGLKGLGITF ISVGLMALGF MSFSGIQL //