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Protein

Na(+)-translocating NADH-quinone reductase subunit E

Gene

nqrE

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.UniRule annotation

Catalytic activityi

NADH + ubiquinone + n Na+(In) = NAD+ + ubiquinol + n Na+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

NAD, Sodium, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)-translocating NADH-quinone reductase subunit EUniRule annotation (EC:1.6.5.8UniRule annotation)
Short name:
Na(+)-NQR subunit EUniRule annotation
Short name:
Na(+)-translocating NQR subunit EUniRule annotation
Alternative name(s):
NQR complex subunit EUniRule annotation
NQR-1 subunit EUniRule annotation
Gene namesi
Name:nqrEUniRule annotation
Ordered Locus Names:HI_0170
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalUniRule annotationAdd BLAST21
Transmembranei35 – 55HelicalUniRule annotationAdd BLAST21
Transmembranei77 – 97HelicalUniRule annotationAdd BLAST21
Transmembranei110 – 130HelicalUniRule annotationAdd BLAST21
Transmembranei140 – 160HelicalUniRule annotationAdd BLAST21
Transmembranei176 – 196HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002142521 – 198Na(+)-translocating NADH-quinone reductase subunit EAdd BLAST198

Interactioni

Subunit structurei

Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0170.

Family & Domainsi

Sequence similaritiesi

Belongs to the NqrDE/RnfAE family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108IUB. Bacteria.
COG2209. LUCA.
KOiK00350.
OMAiYFLGMCS.
PhylomeDBiP71342.

Family and domain databases

HAMAPiMF_00429. NqrE. 1 hit.
InterProiIPR010967. NqrE.
IPR003667. Rnf-Nqr.
[Graphical view]
PANTHERiPTHR30335:SF1. PTHR30335:SF1. 1 hit.
PfamiPF02508. Rnf-Nqr. 1 hit.
[Graphical view]
PIRSFiPIRSF006102. NQR_DE. 1 hit.
TIGRFAMsiTIGR01940. nqrE. 1 hit.

Sequencei

Sequence statusi: Complete.

P71342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHYISLFVK AVFIENMALS FFLGMCTFLA VSKKVSPAFG LGIAVTFVLG
60 70 80 90 100
IAVPVNQLIY ANVLKENALI EGVDLSFLNF ITFIGVIAGL VQILEMVLDK
110 120 130 140 150
FMPSLYNALG IFLPLIAVNC AIFGGVSFMV QRDYNFPESI VYGFGSGLGW
160 170 180 190
MLAIVALAGL TEKMKYADIP AGLKGLGITF ISVGLMALGF MSFSGIQL
Length:198
Mass (Da):21,306
Last modified:February 1, 1997 - v1
Checksum:i29C6544D4BF71BDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21840.1.
RefSeqiNP_438338.1. NC_000907.1.
WP_010868950.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21840; AAC21840; HI_0170.
GeneIDi951077.
KEGGihin:HI0170.
PATRICi20188835. VBIHaeInf48452_0174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21840.1.
RefSeqiNP_438338.1. NC_000907.1.
WP_010868950.1. NC_000907.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0170.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21840; AAC21840; HI_0170.
GeneIDi951077.
KEGGihin:HI0170.
PATRICi20188835. VBIHaeInf48452_0174.

Phylogenomic databases

eggNOGiENOG4108IUB. Bacteria.
COG2209. LUCA.
KOiK00350.
OMAiYFLGMCS.
PhylomeDBiP71342.

Family and domain databases

HAMAPiMF_00429. NqrE. 1 hit.
InterProiIPR010967. NqrE.
IPR003667. Rnf-Nqr.
[Graphical view]
PANTHERiPTHR30335:SF1. PTHR30335:SF1. 1 hit.
PfamiPF02508. Rnf-Nqr. 1 hit.
[Graphical view]
PIRSFiPIRSF006102. NQR_DE. 1 hit.
TIGRFAMsiTIGR01940. nqrE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNQRE_HAEIN
AccessioniPrimary (citable) accession number: P71342
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.