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P71342

- NQRE_HAEIN

UniProt

P71342 - NQRE_HAEIN

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Protein

Na(+)-translocating NADH-quinone reductase subunit E

Gene

nqrE

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

Catalytic activityi

NADH + ubiquinone + Na+(In) = NAD+ + ubiquinol + Na+(Out).

GO - Molecular functioni

  1. oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. respiratory electron transport chain Source: InterPro
  2. sodium ion transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

NAD, Sodium, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)-translocating NADH-quinone reductase subunit E (EC:1.6.5.-)
Short name:
Na(+)-NQR subunit E
Short name:
Na(+)-translocating NQR subunit E
Alternative name(s):
NQR complex subunit E
NQR-1 subunit E
Gene namesi
Name:nqrE
Ordered Locus Names:HI_0170
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. Gram-negative-bacterium-type cell wall Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Na(+)-translocating NADH-quinone reductase subunit EPRO_0000214252Add
BLAST

Interactioni

Subunit structurei

Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.By similarity

Protein-protein interaction databases

STRINGi71421.HI0170.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the NqrDE/RnfAE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2209.
KOiK00350.
OMAiKIRYSNV.
OrthoDBiEOG6GBMG7.
PhylomeDBiP71342.

Family and domain databases

HAMAPiMF_00429. NqrE.
InterProiIPR003667. Elect_transpt_cplx_Rnf/Nqr.
IPR010967. NADH_UbQ_OxRdtase_suE.
[Graphical view]
PfamiPF02508. Rnf-Nqr. 1 hit.
[Graphical view]
PIRSFiPIRSF006102. NQR_DE. 1 hit.
TIGRFAMsiTIGR01940. nqrE. 1 hit.

Sequencei

Sequence statusi: Complete.

P71342-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEHYISLFVK AVFIENMALS FFLGMCTFLA VSKKVSPAFG LGIAVTFVLG
60 70 80 90 100
IAVPVNQLIY ANVLKENALI EGVDLSFLNF ITFIGVIAGL VQILEMVLDK
110 120 130 140 150
FMPSLYNALG IFLPLIAVNC AIFGGVSFMV QRDYNFPESI VYGFGSGLGW
160 170 180 190
MLAIVALAGL TEKMKYADIP AGLKGLGITF ISVGLMALGF MSFSGIQL
Length:198
Mass (Da):21,306
Last modified:February 1, 1997 - v1
Checksum:i29C6544D4BF71BDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21840.1.
RefSeqiNP_438338.1. NC_000907.1.
WP_010868950.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21840; AAC21840; HI_0170.
GeneIDi951077.
KEGGihin:HI0170.
PATRICi20188835. VBIHaeInf48452_0174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21840.1 .
RefSeqi NP_438338.1. NC_000907.1.
WP_010868950.1. NC_000907.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0170.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21840 ; AAC21840 ; HI_0170 .
GeneIDi 951077.
KEGGi hin:HI0170.
PATRICi 20188835. VBIHaeInf48452_0174.

Phylogenomic databases

eggNOGi COG2209.
KOi K00350.
OMAi KIRYSNV.
OrthoDBi EOG6GBMG7.
PhylomeDBi P71342.

Family and domain databases

HAMAPi MF_00429. NqrE.
InterProi IPR003667. Elect_transpt_cplx_Rnf/Nqr.
IPR010967. NADH_UbQ_OxRdtase_suE.
[Graphical view ]
Pfami PF02508. Rnf-Nqr. 1 hit.
[Graphical view ]
PIRSFi PIRSF006102. NQR_DE. 1 hit.
TIGRFAMsi TIGR01940. nqrE. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Existence of Na+-translocating NADH-quinone reductase in Haemophilus influenzae."
    Hayashi M., Nakayama Y., Unemoto T.
    FEBS Lett. 381:174-176(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS NQR SYSTEM.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiNQRE_HAEIN
AccessioniPrimary (citable) accession number: P71342
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3