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P71342

- NQRE_HAEIN

UniProt

P71342 - NQRE_HAEIN

Protein

Na(+)-translocating NADH-quinone reductase subunit E

Gene

nqrE

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

    Catalytic activityi

    NADH + ubiquinone + Na+(In) = NAD+ + ubiquinol + Na+(Out).

    GO - Molecular functioni

    1. oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. respiratory electron transport chain Source: InterPro
    2. sodium ion transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    NAD, Sodium, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Na(+)-translocating NADH-quinone reductase subunit E (EC:1.6.5.-)
    Short name:
    Na(+)-NQR subunit E
    Short name:
    Na(+)-translocating NQR subunit E
    Alternative name(s):
    NQR complex subunit E
    NQR-1 subunit E
    Gene namesi
    Name:nqrE
    Ordered Locus Names:HI_0170
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. Gram-negative-bacterium-type cell wall Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Na(+)-translocating NADH-quinone reductase subunit EPRO_0000214252Add
    BLAST

    Interactioni

    Subunit structurei

    Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI0170.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NqrDE/RnfAE family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2209.
    KOiK00350.
    OMAiKIRYSNV.
    OrthoDBiEOG6GBMG7.
    PhylomeDBiP71342.

    Family and domain databases

    HAMAPiMF_00429. NqrE.
    InterProiIPR003667. Elect_transpt_cplx_Rnf/Nqr.
    IPR010967. NADH_UbQ_OxRdtase_suE.
    [Graphical view]
    PfamiPF02508. Rnf-Nqr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006102. NQR_DE. 1 hit.
    TIGRFAMsiTIGR01940. nqrE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P71342-1 [UniParc]FASTAAdd to Basket

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    MEHYISLFVK AVFIENMALS FFLGMCTFLA VSKKVSPAFG LGIAVTFVLG    50
    IAVPVNQLIY ANVLKENALI EGVDLSFLNF ITFIGVIAGL VQILEMVLDK 100
    FMPSLYNALG IFLPLIAVNC AIFGGVSFMV QRDYNFPESI VYGFGSGLGW 150
    MLAIVALAGL TEKMKYADIP AGLKGLGITF ISVGLMALGF MSFSGIQL 198
    Length:198
    Mass (Da):21,306
    Last modified:February 1, 1997 - v1
    Checksum:i29C6544D4BF71BDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21840.1.
    RefSeqiNP_438338.1. NC_000907.1.
    WP_010868950.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21840; AAC21840; HI_0170.
    GeneIDi951077.
    KEGGihin:HI0170.
    PATRICi20188835. VBIHaeInf48452_0174.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21840.1 .
    RefSeqi NP_438338.1. NC_000907.1.
    WP_010868950.1. NC_000907.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0170.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21840 ; AAC21840 ; HI_0170 .
    GeneIDi 951077.
    KEGGi hin:HI0170.
    PATRICi 20188835. VBIHaeInf48452_0174.

    Phylogenomic databases

    eggNOGi COG2209.
    KOi K00350.
    OMAi KIRYSNV.
    OrthoDBi EOG6GBMG7.
    PhylomeDBi P71342.

    Family and domain databases

    HAMAPi MF_00429. NqrE.
    InterProi IPR003667. Elect_transpt_cplx_Rnf/Nqr.
    IPR010967. NADH_UbQ_OxRdtase_suE.
    [Graphical view ]
    Pfami PF02508. Rnf-Nqr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006102. NQR_DE. 1 hit.
    TIGRFAMsi TIGR01940. nqrE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. "Existence of Na+-translocating NADH-quinone reductase in Haemophilus influenzae."
      Hayashi M., Nakayama Y., Unemoto T.
      FEBS Lett. 381:174-176(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION AS NQR SYSTEM.
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiNQRE_HAEIN
    AccessioniPrimary (citable) accession number: P71342
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3