Putative metalloprotease HI0004 - Haemophilus influenzae

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Reviewed, UniProtKB/Swiss-Prot P71335 (Y004_HAEIN)

Last modified November 3, 2009. Version 65. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Putative metalloprotease HI0004
EC=3.4.24.-

Gene names

Ordered Locus Names:

HI0004

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

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Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May have metalloprotease activity Potential.
Cofactor	Binds 1 zinc ion. HAMAP MF_00009
Sequence similarities	Belongs to the UPF0054 family.

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Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Molecular function	metallopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 154

154

Putative metalloprotease HI0004 HAMAP MF_00009

PRO_0000102463

Sites

Metal binding

114

Zinc; catalytic By similarity

Metal binding

118

Zinc; catalytic By similarity

Metal binding

124

Zinc; catalytic By similarity

Secondary structure

154

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P71335-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: C066F7AB7F9CA7AD
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FASTA

154

17,355

        10         20         30         40         50         60 
MGSVLVDLQI ATENIEGLPT EEQIVQWATG AVQPEGNEVE MTVRIVDEAE SHELNLTYRG 

        70         80         90        100        110        120 
KDRPTNVLSF PFECPDEVEL PLLGDLVICR QVVEREASEQ EKPLMAHWAH MVVHGSLHLL 

       130        140        150 
GYDHIEDDEA EEMESLETQI MQGLGFDDPY LAEK

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"NMR structure of HI0004, a putative essential gene product from Haemophilus influenzae, and comparison with the X-ray structure of an Aquifex aeolicus homolog." Yeh D.C., Parsons L.M., Parsons J.F., Liu F., Eisenstein E., Orban J. Protein Sci. 14:424-430(2005) [PubMed: 15632286] [Abstract] Cited for: STRUCTURE BY NMR, FUNCTION, ZINC BINDING.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

L42023 Genomic DNA. Translation: AAC21683.1.

PIR

A64140.

RefSeq

NP_438177.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XAX	NMR	-	A	1-154	[»]

ModBase

Search...

Genome annotation databases

GeneID

950900.

GenomeReviews

Gene locus HI0004 in contig L42023_GR.

KEGG

hin:HI0004.

NMPDR

fig|71421.1.peg.4.

TIGR

HI0004.

Phylogenomic databases

HOGENOM

P71335.

OMA

FTDPYKE.

Enzyme and pathway databases

BioCyc

HINF71421:HI_0004-MON.

Family and domain databases

HAMAP

MF_00009.
[Tree]

InterPro

IPR002036. UPF0054.
IPR020549. UPF0054_CS.
[Graphical view]

Pfam

PF02130. UPF0054. 1 hit.
[Graphical view]

ProDom

PD005688. UPF0054. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR00043. UPF0054. 1 hit.

PROSITE

PS01306. UPF0054. 1 hit.
[Graphical view]

ProtoNet

Search...

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Entry information

Entry name

Y004_HAEIN

Accession

Primary (citable) accession number: P71335

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 3, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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