P71317 (STHA_PECCC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Soluble pyridine nucleotide transhydrogenase
Short name=STH
EC=1.6.1.1

Alternative name(s):
NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Synonyms:	udhA

Organism

Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora)

Taxonomic identifier

555 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length	150 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity. HAMAP MF_00247
Catalytic activity	NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247
Cofactor	Binds 1 FAD per subunit By similarity. HAMAP MF_00247
Subcellular location	Cytoplasm By similarity HAMAP MF_00247.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 150	›150	Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247		PRO_0000068064
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P71317 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 90E962952FB2C2A1	FASTA	150	16,451
	10 20 30 40 50 60 SLASAAYDQG RLAAQAIIKG DASAHLIEDI PTGIYTIPEI SSVGKTEQEL TAMKVPYEVG 70 80 90 100 110 120 RAQFKHLARA QIVGMNVGSL KILFHRETKQ ILGIHCFGER AAEIIHIGQA IMEQKGEGNT 130 140 150 IEYFVNTTFN YPTMAEAYRV AALNGLNRLF

References

[1]	"The oxyR gene from Erwinia carotovora: cloning, sequence analysis and expression in Escherichia coli." Calcutt M.J., Lewis M.S., Eisenstark A. FEMS Microbiol. Lett. 167:295-301(1998) [PubMed: 9809430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 71.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U74302 Genomic DNA. Translation: AAC72240.1.
3D structure databases
ProteinModelPortal	P71317.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00247. SthA. [Tree]
InterPro	IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
Pfam	PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
SUPFAM	SSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
ProtoNet	Search...

Entry information

Entry name

STHA_PECCC

Accession

Primary (citable) accession number: P71317

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	February 1, 1997
Last modified:	September 21, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program