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Protein

HTH-type transcriptional regulator EcpR

Gene

ecpR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Positively regulates the expression of the ecp operon (By similarity). Also represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon (Probable).By similarityCurated1 Publication

Miscellaneous

Expressed in strain K12.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi162 – 181H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G6165-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator EcpR
Gene namesi
Name:ecpR
Synonyms:matA, ykgK
Ordered Locus Names:b0294, JW5031
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14324 ecpR

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi179H → P: Slightly increases motility. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001841991 – 196HTH-type transcriptional regulator EcpRAdd BLAST196

Proteomic databases

PaxDbiP71301
PRIDEiP71301

Expressioni

Inductioni

Negatively regulated by H-NS. Positively autoregulated. Also positively regulated by IHF (By similarity).By similarity

Interactioni

Protein-protein interaction databases

BioGridi4259793, 6 interactors
IntActiP71301, 1 interactor
STRINGi316385.ECDH10B_0282

Structurei

3D structure databases

ProteinModelPortaliP71301
SMRiP71301
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 196HTH luxR-typePROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Belongs to the EcpR/MatA family.Curated

Phylogenomic databases

eggNOGiENOG4106JB4 Bacteria
ENOG410Y9ZI LUCA
HOGENOMiHOG000059412
KOiK21963
OMAiCIWPAHD

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR000792 Tscrpt_reg_LuxR_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00196 GerE, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
PROSITEiView protein in PROSITE
PS50043 HTH_LUXR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P71301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWQSDYSRD YEVKNHMECQ NRSDKYIWSP HDAYFYKGLS ELIVDIDRLI
60 70 80 90 100
YLSLEKIRKD FVFINLSTDS LSEFINRDNE WLSAVKGKQV VLIAARKSEA
110 120 130 140 150
LANYWYYNSN IRGVVYAGLS RDIRKELVYV INGRFLRKDI KKDKITDREM
160 170 180 190
EIIRMTAQGM QPKSIARIEN CSVKTVYTHR RNAEAKLYSK IYKLVQ
Length:196
Mass (Da):23,274
Last modified:February 1, 1997 - v1
Checksum:i5A3676E17E9793B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA Translation: AAB18023.1
U00096 Genomic DNA Translation: AAC73397.1
AP009048 Genomic DNA Translation: BAE76078.1
PIRiF64755
RefSeqiNP_414828.1, NC_000913.3
WP_000220247.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73397; AAC73397; b0294
BAE76078; BAE76078; BAE76078
GeneIDi944966
KEGGiecj:JW5031
eco:b0294
PATRICifig|511145.12.peg.298

Similar proteinsi

Entry informationi

Entry nameiECPR_ECOLI
AccessioniPrimary (citable) accession number: P71301
Secondary accession number(s): Q2MCC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health