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Protein

Prophage integrase IntF

Gene

intF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei432O-(3'-phospho-DNA)-tyrosine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Enzyme and pathway databases

BioCyciEcoCyc:G6152-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Prophage integrase IntFCurated
Alternative name(s):
Putative prophage CP4-6 integrase
Gene namesi
Name:intF
Synonyms:yagO
Ordered Locus Names:b0281, JW0275
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13554 intF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975151 – 466Prophage integrase IntFAdd BLAST466

Proteomic databases

PaxDbiP71298
PRIDEiP71298

Interactioni

Protein-protein interaction databases

BioGridi425978413 interactors.
IntActiP71298 1 interactor.
STRINGi316385.ECDH10B_0269

Structurei

3D structure databases

ProteinModelPortaliP71298
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

eggNOGiENOG41067CV Bacteria
COG0582 LUCA
HOGENOMiHOG000258764
InParanoidiP71298
OMAiDFRWRSL

Family and domain databases

Gene3Di1.10.150.1301 hit
1.10.443.101 hit
3.30.160.3901 hit
InterProiView protein in InterPro
IPR011010 DNA_brk_join_enz
IPR013762 Integrase-like_cat_sf
IPR002104 Integrase_catalytic
IPR038488 Integrase_DNA-bd_sf
IPR025166 Integrase_DNA_bind_dom
IPR010998 Integrase_recombinase_N
PfamiView protein in Pfam
PF13356 Arm-DNA-bind_3, 1 hit
PF00589 Phage_integrase, 1 hit
SUPFAMiSSF56349 SSF56349, 1 hit

Sequencei

Sequence statusi: Complete.

P71298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIPSIYLHQ QLHYCKTAIL NWSRKMALSR QKFTFERLRR FTLPEGKKQT
60 70 80 90 100
FLWDADVTTL ACRATSGAKA FVFQSVYAGK TLRMTIGNIN DWKIDDARAE
110 120 130 140 150
ARRLQTLIDT GIDPRIAKAV KIAEAESLQA ESRKTKVTFS VAWEDYLQEL
160 170 180 190 200
RTGISAKTKR PYSTRYIADH INLSSRGGES KKRGQGPTSA GPLASLLNLP
210 220 230 240 250
LSELTPDYIA AWLSTERQNR PTVTAHAYRL LRAFIKWSNY QKKYQGIIPG
260 270 280 290 300
DLAQDYNVRK MVPVSASKAD DCLQKEQLKS WFSAVRSLNN PIASAYLQVL
310 320 330 340 350
LLTGARREEI ASLRWSDVDF KWSSMRIKDK IEGERIIPLT PYVSELLNVL
360 370 380 390 400
AQSPNSDVNK EGWVFRSNSK SGKIIEPRSA HNRALVLAEL PHISLHGLRR
410 420 430 440 450
SFGTLAEWVE VPTGIVAQIM GHKPSALAEK HYRRRPLDLL RKWHEKIETW
460
ILNEAGITIK NNVDMR
Length:466
Mass (Da):53,074
Last modified:February 1, 1997 - v1
Checksum:i4876E3F1898CE465
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA Translation: AAB18010.1
U00096 Genomic DNA Translation: AAC73384.1
AP009048 Genomic DNA Translation: BAE76065.1
PIRiA64754
RefSeqiNP_414815.1, NC_000913.3
WP_001407714.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73384; AAC73384; b0281
BAE76065; BAE76065; BAE76065
GeneIDi947351
KEGGiecj:JW0275
eco:b0281
PATRICifig|511145.12.peg.285

Similar proteinsi

Entry informationi

Entry nameiINTF_ECOLI
AccessioniPrimary (citable) accession number: P71298
Secondary accession number(s): Q2MCE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome