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Protein

Colanic acid biosynthesis protein WcaK

Gene

wcaK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Pathwayi: slime polysaccharide biosynthesis

This protein is involved in the pathway slime polysaccharide biosynthesis, which is part of Slime biogenesis.
View all proteins of this organism that are known to be involved in the pathway slime polysaccharide biosynthesis and in Slime biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:G7096-MONOMER.
ECOL316407:JW2030-MONOMER.
UniPathwayiUPA00936.

Names & Taxonomyi

Protein namesi
Recommended name:
Colanic acid biosynthesis protein WcaK (EC:2.-.-.-)
Gene namesi
Name:wcaK
Ordered Locus Names:b2045, JW2030
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13577. wcaK.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Colanic acid biosynthesis protein WcaKPRO_0000073216Add
BLAST

Proteomic databases

PaxDbiP71242.
PRIDEiP71242.

Interactioni

Protein-protein interaction databases

BioGridi4261185. 157 interactions.
IntActiP71242. 21 interactions.
STRINGi511145.b2045.

Structurei

3D structure databases

ProteinModelPortaliP71242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C74. Bacteria.
COG2327. LUCA.
HOGENOMiHOG000121954.
InParanoidiP71242.
KOiK16710.
OMAiIMQQLGM.

Family and domain databases

InterProiIPR023918. Colanic_acid_synth_WcaK.
IPR007345. Polysacch_pyruvyl_Trfase.
[Graphical view]
PfamiPF04230. PS_pyruv_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04006. wcaK. 1 hit.

Sequencei

Sequence statusi: Complete.

P71242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLILGNHT CGNRGDSAIL RGLLDAINIL NPHAEVDVMS RYPVSSSWLL
60 70 80 90 100
NRPVMGDPLF LQMKQHNSAA GVVGRVKKVL RRRYQHQVLL SRVTDTGKLR
110 120 130 140 150
NIAIAQGFTD FVRLLSGYDA IIQVGGSFFV DLYGVPQFEH ALCTFMAKKP
160 170 180 190 200
LFMIGHSVGP FQDEQFNQLA NYVFGHCDAL ILRESVSFDL MKRSNITTAK
210 220 230 240 250
VEHGVDTAWL VDHHTEDFTA SYAVQHWLDV AAQQKTVAIT LRELAPFDKR
260 270 280 290 300
LGTTQQAYEK AFAGVVNRIL DEGYQVIALS TCTGIDSYNK DDRMVALNLR
310 320 330 340 350
QHISDPARYH VVMDELNDLE MGKILGACEL TVGTRLHSAI ISMNFATPAI
360 370 380 390 400
AINYEHKSAG IMQQLGLPEM AIDIRHLLDG SLQAMVADTL GQLPALNARL
410 420
SEAVSRERQT GMQMVQSVLE RIGEVK
Length:426
Mass (Da):47,344
Last modified:November 1, 1997 - v2
Checksum:iF0B7D87A9A3E594C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771K → I in AAC77850 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA. Translation: AAC77850.1.
U00096 Genomic DNA. Translation: AAC75106.1.
AP009048 Genomic DNA. Translation: BAE76571.1.
PIRiD64970.
RefSeqiNP_416549.1. NC_000913.3.
WP_000770780.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75106; AAC75106; b2045.
BAE76571; BAE76571; BAE76571.
GeneIDi946569.
KEGGiecj:JW2030.
eco:b2045.
PATRICi32119423. VBIEscCol129921_2122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA. Translation: AAC77850.1.
U00096 Genomic DNA. Translation: AAC75106.1.
AP009048 Genomic DNA. Translation: BAE76571.1.
PIRiD64970.
RefSeqiNP_416549.1. NC_000913.3.
WP_000770780.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP71242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261185. 157 interactions.
IntActiP71242. 21 interactions.
STRINGi511145.b2045.

Proteomic databases

PaxDbiP71242.
PRIDEiP71242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75106; AAC75106; b2045.
BAE76571; BAE76571; BAE76571.
GeneIDi946569.
KEGGiecj:JW2030.
eco:b2045.
PATRICi32119423. VBIEscCol129921_2122.

Organism-specific databases

EchoBASEiEB3347.
EcoGeneiEG13577. wcaK.

Phylogenomic databases

eggNOGiENOG4105C74. Bacteria.
COG2327. LUCA.
HOGENOMiHOG000121954.
InParanoidiP71242.
KOiK16710.
OMAiIMQQLGM.

Enzyme and pathway databases

UniPathwayiUPA00936.
BioCyciEcoCyc:G7096-MONOMER.
ECOL316407:JW2030-MONOMER.

Miscellaneous databases

PROiP71242.

Family and domain databases

InterProiIPR023918. Colanic_acid_synth_WcaK.
IPR007345. Polysacch_pyruvyl_Trfase.
[Graphical view]
PfamiPF04230. PS_pyruv_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04006. wcaK. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWCAK_ECOLI
AccessioniPrimary (citable) accession number: P71242
Secondary accession number(s): P76380, Q2MAY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.