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Protein

Putative colanic acid polymerase

Gene

wcaD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Pathwayi: slime polysaccharide biosynthesis

This protein is involved in the pathway slime polysaccharide biosynthesis, which is part of Slime biogenesis.
View all proteins of this organism that are known to be involved in the pathway slime polysaccharide biosynthesis and in Slime biogenesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:G7101-MONOMER.
ECOL316407:JW2041-MONOMER.
UniPathwayiUPA00936.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative colanic acid polymerase
Gene namesi
Name:wcaD
Ordered Locus Names:b2056, JW2041
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13572. wcaD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659551 – 405Putative colanic acid polymeraseAdd BLAST405

Proteomic databases

PaxDbiP71238.
PRIDEiP71238.

Interactioni

Protein-protein interaction databases

BioGridi4259688. 156 interactors.
DIPiDIP-11120N.
IntActiP71238. 1 interactor.
MINTiMINT-1239365.
STRINGi511145.b2056.

Structurei

3D structure databases

ProteinModelPortaliP71238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108NYJ. Bacteria.
ENOG410ZIK0. LUCA.
HOGENOMiHOG000267975.
KOiK13620.
OMAiWRSMSTS.

Family and domain databases

InterProiIPR024013. Colanic_acid_synth_WcaD.
[Graphical view]
TIGRFAMsiTIGR04010. WcaD. 1 hit.

Sequencei

Sequence statusi: Complete.

P71238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSIRICSY LLLPLIYLLV NVKIAQLGES FPITIVTFLP VLLLLFLERI
60 70 80 90 100
SVKKLMIALG IGAGLTAFNY LFGQSLDASK YVTSTMLFVY IVIIIGMVWS
110 120 130 140 150
IRFKTISPHN HRKILRFFYL VVGLVVALAA VEMAQIILTG GSSIMESISK
160 170 180 190 200
YLIYSNSYVL NFIKFGGKRT TALYFEPAFF ALALISIWLS IKQFGIKTPK
210 220 230 240 250
TDAMILAGII LSGSFSGVMT FILFYLLEWA FQYLNKEAIK KKLPLALISL
260 270 280 290 300
AVFLVGVVIA FPYISTRLGD LGTEGSSSYY RIVGPLVMVG YSLTHIDGVV
310 320 330 340 350
RFGSLYEYVA SFGIFNGADV GKTIDNGLYL LIIYFSWFAV FLSLWYMGKV
360 370 380 390 400
IKMMINAFGD NRNFRVQLYL FTPVSLFFTG SIFSPEYAFL IVCPFILRKA

LNITR
Length:405
Mass (Da):45,409
Last modified:November 1, 1997 - v2
Checksum:iA3D9D91255686043
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108P → A in AAC77839 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA. Translation: AAC77839.1.
U00096 Genomic DNA. Translation: AAC75117.1.
AP009048 Genomic DNA. Translation: BAE76573.1.
PIRiG64971.
RefSeqiNP_416560.1. NC_000913.3.
WP_000107816.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75117; AAC75117; b2056.
BAE76573; BAE76573; BAE76573.
GeneIDi946550.
KEGGiecj:JW2041.
eco:b2056.
PATRICi32119445. VBIEscCol129921_2133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA. Translation: AAC77839.1.
U00096 Genomic DNA. Translation: AAC75117.1.
AP009048 Genomic DNA. Translation: BAE76573.1.
PIRiG64971.
RefSeqiNP_416560.1. NC_000913.3.
WP_000107816.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP71238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259688. 156 interactors.
DIPiDIP-11120N.
IntActiP71238. 1 interactor.
MINTiMINT-1239365.
STRINGi511145.b2056.

Proteomic databases

PaxDbiP71238.
PRIDEiP71238.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75117; AAC75117; b2056.
BAE76573; BAE76573; BAE76573.
GeneIDi946550.
KEGGiecj:JW2041.
eco:b2056.
PATRICi32119445. VBIEscCol129921_2133.

Organism-specific databases

EchoBASEiEB3342.
EcoGeneiEG13572. wcaD.

Phylogenomic databases

eggNOGiENOG4108NYJ. Bacteria.
ENOG410ZIK0. LUCA.
HOGENOMiHOG000267975.
KOiK13620.
OMAiWRSMSTS.

Enzyme and pathway databases

UniPathwayiUPA00936.
BioCyciEcoCyc:G7101-MONOMER.
ECOL316407:JW2041-MONOMER.

Miscellaneous databases

PROiP71238.

Family and domain databases

InterProiIPR024013. Colanic_acid_synth_WcaD.
[Graphical view]
TIGRFAMsiTIGR04010. WcaD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWCAD_ECOLI
AccessioniPrimary (citable) accession number: P71238
Secondary accession number(s): P76385, Q2MAY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.