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Protein

Heme oxygenase

Gene

hmuO

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Allows the bacteria to use the host heme as an iron source. Involved in the oxidation of heme and subsequent release of iron from the heme moiety.

Catalytic activityi

Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi20Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.99.3. 1645.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase (EC:1.14.14.18By similarity)
Gene namesi
Name:hmuO
Ordered Locus Names:DIP1669
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000002198 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097031 – 215Heme oxygenaseAdd BLAST215

Interactioni

Protein-protein interaction databases

DIPiDIP-61184N.

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 24Combined sources17
Helixi27 – 33Combined sources7
Helixi39 – 66Combined sources28
Turni70 – 72Combined sources3
Helixi75 – 77Combined sources3
Helixi80 – 91Combined sources12
Beta strandi92 – 94Combined sources3
Helixi96 – 99Combined sources4
Helixi104 – 119Combined sources16
Helixi122 – 151Combined sources30
Helixi155 – 157Combined sources3
Helixi159 – 162Combined sources4
Helixi169 – 182Combined sources14
Helixi187 – 212Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IW0X-ray1.40A/B/C1-215[»]
1IW1X-ray1.50A/B/C1-215[»]
1V8XX-ray1.85A/B/C1-215[»]
1WNVX-ray1.85A/B/C1-215[»]
1WNWX-ray1.70A/B/C1-215[»]
1WNXX-ray1.85A/B1-215[»]
1WZDX-ray1.35A/B1-215[»]
1WZFX-ray1.85A/B1-215[»]
1WZGX-ray1.75A/B1-215[»]
ProteinModelPortaliP71119.
SMRiP71119.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP71119.

Family & Domainsi

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Phylogenomic databases

HOGENOMiHOG000233221.
KOiK00510.
OMAiEHPVIKP.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P71119-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTATAGLAV ELKQSTAQAH EKAEHSTFMS DLLEGRLGVA EFTRLQEQAW
60 70 80 90 100
LFYTALEQAA DAVRASGFAE SLLDPALNRA EVLARDLDKL NDGSEWRSRI
110 120 130 140 150
TASPAVIDYV NRLEEIRDNV DGPALVAHHY VRYLGDLSGG QVIARMMQRH
160 170 180 190 200
YGVDPEALGF YHFEGIAKLK VYKDEYREKL NNLELSDEQR ENLLKEATDA
210
FVFNHQVFAD LGKGL
Length:215
Mass (Da):24,116
Last modified:November 28, 2003 - v2
Checksum:i60D9E8E2ED7ED456
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34E → K in AAC44832 (PubMed:9006041).Curated1
Sequence conflicti60A → V in AAC44832 (PubMed:9006041).Curated1
Sequence conflicti92 – 93DG → GS in AAC44832 (PubMed:9006041).Curated2
Sequence conflicti192N → H in AAC44832 (PubMed:9006041).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73860 Genomic DNA. Translation: AAC44832.1.
BX248358 Genomic DNA. Translation: CAE50198.1.
RefSeqiWP_010935240.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50198; CAE50198; DIP1669.
GeneIDi2648714.
KEGGicdi:DIP1669.
PATRICi21484548. VBICorDip47633_1650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73860 Genomic DNA. Translation: AAC44832.1.
BX248358 Genomic DNA. Translation: CAE50198.1.
RefSeqiWP_010935240.1. NC_002935.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IW0X-ray1.40A/B/C1-215[»]
1IW1X-ray1.50A/B/C1-215[»]
1V8XX-ray1.85A/B/C1-215[»]
1WNVX-ray1.85A/B/C1-215[»]
1WNWX-ray1.70A/B/C1-215[»]
1WNXX-ray1.85A/B1-215[»]
1WZDX-ray1.35A/B1-215[»]
1WZFX-ray1.85A/B1-215[»]
1WZGX-ray1.75A/B1-215[»]
ProteinModelPortaliP71119.
SMRiP71119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61184N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE50198; CAE50198; DIP1669.
GeneIDi2648714.
KEGGicdi:DIP1669.
PATRICi21484548. VBICorDip47633_1650.

Phylogenomic databases

HOGENOMiHOG000233221.
KOiK00510.
OMAiEHPVIKP.

Enzyme and pathway databases

BRENDAi1.14.99.3. 1645.

Miscellaneous databases

EvolutionaryTraceiP71119.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMUO_CORDI
AccessioniPrimary (citable) accession number: P71119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 28, 2003
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.