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P71119

- HMUO_CORDI

UniProt

P71119 - HMUO_CORDI

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Protein

Heme oxygenase

Gene
hmuO, DIP1669
Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Allows the bacteria to use the host heme as an iron source. Involved in the oxidation of heme and subsequent release of iron from the heme moiety.

Catalytic activityi

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme oxidation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase (EC:1.14.99.3)
Gene namesi
Name:hmuO
Ordered Locus Names:DIP1669
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Heme oxygenasePRO_0000209703Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257309.DIP1669.

Structurei

Secondary structure

1
215
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 2417
Helixi27 – 337
Helixi39 – 6628
Turni70 – 723
Helixi75 – 773
Helixi80 – 9112
Beta strandi92 – 943
Helixi96 – 994
Helixi104 – 11916
Helixi122 – 15130
Helixi155 – 1573
Helixi159 – 1624
Helixi169 – 18214
Helixi187 – 21226

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IW0X-ray1.40A/B/C1-215[»]
1IW1X-ray1.50A/B/C1-215[»]
1V8XX-ray1.85A/B/C1-215[»]
1WNVX-ray1.85A/B/C1-215[»]
1WNWX-ray1.70A/B/C1-215[»]
1WNXX-ray1.85A/B1-215[»]
1WZDX-ray1.35A/B1-215[»]
1WZFX-ray1.85A/B1-215[»]
1WZGX-ray1.75A/B1-215[»]
ProteinModelPortaliP71119.
SMRiP71119. Positions 2-213.

Miscellaneous databases

EvolutionaryTraceiP71119.

Family & Domainsi

Sequence similaritiesi

Belongs to the heme oxygenase family.

Phylogenomic databases

eggNOGiCOG5398.
HOGENOMiHOG000233221.
KOiK00510.
OMAiEISAHEP.
OrthoDBiEOG69PQ2G.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P71119-1 [UniParc]FASTAAdd to Basket

« Hide

MTTATAGLAV ELKQSTAQAH EKAEHSTFMS DLLEGRLGVA EFTRLQEQAW    50
LFYTALEQAA DAVRASGFAE SLLDPALNRA EVLARDLDKL NDGSEWRSRI 100
TASPAVIDYV NRLEEIRDNV DGPALVAHHY VRYLGDLSGG QVIARMMQRH 150
YGVDPEALGF YHFEGIAKLK VYKDEYREKL NNLELSDEQR ENLLKEATDA 200
FVFNHQVFAD LGKGL 215
Length:215
Mass (Da):24,116
Last modified:November 28, 2003 - v2
Checksum:i60D9E8E2ED7ED456
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341E → K in AAC44832. 1 Publication
Sequence conflicti60 – 601A → V in AAC44832. 1 Publication
Sequence conflicti92 – 932DG → GS in AAC44832. 1 Publication
Sequence conflicti192 – 1921N → H in AAC44832. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73860 Genomic DNA. Translation: AAC44832.1.
BX248358 Genomic DNA. Translation: CAE50198.1.
RefSeqiNP_940009.1. NC_002935.2.
WP_010935240.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50198; CAE50198; DIP1669.
GeneIDi2648714.
KEGGicdi:DIP1669.
PATRICi21484548. VBICorDip47633_1650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73860 Genomic DNA. Translation: AAC44832.1 .
BX248358 Genomic DNA. Translation: CAE50198.1 .
RefSeqi NP_940009.1. NC_002935.2.
WP_010935240.1. NC_002935.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IW0 X-ray 1.40 A/B/C 1-215 [» ]
1IW1 X-ray 1.50 A/B/C 1-215 [» ]
1V8X X-ray 1.85 A/B/C 1-215 [» ]
1WNV X-ray 1.85 A/B/C 1-215 [» ]
1WNW X-ray 1.70 A/B/C 1-215 [» ]
1WNX X-ray 1.85 A/B 1-215 [» ]
1WZD X-ray 1.35 A/B 1-215 [» ]
1WZF X-ray 1.85 A/B 1-215 [» ]
1WZG X-ray 1.75 A/B 1-215 [» ]
ProteinModelPortali P71119.
SMRi P71119. Positions 2-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257309.DIP1669.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE50198 ; CAE50198 ; DIP1669 .
GeneIDi 2648714.
KEGGi cdi:DIP1669.
PATRICi 21484548. VBICorDip47633_1650.

Phylogenomic databases

eggNOGi COG5398.
HOGENOMi HOG000233221.
KOi K00510.
OMAi EISAHEP.
OrthoDBi EOG69PQ2G.

Miscellaneous databases

EvolutionaryTracei P71119.

Family and domain databases

Gene3Di 1.20.910.10. 1 hit.
InterProi IPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view ]
PANTHERi PTHR10720. PTHR10720. 1 hit.
Pfami PF01126. Heme_oxygenase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000343. Haem_Oase. 1 hit.
PRINTSi PR00088. HAEMOXYGNASE.
SUPFAMi SSF48613. SSF48613. 1 hit.
PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Utilization of host iron sources by Corynebacterium diphtheriae: identification of a gene whose product is homologous to eukaryotic heme oxygenases and is required for acquisition of iron from heme and hemoglobin."
    Schmitt M.P.
    J. Bacteriol. 179:838-845(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C7.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiHMUO_CORDI
AccessioniPrimary (citable) accession number: P71119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 28, 2003
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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