Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Major cardiolipin synthase ClsA

Gene

clsA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation1 Publication

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei222UniRule annotation1
Active sitei224UniRule annotation1
Active sitei229UniRule annotation1
Active sitei400UniRule annotation1
Active sitei402UniRule annotation1
Active sitei407UniRule annotation1

GO - Molecular functioni

  • cardiolipin synthase activity Source: UniProtKB

GO - Biological processi

  • cardiolipin biosynthetic process Source: UniProtKB
  • sporulation Source: UniProtKB
  • transmembrane transport Source: InterPro

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciBSUB:BSU36590-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Major cardiolipin synthase ClsA (EC:2.7.8.-UniRule annotation)
Short name:
CL synthase 2UniRule annotation
Gene namesi
Name:clsA
Synonyms:ywnE
Ordered Locus Names:BSU36590
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei34 – 54HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene show a lack of cardiolipin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012481 – 482Major cardiolipin synthase ClsAAdd BLAST482

Proteomic databases

PaxDbiP71040
PRIDEiP71040

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100019781

Structurei

3D structure databases

ProteinModelPortaliP71040
SMRiP71040
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 244PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini395 – 422PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX Bacteria
COG1502 LUCA
HOGENOMiHOG000077402
InParanoidiP71040
KOiK06131
OMAiGGHNVGD
PhylomeDBiP71040

Family and domain databases

CDDicd06261 TM_PBP2, 1 hit
HAMAPiMF_01916 Cardiolipin_synth_Cls, 1 hit
InterProiView protein in InterPro
IPR030874 Cardiolipin_synth_Firmi
IPR022924 Cardiolipin_synthase
IPR027379 CLS_N
IPR000515 MetI-like
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

P71040-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISSILLSL FFILNILLAI IVIFKERRDA SASWAWLLVL FFIPVLGFIL
60 70 80 90 100
YLLFGHNLRR KHLFQWEDRK KIGIERLLKH QLEDLETKQF QFNNRATFDN
110 120 130 140 150
KDLIYMLIMN NHAVFTEDNS VDVITDGRDK FQRLLSDISK AKDHIHLQYY
160 170 180 190 200
IYKGDELGKK LRDALIQKAK EGVQVRVLYD ELGSRTLRKK FFKELREAGG
210 220 230 240 250
HVEVFFPSKL RPINLRLNYR NHRKLVIIDG MTGYVGGFNV GDEYLGLNPK
260 270 280 290 300
FGYWRDTHIR LQGTAVHAIQ TRFILDWNQA SHHHTLTYIP NHFPDYGPKG
310 320 330 340 350
NVGMQIVTSG PDSEWEQIKN GYIKMISNAK RSILIQTPYF IPDASLLDAL
360 370 380 390 400
RIACLSGIDV NIMIPNKPDH AFVYWATLSY IGDLLKAGAT VYIYDNGFIH
410 420 430 440 450
AKTIVVDDEI ASVGTANIDV RSFRLNFEVN AFIYDITIAK KLVSTFKEDL
460 470 480
LVSRKFTYEE YLQRPLWIRI KESVSRLLSP IL
Length:482
Mass (Da):55,866
Last modified:July 1, 1997 - v2
Checksum:i8231FC35DB3CAC63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08559 Genomic DNA Translation: CAA69864.1
AL009126 Genomic DNA Translation: CAB15676.1
PIRiG70063
RefSeqiNP_391540.1, NC_000964.3
WP_003243311.1, NZ_JNCM01000034.1

Genome annotation databases

EnsemblBacteriaiCAB15676; CAB15676; BSU36590
GeneIDi936957
KEGGibsu:BSU36590
PATRICifig|224308.179.peg.3960

Similar proteinsi

Entry informationi

Entry nameiCLSA_BACSU
AccessioniPrimary (citable) accession number: P71040
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health