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P71019 (FABD_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malonyl CoA-acyl carrier protein transacylase

Short name=MCT
EC=2.3.1.39
Gene names
Name:fabD
Synonyms:ylpE
Ordered Locus Names:BSU15900
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Sequence similarities

Belongs to the FabD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Malonyl CoA-acyl carrier protein transacylase
PRO_0000194210

Sites

Active site911 By similarity
Active site2011 By similarity

Experimental info

Sequence conflict124 – 1318VPAGEGAM → GCRLAKEQW Ref.1

Sequences

Sequence LengthMass (Da)Tools
P71019 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 191AE828B1C91D7F

FASTA31734,035
        10         20         30         40         50         60 
MSKIAFLFPG QGSQFIGMGK ELYEQVPAAK RLFDEADETL ETKLSSLIFE GDAEELTLTY 

        70         80         90        100        110        120 
NAQPALLTTS IAVLEKFKES GITPDFTAGH SLGEYSALVA AGALSFKDAV YTVRKRGEFM 

       130        140        150        160        170        180 
NEAVPAGEGA MAAILGMDAE ALKQVTDKVT EEGNLVQLAN LNCPGQIVIS GTAKGVELAS 

       190        200        210        220        230        240 
ELAKENGAKR AIPLEVSGPF HSELMKPAAE KLKEVLDACD IKDADVPVIS NVSADVMTEK 

       250        260        270        280        290        300 
ADIKEKLIEQ LYSPVRFEES INKLIAEGVT TFIEIGPGKV LSGLVKKVNR RLKTIAVSDP 

       310 
ETIELAIQTL KEENDNA 

« Hide

References

« Hide 'large scale' references
[1]"Bacillus subtilis acyl carrier protein is encoded in a cluster of lipid biosynthesis genes."
Morbidoni H.R., de Mendoza D., Cronan J.E. Jr.
J. Bacteriol. 178:4794-4800(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"A 28 kbp segment from the spoVM region of the Bacillus subtilis 168 genome."
Foulger D., Errington J.
Microbiology 144:801-805(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59433 Genomic DNA. Translation: AAC44306.1.
Y13937 Genomic DNA. Translation: CAA74249.1.
AL009126 Genomic DNA. Translation: CAB13463.1.
PIRH69620.
RefSeqNP_389472.1. NC_000964.3.

3D structure databases

ProteinModelPortalP71019.
SMRP71019. Positions 1-311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP71019. 1 interaction.
MINTMINT-8366726.
STRING224308.BSU15900.

Proteomic databases

PaxDbP71019.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB13463; CAB13463; BSU15900.
GeneID938488.
KEGGbsu:BSU15900.
PATRIC18974985. VBIBacSub10457_1684.

Organism-specific databases

GenoListBSU15900. [Micado]

Phylogenomic databases

eggNOGCOG0331.
HOGENOMHOG000036504.
KOK00645.
OMAIWRVWQE.
OrthoDBEOG6W19KW.
PhylomeDBP71019.

Enzyme and pathway databases

BioCycBSUB:BSU15900-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.366.10. 2 hits.
InterProIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFPIRSF000446. Mct. 1 hit.
SUPFAMSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsTIGR00128. fabD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABD_BACSU
AccessionPrimary (citable) accession number: P71019
Secondary accession number(s): O34463
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList