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P71016

- BETB_BACSU

UniProt

P71016 - BETB_BACSU

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Protein
Betaine aldehyde dehydrogenase
Gene
gbsA, BSU31060
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This is a soluble NAD-dependent betaine aldehyde-specific dehydrogenase. Essential for the utilization of choline as a precursor.1 Publication

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei249 – 2491 By similarity
Active sitei283 – 2831 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi227 – 2326NAD By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBSUB:BSU31060-MONOMER.
MetaCyc:MONOMER-8602.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:gbsA
Ordered Locus Names:BSU31060
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU31060. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Betaine aldehyde dehydrogenase
PRO_0000056533Add
BLAST

Proteomic databases

PaxDbiP71016.

Expressioni

Inductioni

By choline and by high osmolarity in the presence of choline. Repressed by GbsR.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU31060.

Structurei

3D structure databases

ProteinModelPortaliP71016.
SMRiP71016. Positions 1-489.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiFGPVVSM.
OrthoDBiEOG6BS8QW.
PhylomeDBiP71016.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P71016-1 [UniParc]FASTAAdd to Basket

« Hide

MSQTLFIDGE WISAEKEQIR SIINPFNQEE IATVSEGGRE DAIKAIAAAR    50
RAFDKGEWSS LSGLERGKIV LKIAELIRRD LEELAELESL DTGKTLEESK 100
ADMDDIANVF QYYAGLADKD GGEIISSPIP DSESKIIREP IGVCGQITPW 150
NYPLLQASWK IAPALAAGNT IVMKPSEITP LTTIKVFKLM EEAGVPKGVA 200
NLVLGPGATV GDELAVNKDV DLISFTGGIE TGKKIMRAAS GNVKKIALEL 250
GGKNPNIVFK DADLEVAVDQ ALNAVFFHAG QVCSAGSRLL VEDAIHDQFL 300
AELVKRAKRI KLGNGFHAET ESGPLISAEH RAKVEKYVEI GIEEGAKLET 350
GGKRPEDPEL QNGFFYEPTI FSNCNSDMRI VQEEVFGPVL TVETFSSEEE 400
VIELANDTIY GLAGAVWSKD IEKCERVAAR LRMGTVWIND FHPYFAQAPW 450
GGYKQSGFGR ELGKIGLEEY TEVKHVYRNT KPAAVNWFNS 490
Length:490
Mass (Da):53,666
Last modified:February 1, 1997 - v1
Checksum:i67F44C5818B4AD55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U47861 Genomic DNA. Translation: AAC44364.1.
AL009126 Genomic DNA. Translation: CAB15084.1.
PIRiA69629.
RefSeqiNP_390984.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15084; CAB15084; BSU31060.
GeneIDi938829.
KEGGibsu:BSU31060.
PATRICi18978166. VBIBacSub10457_3247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U47861 Genomic DNA. Translation: AAC44364.1 .
AL009126 Genomic DNA. Translation: CAB15084.1 .
PIRi A69629.
RefSeqi NP_390984.1. NC_000964.3.

3D structure databases

ProteinModelPortali P71016.
SMRi P71016. Positions 1-489.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224308.BSU31060.

Proteomic databases

PaxDbi P71016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15084 ; CAB15084 ; BSU31060 .
GeneIDi 938829.
KEGGi bsu:BSU31060.
PATRICi 18978166. VBIBacSub10457_3247.

Organism-specific databases

GenoListi BSU31060. [Micado ]

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi FGPVVSM.
OrthoDBi EOG6BS8QW.
PhylomeDBi P71016.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci BSUB:BSU31060-MONOMER.
MetaCyc:MONOMER-8602.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Synthesis of the osmoprotectant glycine betaine in Bacillus subtilis: characterization of the gbsAB genes."
    Boch J., Kempf B., Schmid R., Bremer E.
    J. Bacteriol. 178:5121-5129(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25, FUNCTION, PATHWAY, INDUCTION.
    Strain: 168 / JH642.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Genetic control of osmoadaptive glycine betaine synthesis in Bacillus subtilis through the choline-sensing and glycine betaine-responsive GbsR repressor."
    Nau-Wagner G., Opper D., Rolbetzki A., Boch J., Kempf B., Hoffmann T., Bremer E.
    J. Bacteriol. 194:2703-2714(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: 168 / JH642.

Entry informationi

Entry nameiBETB_BACSU
AccessioniPrimary (citable) accession number: P71016
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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