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P71016 (BETB_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase

Short name=BADH
EC=1.2.1.8
Gene names
Name:gbsA
Ordered Locus Names:BSU31060
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a soluble NAD-dependent betaine aldehyde-specific dehydrogenase. Essential for the utilization of choline as a precursor. Ref.1

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. Ref.1

Induction

By choline and by high osmolarity in the presence of choline. Repressed by GbsR. Ref.1 Ref.3

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Betaine aldehyde dehydrogenase
PRO_0000056533

Regions

Nucleotide binding227 – 2326NAD By similarity

Sites

Active site2491 By similarity
Active site2831 By similarity

Sequences

Sequence LengthMass (Da)Tools
P71016 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 67F44C5818B4AD55

FASTA49053,666
        10         20         30         40         50         60 
MSQTLFIDGE WISAEKEQIR SIINPFNQEE IATVSEGGRE DAIKAIAAAR RAFDKGEWSS 

        70         80         90        100        110        120 
LSGLERGKIV LKIAELIRRD LEELAELESL DTGKTLEESK ADMDDIANVF QYYAGLADKD 

       130        140        150        160        170        180 
GGEIISSPIP DSESKIIREP IGVCGQITPW NYPLLQASWK IAPALAAGNT IVMKPSEITP 

       190        200        210        220        230        240 
LTTIKVFKLM EEAGVPKGVA NLVLGPGATV GDELAVNKDV DLISFTGGIE TGKKIMRAAS 

       250        260        270        280        290        300 
GNVKKIALEL GGKNPNIVFK DADLEVAVDQ ALNAVFFHAG QVCSAGSRLL VEDAIHDQFL 

       310        320        330        340        350        360 
AELVKRAKRI KLGNGFHAET ESGPLISAEH RAKVEKYVEI GIEEGAKLET GGKRPEDPEL 

       370        380        390        400        410        420 
QNGFFYEPTI FSNCNSDMRI VQEEVFGPVL TVETFSSEEE VIELANDTIY GLAGAVWSKD 

       430        440        450        460        470        480 
IEKCERVAAR LRMGTVWIND FHPYFAQAPW GGYKQSGFGR ELGKIGLEEY TEVKHVYRNT 

       490 
KPAAVNWFNS 

« Hide

References

« Hide 'large scale' references
[1]"Synthesis of the osmoprotectant glycine betaine in Bacillus subtilis: characterization of the gbsAB genes."
Boch J., Kempf B., Schmid R., Bremer E.
J. Bacteriol. 178:5121-5129(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25, FUNCTION, PATHWAY, INDUCTION.
Strain: 168 / JH642.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"Genetic control of osmoadaptive glycine betaine synthesis in Bacillus subtilis through the choline-sensing and glycine betaine-responsive GbsR repressor."
Nau-Wagner G., Opper D., Rolbetzki A., Boch J., Kempf B., Hoffmann T., Bremer E.
J. Bacteriol. 194:2703-2714(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
Strain: 168 / JH642.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U47861 Genomic DNA. Translation: AAC44364.1.
AL009126 Genomic DNA. Translation: CAB15084.1.
PIRA69629.
RefSeqNP_390984.1. NC_000964.3.

3D structure databases

ProteinModelPortalP71016.
SMRP71016. Positions 1-489.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU31060.

Proteomic databases

PaxDbP71016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB15084; CAB15084; BSU31060.
GeneID938829.
KEGGbsu:BSU31060.
PATRIC18978166. VBIBacSub10457_3247.

Organism-specific databases

GenoListBSU31060. [Micado]

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMAFGPVVSM.
OrthoDBEOG6BS8QW.
PhylomeDBP71016.

Enzyme and pathway databases

BioCycBSUB:BSU31060-MONOMER.
MetaCyc:MONOMER-8602.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_BACSU
AccessionPrimary (citable) accession number: P71016
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList