P71016 (BETB_BACSU) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 97.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Betaine aldehyde dehydrogenase Short name=BADH EC=1.2.1.8 | ||||
| Gene names |
| ||||
| Organism | Bacillus subtilis (strain 168) [Reference proteome] [HAMAP] | ||||
| Taxonomic identifier | 224308 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › ![]() |
Protein attributes
| Sequence length | 490 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | This is a soluble NAD-dependent betaine aldehyde-specific dehydrogenase. Essential for the utilization of choline as a precursor. |
| Catalytic activity | Betaine aldehyde + NAD+ + H2O = betaine + NADH. |
| Pathway | |
| Induction | By choline and by high osmolarity in the presence of choline. |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: UniProtKB-UniPathway |
| Molecular_function | betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Synthesis of the osmoprotectant glycine betaine in Bacillus subtilis: characterization of the gbsAB genes." Boch J., Kempf B., Schmid R., Bremer E. J. Bacteriol. 178:5121-5129(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25. Strain: 168 / JH642. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U47861 Genomic DNA. Translation: AAC44364.1. AL009126 Genomic DNA. Translation: CAB15084.1. |
| PIR | A69629. |
| RefSeq | NP_390984.1. NC_000964.3. |
3D structure databases | |
| ProteinModelPortal | P71016. |
| SMR | P71016. Positions 1-489. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 224308.BSU31060. |
Proteomic databases | |
| PaxDb | P71016. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | CAB15084; CAB15084; BSU31060. |
| GeneID | 938829. |
| KEGG | bsu:BSU31060. |
| PATRIC | 18978166. VBIBacSub10457_3247. |
Organism-specific databases | |
| GenoList | BSU31060. [Micado] |
Phylogenomic databases | |
| eggNOG | COG1012. |
| HOGENOM | HOG000271505. |
| KO | K00130. |
| OMA | HIMKQAA. |
| ProtClustDB | CLSK2518267. |
Enzyme and pathway databases | |
| BioCyc | BSUB:BSU31060-MONOMER. MetaCyc:MONOMER-8602. |
| UniPathway | UPA00529; UER00386. |
Family and domain databases | |
| Gene3D | 3.40.309.10. 1 hit. 3.40.605.10. 1 hit. |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR011264. Betaine_Ald_DH. [Graphical view] |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| SUPFAM | SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit. |
| TIGRFAMs | TIGR01804. BADH. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | BETB_BACSU | ||||||||
| Accession | Primary (citable) accession number: P71016 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
