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Protein

Betaine aldehyde dehydrogenase

Gene

gbsA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a soluble NAD-dependent betaine aldehyde-specific dehydrogenase. Essential for the utilization of choline as a precursor.1 Publication

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.1 Publication
Proteins known to be involved in this subpathway in this organism are:
  1. Betaine aldehyde dehydrogenase (gbsA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei249By similarity1
Active sitei283By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi227 – 232NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciBSUB:BSU31060-MONOMER
MetaCyc:MONOMER-8602
UniPathwayiUPA00529; UER00386

Names & Taxonomyi

Protein namesi
Recommended name:
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:gbsA
Ordered Locus Names:BSU31060
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

No effect on vanillin degradation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000565331 – 490Betaine aldehyde dehydrogenaseAdd BLAST490

Proteomic databases

PaxDbiP71016
PRIDEiP71016

Expressioni

Inductioni

By choline and by high osmolarity in the presence of choline. Repressed by GbsR.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100016891

Structurei

3D structure databases

ProteinModelPortaliP71016
SMRiP71016
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG1012 LUCA
HOGENOMiHOG000271505
InParanoidiP71016
KOiK00130
OMAiSFGYTRR
PhylomeDBiP71016

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR011264 BADH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01804 BADH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

P71016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTLFIDGE WISAEKEQIR SIINPFNQEE IATVSEGGRE DAIKAIAAAR
60 70 80 90 100
RAFDKGEWSS LSGLERGKIV LKIAELIRRD LEELAELESL DTGKTLEESK
110 120 130 140 150
ADMDDIANVF QYYAGLADKD GGEIISSPIP DSESKIIREP IGVCGQITPW
160 170 180 190 200
NYPLLQASWK IAPALAAGNT IVMKPSEITP LTTIKVFKLM EEAGVPKGVA
210 220 230 240 250
NLVLGPGATV GDELAVNKDV DLISFTGGIE TGKKIMRAAS GNVKKIALEL
260 270 280 290 300
GGKNPNIVFK DADLEVAVDQ ALNAVFFHAG QVCSAGSRLL VEDAIHDQFL
310 320 330 340 350
AELVKRAKRI KLGNGFHAET ESGPLISAEH RAKVEKYVEI GIEEGAKLET
360 370 380 390 400
GGKRPEDPEL QNGFFYEPTI FSNCNSDMRI VQEEVFGPVL TVETFSSEEE
410 420 430 440 450
VIELANDTIY GLAGAVWSKD IEKCERVAAR LRMGTVWIND FHPYFAQAPW
460 470 480 490
GGYKQSGFGR ELGKIGLEEY TEVKHVYRNT KPAAVNWFNS
Length:490
Mass (Da):53,666
Last modified:February 1, 1997 - v1
Checksum:i67F44C5818B4AD55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47861 Genomic DNA Translation: AAC44364.1
AL009126 Genomic DNA Translation: CAB15084.1
PIRiA69629
RefSeqiNP_390984.1, NC_000964.3
WP_003243430.1, NZ_JNCM01000033.1

Genome annotation databases

EnsemblBacteriaiCAB15084; CAB15084; BSU31060
GeneIDi938829
KEGGibsu:BSU31060
PATRICifig|224308.179.peg.3366

Similar proteinsi

Entry informationi

Entry nameiBETB_BACSU
AccessioniPrimary (citable) accession number: P71016
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health