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Protein

Signal peptidase I T

Gene

sipT

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

B.subtilis contains five chromosomal type I signal peptidases: SipS, SipT, SipU, SipV and SipW. They have different, but overlapping, substrate specificities and have different transcription patterns.

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51By similarity1
Active sitei93By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

BioCyciBSUB:BSU14410-MONOMER

Protein family/group databases

MEROPSiS26.004

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase I T (EC:3.4.21.89)
Short name:
SPase I
Alternative name(s):
Leader peptidase I
Gene namesi
Name:sipT
Ordered Locus Names:BSU14410
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 42HelicalSequence analysisAdd BLAST17
Topological domaini43 – 193ExtracellularSequence analysisAdd BLAST151

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095001 – 193Signal peptidase I TAdd BLAST193

Proteomic databases

PaxDbiP71013
PRIDEiP71013

Expressioni

Inductioni

Expressed at the postexponential growth phase; regulated by the DegS-DegU system.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100007991

Structurei

3D structure databases

ProteinModelPortaliP71013
SMRiP71013
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C3F Bacteria
COG0681 LUCA
HOGENOMiHOG000003673
InParanoidiP71013
KOiK03100
OMAiLLKYPRW
PhylomeDBiP71013

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR019757 Pept_S26A_signal_pept_1_Lys-AS
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
PS00760 SPASE_I_2, 1 hit
PS00761 SPASE_I_3, 1 hit

Sequencei

Sequence statusi: Complete.

P71013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEEKNTNTE KTAKKKTNTY LEWGKAIVIA VLLALLIRHF LFEPYLVEGS
60 70 80 90 100
SMYPTLHDGE RLFVNKTVNY IGELKRGDIV IINGETSKIH YVKRLIGKPG
110 120 130 140 150
ETVQMKDDTL YINGKKVAEP YLSKNKKEAE KLGVSLTGDF GPVKVPKGKY
160 170 180 190
FVMGDNRLNS MDSRNGLGLI AEDRIVGTSK FVFFPFNEMR QTK
Length:193
Mass (Da):21,854
Last modified:February 1, 1997 - v1
Checksum:i6746B4C38037F3C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45883 Genomic DNA Translation: AAB07348.1
AF012285 Genomic DNA Translation: AAC24916.1
AL009126 Genomic DNA Translation: CAB13314.1
PIRiG69707
RefSeqiNP_389324.1, NC_000964.3
WP_003232348.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13314; CAB13314; BSU14410
GeneIDi938763
KEGGibsu:BSU14410
PATRICifig|224308.179.peg.1571

Similar proteinsi

Entry informationi

Entry nameiLEPT_BACSU
AccessioniPrimary (citable) accession number: P71013
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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