P71011 (ALBA_BACSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Antilisterial bacteriocin subtilosin biosynthesis protein AlbA

Gene names

Name:	albA
Synonyms:	ywiA
Ordered Locus Names:	BSU37370

Organism

Bacillus subtilis

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for production of the bacteriocin subtilosin. May activate a metalloenzyme that catalyzes a modification of prosubtilosin. Ref.4 Ref.5
Cofactor	Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.
Induction	Transcription is highly induced by oxygen limitation and is under dual and independent control of Spo0A-AbrB and ResDE. Ref.6

Ontologies

Keywords
Biological process	Antibiotic biosynthesis Bacteriocin biosynthesis
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	bacteriocin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW catalytic activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Antilisterial bacteriocin subtilosin biosynthesis protein AlbA		PRO_0000064542
Sites
	Metal binding	129	1	Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
	Metal binding	133	1	Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
	Metal binding	136	1	Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Natural variations
	Natural variant	91	1	Q → L in strain: ATCC 6633.
	Natural variant	96	1	I → V in strain: ATCC 6633.
	Natural variant	99 – 108	10	GNRASRHTIT → ENQSTRHAIN in strain: ATCC 6633.
	Natural variant	214	1	T → A in strain: ATCC 6633.
	Natural variant	232	1	V → I in strain: ATCC 6633.
	Natural variant	309	1	D → N in strain: ATCC 6633.
	Natural variant	322 – 323	2	HV → NI in strain: ATCC 6633.
	Natural variant	412	1	G → S in strain: ATCC 6633.

Sequences

	Sequence		Length	Mass (Da)
	P71011 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: DA3247604BC8CCAA	FASTA	448	51,514
	10 20 30 40 50 60 MFIEQMFPFI NESVRVHQLP EGGVLEIDYL RDNVSISDFE YLDLNKTAYE LCMRMDGQKT 70 80 90 100 110 120 AEQILAEQCA VYDESPEDHK DWYYDMLNML QNKQVIQLGN RASRHTITTS GSNEFPMPLH 130 140 150 160 170 180 ATFELTHRCN LKCAHCYLES SPEALGTVSI EQFKKTADML FDNGVLTCEI TGGEIFVHPN 190 200 210 220 230 240 ANEILDYVCK KFKKVAVLTN GTLMRKESLE LLKTYKQKII VGISLDSVNS EVHDSFRGRK 250 260 270 280 290 300 GSFAQTCKTI KLLSDHGIFV RVAMSVFEKN MWEIHDMAQK VRDLGAKAFS YNWVDDFGRG 310 320 330 340 350 360 RDIVHPTKDA EQHRKFMEYE QHVIDEFKDL IPIIPYERKR AANCGAGWKS IVISPFGEVR 370 380 390 400 410 420 PCALFPKEFS LGNIFHDSYE SIFNSPLVHK LWQAQAPRFS EHCMKDKCPF SGYCGGCYLK 430 440 GLNSNKYHRK NICSWAKNEQ LEDVVQLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Subtilosin A biosynthesis is conserved among two different classes of Bacillus subtilis strains." Stein T., Duesterhus S., Entian K.-D. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 6633 / PCI 219 / NRS 231.
[2]	"The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees)." Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V., Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H., Villani G., Kunst F., Danchin A., Glaser P. Microbiology 143:3313-3328(1997) [PubMed: 9353933] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[3]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[4]	"Genes of the sbo-alb locus of Bacillus subtilis are required for production of the antilisterial bacteriocin subtilosin." Zheng G., Yan L.Z., Vederas J.C., Zuber P. J. Bacteriol. 181:7346-7355(1999) [PubMed: 10572140] [Abstract] Cited for: FUNCTION. Strain: 168 / JH642 and 22a.
[5]	"Mutational analysis of the sbo-alb locus of Bacillus subtilis: identification of genes required for subtilosin production and immunity." Zheng G., Hehn R., Zuber P. J. Bacteriol. 182:3266-3273(2000) [PubMed: 10809709] [Abstract] Cited for: FUNCTION. Strain: 168 / JH642.
[6]	"Dual control of sbo-alb operon expression by the Spo0 and ResDE systems of signal transduction under anaerobic conditions in Bacillus subtilis." Nakano M.M., Zheng G., Zuber P. J. Bacteriol. 182:3274-3277(2000) [PubMed: 10809710] [Abstract] Cited for: TRANSCRIPTIONAL REGULATION. Strain: 168 / JH642.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ430547 Genomic DNA. Translation: CAD23199.1. Z80360 Genomic DNA. Translation: CAB02509.1. Z97024 Genomic DNA. Translation: CAB09700.1. AL009126 Genomic DNA. Translation: CAB15764.1.
PIR	B70059.
RefSeq	NP_391617.1. NC_000964.3.
3D structure databases
ProteinModelPortal	P71011.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000001351; EBBACP00000001351; EBBACG00000001349.
GeneID	937059.
GenomeReviews	Gene locus BSU37370 in contig AL009126_GR.
KEGG	bsu:BSU37370.
NMPDR	fig|224308.1.peg.3743.
PATRIC	18979510. VBIBacSub10457_3917.
Organism-specific databases
GenoList	BSU37370. [Micado]
Phylogenomic databases
GeneTree	EBGT00050000004668.
OMA	GAGWRTF.
PhylomeDB	P71011.
ProtClustDB	CLSK2752545.
Enzyme and pathway databases
BioCyc	BSUB:BSU37370-MONOMER.
Family and domain databases
InterPro	IPR023885. 4Fe4S-binding_SPASM_dom. IPR006638. Elp3/MiaB/NifB. IPR008792. PQQ_synth_PqqD. IPR007197. rSAM. [Graphical view]
Pfam	PF05402. PqqD. 1 hit. PF04055. Radical_SAM. 1 hit. [Graphical view]
SMART	SM00729. Elp3. 1 hit. [Graphical view]
TIGRFAMs	TIGR04085. RSAM_more_4Fe4S. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ALBA_BACSU

Accession

Primary (citable) accession number: P71011
Secondary accession number(s): Q8RKH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program