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Protein

Agmatinase

Gene

speB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of putrescine from agmatine.

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Mn2+PROSITE-ProRule annotation

Pathwayi: putrescine biosynthesis via agmatine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from agmatine.
Proteins known to be involved in this subpathway in this organism are:
  1. Agmatinase (speB)
This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi112ManganesePROSITE-ProRule annotation1
Metal bindingi135ManganesePROSITE-ProRule annotation1
Metal bindingi137ManganesePROSITE-ProRule annotation1
Metal bindingi139ManganesePROSITE-ProRule annotation1
Metal bindingi216ManganesePROSITE-ProRule annotation1
Metal bindingi218ManganesePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPolyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU37490-MONOMER
MetaCyc:SPEBBACSU-MONOMER
UniPathwayiUPA00534; UER00287

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:speB
Synonyms:ywhG
Ordered Locus Names:BSU37490
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737281 – 290AgmatinaseAdd BLAST290

Proteomic databases

PaxDbiP70999
PRIDEiP70999

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100020256

Structurei

3D structure databases

ProteinModelPortaliP70999
SMRiP70999
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CYW Bacteria
COG0010 LUCA
HOGENOMiHOG000204321
InParanoidiP70999
KOiK01480
OMAiDTYFGAE
PhylomeDBiP70999

Family and domain databases

InterProiView protein in InterPro
IPR005925 Agmatinase-rel
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01230 agmatinase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P70999-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFDEAYSGK VFIASRPEWE EADAILYGMP MDWTVSYRPG SRFGPSRIRE
60 70 80 90 100
VSIGLEEYSP YLDRDLADLN FFDAGDIPLP FGNPQRSLDM IEEYVDSILE
110 120 130 140 150
KGKFPMGMGG EHLVSWPVIK AMYKKYPDLA IIHFDAHTDL RVDYEGEPLS
160 170 180 190 200
HSTPIRKAAE LIGPHNVYSF GIRSGMKEEF EWAKENGMHI SKFEVLEPLK
210 220 230 240 250
EVLPKLAGRP VYVTIDIDVL DPAHAPGTGT VDAGGITSKE LLASVHEIAR
260 270 280 290
SEVNVKGADL VEVAPVYDHS EQTANTASKI IREMLLGFVK
Length:290
Mass (Da):32,417
Last modified:February 1, 1997 - v1
Checksum:iB14C4AAD1B1BC964
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z80360 Genomic DNA Translation: CAB02517.1
AL009126 Genomic DNA Translation: CAB15776.1
PIRiH70057
RefSeqiNP_391629.1, NC_000964.3
WP_003227545.1, NZ_JNCM01000034.1

Genome annotation databases

EnsemblBacteriaiCAB15776; CAB15776; BSU37490
GeneIDi937205
KEGGibsu:BSU37490
PATRICifig|224308.179.peg.4060

Similar proteinsi

Entry informationi

Entry nameiSPEB_BACSU
AccessioniPrimary (citable) accession number: P70999
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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