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P70999

- SPEB_BACSU

UniProt

P70999 - SPEB_BACSU

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Protein
Agmatinase
Gene
speB, ywhG, BSU37490
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the formation of putrescine from agmatine.

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Manganese By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi112 – 1121Manganese By similarity
Metal bindingi135 – 1351Manganese By similarity
Metal bindingi137 – 1371Manganese By similarity
Metal bindingi139 – 1391Manganese By similarity
Metal bindingi216 – 2161Manganese By similarity
Metal bindingi218 – 2181Manganese By similarity

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
  2. spermidine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU37490-MONOMER.
MetaCyc:SPEBBACSU-MONOMER.
UniPathwayiUPA00534; UER00287.

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:speB
Synonyms:ywhG
Ordered Locus Names:BSU37490
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU37490. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Agmatinase
PRO_0000173728Add
BLAST

Proteomic databases

PaxDbiP70999.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU37490.

Structurei

3D structure databases

ProteinModelPortaliP70999.
SMRiP70999. Positions 18-290.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204321.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG6R2GW5.
PhylomeDBiP70999.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70999-1 [UniParc]FASTAAdd to Basket

« Hide

MRFDEAYSGK VFIASRPEWE EADAILYGMP MDWTVSYRPG SRFGPSRIRE    50
VSIGLEEYSP YLDRDLADLN FFDAGDIPLP FGNPQRSLDM IEEYVDSILE 100
KGKFPMGMGG EHLVSWPVIK AMYKKYPDLA IIHFDAHTDL RVDYEGEPLS 150
HSTPIRKAAE LIGPHNVYSF GIRSGMKEEF EWAKENGMHI SKFEVLEPLK 200
EVLPKLAGRP VYVTIDIDVL DPAHAPGTGT VDAGGITSKE LLASVHEIAR 250
SEVNVKGADL VEVAPVYDHS EQTANTASKI IREMLLGFVK 290
Length:290
Mass (Da):32,417
Last modified:February 1, 1997 - v1
Checksum:iB14C4AAD1B1BC964
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z80360 Genomic DNA. Translation: CAB02517.1.
AL009126 Genomic DNA. Translation: CAB15776.1.
PIRiH70057.
RefSeqiNP_391629.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15776; CAB15776; BSU37490.
GeneIDi937205.
KEGGibsu:BSU37490.
PATRICi18979534. VBIBacSub10457_3929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z80360 Genomic DNA. Translation: CAB02517.1 .
AL009126 Genomic DNA. Translation: CAB15776.1 .
PIRi H70057.
RefSeqi NP_391629.1. NC_000964.3.

3D structure databases

ProteinModelPortali P70999.
SMRi P70999. Positions 18-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU37490.

Proteomic databases

PaxDbi P70999.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15776 ; CAB15776 ; BSU37490 .
GeneIDi 937205.
KEGGi bsu:BSU37490.
PATRICi 18979534. VBIBacSub10457_3929.

Organism-specific databases

GenoListi BSU37490. [Micado ]

Phylogenomic databases

eggNOGi COG0010.
HOGENOMi HOG000204321.
KOi K01480.
OMAi KPDYSLY.
OrthoDBi EOG6R2GW5.
PhylomeDBi P70999.

Enzyme and pathway databases

UniPathwayi UPA00534 ; UER00287 .
BioCyci BSUB:BSU37490-MONOMER.
MetaCyc:SPEBBACSU-MONOMER.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
InterProi IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
TIGRFAMsi TIGR01230. agmatinase. 1 hit.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees)."
    Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V., Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H., Villani G., Kunst F., Danchin A., Glaser P.
    Microbiology 143:3313-3328(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Characterization of polyamine synthesis pathway in Bacillus subtilis 168."
    Sekowska A., Bertin P., Danchin A.
    Mol. Microbiol. 29:851-858(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF POLYAMINE PATHWAY.

Entry informationi

Entry nameiSPEB_BACSU
AccessioniPrimary (citable) accession number: P70999
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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