Reviewed, UniProtKB/Swiss-Prot P70965 (MURA1_BACSU)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
    EC=2.5.1.7
Alternative name(s):
    Enoylpyruvate transferase 1
    UDP-N-acetylglucosamine enolpyruvyl transferase 1
      Short name=EPT 1

Gene names

Name:	murAA
Synonyms:	murA
Ordered Locus Names:	BSU36760

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Essential for cell growth. HAMAP MF_00111
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP MF_00111		PRO_0000178848
Sites
	Active site	117	1	Proton donor By similarity
	Binding site	117	1	Phosphoenolpyruvate (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P70965-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 028B27701D21B238	FASTA	436	46,701
	10 20 30 40 50 60 MEKIIVRGGQ KLNGTVKVEG AKNAVLPVIA ASLLASEEKS VICDVPTLSD VYTINEVLRH 70 80 90 100 110 120 LGADVHFENN EVTVNASYAL QTEAPFEYVR KMRASVLVMG PLLARTGHAR VALPGGCAIG 130 140 150 160 170 180 SRPIDQHLKG FEAMGAEIKV GNGFIEAEVK GRLQGAKIYL DFPSVGATEN LIMAAALAEG 190 200 210 220 230 240 TTTLENVAKE PEIVDLANYI NGMGGKIRGA GTGTIKIEGV EKLHGVKHHI IPDRIEAGTF 250 260 270 280 290 300 MVAAAITEGN VLVKGAVPEH LTSLIAKMEE MGVTIKDEGE GLRVIGPKEL KPIDIKTMPH 310 320 330 340 350 360 PGFPTDMQSQ MMALLLRASG TSMITETVFE NRFMHAEEFR RMNGDIKIEG RSVIINGPVQ 370 380 390 400 410 420 LQGAEVAATD LRAGAALILA GLVAEGHTRV TELKHLDRGY VDFHQKLAAL GADIERVNDE 430 SASEQENKEV VSDLNA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bacillus subtilis atpC to ureA chromosomal region." Glaser P., Danchin A., Kunst F., Moszer I. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[3]	"Possible roles of the murAA (murA) and murAB (murZ) duett in B.subtilis." Studer R.E., Roten C.A.H., Kamarata D. (In) Proceedings of Genome 2000: international conference of microbial and model genomes, pp.73-73, Institut Pasteur, Paris (2000) Cited for: CHARACTERIZATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z81356 Genomic DNA. Translation: CAB03688.1. AL009126 Genomic DNA. Translation: CAB15693.1.
PIR	A69662.
RefSeq	NP_391557.1.
3D structure databases
HSSP	HSSP built from PDB template 1DLG based on UniProtKB P33038.
ModBase	Search...
Genome annotation databases
GeneID	936980.
GenomeReviews	Gene locus BSU36760 in contig AL009126_GR.
KEGG	bsu:BSU36760.
NMPDR	fig|224308.1.peg.3683.
Organism-specific databases
SubtiList	BG11955. murAA. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	P70965.
OMA	MPGGCSI.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU3674-MON.
BRENDA	2.5.1.7. 150.
Family and domain databases
HAMAP	MF_00111. [Tree]
InterPro	IPR001986. EPSP_synthase_core. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 1 hit.
PANTHER	PTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01072. murA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURA1_BACSU

Accession

Primary (citable) accession number: P70965

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 1, 1997
Last modified:	November 3, 2009
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)