P70938 (TRPF_BACMQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase
Short name=PRAI
EC=5.3.1.24

Gene names

Name:	trpF
Ordered Locus Names:	BMQ_4320

Organism

Bacillus megaterium (strain ATCC 12872 / QMB1551) [Complete proteome] [HAMAP]

Taxonomic identifier

545693 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus megaterium

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. HAMAP-Rule MF_00135
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. HAMAP-Rule MF_00135
Sequence similarities	Belongs to the TrpF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	phosphoribosylanthranilate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	N-(5'-phosphoribosyl)anthranilate isomerase HAMAP-Rule MF_00135		PRO_0000154346

Sequences

	Sequence		Length	Mass (Da)
	P70938 [UniParc]. Last modified August 10, 2010. Version 2. Checksum: 3E4EF5CD8A1E869C	FASTA	208	23,399
	10 20 30 40 50 60 MLIKYCGIRS KQDIALIEKS AATHIGFIFY PRSKRYVKPE RVNEFVTDEI KKQVSLVGVF 70 80 90 100 110 120 VNTPVDQILE IASVTNLDVI QCHGQETAAD VRQLKQRGYE VWKALPHNKE TLQQMHVYEE 130 140 150 160 170 180 ADGYVIDSKV KEQFGGTGVA FDWSFVPQYE SAAQRLGKKC FIAGGINACN IENLLPYQPG 190 200 AIDISGGIET NGTKDYTKII EIERKIIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequences of the industrial vitamin B12-producers B. megaterium QM B1551 and DSM319 reveal new insights into the Bacillus genome evolution and pan-genome structure." Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K., Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J., Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J., Vary P.S. Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12872 / QMB1551.
[2]	Jablonski L.M., Vary P.S., Hudspeth D.S. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-113.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001983 Genomic DNA. Translation: ADE71330.1. U67986 Genomic DNA. Translation: AAB07593.1.
RefSeq	YP_003564764.1. NC_014019.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADE71330; ADE71330; BMQ_4320.
GeneID	8988758.
KEGG	bmq:BMQ_4320.
PATRIC	35485408. VBIBacMeg35839_4364.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000161598.
KO	K01817.
ProtClustDB	CLSK2840596.
Enzyme and pathway databases
BioCyc	BMEG545693:GHSY-4701-MONOMER.
UniPathway	UPA00035; UER00042.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00135. PRAI.
InterPro	IPR013785. Aldolase_TIM. IPR001240. PRAI. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00697. PRAI. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPF_BACMQ

Accession

Primary (citable) accession number: P70938
Secondary accession number(s): D5DRF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	August 10, 2010
Last modified:	May 1, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program