P70937 (TRPC_BACMQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BMQ_4321

Organism

Bacillus megaterium (strain ATCC 12872 / QMB1551) [Complete proteome] [HAMAP]

Taxonomic identifier

545693 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_0000154211

Sequences

	Sequence		Length	Mass (Da)
	P70937 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: BB2B4A21114B6430	FASTA	255	28,689
	10 20 30 40 50 60 MLNKIIETKK EEIQNLQLPE QQNVAKRSFL DALSNPNREL ALIAEVKKAS PSKGLIKENF 70 80 90 100 110 120 QPVEIAKAYE KGKADALSVL TDQHYFQGHR TFLSDIKQHV SVPVLRKDFI IDSIQVEESA 130 140 150 160 170 180 RIGADAILLI GEALEPLKLQ ELYLQAAEKE LDCLVEVHSL ETLEKLLAVF TPKIIGINNR 190 200 210 220 230 240 NLHTFETSLQ QTKEIAKHVP KDQLLVSESG IYLYDDVSYV KEAGAKAILV GESLMRQDNQ 250 TKAIEKLFGE SEYAH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Jablonski L.M., Vary P.S., Hudspeth D.S. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genome sequences of the industrial vitamin B12-producers B. megaterium QM B1551 and DSM319 reveal new insights into the Bacillus genome evolution and pan-genome structure." Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K., Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J., Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J., Vary P.S. Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12872 / QMB1551.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U67986 Genomic DNA. Translation: AAB07592.1. CP001983 Genomic DNA. Translation: ADE71331.1.
RefSeq	YP_003564765.1. NC_014019.1.
3D structure databases
ProteinModelPortal	P70937.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000390556; EBBACP00000382949; EBBACG00000391052.
GeneID	8988759.
GenomeReviews	Gene locus BMQ_4321 in contig CP001983_GR.
KEGG	bmq:BMQ_4321.
PATRIC	35485410. VBIBacMeg35839_4365.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000001798.
ProtClustDB	PRK00278.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACMQ

Accession

Primary (citable) accession number: P70937
Secondary accession number(s): D5DRF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program