Reviewed, UniProtKB/Swiss-Prot P70865 (SYA_BARBA)

Names and origin

Protein names

Recommended name:
    Alanyl-tRNA synthetase
    EC=6.1.1.7
Alternative name(s):
    Alanine--tRNA ligase
      Short name=AlaRS

Gene names

Name:

alaS

Organism

Bartonella bacilliformis

Taxonomic identifier

774 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	886 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). HAMAP MF_00036
Subcellular location	Cytoplasm. HAMAP MF_00036
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Gene Ontology (GO)
Biological process	alanyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP alanine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 886	886	Alanyl-tRNA synthetase HAMAP MF_00036		PRO_0000075062

Sequences

	Sequence		Length	Mass (Da)
	P70865-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 845AADB4611BCA42	FASTA	886	97,908
	10 20 30 40 50 60 MNSVNNIRST FLDYFHRNGH EVLSSSPLVP RNDPTLMFTN AGMVDFKNVF TGLEKHSYNR 70 80 90 100 110 120 ATTAQKCVRA GGKHNDLDNV GYTARHHTFF EMLGNFSFSN YFKEEAIFYA WNLLTKEFCL 130 140 150 160 170 180 SKDKLLVTVY HDDDVAAGLW RKISGLSEEK IIRIATNDNF WMMGDTGPCG PCSEIFYDHG 190 200 210 220 230 240 DKIWGGPPGS ADEDGDRFIE IWNLVFMQYE QLSKEKRIEL PQPSIDTGMG LERIAAVLQG 250 260 270 280 290 300 VHDNYDIDLF RTLIHASQEI IGVKATGDFF ASHRVIADHL RSSAFLIADG IMPSNEGRGY 310 320 330 340 350 360 VLRRIMRRAM RHAHLLGSKD LLMWRLVPVL ISEMGQAYPE LVRAESLISE ILKLEETRFR 370 380 390 400 410 420 KTLERGLGLL NEASTHLEEG DYFNGEVAFK LYDTYGFPLD LTQDALRRRG ISVDVDAFDK 430 440 450 460 470 480 AMKRQKAEAR ANWSGSGDCV TETVWFSIRD QVGATEFLGY ETEKAEGIIT ALIRDGEVVD 490 500 510 520 530 540 HIDLGQKAMI VVNQTPFYGE SGGQVGDSGI ISGANFIFEV HDTQKKGDNV FIHIGEIKTG 550 560 570 580 590 600 QAKKHDCVEL IVDSARRRKI RANHSATHLL HESLRQTLGS HVVQKGSFVS PDRLRFDFSH 610 620 630 640 650 660 PKSISSEELK KIEDLANDIV LQNSKVTTRL MAIDDAIAEG AMALFGEKYG DEVRVISMGN 670 680 690 700 710 720 NLEQTGSKKW WSIELCGGTH VQRTGDIGLI HIISETSVAA GVRRIEALTA TAARLYLHGQ 730 740 750 760 770 780 DRRVYEIAGL LKTSPADVQE RVQTLLDERR KLEKELNDSR KKIALNGGSV NSQGDIQTIN 790 800 810 820 830 840 GISFMGGVVS NILPKDLKAL VDSGKKKIGS GVVAFISVSE DGKGSAVVGV TDDLTDTLNA 850 860 870 880 VDLVRIISVT LGGQGGGGRR DMAQAGGSEG GKADEALVAL KDSLKG

References

[1]	Upeslacis E., Ihler G.M. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U68242 Genomic DNA. Translation: AAB09037.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	6.1.1.7. 98060.
Family and domain databases
HAMAP	MF_00036. [Tree]
InterPro	IPR002318. Ala-tRNA-synth_IIc. IPR018165. Ala-tRNA-synth_IIc_cons-reg. IPR018164. Ala-tRNA-synth_IIc_N. IPR003156. Pesterase_DHHA1. IPR012947. tRNA_SAD. [Graphical view]
Pfam	PF02272. DHHA1. 1 hit. PF01411. tRNA-synt_2c. 1 hit. PF07973. tRNA_SAD. 1 hit. [Graphical view]
PRINTS	PR00980. TRNASYNTHALA.
TIGRFAMs	TIGR00344. alaS. 1 hit.
PROSITE	PS50860. AA_TRNA_LIGASE_II_ALA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYA_BARBA

Accession

Primary (citable) accession number: P70865

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)