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P70826 (P70826_BORBG) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
EC=2.7.1.90 EMBL CAA11968.1
Gene names
Name:pfpB EMBL CAA11968.1
OrganismBorrelia burgdorferi (Lyme disease spirochete) EMBL CAA11968.1
Taxonomic identifier139 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region102 – 1043Sulfate 2 binding PDB 1KZH
Region175 – 1784Sulfate 3 binding PDB 1KZH
Region175 – 1784Sulfate 5 binding PDB 1KZH
Region203 – 2064Fructose-1-6-diphosphate binding PDB 2F48
Region243 – 2442Fructose-1-6-diphosphate binding PDB 2F48
Region243 – 2442Sulfate 7 binding PDB 1KZH
Region428 – 4314Fructose-1-6-diphosphate binding PDB 2F48

Sites

Binding site241Sulfate 1; via amide nitrogen PDB 1KZH
Binding site721Sulfate 2; via amide nitrogen PDB 1KZH
Binding site801Sulfate 3 PDB 1KZH
Binding site821Fructose-1-6-diphosphate; via amide nitrogen PDB 2F48
Binding site1461Fructose-1-6-diphosphate PDB 2F48
Binding site1461Sulfate 3 PDB 1KZH
Binding site1461Sulfate 4 PDB 1KZH
Binding site1461Sulfate 5 PDB 1KZH
Binding site1461Sulfate 6 PDB 1KZH
Binding site2031Sulfate 5 PDB 1KZH
Binding site2531Fructose-1-6-diphosphate PDB 2F48
Binding site3121Fructose-1-6-diphosphate PDB 2F48
Binding site4251Sulfate 8; via amide nitrogen PDB 1KZH
Binding site4311Sulfate 4 PDB 1KZH
Binding site4311Sulfate 6 PDB 1KZH

Sequences

Sequence LengthMass (Da)Tools
P70826 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: 0FEAC1077DA6127F

FASTA55562,443
        10         20         30         40         50         60 
MNTSLFKQER QKYIPKLPNI LKKDFNNISL VYGENTEAIQ DRQALKEFFK NTYGLPIISF 

        70         80         90        100        110        120 
TEGESSLSFS KALNIGIILS GGPAPGGHNV ISGVFDAIKK FNPNSKLFGF KGGPLGLLEN 

       130        140        150        160        170        180 
DKIELTESLI NSYRNTGGFD IVSSGRTKIE TEEHYNKALF VAKENNLNAI IIIGGDDSNT 

       190        200        210        220        230        240 
NAAILAEYFK KNGENIQVIG VPKTIDADLR NDHIEISFGF DSATKIYSEL IGNLCRDAMS 

       250        260        270        280        290        300 
TKKYWHFVKL MGRSASHVAL ECALKTHPNI CIVSEEVLAK KKTLSEIIDE MVSVILKRSL 

       310        320        330        340        350        360 
NGDNFGVVIV PEGLIEFIPE VKSLMLELCD IFDKNEGEFK GLNIEKMKEI FVAKLSDYMK 

       370        380        390        400        410        420 
GVYLSLPLFI QFELIKSILE RDPHGNFNVS RVPTEKLFIE MIQSRLNDMK KRGEYKGSFT 

       430        440        450        460        470        480 
PVDHFFGYEG RSAFPSNFDS DYCYSLGYNA VVLILNGLTG YMSCIKNLNL KPTDWIAGGV 

       490        500        510        520        530        540 
PLTMLMNMEE RYGEKKPVIK KALVDLEGRP FKEFVKNRDK WALNNLYLYP GPVQYFGSSE 

       550 
IVDEITETLK LELLK 

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References

[1]"Homologues of helicase genes priA and ruvAB of Borrelia burgdorferi, the Lyme borreliosis agent."
Boursaux-Eude C., Margarita D., Belfaiza J., Old I.G., Saint-Girons I.
Res. Microbiol. 149:235-245(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HB19 EMBL CAA11968.1.
[2]"The structure of a pyrophosphate-dependent phosphofructokinase from the Lyme disease spirochete Borrelia burgdorferi."
Moore S.A., Ronimus R.S., Roberson R.S., Morgan H.W.
Structure 10:659-671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 1-553 IN COMPLEX WITH SULFATE.
[3]"Crystal Structure of A Novel Fructose 1,6-Bisphosphate and AlF3 containing Pyrophosphate-dependent Phosphofructo-1-kinase Complex from Borreliaburgdorferi."
Wang M., Grum-Tokars V.
Submitted (NOV-2005) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.11 ANGSTROMS) OF 1-553 IN COMPLEX WITH FRUCTOSE-1-6-DIPHOSPHATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ224475 Genomic DNA. Translation: CAA11968.1.
PIRD70102.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1KZHX-ray2.55A/B1-553[»]
2F48X-ray2.11A/B1-553[»]
ProteinModelPortalP70826.
SMRP70826. Positions 4-553.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.10.480. 1 hit.
InterProIPR011183. PfpB_PPi_PFK.
IPR022953. Phosphofructokinase.
IPR000023. Phosphofructokinase_dom.
IPR013981. PPi-dep_PFK_a-hlx.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF005677. PPi_PFK_PfpB. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
TIGRFAMsTIGR02477. PFKA_PPi. 1 hit.
ProtoNetSearch...

Entry information

Entry nameP70826_BORBG
AccessionPrimary (citable) accession number: P70826
Entry history
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)