P70792 (TTUC4_AGRVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tartrate dehydrogenase/decarboxylase ttuC'
Short name=TDH
EC=1.1.1.93
EC=4.1.1.73

Alternative name(s):
D-malate dehydrogenase [decarboxylating]
EC=1.1.1.83

Gene names

Name:

ttuC'

Encoded on

Plasmid pTrAB3

Organism

Agrobacterium vitis (Rhizobium vitis)

Taxonomic identifier

373 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Tartrate + NAD+ = oxaloglycolate + NADH. Meso-tartrate + NAD+ = oxaloglycolate + NADH. (R,R)-tartrate + NAD+ = oxaloglycolate + NADH. (R,R)-tartrate = D-glycerate + CO2. (R)-malate + NAD+ = pyruvate + CO2 + NADH.
Pathway	Carbohydrate acid metabolism; tartrate degradation; 2-hydroxy-3-oxosuccinate from L-tartrate: step 1/1. Carbohydrate acid metabolism; tartrate degradation; 2-hydroxy-3-oxosuccinate from meso-tartrate: step 1/1. Carbohydrate acid metabolism; tartrate degradation; D-glycerate from L-tartrate: step 1/1.
Subcellular location	Cytoplasm By similarity.
Induction	By tartrate.
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase Oxidoreductase
Technical term	Plasmid
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-malate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro tartrate decarboxylase activity Inferred from electronic annotation. Source: EC tartrate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Probable tartrate dehydrogenase/decarboxylase ttuC'		PRO_0000083816

Sequences

	Sequence		Length	Mass (Da)
	P70792 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: BA3EC462A7D74F4E	FASTA	358	38,726
	10 20 30 40 50 60 MREYKIAAIP ADGIGPEVIA AGLQVLEALE KRSGDFSIHT ETFDWGSDYY KKNGVMMPAD 70 80 90 100 110 120 GLEQLKKFDA IFFGAVGAPD VPDHITLWGL RLPICQGFDQ YANVRPTKVL PGITPPLRNC 130 140 150 160 170 180 GPGDLDWVIV RENSEGEYSG HGGRAHKGLP EEVGTEVAIF TRVGVTRIMR YAFKLAQARP 190 200 210 220 230 240 RKLLTVVTKS NAQRHGMVMW DEIAAEVSKE FPDVTWDKML VDAMTVRMTL KPQSLDTIVA 250 260 270 280 290 300 TNLHADILSD LAGALAGSLG VAPTANIDPE RRFPSMFEPI HGSAFDITGK GIANPVATFW 310 320 330 340 350 TAAQMLEHLG EKDAATRLMS AVERVTEAGI LTPDVGGTAN TQQVTDAVCE AIAGSNIL

References

[1]	"Characterization and distribution of tartrate utilization genes in the grapevine pathogen Agrobacterium vitis." Salomone J.-Y., Crouzet P., de Ruffray P., Otten L. Mol. Plant Microbe Interact. 9:401-408(1996) [PubMed: 8672817] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AB3.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U32375 Genomic DNA. Translation: AAB61628.1.
3D structure databases
ProteinModelPortal	P70792.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR024084. IsoPropMal-DH-like_dom. IPR011829. TTC_DH. [Graphical view]
Gene3D	G3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHER	PTHR11835. IDH_IMDH_dimeric. 1 hit. PTHR11835:SF8. TTC_DH. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR02089. TTC. 1 hit.
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TTUC4_AGRVI

Accession

Primary (citable) accession number: P70792

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	February 1, 1997
Last modified:	September 21, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program