Reviewed, UniProtKB/Swiss-Prot P70787 (TTUC2_AGRVI)

Names and origin

Protein names

Recommended name:
    Probable tartrate dehydrogenase/decarboxylase ttuC
      Short name=TDH
    EC=1.1.1.93
    EC=4.1.1.73
Alternative name(s):
    D-malate dehydrogenase [decarboxylating]
    EC=1.1.1.83

Gene names

Name:

ttuC

Encoded on

Plasmid pTrAB3

Organism

Agrobacterium vitis (Rhizobium vitis)

Taxonomic identifier

373 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Tartrate + NAD(+) = oxaloglycolate + NADH. Meso-tartrate + NAD(+) = oxaloglycolate + NADH. (R,R)-tartrate + NAD(+) = oxaloglycolate + NADH. (R,R)-tartrate = D-glycerate + CO(2). (R)-malate + NAD(+) = pyruvate + CO(2) + NADH.
Pathway	Carbohydrate acid metabolism; tartaric acid degradation; 2-hydroxy-3-oxosuccinic acid from L-tartaric acid: step 1/1. Carbohydrate acid metabolism; tartaric acid degradation; 2-hydroxy-3-oxosuccinic acid from meso-tartaric acid: step 1/1. Carbohydrate acid metabolism; tartaric acid degradation; D-glyceric acid from L-tartaric acid: step 1/1.
Subcellular location	CytoplasmBy similarity.
Induction	By tartrate.
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase Oxidoreductase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-malate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro tartrate decarboxylase activity Inferred from electronic annotation. Source: EC tartrate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Probable tartrate dehydrogenase/decarboxylase ttuC		PRO_0000083814

Sequences

	Sequence		Length	Mass (Da)
	P70787-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: D05BED66A360BA3E	FASTA	364	39,271
	10 20 30 40 50 60 MREYKIAAIP ADGIGPEVIA AGLQVLEALE KRSGDFSIHT ETFDWGSDYY KKNGVMMPAD 70 80 90 100 110 120 GLEQLKKFDA IFFGAVGAPD VPDHITLWGL RLPICQGFDQ YANVRPTKVL PGITPPLRNC 130 140 150 160 170 180 GPGDLDWVIV RENSEGEYSG HGGRAHKGLP EEVGTEVAIF TRVGVTRIMR YAFKLAQARP 190 200 210 220 230 240 RKLLTVVTKS NAQRHGMVMW DEIAAEVSKE FPDVTWDKML VDAMTVRMTL KPQSLDTIVA 250 260 270 280 290 300 TNLHADILSD LAGALAGSLG VAPTANIDPE RRFPSMFEPI HGSAFDITGK GIANPVATFW 310 320 330 340 350 360 TAAQMLEHLG EKDAATRLMS AVERVTEAGI LTPDVGGTAD TQQVTDAVCE AIAGSNILNM AAVG

References

[1]	"Characterization and distribution of tartrate utilization genes in the grapevine pathogen Agrobacterium vitis." Salomone J.-Y., Crouzet P., de Ruffray P., Otten L. Mol. Plant Microbe Interact. 9:401-408(1996) [PubMed: 8672817] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AB3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U32375 Genomic DNA. Translation: AAB61623.1.
3D structure databases
HSSP	HSSP built from PDB template 1XAA based on UniProtKB P00351.
ModBase	Search...
Family and domain databases
InterPro	IPR001804. IsoCit_IM_DHase. IPR011829. TTC_DH. [Graphical view]
Gene3D	G3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHER	PTHR11835. IDH_IMDH_dimeric. 1 hit. PTHR11835:SF8. TTC_DH. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR02089. TTC. 1 hit.
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TTUC2_AGRVI

Accession

Primary (citable) accession number: P70787

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	February 1, 1997
Last modified:	November 25, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)