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Protein

Beta-galactosidase

Gene

lacZ

Organism
Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei455Proton donorBy similarity1
Active sitei526NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH2 Glycoside Hydrolase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
OrganismiActinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Taxonomic identifieri715 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000576541 – 1005Beta-galactosidaseAdd BLAST1005

Proteomic databases

PRIDEiP70753

Structurei

3D structure databases

ProteinModelPortaliP70753
SMRiP70753
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Phylogenomic databases

eggNOGiENOG4105CNT Bacteria
COG3250 LUCA

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR004199 B-gal_small/dom_5
IPR036156 Beta-gal/glucu_dom_sf
IPR011013 Gal_mutarotase_sf_dom
IPR008979 Galactose-bd-like_sf
IPR014718 GH-type_carb-bd
IPR006101 Glyco_hydro_2
IPR023232 Glyco_hydro_2_AS
IPR006103 Glyco_hydro_2_cat
IPR023230 Glyco_hydro_2_CS
IPR006102 Glyco_hydro_2_Ig-like
IPR006104 Glyco_hydro_2_N
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
IPR032312 LacZ_4
PfamiView protein in Pfam
PF02929 Bgal_small_N, 1 hit
PF16353 DUF4981, 1 hit
PF00703 Glyco_hydro_2, 1 hit
PF02836 Glyco_hydro_2_C, 1 hit
PF02837 Glyco_hydro_2_N, 1 hit
PRINTSiPR00132 GLHYDRLASE2
SMARTiView protein in SMART
SM01038 Bgal_small_N, 1 hit
SUPFAMiSSF49303 SSF49303, 2 hits
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 2 hits
SSF74650 SSF74650, 1 hit
PROSITEiView protein in PROSITE
PS00719 GLYCOSYL_HYDROL_F2_1, 1 hit
PS00608 GLYCOSYL_HYDROL_F2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P70753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILPNYFQDP NTLHVNTVEH HAYFIPHQQN ETALSGKREQ SDYFTLLNGQ
60 70 80 90 100
WDFNYFQSYH DLPDNFLDIA FEHKIPVPAN WQNHGFDHHH YTNINYPFPF
110 120 130 140 150
EPPFVPHQNP CGVYHRTLQL TPKHKRYLLN FEGVDSCLFV YVNKQFVGYS
160 170 180 190 200
QISHNTSEFD VSDYLQAGTN HLTVVVLKWC DGSYLEDQDK FRMSGIFRDV
210 220 230 240 250
YLLEREQNYL QDFFIQYELD DELRHANLKV ETLFSRQPQA IEYQLLNPNG
260 270 280 290 300
FTVFNQTDTH LNIEVEDIQL WNAEKPQLYT LILHTAEEVI VQKIGFRKVE
310 320 330 340 350
IKDGILLFNQ QPIKFKGVNR HDSDPKTGYA ITYAQAHKDL QLMKQHNINA
360 370 380 390 400
IRTAHYPNAP WFSELCDQYG FYLIGESDVE SHGASMLTVK MPEPSILLNH
410 420 430 440 450
QNDLQTERIR QDMIDNYCYF ARDPLFKKAI LDRQQANVER DKNRTSIIIW
460 470 480 490 500
SLGNEAGYGA NFEAAAAWIK QRDKSRLVHY ESSIYQHSAD NNDLSNLDFY
510 520 530 540 550
SEMYGSTEDI DRYCATAQRK PFVLCEYSHA MGNSNGDAED YWQAFHRHPQ
560 570 580 590 600
SCGGFVWEWC DHAPYRANGQ FGYGGDFGES PHDGNFCMDG LVSPDRIPHS
610 620 630 640 650
NLLELKNVNR PARAELIDNQ IVIHNYLDFT DLADYLTIDY EFVENGVVTS
660 670 680 690 700
GGNLSVSCKP HSSVILPIEL PKNNGHLWLL NLDYRLNTAT ELLEAEHSLG
710 720 730 740 750
FEQLNLFSEN KLVLPKFTIE KSTFEVQEDH FRINVHNGQF SYQLDKQKGI
760 770 780 790 800
FSRIEKAGKA IIQQPLDFNI WRAPTDNDRL IREAWQNAGY DKAYTRAYEI
810 820 830 840 850
QWQQSEQAVE FSVKSAIVSI SRGRILTLDI RYRIFNDGQI SVEINAIRPT
860 870 880 890 900
ELPYLPRFGL RFWLAKAENT VEYFGYGEQE SYVDKHHLAN LGIYHTTAKQ
910 920 930 940 950
NHTDYVKPQE NGSHYGCEYL KSENLFVSAS QPFSFNLSPY TQEELTEKKH
960 970 980 990 1000
YYELQESDYS VLCIDYKMSG IGSNSCGPNL KDQYRLMESE FKIRFDLIFD

KTIRQ
Length:1,005
Mass (Da):117,009
Last modified:February 1, 1997 - v1
Checksum:i12254482581C710E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62625 Genomic DNA Translation: AAB17954.1
PIRiT31333

Similar proteinsi

Entry informationi

Entry nameiBGAL_ACTPL
AccessioniPrimary (citable) accession number: P70753
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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