Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADPBy similarity1
Binding sitei87NADP; via carbonyl oxygenBy similarity1
Binding sitei140SubstrateBy similarity1
Active sitei153Proton acceptorBy similarity1
Binding sitei186NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 12NADPBy similarity4
Nucleotide bindingi60 – 61NADPBy similarity2
Nucleotide bindingi153 – 157NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
OrganismiAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Taxonomic identifieri714 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546631 – 2423-oxoacyl-[acyl-carrier-protein] reductase FabGAdd BLAST242

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi694569.D7S_1371.

Structurei

3D structure databases

ProteinModelPortaliP70720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C2D. Bacteria.
COG1028. LUCA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011285. FabG-rel.
IPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01831. fabG_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

P70720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETILITGS SRGIGKAIAL RLAQAGFDIV VHCRSRIEEA EAVAQAVREL
60 70 80 90 100
GQNARVLQFD VSCRSEAADK LTADVEAHGA YYGVVLNAGL TRDNAFPALT
110 120 130 140 150
DEDWDRVLRT NLDGFYNVLH PIMMPMIRRR KAGRIVCITS VSGLIGNRGQ
160 170 180 190 200
VNYSASKAGI IGAAKALAVE LAKRKITVNC VAPGLIDTDI LDENVPIDEI
210 220 230 240
LKMIPAGRMG DPEEVAHAVN FLMGEKAAYV TRQVIAVNGG LC
Length:242
Mass (Da):25,987
Last modified:February 1, 1997 - v1
Checksum:i1BC08625504F9D19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88189 Genomic DNA. Translation: BAA13560.1.
RefSeqiWP_005545124.1. NZ_CP012958.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88189 Genomic DNA. Translation: BAA13560.1.
RefSeqiWP_005545124.1. NZ_CP012958.1.

3D structure databases

ProteinModelPortaliP70720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi694569.D7S_1371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105C2D. Bacteria.
COG1028. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011285. FabG-rel.
IPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01831. fabG_rel. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFABG_AGGAC
AccessioniPrimary (citable) accession number: P70720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.