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P70720 (FABG_AGGAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG

EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene names
Name:fabG
OrganismAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Taxonomic identifier714 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2422423-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054663

Regions

Nucleotide binding9 – 124NADP By similarity
Nucleotide binding60 – 612NADP By similarity
Nucleotide binding153 – 1575NADP By similarity

Sites

Active site1531Proton acceptor By similarity
Binding site341NADP By similarity
Binding site871NADP; via carbonyl oxygen By similarity
Binding site1401Substrate By similarity
Binding site1861NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P70720 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 1BC08625504F9D19

FASTA24225,987
        10         20         30         40         50         60 
MSETILITGS SRGIGKAIAL RLAQAGFDIV VHCRSRIEEA EAVAQAVREL GQNARVLQFD 

        70         80         90        100        110        120 
VSCRSEAADK LTADVEAHGA YYGVVLNAGL TRDNAFPALT DEDWDRVLRT NLDGFYNVLH 

       130        140        150        160        170        180 
PIMMPMIRRR KAGRIVCITS VSGLIGNRGQ VNYSASKAGI IGAAKALAVE LAKRKITVNC 

       190        200        210        220        230        240 
VAPGLIDTDI LDENVPIDEI LKMIPAGRMG DPEEVAHAVN FLMGEKAAYV TRQVIAVNGG 


LC 

« Hide

References

[1]"The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA."
Yoshida Y., Nakano Y., Yamashita Y., Koga T.
Biochem. Biophys. Res. Commun. 230:220-225(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 43718 / FDC Y4 / Serotype b.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D88189 Genomic DNA. Translation: BAA13560.1.

3D structure databases

ProteinModelPortalP70720.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR011285. FabG-rel.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01831. fabG_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABG_AGGAC
AccessionPrimary (citable) accession number: P70720
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways