Reviewed, UniProtKB/Swiss-Prot P70720 (FABG_ACTAC)

Names and origin

Protein names

Recommended name:
    3-oxoacyl-[acyl-carrier-protein] reductase
    EC=1.1.1.100
Alternative name(s):
    3-ketoacyl-acyl carrier protein reductase

Gene names

Name:

fabG

Organism

Actinobacillus actinomycetemcomitans (Haemophilus actinomycetemcomitans)

Taxonomic identifier

714 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Aggregatibacter

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxoacyl-[acyl-carrier-protein] reductase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	3-oxoacyl-[acyl-carrier-protein] reductase		PRO_0000054663
Regions
	Nucleotide binding	7 – 32	26	NADP By similarity
Sites
	Active site	153	1	Proton acceptor By similarity
	Binding site	140	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P70720-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 1BC08625504F9D19	FASTA	242	25,987
	10 20 30 40 50 60 MSETILITGS SRGIGKAIAL RLAQAGFDIV VHCRSRIEEA EAVAQAVREL GQNARVLQFD 70 80 90 100 110 120 VSCRSEAADK LTADVEAHGA YYGVVLNAGL TRDNAFPALT DEDWDRVLRT NLDGFYNVLH 130 140 150 160 170 180 PIMMPMIRRR KAGRIVCITS VSGLIGNRGQ VNYSASKAGI IGAAKALAVE LAKRKITVNC 190 200 210 220 230 240 VAPGLIDTDI LDENVPIDEI LKMIPAGRMG DPEEVAHAVN FLMGEKAAYV TRQVIAVNGG LC

References

[1]

"The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA." Yoshida Y., Nakano Y., Yamashita Y., Koga T. Biochem. Biophys. Res. Commun. 230:220-225(1997) [PubMed: 9020051] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43718 / FDC Y4 / Serotype b.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D88189 Genomic DNA. Translation: BAA13560.1.
3D structure databases
HSSP	HSSP built from PDB template 1EDO based on UniProtKB Q93X62.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.100. 164755.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR011285. FabG_rel. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit. PTHR19410:SF92. FabG_rel. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
TIGRFAMs	TIGR01831. fabG_rel. 1 hit.
PROSITE	PS00061. ADH_SHORT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABG_ACTAC

Accession

Primary (citable) accession number: P70720

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)