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P70718

- 6PGD_AGGAC

UniProt

P70718 - 6PGD_AGGAC

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Protein
6-phosphogluconate dehydrogenase, decarboxylating
Gene
gnd
Organism
Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041NADP By similarity
Binding sitei104 – 1041Substrate By similarity
Active sitei185 – 1851Proton acceptor By similarity
Active sitei192 – 1921Proton donor By similarity
Binding sitei193 – 1931Substrate By similarity
Binding sitei262 – 2621Substrate; via amide nitrogen By similarity
Binding sitei289 – 2891Substrate By similarity
Binding sitei447 – 4471Substrate; shared with dimeric partner By similarity
Binding sitei453 – 4531Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADP By similarity
Nucleotide bindingi34 – 363NADP By similarity
Nucleotide bindingi76 – 783NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
OrganismiAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Taxonomic identifieri714 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4844846-phosphogluconate dehydrogenase, decarboxylating
PRO_0000090024Add
BLAST

Proteomic databases

PRIDEiP70718.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP70718.
SMRiP70718. Positions 4-475.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1323Substrate binding By similarity
Regioni188 – 1892Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70718-1 [UniParc]FASTAAdd to Basket

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MSVKGDIGVI GLAVMGQNLI LNMNDHGFKV VAYNRTTSKV DEFLEGAAKG    50
TNIIGAYSLE DLANKLEKPR KVMLMVRAGE VVDHFIDALL PHLEAGDIII 100
DGGNSNYPDT NRRVAALREK GIRFIGTGVS GGEEGARHGP SIMPGGNEEA 150
WQFVKPVLQA ISAKTEQGEP CCDWVGKDGA GHFVKMVHNG IEYGDMQLIC 200
EAYQFLKEGV GLSDDELQAT FNEWRNTELD SYLIDITADI LGYKDADGSR 250
LVDKVLDTAG QKGTGKWTGI NALDFGIPLT LITESVFARC VSAFKDQRVA 300
ASKLFHKTIG KVEGDKKVWI EAVRKALLAS KIISYAQGFM LIREASEHFN 350
WNINYGNTAL LWREGCIIRS RFLGNIRDAY EANPDLIFLG SDSYFKGILE 400
NAMSDWRKVV AKSIEVGIPM PCMASAITFL DGYTSARLPA NLLQAQRDYF 450
GAHTYERTDK PRGEFFHTNW TGRGGNTAST TYDV 484
Length:484
Mass (Da):53,289
Last modified:February 1, 1997 - v1
Checksum:iF7BD0B2EA3BF624D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D88189 Genomic DNA. Translation: BAA13558.1.
PIRiJC5282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D88189 Genomic DNA. Translation: BAA13558.1 .
PIRi JC5282.

3D structure databases

ProteinModelPortali P70718.
SMRi P70718. Positions 4-475.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P70718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA."
    Yoshida Y., Nakano Y., Yamashita Y., Koga T.
    Biochem. Biophys. Res. Commun. 230:220-225(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43718 / FDC Y4 / Serotype b.

Entry informationi

Entry namei6PGD_AGGAC
AccessioniPrimary (citable) accession number: P70718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 16, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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