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P70718

- 6PGD_AGGAC

UniProt

P70718 - 6PGD_AGGAC

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041NADPBy similarity
    Binding sitei104 – 1041SubstrateBy similarity
    Active sitei185 – 1851Proton acceptorBy similarity
    Active sitei192 – 1921Proton donorBy similarity
    Binding sitei193 – 1931SubstrateBy similarity
    Binding sitei262 – 2621Substrate; via amide nitrogenBy similarity
    Binding sitei289 – 2891SubstrateBy similarity
    Binding sitei447 – 4471Substrate; shared with dimeric partnerBy similarity
    Binding sitei453 – 4531Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADPBy similarity
    Nucleotide bindingi34 – 363NADPBy similarity
    Nucleotide bindingi76 – 783NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:gnd
    OrganismiAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
    Taxonomic identifieri714 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4844846-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090024Add
    BLAST

    Proteomic databases

    PRIDEiP70718.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP70718.
    SMRiP70718. Positions 4-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1323Substrate bindingBy similarity
    Regioni188 – 1892Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70718-1 [UniParc]FASTAAdd to Basket

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    MSVKGDIGVI GLAVMGQNLI LNMNDHGFKV VAYNRTTSKV DEFLEGAAKG    50
    TNIIGAYSLE DLANKLEKPR KVMLMVRAGE VVDHFIDALL PHLEAGDIII 100
    DGGNSNYPDT NRRVAALREK GIRFIGTGVS GGEEGARHGP SIMPGGNEEA 150
    WQFVKPVLQA ISAKTEQGEP CCDWVGKDGA GHFVKMVHNG IEYGDMQLIC 200
    EAYQFLKEGV GLSDDELQAT FNEWRNTELD SYLIDITADI LGYKDADGSR 250
    LVDKVLDTAG QKGTGKWTGI NALDFGIPLT LITESVFARC VSAFKDQRVA 300
    ASKLFHKTIG KVEGDKKVWI EAVRKALLAS KIISYAQGFM LIREASEHFN 350
    WNINYGNTAL LWREGCIIRS RFLGNIRDAY EANPDLIFLG SDSYFKGILE 400
    NAMSDWRKVV AKSIEVGIPM PCMASAITFL DGYTSARLPA NLLQAQRDYF 450
    GAHTYERTDK PRGEFFHTNW TGRGGNTAST TYDV 484
    Length:484
    Mass (Da):53,289
    Last modified:February 1, 1997 - v1
    Checksum:iF7BD0B2EA3BF624D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88189 Genomic DNA. Translation: BAA13558.1.
    PIRiJC5282.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88189 Genomic DNA. Translation: BAA13558.1 .
    PIRi JC5282.

    3D structure databases

    ProteinModelPortali P70718.
    SMRi P70718. Positions 4-475.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P70718.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA."
      Yoshida Y., Nakano Y., Yamashita Y., Koga T.
      Biochem. Biophys. Res. Commun. 230:220-225(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 43718 / FDC Y4 / Serotype b.

    Entry informationi

    Entry namei6PGD_AGGAC
    AccessioniPrimary (citable) accession number: P70718
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3