P70715 (6PGL_AGGAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconolactonase
Short name=6PGL
EC=3.1.1.31

Gene names

Name:	pgl
Synonyms:	devB

Organism

Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)

Taxonomic identifier

714 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Aggregatibacter

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
Sequence caution	The sequence BAA13555.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	6-phosphogluconolactonase		PRO_0000090088

Sequences

	Sequence		Length	Mass (Da)
	P70715 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 578F29F1751CC40A	FASTA	232	26,224
	10 20 30 40 50 60 MNYITFPTAQ HAVEKIAQEF VIYSQLNHPA HISLSGGSTP KLLFKTLAQS PYAEQINWRN 70 80 90 100 110 120 LHFWWGDDRM VSPSDPESNY GEVQKLLFDH IQIPAENIHR IRGENEPHFE LKRFQAELSA 130 140 150 160 170 180 VISDGVFDWI ILGMGADGHT SSLFPHQTNF DDENLAVIAK HPESGQIRIS KTAKLIEQAK 190 200 210 220 230 RITYLVTGEG KAEILKEIQS TPAENLPYPA AKIYAKNGVT EWYLDKDAAK LL

References

[1]	"The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA." Yoshida Y., Nakano Y., Yamashita Y., Koga T. Biochem. Biophys. Res. Commun. 230:220-225(1997) [PubMed: 9020051] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43718 / FDC Y4 / Serotype b.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D88189 Genomic DNA. Translation: BAA13555.1. Different initiation.
3D structure databases
ProteinModelPortal	P70715.
SMR	P70715. Positions 1-229.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005900. 6-phosphogluconolactonase_DevB. IPR006148. Glc/Gal-6P_isomerase. [Graphical view]
Pfam	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
TIGRFAMs	TIGR01198. Pgl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

6PGL_AGGAC

Accession

Primary (citable) accession number: P70715

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 30, 2000
Last modified:	May 31, 2011
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program