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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathway:ipentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
OrganismiAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Taxonomic identifieri714 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2322326-phosphogluconolactonasePRO_0000090088Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi694569.D7S_0831.

Structurei

3D structure databases

ProteinModelPortaliP70715.
SMRiP70715. Positions 1-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

P70715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYITFPTAQ HAVEKIAQEF VIYSQLNHPA HISLSGGSTP KLLFKTLAQS
60 70 80 90 100
PYAEQINWRN LHFWWGDDRM VSPSDPESNY GEVQKLLFDH IQIPAENIHR
110 120 130 140 150
IRGENEPHFE LKRFQAELSA VISDGVFDWI ILGMGADGHT SSLFPHQTNF
160 170 180 190 200
DDENLAVIAK HPESGQIRIS KTAKLIEQAK RITYLVTGEG KAEILKEIQS
210 220 230
TPAENLPYPA AKIYAKNGVT EWYLDKDAAK LL
Length:232
Mass (Da):26,224
Last modified:May 30, 2000 - v2
Checksum:i578F29F1751CC40A
GO

Sequence cautioni

The sequence BAA13555.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88189 Genomic DNA. Translation: BAA13555.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88189 Genomic DNA. Translation: BAA13555.1. Different initiation.

3D structure databases

ProteinModelPortaliP70715.
SMRiP70715. Positions 1-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi694569.D7S_0831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA."
    Yoshida Y., Nakano Y., Yamashita Y., Koga T.
    Biochem. Biophys. Res. Commun. 230:220-225(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43718 / FDC Y4 / Serotype b.

Entry informationi

Entry namei6PGL_AGGAC
AccessioniPrimary (citable) accession number: P70715
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: June 24, 2015
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.