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Protein

Ubiquitin-conjugating enzyme E2 D2B

Gene

Ube2d2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection Plays a role in early maturation of the testis.PROSITE-ProRule annotationBy similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotationBy similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-RNO-202424. Downstream TCR signaling.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.
R-RNO-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
R-RNO-8866654. E3 ubiquitin ligases ubiquitinate target proteins.
R-RNO-8951664. Neddylation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 D2B (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme D2B
Ubiquitin carrier protein D2B
Ubiquitin-conjugating enzyme E2(17)KB 2B
Ubiquitin-conjugating enzyme E2-17 kDa 2B
Ubiquitin-protein ligase D2B
Gene namesi
Name:Ube2d2b
Synonyms:Ube2d2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi69425. RGD69425.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000824691 – 147Ubiquitin-conjugating enzyme E2 D2BAdd BLAST147

Proteomic databases

PaxDbiP70711.
PRIDEiP70711.

PTM databases

iPTMnetiP70711.
PhosphoSitePlusiP70711.

Expressioni

Tissue specificityi

Testis-specific. Mainly expressed in the round spermatids (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000034016.
GenevisibleiP70711. RN.

Interactioni

Subunit structurei

Interacts with CNOT4 (via RING domain).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039621.

Structurei

3D structure databases

ProteinModelPortaliP70711.
SMRiP70711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00760000119012.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
InParanoidiP70711.
KOiK06689.
OMAiXVAFTTR.
OrthoDBiEOG091G0GF8.
PhylomeDBiP70711.
TreeFamiTF101108.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P70711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKRIHKEL NDLAQDPPAQ CSAGPVGEDM FHWQATIMGP NDSPYQGGAF
60 70 80 90 100
FLTIDFPTEY PFKPPKVEFT TRIYHPNVNS NGSICLDILR SQWSPALTIS
110 120 130 140
KVLLSISSLL CDPNPDDPLV PEIAQIYKTD RDKYNRTARE WTQKYAM
Length:147
Mass (Da):16,659
Last modified:February 1, 1997 - v1
Checksum:iE950720AEC2AB2B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56407 mRNA. Translation: AAC52942.1.
BC078808 mRNA. Translation: AAH78808.1.
RefSeqiNP_112263.1. NM_031001.2.
UniGeneiRn.113868.

Genome annotation databases

EnsembliENSRNOT00000049772; ENSRNOP00000039621; ENSRNOG00000034016.
GeneIDi79435.
KEGGirno:79435.
UCSCiRGD:69425. rat.

Similar proteinsi

Entry informationi

Entry nameiU2D2B_RAT
AccessioniPrimary (citable) accession number: P70711
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 27, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families