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Protein

Ubiquitin-conjugating enzyme E2 D2B

Gene

Ube2d2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection Plays a role in early maturation of the testis.PROSITE-ProRule annotationBy similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotationBy similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-RNO-202424 Downstream TCR signaling
R-RNO-2871837 FCERI mediated NF-kB activation
R-RNO-5607764 CLEC7A (Dectin-1) signaling
R-RNO-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-RNO-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-RNO-8951664 Neddylation
R-RNO-9033241 Peroxisomal protein import
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 D2B (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme D2B
Ubiquitin carrier protein D2B
Ubiquitin-conjugating enzyme E2(17)KB 2B
Ubiquitin-conjugating enzyme E2-17 kDa 2B
Ubiquitin-protein ligase D2B
Gene namesi
Name:Ube2d2b
Synonyms:Ube2d2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi69425 RGD69425

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000824691 – 147Ubiquitin-conjugating enzyme E2 D2BAdd BLAST147

Proteomic databases

PaxDbiP70711
PRIDEiP70711

PTM databases

iPTMnetiP70711
PhosphoSitePlusiP70711

Expressioni

Tissue specificityi

Testis-specific. Mainly expressed in the round spermatids (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000034016
GenevisibleiP70711 RN

Interactioni

Subunit structurei

Interacts with CNOT4 (via RING domain).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039621

Structurei

3D structure databases

ProteinModelPortaliP70711
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00910000143990
HOGENOMiHOG000233455
HOVERGENiHBG063308
InParanoidiP70711
KOiK06689
OMAiXVAFTTR
OrthoDBiEOG091G0GF8
PhylomeDBiP70711
TreeFamiTF101108

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P70711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKRIHKEL NDLAQDPPAQ CSAGPVGEDM FHWQATIMGP NDSPYQGGAF
60 70 80 90 100
FLTIDFPTEY PFKPPKVEFT TRIYHPNVNS NGSICLDILR SQWSPALTIS
110 120 130 140
KVLLSISSLL CDPNPDDPLV PEIAQIYKTD RDKYNRTARE WTQKYAM
Length:147
Mass (Da):16,659
Last modified:February 1, 1997 - v1
Checksum:iE950720AEC2AB2B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56407 mRNA Translation: AAC52942.1
BC078808 mRNA Translation: AAH78808.1
RefSeqiNP_112263.1, NM_031001.2
UniGeneiRn.113868

Genome annotation databases

EnsembliENSRNOT00000049772; ENSRNOP00000039621; ENSRNOG00000034016
GeneIDi79435
KEGGirno:79435
UCSCiRGD:69425 rat

Similar proteinsi

Entry informationi

Entry nameiU2D2B_RAT
AccessioniPrimary (citable) accession number: P70711
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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