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Protein

Protein-arginine deiminase type-3

Gene

Padi3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • protein-arginine deiminase activity Source: UniProtKB

GO - Biological processi

  • arginine deiminase pathway Source: RGD
  • protein citrullination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BRENDAi3.5.3.15. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-3 (EC:3.5.3.15)
Alternative name(s):
Peptidylarginine deiminase III
Protein-arginine deiminase type III
Gene namesi
Name:Padi3
Synonyms:Pad3, Pdi3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3289. Padi3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 664664Protein-arginine deiminase type-3PRO_0000220031Add
BLAST

Proteomic databases

PaxDbiP70708.
PRIDEiP70708.

PTM databases

iPTMnetiP70708.
PhosphoSiteiP70708.

Expressioni

Tissue specificityi

Epidermis and hair follicles.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009230.

Structurei

3D structure databases

ProteinModelPortaliP70708.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG410IF3F. Eukaryota.
ENOG410ZKF3. LUCA.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiP70708.
KOiK01481.
PhylomeDBiP70708.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.

Sequencei

Sequence statusi: Complete.

P70708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQRTVRVS LEHPTSAVCV AGVETIVDIY GSVPEGTDMF EVYGTPGVDI
60 70 80 90 100
YVSPSMERNR ERADTRRWCF NKGLEIIVVM NSPSNDLNDS HVQIAYHSSH
110 120 130 140 150
EHLPLAYAVL YLTCVDITLD CDMNCADRQD RSFVDKRQWM WGPDGYGAIL
160 170 180 190 200
LVNCDRDEVS SDAQDNCDQC VRCLQDLEDM SVMVLRTQGP ESLFDDHRLI
210 220 230 240 250
LHTSSCDAER ARVFHVCGPE DSCEAYRCVL GPDRMSYEVP RLKGYEERFY
260 270 280 290 300
VEGLSFPDAG FPGILSFHIT LLDDSNEDYS ETPIFTDTVV FRVAPWIMTP
310 320 330 340 350
STLPPLEVYV CQVRNNTCFV EAVEELARKA GCKLTICPQA ENRNDRWIQD
360 370 380 390 400
EMELGYTQAP HKTLPVVFDS PRNGELQGFP YKRILGLDFG YVTREPPDSS
410 420 430 440 450
VSGLDSFGNL EVSPPVVANG KEYPLGRILI GGNLPGSRGR RVTQVVRDFL
460 470 480 490 500
HAQKVQPLVE LFVDWLAVGH VDEFLSFVPA PDGKGFRLLL ASPGACFRLF
510 520 530 540 550
QEKQKWGHGR SLLFEGVIGD RRVQTISINQ VLSNQSLINF NKFAQSCIDW
560 570 580 590 600
NREVLKRELG LGESDIIDIP QLFKSEKRKA VAFFPDLVNM LVLGKHLGIP
610 620 630 640 650
KPFGPIINGR CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV
660
RREPFAFKWW HMVP
Length:664
Mass (Da):75,038
Last modified:February 1, 1997 - v1
Checksum:iE5E6DDBCFADC66F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88034 mRNA. Translation: BAA13532.1.
PIRiJC5440.
RefSeqiNP_058926.1. NM_017230.2.
UniGeneiRn.32094.

Genome annotation databases

GeneIDi29520.
KEGGirno:29520.
UCSCiRGD:3289. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88034 mRNA. Translation: BAA13532.1.
PIRiJC5440.
RefSeqiNP_058926.1. NM_017230.2.
UniGeneiRn.32094.

3D structure databases

ProteinModelPortaliP70708.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009230.

PTM databases

iPTMnetiP70708.
PhosphoSiteiP70708.

Proteomic databases

PaxDbiP70708.
PRIDEiP70708.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29520.
KEGGirno:29520.
UCSCiRGD:3289. rat.

Organism-specific databases

CTDi51702.
RGDi3289. Padi3.

Phylogenomic databases

eggNOGiENOG410IF3F. Eukaryota.
ENOG410ZKF3. LUCA.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiP70708.
KOiK01481.
PhylomeDBiP70708.

Enzyme and pathway databases

BRENDAi3.5.3.15. 5301.

Miscellaneous databases

PROiP70708.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPADI3_RAT
AccessioniPrimary (citable) accession number: P70708
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.