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P70705

- ATP7A_RAT

UniProt

P70705 - ATP7A_RAT

Protein

Copper-transporting ATPase 1

Gene

Atp7a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells By similarity.By similarity

    Catalytic activityi

    ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1036 – 103614-aspartylphosphate intermediateBy similarity
    Metal bindingi1293 – 12931MagnesiumPROSITE-ProRule annotation
    Metal bindingi1297 – 12971MagnesiumPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. copper-exporting ATPase activity Source: Ensembl
    3. copper ion transmembrane transporter activity Source: RGD
    4. superoxide dismutase copper chaperone activity Source: Ensembl

    GO - Biological processi

    1. blood vessel development Source: Ensembl
    2. blood vessel remodeling Source: Ensembl
    3. cartilage development Source: Ensembl
    4. cellular copper ion homeostasis Source: RGD
    5. cerebellar Purkinje cell differentiation Source: Ensembl
    6. collagen fibril organization Source: Ensembl
    7. copper ion import Source: Ensembl
    8. dendrite morphogenesis Source: Ensembl
    9. detoxification of copper ion Source: Ensembl
    10. dopamine metabolic process Source: Ensembl
    11. elastic fiber assembly Source: Ensembl
    12. elastin biosynthetic process Source: Ensembl
    13. epinephrine metabolic process Source: Ensembl
    14. hair follicle morphogenesis Source: Ensembl
    15. in utero embryonic development Source: RGD
    16. lactation Source: RGD
    17. locomotory behavior Source: Ensembl
    18. lung alveolus development Source: Ensembl
    19. negative regulation of metalloenzyme activity Source: Ensembl
    20. negative regulation of neuron apoptotic process Source: Ensembl
    21. norepinephrine biosynthetic process Source: Ensembl
    22. peptidyl-lysine modification Source: Ensembl
    23. pigmentation Source: Ensembl
    24. plasma membrane copper ion transport Source: RGD
    25. positive regulation of metalloenzyme activity Source: Ensembl
    26. positive regulation of oxidoreductase activity Source: Ensembl
    27. pyramidal neuron development Source: Ensembl
    28. regulation of gene expression Source: Ensembl
    29. regulation of oxidative phosphorylation Source: Ensembl
    30. release of cytochrome c from mitochondria Source: Ensembl
    31. removal of superoxide radicals Source: Ensembl
    32. response to copper ion Source: RGD
    33. response to iron(III) ion Source: RGD
    34. response to zinc ion Source: RGD
    35. serotonin metabolic process Source: Ensembl
    36. T-helper cell differentiation Source: Ensembl
    37. tryptophan metabolic process Source: Ensembl
    38. tyrosine metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Copper transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi3.6.3.4. 5301.
    ReactomeiREACT_213899. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Copper-transporting ATPase 1 (EC:3.6.3.54)
    Alternative name(s):
    Copper pump 1
    Menkes disease-associated protein homolog
    Gene namesi
    Name:Atp7a
    Synonyms:Mnk
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi2179. Atp7a.

    Subcellular locationi

    Golgi apparatustrans-Golgi network membrane By similarity; Multi-pass membrane protein By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Constitutively cycles between the trans-Golgi network (TGN) and the plasma membrane. Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels By similarity.By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: RGD
    2. brush border membrane Source: RGD
    3. Golgi apparatus Source: MGI
    4. integral component of membrane Source: MGI
    5. late endosome Source: Ensembl
    6. neuronal cell body Source: Ensembl
    7. neuron projection Source: Ensembl
    8. perinuclear region of cytoplasm Source: RGD
    9. secretory granule Source: RGD
    10. trans-Golgi network Source: MGI
    11. trans-Golgi network transport vesicle Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14921492Copper-transporting ATPase 1PRO_0000046313Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei339 – 3391PhosphoserineBy similarity
    Modified residuei357 – 3571PhosphoserineBy similarity
    Glycosylationi678 – 6781N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1204 – 12041Phosphothreonine1 Publication
    Modified residuei1458 – 14581PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP70705.
    PRIDEiP70705.

    PTM databases

    PhosphoSiteiP70705.

    Expressioni

    Gene expression databases

    GenevestigatoriP70705.

    Interactioni

    Subunit structurei

    Monomer. Interacts with PDZD11.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP70705.
    SMRiP70705. Positions 1-79, 164-246, 275-351, 375-444, 475-625.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 645645CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini668 – 70639ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini727 – 7337CytoplasmicSequence Analysis
    Topological domaini755 – 77319ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini795 – 927133CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini952 – 98130ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1004 – 1348345CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1367 – 137711ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1398 – 149295CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei646 – 66722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei707 – 72620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei734 – 75421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei774 – 79421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei928 – 95124HelicalSequence AnalysisAdd
    BLAST
    Transmembranei982 – 100322HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1349 – 136618HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1378 – 139720HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 7567HMA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini172 – 23867HMA 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini278 – 34467HMA 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini378 – 44467HMA 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini481 – 54767HMA 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini557 – 62367HMA 6PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1478 – 149215PDZD11-bindingBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1479 – 14802Endocytosis signalBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi356 – 3627Poly-Ser

    Domaini

    The C-terminal di-leucine, 1479-Leu-Leu-1480, is an endocytic targeting signal which functions in retrieving recycling from the plasma membrane to the TGN. Mutation of the di-leucine signal results in the accumulation of the protein in the plasma membrane By similarity.By similarity

    Sequence similaritiesi

    Contains 6 HMA domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2217.
    GeneTreeiENSGT00530000063773.
    HOGENOMiHOG000250397.
    HOVERGENiHBG050616.
    KOiK17686.
    OMAiEYEDREQ.
    OrthoDBiEOG7C2R0G.
    PhylomeDBiP70705.

    Family and domain databases

    Gene3Di2.70.150.10. 1 hit.
    3.40.1110.10. 2 hits.
    3.40.50.1000. 2 hits.
    InterProiIPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR027256. Cation_transp_P-typ_ATPase_IB.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    IPR017969. Heavy-metal-associated_CS.
    IPR006121. HeavyMe-assoc_HMA.
    IPR006122. HMA_Cu_ion-bd.
    [Graphical view]
    PfamiPF00122. E1-E2_ATPase. 1 hit.
    PF00403. HMA. 6 hits.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SUPFAMiSSF55008. SSF55008. 6 hits.
    SSF56784. SSF56784. 2 hits.
    TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    TIGR00003. TIGR00003. 6 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    PS01047. HMA_1. 6 hits.
    PS50846. HMA_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70705-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPNMDANSI TITVEGMTCI SCVRTIEQQI GKVNGVHHIK VSLEEKSATV     50
    IYNPKLQTPK TLQEAIDDMG FDALLHNANP LPVLTNTVFL TVTAPLALPW 100
    DHIQSTLLKT KGVTGVKISP QQRSAVVTII PSVVSANQIV ELVPDLSLDM 150
    GTQEKKSGTS EEHSTPQAGE VLLKMRVEGM TCHSCTSTIE GKVGKLQGVQ 200
    RIKVSLDNQE ATIVYQPHLI TAEEIKKQIE AVGFPAFIKK QPKYLKLGAI 250
    DVERLKSTPV KSSEGSQQKS PAYPSDSAIT FTIDGMHCKS CVSNIESALS 300
    TLQYVSSIVV SLENRSAIVK YNASLVTPEI LRKAIEAVSP GQYRVSISSE 350
    VESPTSSPSS SSLQKMPLNL VSQPLTQEVV ININGMTCNS CVQSIEGVIS 400
    KKPGVKSIHV SLTNSTGTIE YDPLLTSPEP LREAIEDMGF DAVLPADMKE 450
    PLVVIAQPSL ETPLLPSTTE PENVMTPVQN KCYIQVSGMT CASCVANIER 500
    NLRREEGIYS VLVALMAGKA EVRYNPAVIQ PRVIAELIRE LGFGAVVMEN 550
    AGEGNGILEL VVRGMTCASC VHKIESTLTK HKGIFYCSVA LATNKAHIKY 600
    DPEIIGPRDI IHTIGNLGFE ASLVKKDRSA NHLDHKREIK QWRGSFLVSL 650
    FFCIPVMGLM IYMMVMDHHL ATLNHNQNMS NEEMINMHSS MFLERQILPG 700
    LSIMNLLSLL LCLPVQFCGG WYFYIQAYKA LRHKTANMDV LIVLATTIAF 750
    AYSLVILLVA MYERAKVNPI TFFDTPPMLF VFIALGRWLE HIAKGKTSEA 800
    LAKLISLQAT EATIVTLNSE NLLLSEEQVD VELVQRGDII KVVPGGKFPV 850
    DGRVIEGHSM VDESLITGEA MPVAKKPGST VIAGSINQNG SLLIRATHVG 900
    ADTTLSQIVK LVEEAQTSKA PIQQFADKLS GYFVPFIVLV SIVTLLVWII 950
    IGFQNFEIVE AYFPGYNRSI SRTETIIRFA FQASITVLCI ACPCSLGLAT 1000
    PTAVMVGTGV GAQNGILIKG GEPLEMAHKV KVVVFDKTGT ITHGTPVVNQ 1050
    VKVLVESNKI SRNKILAIVG TAESNSEHPL GAAVTKYCKQ ELDTETLGTC 1100
    TDFQVVPGCG ISCKVTNIEG LLHKSNLKIE ENNIKNASLV QIDAINEQSS 1150
    PSSSMIIDAH LSNAVNTQQY KVLIGNREWM IRNGLVISND VDESMIEHER 1200
    RGRTAVLVTI DDELCGLIAI ADTVKPEAEL AVHILKSMGL EVVLMTGDNS 1250
    KTARSIASQV GITKVFAEVL PSHKVAKVKQ LQEEGKRVAM VGDGINDSPA 1300
    LAMASVGIAI GTGTDVAIEA ADVVLIRNDL LDVVASIDLS RKTVKRIRIN 1350
    FVFALIYNLI GIPIAAGVFL PIGLVLQPWM GSAAMAASSV SVVLSSLFLK 1400
    LYRKPTYDNY ELRPRSHTGQ RSPSEISVHV GIDDTSRNSP RLGLLDRIVN 1450
    YSRASINSLL SDKRSLNSVV TSEPDKHSLL VGDFREDDDT TL 1492
    Length:1,492
    Mass (Da):162,093
    Last modified:February 1, 1997 - v1
    Checksum:i34F75152B105AE9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59245 mRNA. Translation: AAB06393.1.
    PIRiS46483.
    RefSeqiNP_434690.1. NM_052803.2.
    XP_006257057.1. XM_006256995.1.
    XP_006257058.1. XM_006256996.1.
    UniGeneiRn.10554.

    Genome annotation databases

    EnsembliENSRNOT00000065388; ENSRNOP00000063702; ENSRNOG00000002515.
    GeneIDi24941.
    KEGGirno:24941.
    UCSCiRGD:2179. rat.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Heavy metal - Issue 79 of February 2007

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59245 mRNA. Translation: AAB06393.1 .
    PIRi S46483.
    RefSeqi NP_434690.1. NM_052803.2.
    XP_006257057.1. XM_006256995.1.
    XP_006257058.1. XM_006256996.1.
    UniGenei Rn.10554.

    3D structure databases

    ProteinModelPortali P70705.
    SMRi P70705. Positions 1-79, 164-246, 275-351, 375-444, 475-625.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P70705.

    Proteomic databases

    PaxDbi P70705.
    PRIDEi P70705.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000065388 ; ENSRNOP00000063702 ; ENSRNOG00000002515 .
    GeneIDi 24941.
    KEGGi rno:24941.
    UCSCi RGD:2179. rat.

    Organism-specific databases

    CTDi 538.
    RGDi 2179. Atp7a.

    Phylogenomic databases

    eggNOGi COG2217.
    GeneTreei ENSGT00530000063773.
    HOGENOMi HOG000250397.
    HOVERGENi HBG050616.
    KOi K17686.
    OMAi EYEDREQ.
    OrthoDBi EOG7C2R0G.
    PhylomeDBi P70705.

    Enzyme and pathway databases

    BRENDAi 3.6.3.4. 5301.
    Reactomei REACT_213899. Detoxification of Reactive Oxygen Species.

    Miscellaneous databases

    NextBioi 604931.
    PROi P70705.

    Gene expression databases

    Genevestigatori P70705.

    Family and domain databases

    Gene3Di 2.70.150.10. 1 hit.
    3.40.1110.10. 2 hits.
    3.40.50.1000. 2 hits.
    InterProi IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR027256. Cation_transp_P-typ_ATPase_IB.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    IPR017969. Heavy-metal-associated_CS.
    IPR006121. HeavyMe-assoc_HMA.
    IPR006122. HMA_Cu_ion-bd.
    [Graphical view ]
    Pfami PF00122. E1-E2_ATPase. 1 hit.
    PF00403. HMA. 6 hits.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SUPFAMi SSF55008. SSF55008. 6 hits.
    SSF56784. SSF56784. 2 hits.
    TIGRFAMsi TIGR01525. ATPase-IB_hvy. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    TIGR00003. TIGR00003. 6 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    PS01047. HMA_1. 6 hits.
    PS50846. HMA_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a Menkes-type Cu-transporting ATPase from rat C6 glioma cells: comparison of the rat protein with other mammalian Cu-transporting ATPases."
      Qian Y., Tiffany-Castiglioni E., Harris E.D.
      Mol. Cell. Biochem. 181:49-61(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Astrocyte.
    2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiATP7A_RAT
    AccessioniPrimary (citable) accession number: P70705
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 8, 2000
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3