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P70705

- ATP7A_RAT

UniProt

P70705 - ATP7A_RAT

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Protein

Copper-transporting ATPase 1

Gene

Atp7a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells (By similarity).By similarity

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1036 – 103614-aspartylphosphate intermediateBy similarity
Metal bindingi1293 – 12931MagnesiumPROSITE-ProRule annotation
Metal bindingi1297 – 12971MagnesiumPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. copper-exporting ATPase activity Source: Ensembl
  3. copper ion transmembrane transporter activity Source: RGD
  4. superoxide dismutase copper chaperone activity Source: Ensembl

GO - Biological processi

  1. blood vessel development Source: Ensembl
  2. blood vessel remodeling Source: Ensembl
  3. cartilage development Source: Ensembl
  4. cellular copper ion homeostasis Source: RGD
  5. cerebellar Purkinje cell differentiation Source: Ensembl
  6. collagen fibril organization Source: Ensembl
  7. copper ion import Source: Ensembl
  8. dendrite morphogenesis Source: Ensembl
  9. detoxification of copper ion Source: Ensembl
  10. dopamine metabolic process Source: Ensembl
  11. elastic fiber assembly Source: Ensembl
  12. elastin biosynthetic process Source: Ensembl
  13. epinephrine metabolic process Source: Ensembl
  14. hair follicle morphogenesis Source: Ensembl
  15. in utero embryonic development Source: RGD
  16. lactation Source: RGD
  17. locomotory behavior Source: Ensembl
  18. lung alveolus development Source: Ensembl
  19. negative regulation of metalloenzyme activity Source: Ensembl
  20. negative regulation of neuron apoptotic process Source: Ensembl
  21. norepinephrine biosynthetic process Source: Ensembl
  22. peptidyl-lysine modification Source: Ensembl
  23. pigmentation Source: Ensembl
  24. plasma membrane copper ion transport Source: RGD
  25. positive regulation of metalloenzyme activity Source: Ensembl
  26. positive regulation of oxidoreductase activity Source: Ensembl
  27. pyramidal neuron development Source: Ensembl
  28. regulation of gene expression Source: Ensembl
  29. regulation of oxidative phosphorylation Source: Ensembl
  30. release of cytochrome c from mitochondria Source: Ensembl
  31. removal of superoxide radicals Source: Ensembl
  32. response to copper ion Source: RGD
  33. response to iron(III) ion Source: RGD
  34. response to zinc ion Source: RGD
  35. serotonin metabolic process Source: Ensembl
  36. T-helper cell differentiation Source: Ensembl
  37. tryptophan metabolic process Source: Ensembl
  38. tyrosine metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.4. 5301.
ReactomeiREACT_213899. Detoxification of Reactive Oxygen Species.
REACT_247493. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting ATPase 1 (EC:3.6.3.54)
Alternative name(s):
Copper pump 1
Menkes disease-associated protein homolog
Gene namesi
Name:Atp7a
Synonyms:Mnk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi2179. Atp7a.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane By similarity; Multi-pass membrane protein By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Constitutively cycles between the trans-Golgi network (TGN) and the plasma membrane. Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 645645CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei646 – 66722HelicalSequence AnalysisAdd
BLAST
Topological domaini668 – 70639ExtracellularSequence AnalysisAdd
BLAST
Transmembranei707 – 72620HelicalSequence AnalysisAdd
BLAST
Topological domaini727 – 7337CytoplasmicSequence Analysis
Transmembranei734 – 75421HelicalSequence AnalysisAdd
BLAST
Topological domaini755 – 77319ExtracellularSequence AnalysisAdd
BLAST
Transmembranei774 – 79421HelicalSequence AnalysisAdd
BLAST
Topological domaini795 – 927133CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei928 – 95124HelicalSequence AnalysisAdd
BLAST
Topological domaini952 – 98130ExtracellularSequence AnalysisAdd
BLAST
Transmembranei982 – 100322HelicalSequence AnalysisAdd
BLAST
Topological domaini1004 – 1348345CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1349 – 136618HelicalSequence AnalysisAdd
BLAST
Topological domaini1367 – 137711ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1378 – 139720HelicalSequence AnalysisAdd
BLAST
Topological domaini1398 – 149295CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: RGD
  2. brush border membrane Source: RGD
  3. Golgi apparatus Source: MGI
  4. integral component of membrane Source: MGI
  5. late endosome Source: Ensembl
  6. neuronal cell body Source: Ensembl
  7. neuron projection Source: Ensembl
  8. perinuclear region of cytoplasm Source: RGD
  9. secretory granule Source: RGD
  10. trans-Golgi network Source: MGI
  11. trans-Golgi network transport vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14921492Copper-transporting ATPase 1PRO_0000046313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei339 – 3391PhosphoserineBy similarity
Modified residuei357 – 3571PhosphoserineBy similarity
Glycosylationi678 – 6781N-linked (GlcNAc...)Sequence Analysis
Modified residuei1204 – 12041Phosphothreonine1 Publication
Modified residuei1458 – 14581PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70705.
PRIDEiP70705.

PTM databases

PhosphoSiteiP70705.

Expressioni

Gene expression databases

ExpressionAtlasiP70705. baseline and differential.
GenevestigatoriP70705.

Interactioni

Subunit structurei

Monomer. Interacts with PDZD11.By similarity

Structurei

3D structure databases

ProteinModelPortaliP70705.
SMRiP70705. Positions 1-79, 164-246, 275-351, 375-444, 475-625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 7567HMA 1PROSITE-ProRule annotationAdd
BLAST
Domaini172 – 23867HMA 2PROSITE-ProRule annotationAdd
BLAST
Domaini278 – 34467HMA 3PROSITE-ProRule annotationAdd
BLAST
Domaini378 – 44467HMA 4PROSITE-ProRule annotationAdd
BLAST
Domaini481 – 54767HMA 5PROSITE-ProRule annotationAdd
BLAST
Domaini557 – 62367HMA 6PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1478 – 149215PDZD11-bindingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1479 – 14802Endocytosis signalBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi356 – 3627Poly-Ser

Domaini

The C-terminal di-leucine, 1479-Leu-Leu-1480, is an endocytic targeting signal which functions in retrieving recycling from the plasma membrane to the TGN. Mutation of the di-leucine signal results in the accumulation of the protein in the plasma membrane (By similarity).By similarity

Sequence similaritiesi

Contains 6 HMA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2217.
GeneTreeiENSGT00530000063773.
HOGENOMiHOG000250397.
HOVERGENiHBG050616.
InParanoidiP70705.
KOiK17686.
OMAiEYEDREQ.
OrthoDBiEOG7C2R0G.
PhylomeDBiP70705.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR027256. Cation_transp_P-typ_ATPase_IB.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 6 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF55008. SSF55008. 6 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 6 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 6 hits.
PS50846. HMA_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70705-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPNMDANSI TITVEGMTCI SCVRTIEQQI GKVNGVHHIK VSLEEKSATV
60 70 80 90 100
IYNPKLQTPK TLQEAIDDMG FDALLHNANP LPVLTNTVFL TVTAPLALPW
110 120 130 140 150
DHIQSTLLKT KGVTGVKISP QQRSAVVTII PSVVSANQIV ELVPDLSLDM
160 170 180 190 200
GTQEKKSGTS EEHSTPQAGE VLLKMRVEGM TCHSCTSTIE GKVGKLQGVQ
210 220 230 240 250
RIKVSLDNQE ATIVYQPHLI TAEEIKKQIE AVGFPAFIKK QPKYLKLGAI
260 270 280 290 300
DVERLKSTPV KSSEGSQQKS PAYPSDSAIT FTIDGMHCKS CVSNIESALS
310 320 330 340 350
TLQYVSSIVV SLENRSAIVK YNASLVTPEI LRKAIEAVSP GQYRVSISSE
360 370 380 390 400
VESPTSSPSS SSLQKMPLNL VSQPLTQEVV ININGMTCNS CVQSIEGVIS
410 420 430 440 450
KKPGVKSIHV SLTNSTGTIE YDPLLTSPEP LREAIEDMGF DAVLPADMKE
460 470 480 490 500
PLVVIAQPSL ETPLLPSTTE PENVMTPVQN KCYIQVSGMT CASCVANIER
510 520 530 540 550
NLRREEGIYS VLVALMAGKA EVRYNPAVIQ PRVIAELIRE LGFGAVVMEN
560 570 580 590 600
AGEGNGILEL VVRGMTCASC VHKIESTLTK HKGIFYCSVA LATNKAHIKY
610 620 630 640 650
DPEIIGPRDI IHTIGNLGFE ASLVKKDRSA NHLDHKREIK QWRGSFLVSL
660 670 680 690 700
FFCIPVMGLM IYMMVMDHHL ATLNHNQNMS NEEMINMHSS MFLERQILPG
710 720 730 740 750
LSIMNLLSLL LCLPVQFCGG WYFYIQAYKA LRHKTANMDV LIVLATTIAF
760 770 780 790 800
AYSLVILLVA MYERAKVNPI TFFDTPPMLF VFIALGRWLE HIAKGKTSEA
810 820 830 840 850
LAKLISLQAT EATIVTLNSE NLLLSEEQVD VELVQRGDII KVVPGGKFPV
860 870 880 890 900
DGRVIEGHSM VDESLITGEA MPVAKKPGST VIAGSINQNG SLLIRATHVG
910 920 930 940 950
ADTTLSQIVK LVEEAQTSKA PIQQFADKLS GYFVPFIVLV SIVTLLVWII
960 970 980 990 1000
IGFQNFEIVE AYFPGYNRSI SRTETIIRFA FQASITVLCI ACPCSLGLAT
1010 1020 1030 1040 1050
PTAVMVGTGV GAQNGILIKG GEPLEMAHKV KVVVFDKTGT ITHGTPVVNQ
1060 1070 1080 1090 1100
VKVLVESNKI SRNKILAIVG TAESNSEHPL GAAVTKYCKQ ELDTETLGTC
1110 1120 1130 1140 1150
TDFQVVPGCG ISCKVTNIEG LLHKSNLKIE ENNIKNASLV QIDAINEQSS
1160 1170 1180 1190 1200
PSSSMIIDAH LSNAVNTQQY KVLIGNREWM IRNGLVISND VDESMIEHER
1210 1220 1230 1240 1250
RGRTAVLVTI DDELCGLIAI ADTVKPEAEL AVHILKSMGL EVVLMTGDNS
1260 1270 1280 1290 1300
KTARSIASQV GITKVFAEVL PSHKVAKVKQ LQEEGKRVAM VGDGINDSPA
1310 1320 1330 1340 1350
LAMASVGIAI GTGTDVAIEA ADVVLIRNDL LDVVASIDLS RKTVKRIRIN
1360 1370 1380 1390 1400
FVFALIYNLI GIPIAAGVFL PIGLVLQPWM GSAAMAASSV SVVLSSLFLK
1410 1420 1430 1440 1450
LYRKPTYDNY ELRPRSHTGQ RSPSEISVHV GIDDTSRNSP RLGLLDRIVN
1460 1470 1480 1490
YSRASINSLL SDKRSLNSVV TSEPDKHSLL VGDFREDDDT TL
Length:1,492
Mass (Da):162,093
Last modified:February 1, 1997 - v1
Checksum:i34F75152B105AE9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59245 mRNA. Translation: AAB06393.1.
PIRiS46483.
RefSeqiNP_434690.1. NM_052803.2.
XP_006257057.1. XM_006256995.2.
XP_008771556.1. XM_008773334.1.
UniGeneiRn.10554.

Genome annotation databases

EnsembliENSRNOT00000065388; ENSRNOP00000063702; ENSRNOG00000002515.
GeneIDi24941.
KEGGirno:24941.
UCSCiRGD:2179. rat.

Cross-referencesi

Web resourcesi

Protein Spotlight

Heavy metal - Issue 79 of February 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59245 mRNA. Translation: AAB06393.1 .
PIRi S46483.
RefSeqi NP_434690.1. NM_052803.2.
XP_006257057.1. XM_006256995.2.
XP_008771556.1. XM_008773334.1.
UniGenei Rn.10554.

3D structure databases

ProteinModelPortali P70705.
SMRi P70705. Positions 1-79, 164-246, 275-351, 375-444, 475-625.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P70705.

Proteomic databases

PaxDbi P70705.
PRIDEi P70705.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000065388 ; ENSRNOP00000063702 ; ENSRNOG00000002515 .
GeneIDi 24941.
KEGGi rno:24941.
UCSCi RGD:2179. rat.

Organism-specific databases

CTDi 538.
RGDi 2179. Atp7a.

Phylogenomic databases

eggNOGi COG2217.
GeneTreei ENSGT00530000063773.
HOGENOMi HOG000250397.
HOVERGENi HBG050616.
InParanoidi P70705.
KOi K17686.
OMAi EYEDREQ.
OrthoDBi EOG7C2R0G.
PhylomeDBi P70705.

Enzyme and pathway databases

BRENDAi 3.6.3.4. 5301.
Reactomei REACT_213899. Detoxification of Reactive Oxygen Species.
REACT_247493. Ion transport by P-type ATPases.

Miscellaneous databases

NextBioi 604931.
PROi P70705.

Gene expression databases

ExpressionAtlasi P70705. baseline and differential.
Genevestigatori P70705.

Family and domain databases

Gene3Di 2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProi IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR027256. Cation_transp_P-typ_ATPase_IB.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view ]
Pfami PF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 6 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SUPFAMi SSF55008. SSF55008. 6 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsi TIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 6 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 6 hits.
PS50846. HMA_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a Menkes-type Cu-transporting ATPase from rat C6 glioma cells: comparison of the rat protein with other mammalian Cu-transporting ATPases."
    Qian Y., Tiffany-Castiglioni E., Harris E.D.
    Mol. Cell. Biochem. 181:49-61(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Astrocyte.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATP7A_RAT
AccessioniPrimary (citable) accession number: P70705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3