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P70705

- ATP7A_RAT

UniProt

P70705 - ATP7A_RAT

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Protein
Copper-transporting ATPase 1
Gene
Atp7a, Mnk
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells By similarity.

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1036 – 103614-aspartylphosphate intermediate By similarity
Metal bindingi1293 – 12931Magnesium By similarity
Metal bindingi1297 – 12971Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. copper ion transmembrane transporter activity Source: RGD
  3. copper-exporting ATPase activity Source: Ensembl
  4. superoxide dismutase copper chaperone activity Source: Ensembl

GO - Biological processi

  1. T-helper cell differentiation Source: Ensembl
  2. blood vessel development Source: Ensembl
  3. blood vessel remodeling Source: Ensembl
  4. cartilage development Source: Ensembl
  5. cellular copper ion homeostasis Source: RGD
  6. cerebellar Purkinje cell differentiation Source: Ensembl
  7. collagen fibril organization Source: Ensembl
  8. copper ion import Source: Ensembl
  9. dendrite morphogenesis Source: Ensembl
  10. detoxification of copper ion Source: Ensembl
  11. dopamine metabolic process Source: Ensembl
  12. elastic fiber assembly Source: Ensembl
  13. elastin biosynthetic process Source: Ensembl
  14. epinephrine metabolic process Source: Ensembl
  15. hair follicle morphogenesis Source: Ensembl
  16. in utero embryonic development Source: RGD
  17. lactation Source: RGD
  18. locomotory behavior Source: Ensembl
  19. lung alveolus development Source: Ensembl
  20. negative regulation of metalloenzyme activity Source: Ensembl
  21. negative regulation of neuron apoptotic process Source: Ensembl
  22. norepinephrine biosynthetic process Source: Ensembl
  23. peptidyl-lysine modification Source: Ensembl
  24. pigmentation Source: Ensembl
  25. plasma membrane copper ion transport Source: RGD
  26. positive regulation of metalloenzyme activity Source: Ensembl
  27. positive regulation of oxidoreductase activity Source: Ensembl
  28. pyramidal neuron development Source: Ensembl
  29. regulation of gene expression Source: Ensembl
  30. regulation of oxidative phosphorylation Source: Ensembl
  31. release of cytochrome c from mitochondria Source: Ensembl
  32. removal of superoxide radicals Source: Ensembl
  33. response to copper ion Source: RGD
  34. response to iron(III) ion Source: RGD
  35. response to zinc ion Source: RGD
  36. serotonin metabolic process Source: Ensembl
  37. tryptophan metabolic process Source: Ensembl
  38. tyrosine metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.4. 5301.
ReactomeiREACT_213899. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting ATPase 1 (EC:3.6.3.54)
Alternative name(s):
Copper pump 1
Menkes disease-associated protein homolog
Gene namesi
Name:Atp7a
Synonyms:Mnk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi2179. Atp7a.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity
Note: Constitutively cycles between the trans-Golgi network (TGN) and the plasma membrane. Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 645645Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei646 – 66722Helical; Reviewed prediction
Add
BLAST
Topological domaini668 – 70639Extracellular Reviewed prediction
Add
BLAST
Transmembranei707 – 72620Helical; Reviewed prediction
Add
BLAST
Topological domaini727 – 7337Cytoplasmic Reviewed prediction
Transmembranei734 – 75421Helical; Reviewed prediction
Add
BLAST
Topological domaini755 – 77319Extracellular Reviewed prediction
Add
BLAST
Transmembranei774 – 79421Helical; Reviewed prediction
Add
BLAST
Topological domaini795 – 927133Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei928 – 95124Helical; Reviewed prediction
Add
BLAST
Topological domaini952 – 98130Extracellular Reviewed prediction
Add
BLAST
Transmembranei982 – 100322Helical; Reviewed prediction
Add
BLAST
Topological domaini1004 – 1348345Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1349 – 136618Helical; Reviewed prediction
Add
BLAST
Topological domaini1367 – 137711Extracellular Reviewed prediction
Add
BLAST
Transmembranei1378 – 139720Helical; Reviewed prediction
Add
BLAST
Topological domaini1398 – 149295Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. basolateral plasma membrane Source: RGD
  3. brush border membrane Source: RGD
  4. integral component of membrane Source: MGI
  5. late endosome Source: Ensembl
  6. neuron projection Source: Ensembl
  7. neuronal cell body Source: Ensembl
  8. perinuclear region of cytoplasm Source: RGD
  9. secretory granule Source: RGD
  10. trans-Golgi network Source: MGI
  11. trans-Golgi network transport vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14921492Copper-transporting ATPase 1
PRO_0000046313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei339 – 3391Phosphoserine By similarity
Modified residuei357 – 3571Phosphoserine By similarity
Glycosylationi678 – 6781N-linked (GlcNAc...) Reviewed prediction
Modified residuei1204 – 12041Phosphothreonine1 Publication
Modified residuei1458 – 14581Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70705.
PRIDEiP70705.

PTM databases

PhosphoSiteiP70705.

Expressioni

Gene expression databases

GenevestigatoriP70705.

Interactioni

Subunit structurei

Monomer By similarity. Interacts with PDZD11 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP70705.
SMRiP70705. Positions 1-79, 164-246, 275-351, 375-444, 475-625.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 7567HMA 1
Add
BLAST
Domaini172 – 23867HMA 2
Add
BLAST
Domaini278 – 34467HMA 3
Add
BLAST
Domaini378 – 44467HMA 4
Add
BLAST
Domaini481 – 54767HMA 5
Add
BLAST
Domaini557 – 62367HMA 6
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1478 – 149215PDZD11-binding By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1479 – 14802Endocytosis signal By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi356 – 3627Poly-Ser

Domaini

The C-terminal di-leucine, 1479-Leu-Leu-1480, is an endocytic targeting signal which functions in retrieving recycling from the plasma membrane to the TGN. Mutation of the di-leucine signal results in the accumulation of the protein in the plasma membrane By similarity.

Sequence similaritiesi

Contains 6 HMA domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2217.
GeneTreeiENSGT00530000063773.
HOGENOMiHOG000250397.
HOVERGENiHBG050616.
KOiK17686.
OMAiEYEDREQ.
OrthoDBiEOG7C2R0G.
PhylomeDBiP70705.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR027256. Cation_transp_P-typ_ATPase_IB.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 6 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF55008. SSF55008. 6 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 6 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 6 hits.
PS50846. HMA_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70705-1 [UniParc]FASTAAdd to Basket

« Hide

MEPNMDANSI TITVEGMTCI SCVRTIEQQI GKVNGVHHIK VSLEEKSATV     50
IYNPKLQTPK TLQEAIDDMG FDALLHNANP LPVLTNTVFL TVTAPLALPW 100
DHIQSTLLKT KGVTGVKISP QQRSAVVTII PSVVSANQIV ELVPDLSLDM 150
GTQEKKSGTS EEHSTPQAGE VLLKMRVEGM TCHSCTSTIE GKVGKLQGVQ 200
RIKVSLDNQE ATIVYQPHLI TAEEIKKQIE AVGFPAFIKK QPKYLKLGAI 250
DVERLKSTPV KSSEGSQQKS PAYPSDSAIT FTIDGMHCKS CVSNIESALS 300
TLQYVSSIVV SLENRSAIVK YNASLVTPEI LRKAIEAVSP GQYRVSISSE 350
VESPTSSPSS SSLQKMPLNL VSQPLTQEVV ININGMTCNS CVQSIEGVIS 400
KKPGVKSIHV SLTNSTGTIE YDPLLTSPEP LREAIEDMGF DAVLPADMKE 450
PLVVIAQPSL ETPLLPSTTE PENVMTPVQN KCYIQVSGMT CASCVANIER 500
NLRREEGIYS VLVALMAGKA EVRYNPAVIQ PRVIAELIRE LGFGAVVMEN 550
AGEGNGILEL VVRGMTCASC VHKIESTLTK HKGIFYCSVA LATNKAHIKY 600
DPEIIGPRDI IHTIGNLGFE ASLVKKDRSA NHLDHKREIK QWRGSFLVSL 650
FFCIPVMGLM IYMMVMDHHL ATLNHNQNMS NEEMINMHSS MFLERQILPG 700
LSIMNLLSLL LCLPVQFCGG WYFYIQAYKA LRHKTANMDV LIVLATTIAF 750
AYSLVILLVA MYERAKVNPI TFFDTPPMLF VFIALGRWLE HIAKGKTSEA 800
LAKLISLQAT EATIVTLNSE NLLLSEEQVD VELVQRGDII KVVPGGKFPV 850
DGRVIEGHSM VDESLITGEA MPVAKKPGST VIAGSINQNG SLLIRATHVG 900
ADTTLSQIVK LVEEAQTSKA PIQQFADKLS GYFVPFIVLV SIVTLLVWII 950
IGFQNFEIVE AYFPGYNRSI SRTETIIRFA FQASITVLCI ACPCSLGLAT 1000
PTAVMVGTGV GAQNGILIKG GEPLEMAHKV KVVVFDKTGT ITHGTPVVNQ 1050
VKVLVESNKI SRNKILAIVG TAESNSEHPL GAAVTKYCKQ ELDTETLGTC 1100
TDFQVVPGCG ISCKVTNIEG LLHKSNLKIE ENNIKNASLV QIDAINEQSS 1150
PSSSMIIDAH LSNAVNTQQY KVLIGNREWM IRNGLVISND VDESMIEHER 1200
RGRTAVLVTI DDELCGLIAI ADTVKPEAEL AVHILKSMGL EVVLMTGDNS 1250
KTARSIASQV GITKVFAEVL PSHKVAKVKQ LQEEGKRVAM VGDGINDSPA 1300
LAMASVGIAI GTGTDVAIEA ADVVLIRNDL LDVVASIDLS RKTVKRIRIN 1350
FVFALIYNLI GIPIAAGVFL PIGLVLQPWM GSAAMAASSV SVVLSSLFLK 1400
LYRKPTYDNY ELRPRSHTGQ RSPSEISVHV GIDDTSRNSP RLGLLDRIVN 1450
YSRASINSLL SDKRSLNSVV TSEPDKHSLL VGDFREDDDT TL 1492
Length:1,492
Mass (Da):162,093
Last modified:February 1, 1997 - v1
Checksum:i34F75152B105AE9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59245 mRNA. Translation: AAB06393.1.
PIRiS46483.
RefSeqiNP_434690.1. NM_052803.2.
XP_006257057.1. XM_006256995.1.
XP_006257058.1. XM_006256996.1.
UniGeneiRn.10554.

Genome annotation databases

EnsembliENSRNOT00000065388; ENSRNOP00000063702; ENSRNOG00000002515.
GeneIDi24941.
KEGGirno:24941.
UCSCiRGD:2179. rat.

Cross-referencesi

Web resourcesi

Protein Spotlight

Heavy metal - Issue 79 of February 2007

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59245 mRNA. Translation: AAB06393.1 .
PIRi S46483.
RefSeqi NP_434690.1. NM_052803.2.
XP_006257057.1. XM_006256995.1.
XP_006257058.1. XM_006256996.1.
UniGenei Rn.10554.

3D structure databases

ProteinModelPortali P70705.
SMRi P70705. Positions 1-79, 164-246, 275-351, 375-444, 475-625.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P70705.

Proteomic databases

PaxDbi P70705.
PRIDEi P70705.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000065388 ; ENSRNOP00000063702 ; ENSRNOG00000002515 .
GeneIDi 24941.
KEGGi rno:24941.
UCSCi RGD:2179. rat.

Organism-specific databases

CTDi 538.
RGDi 2179. Atp7a.

Phylogenomic databases

eggNOGi COG2217.
GeneTreei ENSGT00530000063773.
HOGENOMi HOG000250397.
HOVERGENi HBG050616.
KOi K17686.
OMAi EYEDREQ.
OrthoDBi EOG7C2R0G.
PhylomeDBi P70705.

Enzyme and pathway databases

BRENDAi 3.6.3.4. 5301.
Reactomei REACT_213899. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

NextBioi 604931.
PROi P70705.

Gene expression databases

Genevestigatori P70705.

Family and domain databases

Gene3Di 2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProi IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR027256. Cation_transp_P-typ_ATPase_IB.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view ]
Pfami PF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 6 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SUPFAMi SSF55008. SSF55008. 6 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsi TIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 6 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 6 hits.
PS50846. HMA_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a Menkes-type Cu-transporting ATPase from rat C6 glioma cells: comparison of the rat protein with other mammalian Cu-transporting ATPases."
    Qian Y., Tiffany-Castiglioni E., Harris E.D.
    Mol. Cell. Biochem. 181:49-61(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Astrocyte.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATP7A_RAT
AccessioniPrimary (citable) accession number: P70705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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