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Protein

Protein Wnt-10a

Gene

Wnt10a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor binding Source: MGI

GO - Biological processi

  • cell-cell signaling Source: MGI
  • cell fate commitment Source: GO_Central
  • cellular response to transforming growth factor beta stimulus Source: Ensembl
  • epidermis morphogenesis Source: MGI
  • hair follicle development Source: MGI
  • hair follicle morphogenesis Source: MGI
  • neural crest cell differentiation Source: MGI
  • neuron differentiation Source: GO_Central
  • odontogenesis Source: MGI
  • organ morphogenesis Source: MGI
  • positive regulation of gene expression Source: MGI
  • regulation of odontogenesis of dentin-containing tooth Source: MGI
  • sebaceous gland development Source: MGI
  • signal transduction Source: MGI
  • skin development Source: MGI
  • tongue development Source: MGI
  • Wnt signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_295052. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-10a
Gene namesi
Name:Wnt10a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:108071. Wnt10a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 417382Protein Wnt-10aPRO_0000041461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi96 ↔ 107By similarity
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi149 ↔ 157By similarity
Disulfide bondi159 ↔ 214By similarity
Disulfide bondi262 ↔ 276By similarity
Disulfide bondi264 ↔ 271By similarity
Lipidationi268 – 2681O-palmitoleyl serine; by PORCNBy similarity
Disulfide bondi362 ↔ 377By similarity
Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi392 ↔ 407By similarity
Disulfide bondi394 ↔ 404By similarity
Disulfide bondi399 ↔ 400By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiP70701.
PRIDEiP70701.

PTM databases

PhosphoSiteiP70701.

Expressioni

Gene expression databases

BgeeiP70701.
CleanExiMM_WNT10A.
GenevisibleiP70701. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006718.

Structurei

3D structure databases

ProteinModelPortaliP70701.
SMRiP70701. Positions 82-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240772.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP70701.
KOiK01357.
OMAiHGVMEHF.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP70701.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013302. Wnt10.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01893. WNT10PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAHPRPWL RLPQGPQPRP EFWALLFFLL LLAAAVPRSA PNDILGLRLP
60 70 80 90 100
PEPVLNANTV CLTLPGLSRR QMEVCVRHPD VAASAIQGIQ IAIHECQHQF
110 120 130 140 150
RDQRWNCSSL ETRNKVPYES PIFSRGFRES AFAYAIAAAG VVHAVSNACA
160 170 180 190 200
LGKLKACGCD ASRRGDEEAF RRKLHRLQLD ALQRGKGLSH GVPEHPAILP
210 220 230 240 250
ASPGLQDSWE WGGCSPDVGF GERFSKDFLD SREPHRDIHA RMRLHNNRVG
260 270 280 290 300
RQAVMENMRR KCKCHGTSGS CQLKTCWQVT PEFRTVGALL RNRFHRATLI
310 320 330 340 350
RPHNRNGGQL EPGPAGAPSP APGTPGLRRR ASHSDLVYFE KSPDFCEREP
360 370 380 390 400
RLDSAGTVGR LCNKSSTGPD GCGSMCCGRG HNILRQTRSE RCHCRFHWCC
410
FVVCEECRIT EWVSVCK
Length:417
Mass (Da):46,454
Last modified:February 1, 1997 - v1
Checksum:i048DEF5E4CB94284
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61969 mRNA. Translation: AAB08085.1.
BC014737 mRNA. Translation: AAH14737.1.
CCDSiCCDS15057.1.
PIRiB59392.
RefSeqiNP_033544.1. NM_009518.2.
UniGeneiMm.5130.

Genome annotation databases

EnsembliENSMUST00000006718; ENSMUSP00000006718; ENSMUSG00000026167.
GeneIDi22409.
KEGGimmu:22409.
UCSCiuc007bnf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61969 mRNA. Translation: AAB08085.1.
BC014737 mRNA. Translation: AAH14737.1.
CCDSiCCDS15057.1.
PIRiB59392.
RefSeqiNP_033544.1. NM_009518.2.
UniGeneiMm.5130.

3D structure databases

ProteinModelPortaliP70701.
SMRiP70701. Positions 82-408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006718.

PTM databases

PhosphoSiteiP70701.

Proteomic databases

PaxDbiP70701.
PRIDEiP70701.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006718; ENSMUSP00000006718; ENSMUSG00000026167.
GeneIDi22409.
KEGGimmu:22409.
UCSCiuc007bnf.2. mouse.

Organism-specific databases

CTDi80326.
MGIiMGI:108071. Wnt10a.

Phylogenomic databases

eggNOGiNOG240772.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP70701.
KOiK01357.
OMAiHGVMEHF.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP70701.
TreeFamiTF105310.

Enzyme and pathway databases

ReactomeiREACT_295052. WNT ligand biogenesis and trafficking.

Miscellaneous databases

NextBioi302805.
PROiP70701.
SOURCEiSearch...

Gene expression databases

BgeeiP70701.
CleanExiMM_WNT10A.
GenevisibleiP70701. MM.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013302. Wnt10.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01893. WNT10PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Murine Wnt10a and Wnt10b: cloning and expression in developing limbs, face and skin of embryos and in adults."
    Wang J., Shackleford G.M.
    Oncogene 13:1537-1544(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiWN10A_MOUSE
AccessioniPrimary (citable) accession number: P70701
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 22, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.