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P70701

- WN10A_MOUSE

UniProt

P70701 - WN10A_MOUSE

Protein

Protein Wnt-10a

Gene

Wnt10a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. receptor binding Source: MGI

    GO - Biological processi

    1. cell-cell signaling Source: MGI
    2. cell fate commitment Source: RefGenome
    3. cellular response to transforming growth factor beta stimulus Source: Ensembl
    4. hair follicle morphogenesis Source: Ensembl
    5. neural crest cell differentiation Source: MGI
    6. neuron differentiation Source: RefGenome
    7. odontogenesis Source: Ensembl
    8. organ morphogenesis Source: MGI
    9. positive regulation of gene expression Source: MGI
    10. regulation of odontogenesis of dentin-containing tooth Source: MGI
    11. sebaceous gland development Source: Ensembl
    12. signal transduction Source: MGI
    13. tongue development Source: Ensembl
    14. Wnt signaling pathway Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-10a
    Gene namesi
    Name:Wnt10a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:108071. Wnt10a.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RefGenome
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 417382Protein Wnt-10aPRO_0000041461Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi96 ↔ 107By similarity
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi149 ↔ 157By similarity
    Disulfide bondi159 ↔ 214By similarity
    Disulfide bondi262 ↔ 276By similarity
    Disulfide bondi264 ↔ 271By similarity
    Disulfide bondi362 ↔ 377By similarity
    Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi392 ↔ 407By similarity
    Disulfide bondi394 ↔ 404By similarity
    Disulfide bondi399 ↔ 400By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP70701.
    PRIDEiP70701.

    PTM databases

    PhosphoSiteiP70701.

    Expressioni

    Gene expression databases

    BgeeiP70701.
    CleanExiMM_WNT10A.
    GenevestigatoriP70701.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000006718.

    Structurei

    3D structure databases

    ProteinModelPortaliP70701.
    SMRiP70701. Positions 82-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG240772.
    GeneTreeiENSGT00690000101857.
    HOGENOMiHOG000039528.
    HOVERGENiHBG001595.
    InParanoidiP70701.
    KOiK01357.
    OMAiVPRSAPN.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiP70701.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013302. Wnt10.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01893. WNT10PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P70701-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSAHPRPWL RLPQGPQPRP EFWALLFFLL LLAAAVPRSA PNDILGLRLP    50
    PEPVLNANTV CLTLPGLSRR QMEVCVRHPD VAASAIQGIQ IAIHECQHQF 100
    RDQRWNCSSL ETRNKVPYES PIFSRGFRES AFAYAIAAAG VVHAVSNACA 150
    LGKLKACGCD ASRRGDEEAF RRKLHRLQLD ALQRGKGLSH GVPEHPAILP 200
    ASPGLQDSWE WGGCSPDVGF GERFSKDFLD SREPHRDIHA RMRLHNNRVG 250
    RQAVMENMRR KCKCHGTSGS CQLKTCWQVT PEFRTVGALL RNRFHRATLI 300
    RPHNRNGGQL EPGPAGAPSP APGTPGLRRR ASHSDLVYFE KSPDFCEREP 350
    RLDSAGTVGR LCNKSSTGPD GCGSMCCGRG HNILRQTRSE RCHCRFHWCC 400
    FVVCEECRIT EWVSVCK 417
    Length:417
    Mass (Da):46,454
    Last modified:February 1, 1997 - v1
    Checksum:i048DEF5E4CB94284
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61969 mRNA. Translation: AAB08085.1.
    BC014737 mRNA. Translation: AAH14737.1.
    CCDSiCCDS15057.1.
    PIRiB59392.
    RefSeqiNP_033544.1. NM_009518.2.
    UniGeneiMm.5130.

    Genome annotation databases

    EnsembliENSMUST00000006718; ENSMUSP00000006718; ENSMUSG00000026167.
    GeneIDi22409.
    KEGGimmu:22409.
    UCSCiuc007bnf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61969 mRNA. Translation: AAB08085.1 .
    BC014737 mRNA. Translation: AAH14737.1 .
    CCDSi CCDS15057.1.
    PIRi B59392.
    RefSeqi NP_033544.1. NM_009518.2.
    UniGenei Mm.5130.

    3D structure databases

    ProteinModelPortali P70701.
    SMRi P70701. Positions 82-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000006718.

    PTM databases

    PhosphoSitei P70701.

    Proteomic databases

    PaxDbi P70701.
    PRIDEi P70701.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006718 ; ENSMUSP00000006718 ; ENSMUSG00000026167 .
    GeneIDi 22409.
    KEGGi mmu:22409.
    UCSCi uc007bnf.2. mouse.

    Organism-specific databases

    CTDi 80326.
    MGIi MGI:108071. Wnt10a.

    Phylogenomic databases

    eggNOGi NOG240772.
    GeneTreei ENSGT00690000101857.
    HOGENOMi HOG000039528.
    HOVERGENi HBG001595.
    InParanoidi P70701.
    KOi K01357.
    OMAi VPRSAPN.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi P70701.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    NextBioi 302805.
    PROi P70701.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70701.
    CleanExi MM_WNT10A.
    Genevestigatori P70701.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013302. Wnt10.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01893. WNT10PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine Wnt10a and Wnt10b: cloning and expression in developing limbs, face and skin of embryos and in adults."
      Wang J., Shackleford G.M.
      Oncogene 13:1537-1544(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiWN10A_MOUSE
    AccessioniPrimary (citable) accession number: P70701
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3