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P70701 (WN10A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-10a
Gene names
Name:Wnt10a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell-cell signaling

Traceable author statement PubMed 9889131. Source: MGI

cellular response to transforming growth factor beta stimulus

Inferred from electronic annotation. Source: Ensembl

hair follicle morphogenesis

Inferred from electronic annotation. Source: Ensembl

neural crest cell differentiation

Inferred from direct assay PubMed 17286598. Source: MGI

neuron differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

odontogenesis

Inferred from electronic annotation. Source: Ensembl

organ morphogenesis

Traceable author statement PubMed 9889131. Source: MGI

positive regulation of gene expression

Inferred from direct assay PubMed 17286598. Source: MGI

regulation of odontogenesis of dentin-containing tooth

Inferred from direct assay PubMed 17286598. Source: MGI

sebaceous gland development

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement PubMed 9889131. Source: MGI

tongue development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

receptor binding

Traceable author statement PubMed 9889131. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Chain36 – 417382Protein Wnt-10a
PRO_0000041461

Amino acid modifications

Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation3631N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P70701 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 048DEF5E4CB94284

FASTA41746,454
        10         20         30         40         50         60 
MGSAHPRPWL RLPQGPQPRP EFWALLFFLL LLAAAVPRSA PNDILGLRLP PEPVLNANTV 

        70         80         90        100        110        120 
CLTLPGLSRR QMEVCVRHPD VAASAIQGIQ IAIHECQHQF RDQRWNCSSL ETRNKVPYES 

       130        140        150        160        170        180 
PIFSRGFRES AFAYAIAAAG VVHAVSNACA LGKLKACGCD ASRRGDEEAF RRKLHRLQLD 

       190        200        210        220        230        240 
ALQRGKGLSH GVPEHPAILP ASPGLQDSWE WGGCSPDVGF GERFSKDFLD SREPHRDIHA 

       250        260        270        280        290        300 
RMRLHNNRVG RQAVMENMRR KCKCHGTSGS CQLKTCWQVT PEFRTVGALL RNRFHRATLI 

       310        320        330        340        350        360 
RPHNRNGGQL EPGPAGAPSP APGTPGLRRR ASHSDLVYFE KSPDFCEREP RLDSAGTVGR 

       370        380        390        400        410 
LCNKSSTGPD GCGSMCCGRG HNILRQTRSE RCHCRFHWCC FVVCEECRIT EWVSVCK 

« Hide

References

« Hide 'large scale' references
[1]"Murine Wnt10a and Wnt10b: cloning and expression in developing limbs, face and skin of embryos and in adults."
Wang J., Shackleford G.M.
Oncogene 13:1537-1544(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U61969 mRNA. Translation: AAB08085.1.
BC014737 mRNA. Translation: AAH14737.1.
PIRB59392.
RefSeqNP_033544.1. NM_009518.2.
UniGeneMm.5130.

3D structure databases

ProteinModelPortalP70701.
SMRP70701. Positions 82-408.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000006718.

PTM databases

PhosphoSiteP70701.

Proteomic databases

PaxDbP70701.
PRIDEP70701.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006718; ENSMUSP00000006718; ENSMUSG00000026167.
GeneID22409.
KEGGmmu:22409.
UCSCuc007bnf.2. mouse.

Organism-specific databases

CTD80326.
MGIMGI:108071. Wnt10a.

Phylogenomic databases

eggNOGNOG240772.
GeneTreeENSGT00690000101857.
HOGENOMHOG000039528.
HOVERGENHBG001595.
InParanoidP70701.
KOK01357.
OMAVPRSAPN.
OrthoDBEOG7C8GJ8.
PhylomeDBP70701.
TreeFamTF105310.

Gene expression databases

BgeeP70701.
CleanExMM_WNT10A.
GenevestigatorP70701.

Family and domain databases

InterProIPR005817. Wnt.
IPR013302. Wnt10.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF11. PTHR12027:SF11. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01893. WNT10PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302805.
PROP70701.
SOURCESearch...

Entry information

Entry nameWN10A_MOUSE
AccessionPrimary (citable) accession number: P70701
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot