P70701 (WN10A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-10a

Gene names

Name:

Wnt10a

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome cell-cell signaling Traceable author statement PubMed 9889131. Source: MGI cellular response to transforming growth factor beta stimulus Inferred from electronic annotation. Source: Compara female gonad development Inferred from Biological aspect of Ancestor. Source: RefGenome hair follicle morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome neural crest cell differentiation Inferred from direct assay PubMed 17286598. Source: MGI odontogenesis Inferred from electronic annotation. Source: Compara organ morphogenesis Traceable author statement PubMed 9889131. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of odontogenesis of dentin-containing tooth Inferred from direct assay PubMed 17286598. Source: MGI sebaceous gland development Inferred from electronic annotation. Source: Compara skin development Inferred from electronic annotation. Source: Compara tongue development Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 35	35	Potential
	Chain	36 – 417	382	Protein Wnt-10a		PRO_0000041461
Amino acid modifications
	Glycosylation	106	1	N-linked (GlcNAc...) Potential
	Glycosylation	363	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P70701 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 048DEF5E4CB94284	FASTA	417	46,454
	10 20 30 40 50 60 MGSAHPRPWL RLPQGPQPRP EFWALLFFLL LLAAAVPRSA PNDILGLRLP PEPVLNANTV 70 80 90 100 110 120 CLTLPGLSRR QMEVCVRHPD VAASAIQGIQ IAIHECQHQF RDQRWNCSSL ETRNKVPYES 130 140 150 160 170 180 PIFSRGFRES AFAYAIAAAG VVHAVSNACA LGKLKACGCD ASRRGDEEAF RRKLHRLQLD 190 200 210 220 230 240 ALQRGKGLSH GVPEHPAILP ASPGLQDSWE WGGCSPDVGF GERFSKDFLD SREPHRDIHA 250 260 270 280 290 300 RMRLHNNRVG RQAVMENMRR KCKCHGTSGS CQLKTCWQVT PEFRTVGALL RNRFHRATLI 310 320 330 340 350 360 RPHNRNGGQL EPGPAGAPSP APGTPGLRRR ASHSDLVYFE KSPDFCEREP RLDSAGTVGR 370 380 390 400 410 LCNKSSTGPD GCGSMCCGRG HNILRQTRSE RCHCRFHWCC FVVCEECRIT EWVSVCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Murine Wnt10a and Wnt10b: cloning and expression in developing limbs, face and skin of embryos and in adults." Wang J., Shackleford G.M. Oncogene 13:1537-1544(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U61969 mRNA. Translation: AAB08085.1. BC014737 mRNA. Translation: AAH14737.1.
IPI	IPI00112771.
PIR	B59392.
RefSeq	NP_033544.1. NM_009518.2.
UniGene	Mm.5130.
3D structure databases
ProteinModelPortal	P70701.
SMR	P70701. Positions 82-408.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000006718.
PTM databases
PhosphoSite	P70701.
Proteomic databases
PaxDb	P70701.
PRIDE	P70701.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000006718; ENSMUSP00000006718; ENSMUSG00000026167.
GeneID	22409.
KEGG	mmu:22409.
UCSC	uc007bnf.2. mouse.
Organism-specific databases
CTD	80326.
MGI	MGI:108071. Wnt10a.
Phylogenomic databases
eggNOG	NOG240772.
GeneTree	ENSGT00690000101771.
HOGENOM	HOG000039528.
HOVERGEN	HBG001595.
InParanoid	P70701.
KO	K01357.
OMA	VPRSAPN.
OrthoDB	EOG4B8JD8.
Gene expression databases
Bgee	P70701.
CleanEx	MM_WNT10A.
Genevestigator	P70701.
GermOnline	ENSMUSG00000026167. Mus musculus.
Family and domain databases
InterPro	IPR005817. Wnt. IPR013302. Wnt10. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF11. PTHR12027:SF11. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01893. WNT10PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	302805.
SOURCE	Search...

Entry information

Entry name

WN10A_MOUSE

Accession

Primary (citable) accession number: P70701

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program