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Protein

CTP synthase 1

Gene

Ctps1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.By similarity

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.By similarity

Enzyme regulationi

Activated by GTP and inhibited by CTP.

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes CTP from UDP.By similarity
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. CTP synthase 2 (Ctps2), CTP synthase 1 (Ctps1)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from UDP, the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei399For GATase activityBy similarity1
Active sitei526For GATase activityBy similarity1
Active sitei528For GATase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processImmunity, Pyrimidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.4.2 3474
ReactomeiR-MMU-499943 Interconversion of nucleotide di- and triphosphates
UniPathwayiUPA00159; UER00277

Protein family/group databases

MEROPSiC26.A36

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthase 1Curated (EC:6.3.4.2By similarity)
Alternative name(s):
CTP synthetase 1
UTP--ammonia ligase 1
Gene namesi
Name:Ctps1
Synonyms:CtpsImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1858304 Ctps

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001382761 – 591CTP synthase 1Add BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100N6-acetyllysineBy similarity1
Modified residuei562PhosphoserineBy similarity1
Modified residuei568PhosphoserineBy similarity1
Modified residuei571PhosphoserineBy similarity1
Modified residuei573PhosphoserineBy similarity1
Modified residuei574PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei578PhosphoserineCombined sources1
Modified residuei587PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP70698
MaxQBiP70698
PaxDbiP70698
PeptideAtlasiP70698
PRIDEiP70698

PTM databases

iPTMnetiP70698
PhosphoSitePlusiP70698
SwissPalmiP70698

Expressioni

Gene expression databases

BgeeiENSMUSG00000028633
CleanExiMM_CTPS
GenevisibleiP70698 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206180, 5 interactors
IntActiP70698, 3 interactors
MINTiP70698
STRINGi10090.ENSMUSP00000030381

Structurei

3D structure databases

ProteinModelPortaliP70698
SMRiP70698
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 554Glutamine amidotransferase type-1Add BLAST255

Sequence similaritiesi

Belongs to the CTP synthase family.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiKOG2387 Eukaryota
COG0504 LUCA
GeneTreeiENSGT00910000144179
HOGENOMiHOG000077514
HOVERGENiHBG002243
InParanoidiP70698
KOiK01937
OMAiEFNNAYR
OrthoDBiEOG091G03OK
PhylomeDBiP70698
TreeFamiTF300379

Family and domain databases

CDDicd01746 GATase1_CTP_Synthase, 1 hit
Gene3Di3.40.50.880, 1 hit
HAMAPiMF_01227 PyrG, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR004468 CTP_synthase
IPR017456 CTP_synthase_N
IPR017926 GATASE
IPR033828 GATase1_CTP_Synthase
IPR027417 P-loop_NTPase
PANTHERiPTHR11550 PTHR11550, 1 hit
PfamiView protein in Pfam
PF06418 CTP_synth_N, 1 hit
PF00117 GATase, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00337 PyrG, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P70698-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYILVTGGV ISGIGKGVIA SSVGTILKSC GLHVTSIKID PYINIDAGTF
60 70 80 90 100
SPYEHGEVFV LDDGGEVDLD LGNYERFLDI RLTKDNNLTT GKIYQYVINK
110 120 130 140 150
ERKGDYLGKT VQVVPHITDA IQEWVMRQAL IPVDEDGLEP QVCVIELGGT
160 170 180 190 200
VGDIESMPFI EAFRQFQFKV KRENFCNIHV SLVPQPSSTG EQKTKPTQNS
210 220 230 240 250
VRELRGLGLS PDLVVCRCSN PLDTSVKEKI SMFCHVEPEQ VICVHDVSSI
260 270 280 290 300
YRVPLLLEEQ GVVDYFLRRL DLPIERQSRK MLMKWKEMAD RYDRLLETCS
310 320 330 340 350
IALVGKYTKF SDSYASVIKA LEHSALAINH KLEIKYIDST DLEPSTLQEE
360 370 380 390 400
PVRYHEAWQK LCSAHGVLVP GGFGVRGTEG KIQAIAWARK QKKPFLGVCL
410 420 430 440 450
GMQLAVVEFS RNVLGWQDAN STEFDPKTSH PVVIDMPEHN PGQMGGTMRL
460 470 480 490 500
GKRRTLFQTK NSVMRKLYGD TDYLEERHRH RFEVNPVLKK CLEEQGLKFV
510 520 530 540 550
GQDVEGERME IVELEDHPFF VGVQYHPEFL SRPIKPSPPY FGLLLASVGR
560 570 580 590
LPHYLQKGCR LSPRDTYSDR SGSSSPDSEI TELKFPSISQ D
Length:591
Mass (Da):66,682
Last modified:July 25, 2006 - v2
Checksum:i81083429870BF0DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37I → F in AAB06942 (Ref. 1) Curated1
Sequence conflicti308T → P in AAB06942 (Ref. 1) Curated1
Sequence conflicti388A → S in AAB06942 (Ref. 1) Curated1
Sequence conflicti402M → I in AAB06942 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49350 mRNA Translation: AAB06942.1
AK148259 mRNA Translation: BAE28443.1
BC006698 mRNA Translation: AAH06698.1
CCDSiCCDS18591.1
RefSeqiNP_058028.2, NM_016748.2
XP_006503288.1, XM_006503225.3
UniGeneiMm.1815

Genome annotation databases

EnsembliENSMUST00000030381; ENSMUSP00000030381; ENSMUSG00000028633
GeneIDi51797
KEGGimmu:51797
UCSCiuc008unj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPYRG1_MOUSE
AccessioniPrimary (citable) accession number: P70698
Secondary accession number(s): Q922Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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