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Protein

Uroporphyrinogen decarboxylase

Gene

Urod

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.By similarity

Catalytic activityi

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Delta-aminolevulinic acid dehydratase (Alad)
  2. Porphobilinogen deaminase (Hmbs)
  3. Uroporphyrinogen-III synthase (Uros)
  4. Uroporphyrinogen decarboxylase (Urod)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55SubstrateBy similarity1
Binding sitei85SubstrateBy similarity1
Binding sitei86SubstrateBy similarity1
Sitei86Transition state stabilizerBy similarity1
Binding sitei164SubstrateBy similarity1
Binding sitei219SubstrateBy similarity1
Binding sitei339SubstrateBy similarity1

GO - Molecular functioni

  • uroporphyrinogen decarboxylase activity Source: MGI

GO - Biological processi

  • heme biosynthetic process Source: MGI
  • heme metabolic process Source: MGI
  • protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processHeme biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14921
ReactomeiR-MMU-189451 Heme biosynthesis
UniPathwayiUPA00251; UER00321

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen decarboxylase (EC:4.1.1.37)
Short name:
UPD
Short name:
URO-D
Gene namesi
Name:Urod
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:98916 Urod

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001875701 – 367Uroporphyrinogen decarboxylaseAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP70697
MaxQBiP70697
PaxDbiP70697
PeptideAtlasiP70697
PRIDEiP70697

PTM databases

iPTMnetiP70697
PhosphoSitePlusiP70697

Expressioni

Gene expression databases

BgeeiENSMUSG00000028684
CleanExiMM_UROD
ExpressionAtlasiP70697 baseline and differential
GenevisibleiP70697 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP70697, 2 interactors
MINTiP70697
STRINGi10090.ENSMUSP00000030446

Structurei

3D structure databases

ProteinModelPortaliP70697
SMRiP70697
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 41Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2872 Eukaryota
COG0407 LUCA
GeneTreeiENSGT00390000018302
HOGENOMiHOG000253896
HOVERGENiHBG000229
InParanoidiP70697
KOiK01599
OMAiSWAGQLS
OrthoDBiEOG091G0EUA
PhylomeDBiP70697
TreeFamiTF300744

Family and domain databases

CDDicd00717 URO-D, 1 hit
Gene3Di3.20.20.210, 1 hit
HAMAPiMF_00218 URO_D, 1 hit
InterProiView protein in InterPro
IPR038071 UROD/MetE-like_sf
IPR006361 Uroporphyrinogen_deCO2ase_HemE
IPR000257 Uroporphyrinogen_deCOase
PfamiView protein in Pfam
PF01208 URO-D, 1 hit
SUPFAMiSSF51726 SSF51726, 1 hit
TIGRFAMsiTIGR01464 hemE, 1 hit
PROSITEiView protein in PROSITE
PS00906 UROD_1, 1 hit
PS00907 UROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P70697-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEANGFGLQN FPELKNDTFL RAAWGEETDY TPVWCMRQAG RYLPEFRETR
60 70 80 90 100
AAQDFFSTCR SPEACCELTL QPLRRFPLDA AIIFSDILVV PQALGMEVTM
110 120 130 140 150
VPGKGPSFPE PLREERDLER LRDPAAAASE LGYVFQAITL TRQRLAGRVP
160 170 180 190 200
LIGFAGAPWT LMTYMVEGGS SSTMAQAKRW LYQRPQASHK LLGILTDVLV
210 220 230 240 250
PYLIGQVAAG AQALQLFESH AGHLGTELFS KFALPYIRDV AKRVKAGLQK
260 270 280 290 300
AGLAPVPMII FAKDGHFALE ELAQAGYEVV GLDWTVAPKK ARERVGKAVT
310 320 330 340 350
LQGNLDPCAL YASEEEIGRL VQQMLDDFGP QRYIANLGHG LYPDMDPERV
360
GAFVDAVHKH SRLLRQN
Length:367
Mass (Da):40,692
Last modified:March 6, 2007 - v2
Checksum:iEDDFD66C3BFA2D84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96M → I in AAB18294 (PubMed:8661721).Curated1
Sequence conflicti333Y → S in AAB18294 (PubMed:8661721).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34691 mRNA Translation: AAB18294.1
AK172426 mRNA Translation: BAE43002.1
AL671671 Genomic DNA No translation available.
BC008109 mRNA Translation: AAH08109.1
CCDSiCCDS18521.1
PIRiT10088
RefSeqiNP_033504.2, NM_009478.4
UniGeneiMm.46484

Genome annotation databases

EnsembliENSMUST00000030446; ENSMUSP00000030446; ENSMUSG00000028684
GeneIDi22275
KEGGimmu:22275
UCSCiuc008uhr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDCUP_MOUSE
AccessioniPrimary (citable) accession number: P70697
Secondary accession number(s): Q91VW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 6, 2007
Last modified: March 28, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health