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Protein

Estradiol 17 beta-dehydrogenase 5

Gene

Akr1c6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Active toward androgens, estrogens, and xenobiotic substrates. Also exhibits low 20 alpha-HSD activity. Shows a-stereospecificity in hydrogen transfer between cofactors and substrates (A-specific). Preferentially catalyzes the reduction of 4-androstenedione, 5-alpha-androstane-3,17-dione, androsterone and dehydroepiandrosterone to testosterone, dihydrotestosterone, 5-alpha-androstane-3-alpha,17-beta-diol and 5-androstene-3-beta,17-beta-diol, respectively.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50NADPBy similarity1
Active sitei55Proton donorBy similarity1
Sitei84Lowers pKa of active site TyrBy similarity1
Binding sitei117SubstrateBy similarity1
Binding sitei190NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 24NADPBy similarity5
Nucleotide bindingi166 – 167NADPBy similarity2
Nucleotide bindingi216 – 221NADPBy similarity6
Nucleotide bindingi270 – 280NADPBy similarityAdd BLAST11

GO - Molecular functioni

GO - Biological processi

  • cellular response to jasmonic acid stimulus Source: MGI
  • daunorubicin metabolic process Source: MGI
  • doxorubicin metabolic process Source: MGI
  • negative regulation of mRNA splicing, via spliceosome Source: MGI
  • response to drug Source: MGI
  • response to estrogen Source: MGI
  • steroid biosynthetic process Source: MGI
  • steroid metabolic process Source: MGI

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-MMU-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-MMU-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-MMU-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-MMU-5365859 RA biosynthesis pathway
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17 beta-dehydrogenase 5 (EC:1.1.1.-)
Alternative name(s):
17-beta-HSD 5
Gene namesi
Name:Akr1c6
Synonyms:Hsd17b5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1933427 Akr1c6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001246521 – 323Estradiol 17 beta-dehydrogenase 5Add BLAST323

Post-translational modificationi

Three forms are detected, probably due to post-translational modifications.

Proteomic databases

PaxDbiP70694
PeptideAtlasiP70694
PRIDEiP70694

2D gel databases

SWISS-2DPAGEiP70694

PTM databases

iPTMnetiP70694
PhosphoSitePlusiP70694
SwissPalmiP70694

Expressioni

Tissue specificityi

Mainly found in liver. Also expressed weakly in kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000021210
CleanExiMM_AKR1C6
ExpressionAtlasiP70694 baseline and differential
GenevisibleiP70694 MM

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiP70694, 3 interactors
MINTiP70694
STRINGi10090.ENSMUSP00000021630

Structurei

3D structure databases

ProteinModelPortaliP70694
SMRiP70694
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
GeneTreeiENSGT00760000119041
HOGENOMiHOG000250272
HOVERGENiHBG000020
InParanoidiP70694
OMAiAPVCWDP
OrthoDBiEOG091G0D69
PhylomeDBiP70694
TreeFamiTF106492

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P70694-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKQQTVRL SDGHFIPILG FGTYAPQEVP KSKATEATKI AIDAGFRHID
60 70 80 90 100
SASMYQNEKE VGLAIRSKIA DGTVKREDIF YTSKVWCTFH RPELVRVCLE
110 120 130 140 150
QSLKQLQLDY VDLYLIHFPM AMKPGENYLP KDENGKLIYD AVDICDTWEA
160 170 180 190 200
MEKCKDAGLA KSIGVSNFNR RQLEKILKKP GLKYKPVCNQ VECHPYLNQG
210 220 230 240 250
KLLDFCRSKD IVLVAYSALG SHREKQWVDQ SSPVLLDNPV LGSMAKKYNR
260 270 280 290 300
TPALIALRYQ LQRGVVVLAK SFSEKRIKEN MQVFEFQLTS EDMKVLDDLN
310 320
KNIRYISGSS FKDHPDFPFW DEY
Length:323
Mass (Da):37,048
Last modified:February 1, 1997 - v1
Checksum:i7A1B195E3074D36D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45850 mRNA Translation: BAA08285.1
AF110414
, AF110408, AF110409, AF110410, AF110411, AF110412, AF110413 Genomic DNA Translation: AAD41250.1
BC056643 mRNA Translation: AAH56643.1
CCDSiCCDS26223.1
PIRiA56424
RefSeqiNP_085114.1, NM_030611.3
UniGeneiMm.196666

Genome annotation databases

EnsembliENSMUST00000021630; ENSMUSP00000021630; ENSMUSG00000021210
GeneIDi83702
KEGGimmu:83702
UCSCiuc007pjo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDHB5_MOUSE
AccessioniPrimary (citable) accession number: P70694
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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