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Protein

UDP-glucuronosyltransferase 1-2

Gene

Ugt1a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-156588 Glucuronidation
R-MMU-189483 Heme degradation

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-2 (EC:2.4.1.17)
Short name:
UDPGT 1-2
Short name:
UGT1*2
Short name:
UGT1-02
Short name:
UGT1.2
Alternative name(s):
Bilirubin-specific UDPGT
UDP-glucuronosyltransferase 1A2
Short name:
UGT1A2
Gene namesi
Name:Ugt1a2
Synonyms:Ugt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3576049 Ugt1a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000003601228 – 533UDP-glucuronosyltransferase 1-2Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP70691
PeptideAtlasiP70691
PRIDEiP70691

PTM databases

iPTMnetiP70691
PhosphoSitePlusiP70691
SwissPalmiP70691

Expressioni

Tissue specificityi

Expressed in kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000090171
GenevisibleiP70691 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037258

Structurei

3D structure databases

ProteinModelPortaliP70691
SMRiP70691
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220832
HOVERGENiHBG004033
InParanoidiP70691
KOiK00699
OMAiAKVFMTH
OrthoDBiEOG091G06JC
PhylomeDBiP70691
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: P70691-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTGLCVPLR GISGLLLLLC ALPWAEGAKV LVLPMEGSQW LSMRDVVREL
60 70 80 90 100
HARGHQTVVL ASEVTVHIKG EDFFTLKTYA FPYTKEEYQQ EILSDIEKTF
110 120 130 140 150
KTQHFVKAFF ETTASIRNFF DLYSNSCIAL LHNKMLIQQL NSSFFDVILT
160 170 180 190 200
DPIFPCGAVL AKYLQIPAVF ILRSLSCGIE YEATQCPNPS SYIPNLLTRL
210 220 230 240 250
SDHMDFLQRV QNMLYYLVLK YICRLSITPY ESLASELLQR EVSLVEVLSH
260 270 280 290 300
ASVWLFRGDF VLDYPRPIMP NMVFIGGINC VTKKPLSQEF EAYVNASGEH
310 320 330 340 350
GIVVFSLGSM VSEIPEKKAM EIAEALGRIP QTVLWRYTGT RPSNLAKNTI
360 370 380 390 400
LVKWLPQNDL LGHPKTRAFI THSGSHGIYE GICNGVPMVM MPLFGDQMDN
410 420 430 440 450
AKRMETRGAG VTLNVLEMTA DDLENALKTV INNKSYKENI MRLSSLHKDR
460 470 480 490 500
PIEPLDLAVF WVEYVMRHKG APHLRPAAHD LTWYQYHSLD VIGFLLAIVL
510 520 530
TVVFIVFKCC AYGCRKCFGG KGRVKKSHKS KTH
Length:533
Mass (Da):60,285
Last modified:February 1, 1997 - v1
Checksum:iFB458439525550FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143S → G in AAP48594 (PubMed:14672974).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87866 mRNA Translation: BAA13482.1
AY227195 mRNA Translation: AAP48594.1
AK002629 mRNA Translation: BAB22243.1
CH466520 Genomic DNA Translation: EDL40122.1
BC138676 mRNA Translation: AAI38677.1
BC145969 mRNA Translation: AAI45970.1
CCDSiCCDS15141.1 [P70691-1]
RefSeqiNP_038729.1, NM_013701.3 [P70691-1]
UniGeneiMm.300095

Genome annotation databases

EnsembliENSMUST00000049289; ENSMUSP00000037258; ENSMUSG00000090171 [P70691-1]
GeneIDi22236
KEGGimmu:22236
UCSCiuc007byi.1 mouse [P70691-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUD12_MOUSE
AccessioniPrimary (citable) accession number: P70691
Secondary accession number(s): Q545X2, Q6XL49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome