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P70689

- CXB6_MOUSE

UniProt

P70689 - CXB6_MOUSE

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Protein
Gap junction beta-6 protein
Gene
Gjb6, Cxn-30
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. apoptotic process Source: Ensembl
  2. cell communication Source: InterPro
  3. ear morphogenesis Source: MGI
  4. inner ear development Source: Ensembl
  5. negative regulation of cell proliferation Source: Ensembl
  6. sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-6 protein
Alternative name(s):
Connexin-30
Short name:
Cx30
Gene namesi
Name:Gjb6
Synonyms:Cxn-30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:107588. Gjb6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei23 – 4523Helical; Reviewed prediction
Add
BLAST
Topological domaini46 – 7530Extracellular Reviewed prediction
Add
BLAST
Transmembranei76 – 9823Helical; Reviewed prediction
Add
BLAST
Topological domaini99 – 13133Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei132 – 15423Helical; Reviewed prediction
Add
BLAST
Topological domaini155 – 19238Extracellular Reviewed prediction
Add
BLAST
Transmembranei193 – 21523Helical; Reviewed prediction
Add
BLAST
Topological domaini216 – 26146Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. connexon complex Source: InterPro
  3. cytosol Source: Ensembl
  4. gap junction Source: MGI
  5. integral component of membrane Source: UniProtKB-KW
  6. intracellular membrane-bounded organelle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Gap junction beta-6 protein
PRO_0000057872Add
BLAST

Proteomic databases

PaxDbiP70689.
PRIDEiP70689.

Expressioni

Tissue specificityi

Highly expressed in adult brain and skin. Less in uterus, lung and eye. Very low in testis and sciatic nerve. No expression before birth.

Gene expression databases

BgeeiP70689.
CleanExiMM_GJB6.
GenevestigatoriP70689.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Tjp1P394473EBI-2615416,EBI-79508

Protein-protein interaction databases

BioGridi199936. 3 interactions.
IntActiP70689. 2 interactions.
MINTiMINT-1891929.
STRINGi10090.ENSMUSP00000035630.

Structurei

3D structure databases

ProteinModelPortaliP70689.
SMRiP70689. Positions 2-216.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39645.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP70689.
KOiK07625.
OMAiQTQRNHP.
OrthoDBiEOG7P2XSS.
PhylomeDBiP70689.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70689-1 [UniParc]FASTAAdd to Basket

« Hide

MDWGTLHTVI GGVNKHSTSI GKVWITVIFI FRVMILVVAA QEVWGDEQED    50
FVCNTLQPGC KNVCYDHFFP VSHIRLWALQ LIFVSTPALL VAMHVAYYRH 100
ETARKFIRGE KRNEFKDLED IKRQKVRIEG SLWWTYTSSI FFRIIFEAAF 150
MYVFYFLYNG YHLPWVLKCG IDPCPNLVDC FISRPTEKTV FTVFMISASV 200
ICMLLNVAEL CYLLLKLCFR RSKRTQAQRN HPNHALKESK QNEMNELISD 250
SGQNAITSFP S 261
Length:261
Mass (Da):30,366
Last modified:February 1, 1997 - v1
Checksum:iAC6D8AA234AA47A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z70023 Genomic DNA. Translation: CAA93845.1.
BC013811 mRNA. Translation: AAH13811.1.
BC016507 mRNA. Translation: AAH16507.1.
BC063762 mRNA. Translation: AAH63762.1.
CCDSiCCDS27154.1.
RefSeqiNP_001010937.1. NM_001010937.2.
NP_001258592.1. NM_001271663.1.
XP_006518623.1. XM_006518560.1.
XP_006518624.1. XM_006518561.1.
UniGeneiMm.25652.

Genome annotation databases

EnsembliENSMUST00000039380; ENSMUSP00000035630; ENSMUSG00000040055.
GeneIDi14623.
KEGGimmu:14623.
UCSCiuc007ucy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z70023 Genomic DNA. Translation: CAA93845.1 .
BC013811 mRNA. Translation: AAH13811.1 .
BC016507 mRNA. Translation: AAH16507.1 .
BC063762 mRNA. Translation: AAH63762.1 .
CCDSi CCDS27154.1.
RefSeqi NP_001010937.1. NM_001010937.2.
NP_001258592.1. NM_001271663.1.
XP_006518623.1. XM_006518560.1.
XP_006518624.1. XM_006518561.1.
UniGenei Mm.25652.

3D structure databases

ProteinModelPortali P70689.
SMRi P70689. Positions 2-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199936. 3 interactions.
IntActi P70689. 2 interactions.
MINTi MINT-1891929.
STRINGi 10090.ENSMUSP00000035630.

Proteomic databases

PaxDbi P70689.
PRIDEi P70689.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039380 ; ENSMUSP00000035630 ; ENSMUSG00000040055 .
GeneIDi 14623.
KEGGi mmu:14623.
UCSCi uc007ucy.1. mouse.

Organism-specific databases

CTDi 10804.
MGIi MGI:107588. Gjb6.

Phylogenomic databases

eggNOGi NOG39645.
HOGENOMi HOG000231127.
HOVERGENi HBG009576.
InParanoidi P70689.
KOi K07625.
OMAi QTQRNHP.
OrthoDBi EOG7P2XSS.
PhylomeDBi P70689.
TreeFami TF329606.

Miscellaneous databases

NextBioi 286456.
PROi P70689.
SOURCEi Search...

Gene expression databases

Bgeei P70689.
CleanExi MM_GJB6.
Genevestigatori P70689.

Family and domain databases

InterProi IPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of mouse connexin-30, a gap junction gene highly expressed in adult brain and skin."
    Dahl E., Manthey D., Chen Y., Schwarz H.-J., Chang Y.S., Lalley P.A., Nicholson B.J., Willecke K.
    J. Biol. Chem. 271:17903-17910(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone and Mammary gland.
  3. "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
    del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
    Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNST.

Entry informationi

Entry nameiCXB6_MOUSE
AccessioniPrimary (citable) accession number: P70689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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