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P70689 (CXB6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction beta-6 protein
Alternative name(s):
Connexin-30
Short name=Cx30
Gene names
Name:Gjb6
Synonyms:Cxn-30
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure

A connexon is composed of a hexamer of connexins. Interacts with CNST. Ref.3

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction.

Tissue specificity

Highly expressed in adult brain and skin. Less in uterus, lung and eye. Very low in testis and sciatic nerve. No expression before birth.

Sequence similarities

Belongs to the connexin family. Beta-type (group I) subfamily.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Tjp1P394473EBI-2615416,EBI-79508

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Gap junction beta-6 protein
PRO_0000057872

Regions

Topological domain1 – 2222Cytoplasmic Potential
Transmembrane23 – 4523Helical; Potential
Topological domain46 – 7530Extracellular Potential
Transmembrane76 – 9823Helical; Potential
Topological domain99 – 13133Cytoplasmic Potential
Transmembrane132 – 15423Helical; Potential
Topological domain155 – 19238Extracellular Potential
Transmembrane193 – 21523Helical; Potential
Topological domain216 – 26146Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P70689 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: AC6D8AA234AA47A6

FASTA26130,366
        10         20         30         40         50         60 
MDWGTLHTVI GGVNKHSTSI GKVWITVIFI FRVMILVVAA QEVWGDEQED FVCNTLQPGC 

        70         80         90        100        110        120 
KNVCYDHFFP VSHIRLWALQ LIFVSTPALL VAMHVAYYRH ETARKFIRGE KRNEFKDLED 

       130        140        150        160        170        180 
IKRQKVRIEG SLWWTYTSSI FFRIIFEAAF MYVFYFLYNG YHLPWVLKCG IDPCPNLVDC 

       190        200        210        220        230        240 
FISRPTEKTV FTVFMISASV ICMLLNVAEL CYLLLKLCFR RSKRTQAQRN HPNHALKESK 

       250        260 
QNEMNELISD SGQNAITSFP S 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and functional expression of mouse connexin-30, a gap junction gene highly expressed in adult brain and skin."
Dahl E., Manthey D., Chen Y., Schwarz H.-J., Chang Y.S., Lalley P.A., Nicholson B.J., Willecke K.
J. Biol. Chem. 271:17903-17910(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone and Mammary gland.
[3]"Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CNST.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z70023 Genomic DNA. Translation: CAA93845.1.
BC013811 mRNA. Translation: AAH13811.1.
BC016507 mRNA. Translation: AAH16507.1.
BC063762 mRNA. Translation: AAH63762.1.
CCDSCCDS27154.1.
RefSeqNP_001010937.1. NM_001010937.2.
NP_001258592.1. NM_001271663.1.
XP_006518623.1. XM_006518560.1.
XP_006518624.1. XM_006518561.1.
UniGeneMm.25652.

3D structure databases

ProteinModelPortalP70689.
SMRP70689. Positions 2-216.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199936. 3 interactions.
IntActP70689. 2 interactions.
MINTMINT-1891929.
STRING10090.ENSMUSP00000035630.

Proteomic databases

PaxDbP70689.
PRIDEP70689.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000039380; ENSMUSP00000035630; ENSMUSG00000040055.
GeneID14623.
KEGGmmu:14623.
UCSCuc007ucy.1. mouse.

Organism-specific databases

CTD10804.
MGIMGI:107588. Gjb6.

Phylogenomic databases

eggNOGNOG39645.
HOGENOMHOG000231127.
HOVERGENHBG009576.
InParanoidP70689.
KOK07625.
OMAQTQRNHP.
OrthoDBEOG7P2XSS.
PhylomeDBP70689.
TreeFamTF329606.

Gene expression databases

BgeeP70689.
CleanExMM_GJB6.
GenevestigatorP70689.

Family and domain databases

InterProIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286456.
PROP70689.
SOURCESearch...

Entry information

Entry nameCXB6_MOUSE
AccessionPrimary (citable) accession number: P70689
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot