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P70689

- CXB6_MOUSE

UniProt

P70689 - CXB6_MOUSE

Protein

Gap junction beta-6 protein

Gene

Gjb6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic process Source: Ensembl
    2. cell communication Source: InterPro
    3. ear morphogenesis Source: MGI
    4. inner ear development Source: Ensembl
    5. negative regulation of cell proliferation Source: Ensembl
    6. sensory perception of sound Source: MGI

    Keywords - Biological processi

    Hearing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction beta-6 protein
    Alternative name(s):
    Connexin-30
    Short name:
    Cx30
    Gene namesi
    Name:Gjb6
    Synonyms:Cxn-30
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:107588. Gjb6.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. connexon complex Source: InterPro
    3. cytosol Source: Ensembl
    4. gap junction Source: MGI
    5. integral component of membrane Source: UniProtKB-KW
    6. intracellular membrane-bounded organelle Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Gap junction beta-6 proteinPRO_0000057872Add
    BLAST

    Proteomic databases

    PaxDbiP70689.
    PRIDEiP70689.

    Expressioni

    Tissue specificityi

    Highly expressed in adult brain and skin. Less in uterus, lung and eye. Very low in testis and sciatic nerve. No expression before birth.

    Gene expression databases

    BgeeiP70689.
    CleanExiMM_GJB6.
    GenevestigatoriP70689.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Tjp1P394473EBI-2615416,EBI-79508

    Protein-protein interaction databases

    BioGridi199936. 3 interactions.
    IntActiP70689. 2 interactions.
    MINTiMINT-1891929.
    STRINGi10090.ENSMUSP00000035630.

    Structurei

    3D structure databases

    ProteinModelPortaliP70689.
    SMRiP70689. Positions 2-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini46 – 7530ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini99 – 13133CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini155 – 19238ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 26146CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei132 – 15423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39645.
    HOGENOMiHOG000231127.
    HOVERGENiHBG009576.
    InParanoidiP70689.
    KOiK07625.
    OMAiQTQRNHP.
    OrthoDBiEOG7P2XSS.
    PhylomeDBiP70689.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70689-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDWGTLHTVI GGVNKHSTSI GKVWITVIFI FRVMILVVAA QEVWGDEQED    50
    FVCNTLQPGC KNVCYDHFFP VSHIRLWALQ LIFVSTPALL VAMHVAYYRH 100
    ETARKFIRGE KRNEFKDLED IKRQKVRIEG SLWWTYTSSI FFRIIFEAAF 150
    MYVFYFLYNG YHLPWVLKCG IDPCPNLVDC FISRPTEKTV FTVFMISASV 200
    ICMLLNVAEL CYLLLKLCFR RSKRTQAQRN HPNHALKESK QNEMNELISD 250
    SGQNAITSFP S 261
    Length:261
    Mass (Da):30,366
    Last modified:February 1, 1997 - v1
    Checksum:iAC6D8AA234AA47A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70023 Genomic DNA. Translation: CAA93845.1.
    BC013811 mRNA. Translation: AAH13811.1.
    BC016507 mRNA. Translation: AAH16507.1.
    BC063762 mRNA. Translation: AAH63762.1.
    CCDSiCCDS27154.1.
    RefSeqiNP_001010937.1. NM_001010937.2.
    NP_001258592.1. NM_001271663.1.
    XP_006518623.1. XM_006518560.1.
    XP_006518624.1. XM_006518561.1.
    UniGeneiMm.25652.

    Genome annotation databases

    EnsembliENSMUST00000039380; ENSMUSP00000035630; ENSMUSG00000040055.
    GeneIDi14623.
    KEGGimmu:14623.
    UCSCiuc007ucy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70023 Genomic DNA. Translation: CAA93845.1 .
    BC013811 mRNA. Translation: AAH13811.1 .
    BC016507 mRNA. Translation: AAH16507.1 .
    BC063762 mRNA. Translation: AAH63762.1 .
    CCDSi CCDS27154.1.
    RefSeqi NP_001010937.1. NM_001010937.2.
    NP_001258592.1. NM_001271663.1.
    XP_006518623.1. XM_006518560.1.
    XP_006518624.1. XM_006518561.1.
    UniGenei Mm.25652.

    3D structure databases

    ProteinModelPortali P70689.
    SMRi P70689. Positions 2-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199936. 3 interactions.
    IntActi P70689. 2 interactions.
    MINTi MINT-1891929.
    STRINGi 10090.ENSMUSP00000035630.

    Proteomic databases

    PaxDbi P70689.
    PRIDEi P70689.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039380 ; ENSMUSP00000035630 ; ENSMUSG00000040055 .
    GeneIDi 14623.
    KEGGi mmu:14623.
    UCSCi uc007ucy.1. mouse.

    Organism-specific databases

    CTDi 10804.
    MGIi MGI:107588. Gjb6.

    Phylogenomic databases

    eggNOGi NOG39645.
    HOGENOMi HOG000231127.
    HOVERGENi HBG009576.
    InParanoidi P70689.
    KOi K07625.
    OMAi QTQRNHP.
    OrthoDBi EOG7P2XSS.
    PhylomeDBi P70689.
    TreeFami TF329606.

    Miscellaneous databases

    NextBioi 286456.
    PROi P70689.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70689.
    CleanExi MM_GJB6.
    Genevestigatori P70689.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of mouse connexin-30, a gap junction gene highly expressed in adult brain and skin."
      Dahl E., Manthey D., Chen Y., Schwarz H.-J., Chang Y.S., Lalley P.A., Nicholson B.J., Willecke K.
      J. Biol. Chem. 271:17903-17910(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone and Mammary gland.
    3. "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
      del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
      Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CNST.

    Entry informationi

    Entry nameiCXB6_MOUSE
    AccessioniPrimary (citable) accession number: P70689
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3