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Protein

Gap junction beta-6 protein

Gene

Gjb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  1. aging Source: Ensembl
  2. apoptotic process Source: Ensembl
  3. cell communication Source: InterPro
  4. cellular response to glucose stimulus Source: Ensembl
  5. ear morphogenesis Source: MGI
  6. inner ear development Source: Ensembl
  7. negative regulation of cell proliferation Source: Ensembl
  8. response to electrical stimulus Source: Ensembl
  9. response to lipopolysaccharide Source: Ensembl
  10. sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-6 protein
Alternative name(s):
Connexin-30
Short name:
Cx30
Gene namesi
Name:Gjb6
Synonyms:Cxn-30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:107588. Gjb6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei23 – 4523HelicalSequence AnalysisAdd
BLAST
Topological domaini46 – 7530ExtracellularSequence AnalysisAdd
BLAST
Transmembranei76 – 9823HelicalSequence AnalysisAdd
BLAST
Topological domaini99 – 13133CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei132 – 15423HelicalSequence AnalysisAdd
BLAST
Topological domaini155 – 19238ExtracellularSequence AnalysisAdd
BLAST
Transmembranei193 – 21523HelicalSequence AnalysisAdd
BLAST
Topological domaini216 – 26146CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. connexon complex Source: InterPro
  3. cytosol Source: Ensembl
  4. gap junction Source: MGI
  5. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Gap junction beta-6 proteinPRO_0000057872Add
BLAST

Proteomic databases

PaxDbiP70689.
PRIDEiP70689.

Expressioni

Tissue specificityi

Highly expressed in adult brain and skin. Less in uterus, lung and eye. Very low in testis and sciatic nerve. No expression before birth.

Gene expression databases

BgeeiP70689.
CleanExiMM_GJB6.
ExpressionAtlasiP70689. baseline and differential.
GenevestigatoriP70689.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Tjp1P394473EBI-2615416,EBI-79508

Protein-protein interaction databases

BioGridi199936. 3 interactions.
IntActiP70689. 2 interactions.
MINTiMINT-1891929.
STRINGi10090.ENSMUSP00000035630.

Structurei

3D structure databases

ProteinModelPortaliP70689.
SMRiP70689. Positions 2-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39645.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP70689.
KOiK07625.
OMAiQTQRNHP.
OrthoDBiEOG7P2XSS.
PhylomeDBiP70689.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70689-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDWGTLHTVI GGVNKHSTSI GKVWITVIFI FRVMILVVAA QEVWGDEQED
60 70 80 90 100
FVCNTLQPGC KNVCYDHFFP VSHIRLWALQ LIFVSTPALL VAMHVAYYRH
110 120 130 140 150
ETARKFIRGE KRNEFKDLED IKRQKVRIEG SLWWTYTSSI FFRIIFEAAF
160 170 180 190 200
MYVFYFLYNG YHLPWVLKCG IDPCPNLVDC FISRPTEKTV FTVFMISASV
210 220 230 240 250
ICMLLNVAEL CYLLLKLCFR RSKRTQAQRN HPNHALKESK QNEMNELISD
260
SGQNAITSFP S
Length:261
Mass (Da):30,366
Last modified:February 1, 1997 - v1
Checksum:iAC6D8AA234AA47A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70023 Genomic DNA. Translation: CAA93845.1.
BC013811 mRNA. Translation: AAH13811.1.
BC016507 mRNA. Translation: AAH16507.1.
BC063762 mRNA. Translation: AAH63762.1.
CCDSiCCDS27154.1.
RefSeqiNP_001010937.1. NM_001010937.2.
NP_001258592.1. NM_001271663.1.
XP_006518623.1. XM_006518560.1.
XP_006518624.1. XM_006518561.1.
UniGeneiMm.25652.

Genome annotation databases

EnsembliENSMUST00000039380; ENSMUSP00000035630; ENSMUSG00000040055.
GeneIDi14623.
KEGGimmu:14623.
UCSCiuc007ucy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70023 Genomic DNA. Translation: CAA93845.1.
BC013811 mRNA. Translation: AAH13811.1.
BC016507 mRNA. Translation: AAH16507.1.
BC063762 mRNA. Translation: AAH63762.1.
CCDSiCCDS27154.1.
RefSeqiNP_001010937.1. NM_001010937.2.
NP_001258592.1. NM_001271663.1.
XP_006518623.1. XM_006518560.1.
XP_006518624.1. XM_006518561.1.
UniGeneiMm.25652.

3D structure databases

ProteinModelPortaliP70689.
SMRiP70689. Positions 2-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199936. 3 interactions.
IntActiP70689. 2 interactions.
MINTiMINT-1891929.
STRINGi10090.ENSMUSP00000035630.

Proteomic databases

PaxDbiP70689.
PRIDEiP70689.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039380; ENSMUSP00000035630; ENSMUSG00000040055.
GeneIDi14623.
KEGGimmu:14623.
UCSCiuc007ucy.1. mouse.

Organism-specific databases

CTDi10804.
MGIiMGI:107588. Gjb6.

Phylogenomic databases

eggNOGiNOG39645.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP70689.
KOiK07625.
OMAiQTQRNHP.
OrthoDBiEOG7P2XSS.
PhylomeDBiP70689.
TreeFamiTF329606.

Miscellaneous databases

NextBioi286456.
PROiP70689.
SOURCEiSearch...

Gene expression databases

BgeeiP70689.
CleanExiMM_GJB6.
ExpressionAtlasiP70689. baseline and differential.
GenevestigatoriP70689.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of mouse connexin-30, a gap junction gene highly expressed in adult brain and skin."
    Dahl E., Manthey D., Chen Y., Schwarz H.-J., Chang Y.S., Lalley P.A., Nicholson B.J., Willecke K.
    J. Biol. Chem. 271:17903-17910(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone and Mammary gland.
  3. "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
    del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
    Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNST.

Entry informationi

Entry nameiCXB6_MOUSE
AccessioniPrimary (citable) accession number: P70689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.