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P70687 (CP17A_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase

EC=1.14.99.9
EC=4.1.2.30
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name=Cytochrome P450c17
Gene names
Name:CYP17A1
Synonyms:CYP17
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Catalytic activity

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.

17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactor

Heme group By similarity.

Enzyme regulation

Regulated predominantly by intracellular cAMP levels By similarity.

Pathway

Lipid metabolism; steroid biosynthesis.

Subcellular location

Membrane Potential.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 511511Steroid 17-alpha-hydroxylase/17,20 lyase
PRO_0000051934

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Secondary structure

....................................................................................... 511
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P70687 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 896E776A7457546C

FASTA51157,459
        10         20         30         40         50         60 
MWELVALLLL TLAYFFWSKS KTCGAKSPKS LPFLPLVGSL PFIPRHGHPH VNFFKLQEKY 

        70         80         90        100        110        120 
GPIYSLRLGS TTTVIIGQYQ LAKEVLVKKG KEFSGRPHMV TLGLLSDQGK GIAFADSGGS 

       130        140        150        160        170        180 
WQLHRKLALS SFALFRDGNQ KLEKIICQKA SSLCDFLLTH NEESIDLSEP IFNSITNIIC 

       190        200        210        220        230        240 
IICFGISYEN RDPILATIKS FTEGILNSLG NDHLVDIFPW LTIFPNKTVD MIKKNVKIRD 

       250        260        270        280        290        300 
EVLSGILEKC KEKFNSDSIS SLMDLLIQAK TNADNNNTSE GQGSNAFSDM HILATIADIF 

       310        320        330        340        350        360 
GAGIETTASV LSWIIAFLLH NPEVKKKIQK EIDQNIGFSR TPTFNDRNHL LMLEATIREV 

       370        380        390        400        410        420 
LRIRPVAPML IPHRANSDMS IGEFSIPKFT PVIINLWALH HSEKEWDQPD RFMPERFLDP 

       430        440        450        460        470        480 
TGSHLITPSL SYLPFGAGAR SCIGEVLARQ ELFLFMAHLL QRFDLDVPDD EQPPCLKGNA 

       490        500        510 
NVVFLIDPFK VKITVRQAWK DAQAEVNTWR P 

« Hide

References

[1]"Cloning and expression of hamster adrenal cytochrome P450C17 cDNA."
Cloutier M., Fleury A., Courtemanche J., Ducharme L., Mason J.I., Lehoux J.-G.
Ann. N. Y. Acad. Sci. 774:294-296(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adrenal gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U66494 mRNA. Translation: AAB07494.1.
RefSeqNP_001268860.1. NM_001281931.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JO9model-A48-501[»]
ProteinModelPortalP70687.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101831170.

Organism-specific databases

CTD1586.

Phylogenomic databases

HOVERGENHBG106944.

Enzyme and pathway databases

UniPathwayUPA00062.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP17A_MESAU
AccessionPrimary (citable) accession number: P70687
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways