Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P70673

- KCJ11_RAT

UniProt

P70673 - KCJ11_RAT

Protein

ATP-sensitive inward rectifier potassium channel 11

Gene

Kcnj11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei160 – 1601Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

    GO - Molecular functioni

    1. ankyrin binding Source: BHF-UCL
    2. ATP-activated inward rectifier potassium channel activity Source: RGD
    3. ATP binding Source: Ensembl
    4. heat shock protein binding Source: RGD
    5. protein binding Source: RGD
    6. protein C-terminus binding Source: RGD

    GO - Biological processi

    1. cellular response to glucose stimulus Source: RGD
    2. cellular response to nicotine Source: RGD
    3. cellular response to tumor necrosis factor Source: RGD
    4. glucose metabolic process Source: Ensembl
    5. negative regulation of insulin secretion Source: Ensembl
    6. neurological system process Source: Ensembl
    7. positive regulation of cation channel activity Source: RGD
    8. potassium ion import Source: Ensembl
    9. potassium ion transport Source: RGD
    10. regulation of membrane potential Source: Ensembl
    11. response to ATP Source: Ensembl
    12. response to drug Source: RGD
    13. response to estradiol Source: RGD
    14. response to ischemia Source: RGD
    15. response to testosterone Source: RGD

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199215. ATP sensitive Potassium channels.

    Protein family/group databases

    TCDBi1.A.2.1.7. inward rectifier k(+) channel (irk-c) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 11
    Alternative name(s):
    BIR
    Inward rectifier K(+) channel Kir6.2
    Potassium channel, inwardly rectifying subfamily J member 11
    Gene namesi
    Name:Kcnj11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi69247. Kcnj11.

    Subcellular locationi

    GO - Cellular componenti

    1. ATP-sensitive potassium channel complex Source: RGD
    2. axolemma Source: RGD
    3. cell body fiber Source: RGD
    4. cytosol Source: RGD
    5. endoplasmic reticulum Source: RGD
    6. endosome Source: RGD
    7. intercalated disc Source: RGD
    8. intracellular membrane-bounded organelle Source: RGD
    9. mitochondrion Source: RGD
    10. myelin sheath Source: RGD
    11. neuronal cell body Source: RGD
    12. nuclear envelope Source: RGD
    13. plasma membrane Source: RGD
    14. sarcolemma Source: RGD
    15. T-tubule Source: RGD
    16. voltage-gated potassium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390ATP-sensitive inward rectifier potassium channel 11PRO_0000154960Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei341 – 3411Phosphothreonine; by MAPK1By similarity
    Modified residuei385 – 3851Phosphoserine; by MAPK1By similarity

    Post-translational modificationi

    Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP70673.

    PTM databases

    PhosphoSiteiP70673.

    Expressioni

    Gene expression databases

    GenevestigatoriP70673.

    Interactioni

    Subunit structurei

    Interacts with ABCC9/SUR2 By similarity. Interacts with ABCC8/SUR.By similarity

    Protein-protein interaction databases

    DIPiDIP-58641N.

    Structurei

    3D structure databases

    ProteinModelPortaliP70673.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6868CytoplasmicBy similarityAdd
    BLAST
    Topological domaini94 – 11623ExtracellularBy similarityAdd
    BLAST
    Topological domaini136 – 1449ExtracellularBy similarity
    Topological domaini167 – 390224CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei117 – 12812Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei129 – 1357Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei69 – 9325Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei145 – 16622Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi130 – 1356Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72812.
    GeneTreeiENSGT00690000102074.
    HOGENOMiHOG000237325.
    HOVERGENiHBG006178.
    InParanoidiP70673.
    KOiK05004.
    OMAiHHQDLEI.
    OrthoDBiEOG7XPZ5K.
    PhylomeDBiP70673.
    TreeFamiTF313676.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003279. K_chnl_inward-rec_Kir6.2.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01332. KIR62CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P70673-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSRKGIIPE EYVLTRLAED PTEPRYRTRE RRARFVSKKG NCNVAHKNIR    50
    EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMVW WLIAFAHGDL 100
    APGEGTNVPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI 150
    VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIT LRHGRLCFML 200
    RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF 250
    LVAPLIIYHV IDSNSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA 300
    RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD 350
    EDRSLLDALT LASSRGPLRK RSVAVAKAKP KFSISPDSLS 390
    Length:390
    Mass (Da):43,608
    Last modified:February 1, 1997 - v1
    Checksum:iC8E59AD298DE4F13
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1911L → P in BAA96239. 1 PublicationCurated
    Sequence conflicti365 – 3651R → Q in AAB01810. (PubMed:8607800)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86039 mRNA. Translation: BAA12971.1.
    X97041 mRNA. Translation: CAA65754.1.
    U44897 mRNA. Translation: AAB01810.1.
    D61687 mRNA. Translation: BAA23630.1.
    AB043638 mRNA. Translation: BAA96239.1.
    PIRiJC4689.
    RefSeqiNP_112648.2. NM_031358.3.
    UniGeneiRn.3985.

    Genome annotation databases

    EnsembliENSRNOT00000028685; ENSRNOP00000028685; ENSRNOG00000021128.
    GeneIDi83535.
    KEGGirno:83535.
    UCSCiRGD:69247. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86039 mRNA. Translation: BAA12971.1 .
    X97041 mRNA. Translation: CAA65754.1 .
    U44897 mRNA. Translation: AAB01810.1 .
    D61687 mRNA. Translation: BAA23630.1 .
    AB043638 mRNA. Translation: BAA96239.1 .
    PIRi JC4689.
    RefSeqi NP_112648.2. NM_031358.3.
    UniGenei Rn.3985.

    3D structure databases

    ProteinModelPortali P70673.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-58641N.

    Chemistry

    BindingDBi P70673.
    ChEMBLi CHEMBL3038487.
    GuidetoPHARMACOLOGYi 442.

    Protein family/group databases

    TCDBi 1.A.2.1.7. inward rectifier k(+) channel (irk-c) family.

    PTM databases

    PhosphoSitei P70673.

    Proteomic databases

    PRIDEi P70673.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028685 ; ENSRNOP00000028685 ; ENSRNOG00000021128 .
    GeneIDi 83535.
    KEGGi rno:83535.
    UCSCi RGD:69247. rat.

    Organism-specific databases

    CTDi 3767.
    RGDi 69247. Kcnj11.

    Phylogenomic databases

    eggNOGi NOG72812.
    GeneTreei ENSGT00690000102074.
    HOGENOMi HOG000237325.
    HOVERGENi HBG006178.
    InParanoidi P70673.
    KOi K05004.
    OMAi HHQDLEI.
    OrthoDBi EOG7XPZ5K.
    PhylomeDBi P70673.
    TreeFami TF313676.

    Enzyme and pathway databases

    Reactomei REACT_199215. ATP sensitive Potassium channels.

    Miscellaneous databases

    NextBioi 616041.
    PROi P70673.

    Gene expression databases

    Genevestigatori P70673.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003279. K_chnl_inward-rec_Kir6.2.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01332. KIR62CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel."
      Isomoto S., Kondo C., Yamada M., Matsumoto S., Higashiguchi O., Horio Y., Matsuzawa Y., Kurachi Y.
      J. Biol. Chem. 271:24321-24324(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Faure C., Partiseti M., Gouhier C., Graham D.
      Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreatic islet.
    3. "Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats."
      Tokuyama Y., Fan Z., Furuta H., Makielski J.C., Polonsky K.S., Bell G.I., Yano H.
      Biochem. Biophys. Res. Commun. 220:532-538(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Pancreatic islet.
    4. Wada Y., Takao K., Nishi M., Takeshima H., Imai K., Yamashita T., Kokubun S., Yoshii M., Nukada T.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Heart ventricle.
    5. Cao K., Wang R.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Vascular smooth muscle.

    Entry informationi

    Entry nameiKCJ11_RAT
    AccessioniPrimary (citable) accession number: P70673
    Secondary accession number(s): Q62906, Q9JM48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3