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P70673

- KCJ11_RAT

UniProt

P70673 - KCJ11_RAT

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Protein

ATP-sensitive inward rectifier potassium channel 11

Gene

Kcnj11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei160 – 1601Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

GO - Molecular functioni

  1. ankyrin binding Source: BHF-UCL
  2. ATP-activated inward rectifier potassium channel activity Source: RGD
  3. ATP binding Source: Ensembl
  4. heat shock protein binding Source: RGD
  5. protein C-terminus binding Source: RGD

GO - Biological processi

  1. cellular response to glucose stimulus Source: RGD
  2. cellular response to nicotine Source: RGD
  3. cellular response to tumor necrosis factor Source: RGD
  4. glucose metabolic process Source: Ensembl
  5. negative regulation of insulin secretion Source: Ensembl
  6. neurological system process Source: Ensembl
  7. positive regulation of cation channel activity Source: RGD
  8. potassium ion import Source: Ensembl
  9. potassium ion transport Source: RGD
  10. regulation of membrane potential Source: Ensembl
  11. response to ATP Source: Ensembl
  12. response to drug Source: RGD
  13. response to estradiol Source: RGD
  14. response to ischemia Source: RGD
  15. response to testosterone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199215. ATP sensitive Potassium channels.

Protein family/group databases

TCDBi1.A.2.1.7. inward rectifier k(+) channel (irk-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 11
Alternative name(s):
BIR
Inward rectifier K(+) channel Kir6.2
Potassium channel, inwardly rectifying subfamily J member 11
Gene namesi
Name:Kcnj11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi69247. Kcnj11.

Subcellular locationi

GO - Cellular componenti

  1. ATP-sensitive potassium channel complex Source: RGD
  2. axolemma Source: RGD
  3. cell body fiber Source: RGD
  4. cytosol Source: RGD
  5. endoplasmic reticulum Source: RGD
  6. endosome Source: RGD
  7. intercalated disc Source: RGD
  8. intracellular membrane-bounded organelle Source: RGD
  9. mitochondrion Source: RGD
  10. myelin sheath Source: RGD
  11. neuronal cell body Source: RGD
  12. nuclear envelope Source: RGD
  13. plasma membrane Source: RGD
  14. sarcolemma Source: RGD
  15. T-tubule Source: RGD
  16. voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390ATP-sensitive inward rectifier potassium channel 11PRO_0000154960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411Phosphothreonine; by MAPK1By similarity
Modified residuei385 – 3851Phosphoserine; by MAPK1By similarity

Post-translational modificationi

Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP70673.

PTM databases

PhosphoSiteiP70673.

Expressioni

Gene expression databases

GenevestigatoriP70673.

Interactioni

Subunit structurei

Interacts with ABCC9/SUR2 (By similarity). Interacts with ABCC8/SUR.By similarity

Protein-protein interaction databases

DIPiDIP-58641N.

Structurei

3D structure databases

ProteinModelPortaliP70673.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6868CytoplasmicBy similarityAdd
BLAST
Topological domaini94 – 11623ExtracellularBy similarityAdd
BLAST
Topological domaini136 – 1449ExtracellularBy similarity
Topological domaini167 – 390224CytoplasmicBy similarityAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei117 – 12812Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei129 – 1357Pore-formingBy similarity

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei69 – 9325Helical; Name=M1By similarityAdd
BLAST
Transmembranei145 – 16622Helical; Name=M2By similarityAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi130 – 1356Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72812.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiP70673.
KOiK05004.
OMAiHHQDLEI.
OrthoDBiEOG7XPZ5K.
PhylomeDBiP70673.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003279. K_chnl_inward-rec_Kir6.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01332. KIR62CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P70673-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRKGIIPE EYVLTRLAED PTEPRYRTRE RRARFVSKKG NCNVAHKNIR
60 70 80 90 100
EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMVW WLIAFAHGDL
110 120 130 140 150
APGEGTNVPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI
160 170 180 190 200
VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIT LRHGRLCFML
210 220 230 240 250
RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF
260 270 280 290 300
LVAPLIIYHV IDSNSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA
310 320 330 340 350
RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD
360 370 380 390
EDRSLLDALT LASSRGPLRK RSVAVAKAKP KFSISPDSLS
Length:390
Mass (Da):43,608
Last modified:February 1, 1997 - v1
Checksum:iC8E59AD298DE4F13
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911L → P in BAA96239. 1 PublicationCurated
Sequence conflicti365 – 3651R → Q in AAB01810. (PubMed:8607800)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86039 mRNA. Translation: BAA12971.1.
X97041 mRNA. Translation: CAA65754.1.
U44897 mRNA. Translation: AAB01810.1.
D61687 mRNA. Translation: BAA23630.1.
AB043638 mRNA. Translation: BAA96239.1.
PIRiJC4689.
RefSeqiNP_112648.2. NM_031358.3.
UniGeneiRn.3985.

Genome annotation databases

EnsembliENSRNOT00000028685; ENSRNOP00000028685; ENSRNOG00000021128.
GeneIDi83535.
KEGGirno:83535.
UCSCiRGD:69247. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86039 mRNA. Translation: BAA12971.1 .
X97041 mRNA. Translation: CAA65754.1 .
U44897 mRNA. Translation: AAB01810.1 .
D61687 mRNA. Translation: BAA23630.1 .
AB043638 mRNA. Translation: BAA96239.1 .
PIRi JC4689.
RefSeqi NP_112648.2. NM_031358.3.
UniGenei Rn.3985.

3D structure databases

ProteinModelPortali P70673.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-58641N.

Chemistry

BindingDBi P70673.
ChEMBLi CHEMBL3038487.
GuidetoPHARMACOLOGYi 442.

Protein family/group databases

TCDBi 1.A.2.1.7. inward rectifier k(+) channel (irk-c) family.

PTM databases

PhosphoSitei P70673.

Proteomic databases

PRIDEi P70673.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028685 ; ENSRNOP00000028685 ; ENSRNOG00000021128 .
GeneIDi 83535.
KEGGi rno:83535.
UCSCi RGD:69247. rat.

Organism-specific databases

CTDi 3767.
RGDi 69247. Kcnj11.

Phylogenomic databases

eggNOGi NOG72812.
GeneTreei ENSGT00760000118842.
HOGENOMi HOG000237325.
HOVERGENi HBG006178.
InParanoidi P70673.
KOi K05004.
OMAi HHQDLEI.
OrthoDBi EOG7XPZ5K.
PhylomeDBi P70673.
TreeFami TF313676.

Enzyme and pathway databases

Reactomei REACT_199215. ATP sensitive Potassium channels.

Miscellaneous databases

NextBioi 616041.
PROi P70673.

Gene expression databases

Genevestigatori P70673.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003279. K_chnl_inward-rec_Kir6.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01332. KIR62CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel."
    Isomoto S., Kondo C., Yamada M., Matsumoto S., Higashiguchi O., Horio Y., Matsuzawa Y., Kurachi Y.
    J. Biol. Chem. 271:24321-24324(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Faure C., Partiseti M., Gouhier C., Graham D.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreatic islet.
  3. "Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats."
    Tokuyama Y., Fan Z., Furuta H., Makielski J.C., Polonsky K.S., Bell G.I., Yano H.
    Biochem. Biophys. Res. Commun. 220:532-538(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Pancreatic islet.
  4. Wada Y., Takao K., Nishi M., Takeshima H., Imai K., Yamashita T., Kokubun S., Yoshii M., Nukada T.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Heart ventricle.
  5. Cao K., Wang R.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Vascular smooth muscle.

Entry informationi

Entry nameiKCJ11_RAT
AccessioniPrimary (citable) accession number: P70673
Secondary accession number(s): Q62906, Q9JM48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3