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P70669 (PHEX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metalloendopeptidase homolog PEX

EC=3.4.24.-
Alternative name(s):
Phosphate regulating neutral endopeptidase
Vitamin D-resistant hypophosphatemic rickets protein
X-linked hypophosphatemia protein
Short name=HYP
Gene names
Name:Phex
Synonyms:Hyp, Pex
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length749 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably involved in bone and dentin mineralization and renal phosphate reabsorption.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Tissue specificity

Bone.

Sequence similarities

Belongs to the peptidase M13 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 749749Metalloendopeptidase homolog PEX
PRO_0000078229

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 3717Helical; Signal-anchor for type II membrane protein; Potential
Topological domain38 – 749712Extracellular Potential

Sites

Active site5811 By similarity
Active site6461Proton donor Potential
Metal binding5801Zinc; catalytic By similarity
Metal binding5841Zinc; catalytic By similarity
Metal binding6421Zinc; catalytic By similarity

Amino acid modifications

Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation2381N-linked (GlcNAc...) Potential
Glycosylation2631N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential
Glycosylation3011N-linked (GlcNAc...) Potential
Glycosylation3771N-linked (GlcNAc...) Potential
Glycosylation4841N-linked (GlcNAc...) Potential
Glycosylation7361N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict4301D → V in AAB47750. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P70669 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: A88FA481C376C18A

FASTA74986,419
        10         20         30         40         50         60 
MEAETGSTME TGKGTNRGIR IALALFIGGT LVLGTLLFLV SQGLLSFQAK QEYCLKPECI 

        70         80         90        100        110        120 
EAAAAIMSKV NLSVDPCENF FRFACDGWIS NNPIPEDMPS YGVYPWLRHN VDLKLKALLE 

       130        140        150        160        170        180 
KSVSRRRDTE AVQKAKILYS SCMNEKAIEK ADAKPLLHIL RHSPFRWPVL EANIGPEGVW 

       190        200        210        220        230        240 
SERKFSLLQT LATFRGQYSN SVFIRLYVSP DDKASNEHIL KLDQATLSLA VREDFLDNTT 

       250        260        270        280        290        300 
EAKSYRDALY KFMVDTAVLL GANSSRAEHD MKSVLRLEIK IAEIMIPHEN RTSEAMYNKM 

       310        320        330        340        350        360 
NISELSAMIP QFDWLGYIKK VIDTRLYPHL KDIGPSENVV VRVPQYFKDL FRILGAERKK 

       370        380        390        400        410        420 
TIANYLVWRM VYSRIPNLSR RFQYRWLEFS RVIQGTTTLL PQWDKCVNFI ESALPYVVGK 

       430        440        450        460        470        480 
MFVNVHFQED KKEMMEELIE GVRWAFIDML EKENEWMDAG TKRKAQEKAR AVLAKVGYPE 

       490        500        510        520        530        540 
FIMNDTYVNE DLKAIKFSES DYFGNVLQTR KYLAQSDFFW LRKAVPKTEW FTNPTTVNAF 

       550        560        570        580        590        600 
YSASTNQIRF PAGELQKPFF WGTEYPRSLS YGAIGVIVGH EFTHGFDNNG RKYDKNGNLD 

       610        620        630        640        650        660 
PWWSVESEEK FKEKTKCMIN QYSNYYWKKA GLNVKGKRTL GENIADNGGL REAFRAYRKW 

       670        680        690        700        710        720 
INDRRQGVEE PLLPGITFTN NQLFFLSYAH VRCNSYRPEA AREQVQIGAH SPPQFRVNGA 

       730        740 
ISNFEEFQKA FNCPRNSTMN RGADSCRLW 

« Hide

References

[1]"cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone."
Du L., Desbarats M., Viel J., Glorieux F.H., Cawthorn C., Ecarot B.
Genomics 36:22-28(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia."
Strom T.M., Francis F., Lorenz B., Boeddrich A., Econs M.J., Lehrach H., Meitinger T.
Hum. Mol. Genet. 6:165-171(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice."
Beck L., Soumounou Y., Martel J., Krishnamurthy G., Gauthier C., Goodyer C.G., Tenenhouse H.S.
J. Clin. Invest. 99:1200-1209(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U49908 mRNA. Translation: AAC36502.1.
U73910 mRNA. Translation: AAC25962.1.
U73912 Genomic DNA. Translation: AAC25964.1.
U73913 Genomic DNA. Translation: AAC25965.1.
U73914 Genomic DNA. Translation: AAC25966.1.
U73911 Genomic DNA. Translation: AAC25963.1.
U73915 Genomic DNA. Translation: AAC25967.1.
U75646 mRNA. Translation: AAB47750.1.
RefSeqNP_035207.1. NM_011077.2.
UniGeneMm.2529.

3D structure databases

ProteinModelPortalP70669.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSM13.091.

PTM databases

PhosphoSiteP70669.

Proteomic databases

PaxDbP70669.
PRIDEP70669.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000079945; ENSMUSP00000078863; ENSMUSG00000057457.
GeneID18675.
KEGGmmu:18675.
UCSCuc009ury.1. mouse.

Organism-specific databases

CTD5251.
MGIMGI:107489. Phex.

Phylogenomic databases

eggNOGCOG3590.
HOGENOMHOG000245574.
HOVERGENHBG005554.
InParanoidP70669.
KOK08636.
OMAKVGYPEF.
PhylomeDBP70669.
TreeFamTF315192.

Gene expression databases

ArrayExpressP70669.
BgeeP70669.
GenevestigatorP70669.

Family and domain databases

Gene3D3.40.390.10. 2 hits.
InterProIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
IPR015603. PHEX.
[Graphical view]
PANTHERPTHR11733. PTHR11733. 1 hit.
PTHR11733:SF21. PTHR11733:SF21. 1 hit.
PfamPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSPR00786. NEPRILYSIN.
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294698.
PROP70669.
SOURCESearch...

Entry information

Entry namePHEX_MOUSE
AccessionPrimary (citable) accession number: P70669
Secondary accession number(s): P97439
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot