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P70669

- PHEX_MOUSE

UniProt

P70669 - PHEX_MOUSE

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Protein
Metalloendopeptidase homolog PEX
Gene
Phex, Hyp, Pex
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably involved in bone and dentin mineralization and renal phosphate reabsorption.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi580 – 5801Zinc; catalytic By similarity
Active sitei581 – 5811 By similarity
Metal bindingi584 – 5841Zinc; catalytic By similarity
Metal bindingi642 – 6421Zinc; catalytic By similarity
Active sitei646 – 6461Proton donor Reviewed prediction

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro

GO - Biological processi

  1. bone mineralization Source: MGI
  2. organophosphate metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM13.091.

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloendopeptidase homolog PEX (EC:3.4.24.-)
Alternative name(s):
Phosphate regulating neutral endopeptidase
Vitamin D-resistant hypophosphatemic rickets protein
X-linked hypophosphatemia protein
Short name:
HYP
Gene namesi
Name:Phex
Synonyms:Hyp, Pex
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:107489. Phex.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei21 – 3717Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini38 – 749712Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. endoplasmic reticulum Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Metalloendopeptidase homolog PEX
PRO_0000078229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi238 – 2381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi263 – 2631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi290 – 2901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi377 – 3771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi484 – 4841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi736 – 7361N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP70669.
PRIDEiP70669.

PTM databases

PhosphoSiteiP70669.

Expressioni

Tissue specificityi

Bone.

Gene expression databases

ArrayExpressiP70669.
BgeeiP70669.
GenevestigatoriP70669.

Structurei

3D structure databases

ProteinModelPortaliP70669.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M13 family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3590.
HOGENOMiHOG000245574.
HOVERGENiHBG005554.
InParanoidiP70669.
KOiK08636.
OMAiKVGYPEF.
PhylomeDBiP70669.
TreeFamiTF315192.

Family and domain databases

Gene3Di3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70669-1 [UniParc]FASTAAdd to Basket

« Hide

MEAETGSTME TGKGTNRGIR IALALFIGGT LVLGTLLFLV SQGLLSFQAK    50
QEYCLKPECI EAAAAIMSKV NLSVDPCENF FRFACDGWIS NNPIPEDMPS 100
YGVYPWLRHN VDLKLKALLE KSVSRRRDTE AVQKAKILYS SCMNEKAIEK 150
ADAKPLLHIL RHSPFRWPVL EANIGPEGVW SERKFSLLQT LATFRGQYSN 200
SVFIRLYVSP DDKASNEHIL KLDQATLSLA VREDFLDNTT EAKSYRDALY 250
KFMVDTAVLL GANSSRAEHD MKSVLRLEIK IAEIMIPHEN RTSEAMYNKM 300
NISELSAMIP QFDWLGYIKK VIDTRLYPHL KDIGPSENVV VRVPQYFKDL 350
FRILGAERKK TIANYLVWRM VYSRIPNLSR RFQYRWLEFS RVIQGTTTLL 400
PQWDKCVNFI ESALPYVVGK MFVNVHFQED KKEMMEELIE GVRWAFIDML 450
EKENEWMDAG TKRKAQEKAR AVLAKVGYPE FIMNDTYVNE DLKAIKFSES 500
DYFGNVLQTR KYLAQSDFFW LRKAVPKTEW FTNPTTVNAF YSASTNQIRF 550
PAGELQKPFF WGTEYPRSLS YGAIGVIVGH EFTHGFDNNG RKYDKNGNLD 600
PWWSVESEEK FKEKTKCMIN QYSNYYWKKA GLNVKGKRTL GENIADNGGL 650
REAFRAYRKW INDRRQGVEE PLLPGITFTN NQLFFLSYAH VRCNSYRPEA 700
AREQVQIGAH SPPQFRVNGA ISNFEEFQKA FNCPRNSTMN RGADSCRLW 749
Length:749
Mass (Da):86,419
Last modified:February 1, 1997 - v1
Checksum:iA88FA481C376C18A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti430 – 4301D → V in AAB47750. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49908 mRNA. Translation: AAC36502.1.
U73910 mRNA. Translation: AAC25962.1.
U73912 Genomic DNA. Translation: AAC25964.1.
U73913 Genomic DNA. Translation: AAC25965.1.
U73914 Genomic DNA. Translation: AAC25966.1.
U73911 Genomic DNA. Translation: AAC25963.1.
U73915 Genomic DNA. Translation: AAC25967.1.
U75646 mRNA. Translation: AAB47750.1.
CCDSiCCDS30497.1.
RefSeqiNP_035207.1. NM_011077.2.
UniGeneiMm.2529.

Genome annotation databases

EnsembliENSMUST00000079945; ENSMUSP00000078863; ENSMUSG00000057457.
GeneIDi18675.
KEGGimmu:18675.
UCSCiuc009ury.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49908 mRNA. Translation: AAC36502.1 .
U73910 mRNA. Translation: AAC25962.1 .
U73912 Genomic DNA. Translation: AAC25964.1 .
U73913 Genomic DNA. Translation: AAC25965.1 .
U73914 Genomic DNA. Translation: AAC25966.1 .
U73911 Genomic DNA. Translation: AAC25963.1 .
U73915 Genomic DNA. Translation: AAC25967.1 .
U75646 mRNA. Translation: AAB47750.1 .
CCDSi CCDS30497.1.
RefSeqi NP_035207.1. NM_011077.2.
UniGenei Mm.2529.

3D structure databases

ProteinModelPortali P70669.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M13.091.

PTM databases

PhosphoSitei P70669.

Proteomic databases

PaxDbi P70669.
PRIDEi P70669.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000079945 ; ENSMUSP00000078863 ; ENSMUSG00000057457 .
GeneIDi 18675.
KEGGi mmu:18675.
UCSCi uc009ury.1. mouse.

Organism-specific databases

CTDi 5251.
MGIi MGI:107489. Phex.

Phylogenomic databases

eggNOGi COG3590.
HOGENOMi HOG000245574.
HOVERGENi HBG005554.
InParanoidi P70669.
KOi K08636.
OMAi KVGYPEF.
PhylomeDBi P70669.
TreeFami TF315192.

Miscellaneous databases

NextBioi 294698.
PROi P70669.
SOURCEi Search...

Gene expression databases

ArrayExpressi P70669.
Bgeei P70669.
Genevestigatori P70669.

Family and domain databases

Gene3Di 3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view ]
PANTHERi PTHR11733. PTHR11733. 1 hit.
Pfami PF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view ]
PRINTSi PR00786. NEPRILYSIN.
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone."
    Du L., Desbarats M., Viel J., Glorieux F.H., Cawthorn C., Ecarot B.
    Genomics 36:22-28(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia."
    Strom T.M., Francis F., Lorenz B., Boeddrich A., Econs M.J., Lehrach H., Meitinger T.
    Hum. Mol. Genet. 6:165-171(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice."
    Beck L., Soumounou Y., Martel J., Krishnamurthy G., Gauthier C., Goodyer C.G., Tenenhouse H.S.
    J. Clin. Invest. 99:1200-1209(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiPHEX_MOUSE
AccessioniPrimary (citable) accession number: P70669
Secondary accession number(s): P97439
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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