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Protein

Guanylate cyclase activator 2B

Gene

Guca2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

GO - Molecular functioni

GO - Biological processi

  • body fluid secretion Source: Ensembl
  • cGMP biosynthetic process Source: Ensembl
  • excretion Source: Ensembl
  • ion homeostasis Source: RGD
  • negative regulation of blood pressure Source: Ensembl
  • regulation of cyclic nucleotide biosynthetic process Source: RGD
  • water homeostasis Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase activator 2B
Cleaved into the following chain:
Uroguanylin
Short name:
UGN
Gene namesi
Name:Guca2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620044. Guca2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000001315422 – 911 PublicationAdd BLAST70
PeptideiPRO_000001315592 – 106UroguanylinAdd BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 75By similarity
Disulfide bondi95 ↔ 103By similarity
Disulfide bondi98 ↔ 106By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP70668.
PRIDEiP70668.

Expressioni

Tissue specificityi

Expressed not only in the gastrointestinal tract but also in the lung, pancreas and kidney.

Gene expression databases

BgeeiENSRNOG00000008979.
GenevisibleiP70668. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012062.

Structurei

3D structure databases

ProteinModelPortaliP70668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3M7. Eukaryota.
ENOG410Z6NA. LUCA.
GeneTreeiENSGT00730000111420.
HOGENOMiHOG000231183.
HOVERGENiHBG051861.
InParanoidiP70668.
OMAiQSVYIQY.
OrthoDBiEOG091G13KI.
PhylomeDBiP70668.
TreeFamiTF330731.

Family and domain databases

Gene3Di3.90.1450.10. 1 hit.
InterProiIPR000879. Guanylin.
[Graphical view]
PANTHERiPTHR11318. PTHR11318. 1 hit.
PfamiPF02058. Guanylin. 1 hit.
[Graphical view]
PIRSFiPIRSF001849. Guanylin. 1 hit.
PRINTSiPR00774. GUANYLIN.
ProDomiPD005588. Guanylin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89890. SSF89890. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSQLWAAV LLLLVLQSAQ GVYIKYHGFQ VQLESVKKLN ELEEKQMSDP
60 70 80 90 100
QQQKSGLLPD VCYNPALPLD LQPVCASQEA ASTFKALRTI ATDECELCIN

VACTGC
Length:106
Mass (Da):11,573
Last modified:February 1, 1997 - v1
Checksum:i9FB5F88A9B1DD077
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73898 mRNA. Translation: AAB18331.1.
U41322 mRNA. Translation: AAB18760.1.
U75186 mRNA. Translation: AAB61209.1.
RefSeqiNP_071620.1. NM_022284.2.
UniGeneiRn.97593.

Genome annotation databases

EnsembliENSRNOT00000012062; ENSRNOP00000012062; ENSRNOG00000008979.
GeneIDi64055.
KEGGirno:64055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73898 mRNA. Translation: AAB18331.1.
U41322 mRNA. Translation: AAB18760.1.
U75186 mRNA. Translation: AAB61209.1.
RefSeqiNP_071620.1. NM_022284.2.
UniGeneiRn.97593.

3D structure databases

ProteinModelPortaliP70668.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012062.

Proteomic databases

PaxDbiP70668.
PRIDEiP70668.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012062; ENSRNOP00000012062; ENSRNOG00000008979.
GeneIDi64055.
KEGGirno:64055.

Organism-specific databases

CTDi2981.
RGDi620044. Guca2b.

Phylogenomic databases

eggNOGiENOG410J3M7. Eukaryota.
ENOG410Z6NA. LUCA.
GeneTreeiENSGT00730000111420.
HOGENOMiHOG000231183.
HOVERGENiHBG051861.
InParanoidiP70668.
OMAiQSVYIQY.
OrthoDBiEOG091G13KI.
PhylomeDBiP70668.
TreeFamiTF330731.

Miscellaneous databases

PROiP70668.

Gene expression databases

BgeeiENSRNOG00000008979.
GenevisibleiP70668. RN.

Family and domain databases

Gene3Di3.90.1450.10. 1 hit.
InterProiIPR000879. Guanylin.
[Graphical view]
PANTHERiPTHR11318. PTHR11318. 1 hit.
PfamiPF02058. Guanylin. 1 hit.
[Graphical view]
PIRSFiPIRSF001849. Guanylin. 1 hit.
PRINTSiPR00774. GUANYLIN.
ProDomiPD005588. Guanylin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89890. SSF89890. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGUC2B_RAT
AccessioniPrimary (citable) accession number: P70668
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.