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Protein

Guanylate cyclase activator 2B

Gene

Guca2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

GO - Molecular functioni

GO - Biological processi

  • body fluid secretion Source: Ensembl
  • cGMP biosynthetic process Source: Ensembl
  • excretion Source: Ensembl
  • ion homeostasis Source: RGD
  • negative regulation of blood pressure Source: Ensembl
  • regulation of cyclic nucleotide biosynthetic process Source: RGD
  • water homeostasis Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-8935690 Digestion

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase activator 2B
Cleaved into the following chain:
Uroguanylin
Short name:
UGN
Gene namesi
Name:Guca2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620044 Guca2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000001315422 – 911 PublicationAdd BLAST70
PeptideiPRO_000001315592 – 106UroguanylinAdd BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 75By similarity
Disulfide bondi95 ↔ 103By similarity
Disulfide bondi98 ↔ 106By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP70668
PRIDEiP70668

Expressioni

Tissue specificityi

Expressed not only in the gastrointestinal tract but also in the lung, pancreas and kidney.

Gene expression databases

BgeeiENSRNOG00000008979
GenevisibleiP70668 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012062

Structurei

3D structure databases

ProteinModelPortaliP70668
SMRiP70668
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3M7 Eukaryota
ENOG410Z6NA LUCA
GeneTreeiENSGT00730000111420
HOGENOMiHOG000231183
HOVERGENiHBG051861
InParanoidiP70668
OMAiQSVYIQY
OrthoDBiEOG091G13KI
PhylomeDBiP70668
TreeFamiTF330731

Family and domain databases

Gene3Di3.90.1450.10, 1 hit
InterProiView protein in InterPro
IPR000879 Guanylin
IPR036382 Guanylin_sf
PANTHERiPTHR11318 PTHR11318, 1 hit
PfamiView protein in Pfam
PF02058 Guanylin, 1 hit
PIRSFiPIRSF001849 Guanylin, 1 hit
PRINTSiPR00774 GUANYLIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005588 Guanylin, 1 hit
SUPFAMiSSF89890 SSF89890, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSQLWAAV LLLLVLQSAQ GVYIKYHGFQ VQLESVKKLN ELEEKQMSDP
60 70 80 90 100
QQQKSGLLPD VCYNPALPLD LQPVCASQEA ASTFKALRTI ATDECELCIN

VACTGC
Length:106
Mass (Da):11,573
Last modified:February 1, 1997 - v1
Checksum:i9FB5F88A9B1DD077
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73898 mRNA Translation: AAB18331.1
U41322 mRNA Translation: AAB18760.1
U75186 mRNA Translation: AAB61209.1
RefSeqiNP_071620.1, NM_022284.2
UniGeneiRn.97593

Genome annotation databases

EnsembliENSRNOT00000012062; ENSRNOP00000012062; ENSRNOG00000008979
GeneIDi64055
KEGGirno:64055

Similar proteinsi

Entry informationi

Entry nameiGUC2B_RAT
AccessioniPrimary (citable) accession number: P70668
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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