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Protein

Neurogenin-3

Gene

Neurog3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.2 Publications

GO - Molecular functioni

  1. chromatin DNA binding Source: UniProtKB
  2. core promoter binding Source: UniProtKB
  3. double-stranded DNA binding Source: Ensembl
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: MGI
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  7. sequence-specific DNA binding transcription factor activity Source: MGI
  8. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. endocrine pancreas development Source: Reactome
  2. epithelial cell differentiation Source: MGI
  3. forebrain development Source: Ensembl
  4. hindbrain development Source: Ensembl
  5. multicellular organismal development Source: MGI
  6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  7. positive regulation of neuron differentiation Source: Ensembl
  8. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  10. regulation of dendrite morphogenesis Source: MGI
  11. spinal cord development Source: Ensembl
  12. transdifferentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_221082. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.
REACT_222486. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-3
Short name:
NGN-3
Alternative name(s):
Helix-loop-helix protein mATH-4B
Short name:
mATH4B
Protein atonal homolog 5
Gene namesi
Name:Neurog3
Synonyms:Ath4b, Atoh5, Ngn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:893591. Neurog3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. intracellular Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Neurogenin-3PRO_0000127403Add
BLAST

Proteomic databases

PRIDEiP70661.

PTM databases

PhosphoSiteiP70661.

Expressioni

Gene expression databases

BgeeiP70661.
CleanExiMM_NEUROG3.
ExpressionAtlasiP70661. baseline and differential.
GenevestigatoriP70661.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Structurei

3D structure databases

ProteinModelPortaliP70661.
SMRiP70661. Positions 83-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 13553bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG327835.
HOGENOMiHOG000063655.
HOVERGENiHBG031743.
InParanoidiP70661.
KOiK08028.
OMAiRKKANDR.
OrthoDBiEOG7TTQB1.
PhylomeDBiP70661.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPHPLDALT IQVSPETQQP FPGASDHEVL SSNSTPPSPT LIPRDCSEAE
60 70 80 90 100
VGDCRGTSRK LRARRGGRNR PKSELALSKQ RRSRRKKAND RERNRMHNLN
110 120 130 140 150
SALDALRGVL PTFPDDAKLT KIETLRFAHN YIWALTQTLR IADHSFYGPE
160 170 180 190 200
PPVPCGELGS PGGGSNGDWG SIYSPVSQAG NLSPTASLEE FPGLQVPSSP
210
SYLLPGALVF SDFL
Length:214
Mass (Da):23,267
Last modified:February 1, 1997 - v1
Checksum:i1AB31183291FB98B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09167 Genomic DNA. Translation: CAA70366.1.
U76208 Genomic DNA. Translation: AAC53029.1.
CCDSiCCDS23887.1.
RefSeqiNP_033849.3. NM_009719.6.
UniGeneiMm.57236.

Genome annotation databases

EnsembliENSMUST00000050103; ENSMUSP00000054054; ENSMUSG00000044312.
GeneIDi11925.
KEGGimmu:11925.
UCSCiuc007fgu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09167 Genomic DNA. Translation: CAA70366.1.
U76208 Genomic DNA. Translation: AAC53029.1.
CCDSiCCDS23887.1.
RefSeqiNP_033849.3. NM_009719.6.
UniGeneiMm.57236.

3D structure databases

ProteinModelPortaliP70661.
SMRiP70661. Positions 83-140.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP70661.

Proteomic databases

PRIDEiP70661.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050103; ENSMUSP00000054054; ENSMUSG00000044312.
GeneIDi11925.
KEGGimmu:11925.
UCSCiuc007fgu.1. mouse.

Organism-specific databases

CTDi50674.
MGIiMGI:893591. Neurog3.

Phylogenomic databases

eggNOGiNOG327835.
HOGENOMiHOG000063655.
HOVERGENiHBG031743.
InParanoidiP70661.
KOiK08028.
OMAiRKKANDR.
OrthoDBiEOG7TTQB1.
PhylomeDBiP70661.
TreeFamiTF315153.

Enzyme and pathway databases

ReactomeiREACT_221082. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.
REACT_222486. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.

Miscellaneous databases

NextBioi280005.
PROiP70661.
SOURCEiSearch...

Gene expression databases

BgeeiP70661.
CleanExiMM_NEUROG3.
ExpressionAtlasiP70661. baseline and differential.
GenevestigatoriP70661.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors."
    Cau E., Gradwohl G., Fode C., Guillemot F.
    Development 124:1611-1621(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS."
    Sommer L., Ma Q., Anderson D.J.
    Mol. Cell. Neurosci. 8:221-241(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas."
    Gradwohl G., Dierich A., LeMeur M., Guillemot F.
    Proc. Natl. Acad. Sci. U.S.A. 97:1607-1611(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3."
    Anderson K.R., Torres C.A., Solomon K., Becker T.C., Newgard C.B., Wright C.V., Hagman J., Sussel L.
    J. Biol. Chem. 284:31236-31248(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNGN3_MOUSE
AccessioniPrimary (citable) accession number: P70661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: February 4, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.