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P70661

- NGN3_MOUSE

UniProt

P70661 - NGN3_MOUSE

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Protein
Neurogenin-3
Gene
Neurog3, Ath4b, Atoh5, Ngn3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.2 Publications

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  2. chromatin DNA binding Source: UniProtKB
  3. core promoter binding Source: UniProtKB
  4. double-stranded DNA binding Source: Ensembl
  5. sequence-specific DNA binding transcription factor activity Source: MGI
  6. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. endocrine pancreas development Source: Reactome
  2. epithelial cell differentiation Source: MGI
  3. forebrain development Source: Ensembl
  4. hindbrain development Source: Ensembl
  5. multicellular organismal development Source: MGI
  6. positive regulation of neuron differentiation Source: Ensembl
  7. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  9. regulation of dendrite morphogenesis Source: MGI
  10. spinal cord development Source: Ensembl
  11. transdifferentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_221082. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.
REACT_222486. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-3
Short name:
NGN-3
Alternative name(s):
Helix-loop-helix protein mATH-4B
Short name:
mATH4B
Protein atonal homolog 5
Gene namesi
Name:Neurog3
Synonyms:Ath4b, Atoh5, Ngn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:893591. Neurog3.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. intracellular Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Neurogenin-3
PRO_0000127403Add
BLAST

Proteomic databases

PRIDEiP70661.

PTM databases

PhosphoSiteiP70661.

Expressioni

Gene expression databases

BgeeiP70661.
CleanExiMM_NEUROG3.
GenevestigatoriP70661.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Structurei

3D structure databases

ProteinModelPortaliP70661.
SMRiP70661. Positions 83-140.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 13553bHLH
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG327835.
HOGENOMiHOG000063655.
HOVERGENiHBG031743.
InParanoidiP70661.
KOiK08028.
OMAiRKKANDR.
OrthoDBiEOG7TTQB1.
PhylomeDBiP70661.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70661-1 [UniParc]FASTAAdd to Basket

« Hide

MAPHPLDALT IQVSPETQQP FPGASDHEVL SSNSTPPSPT LIPRDCSEAE    50
VGDCRGTSRK LRARRGGRNR PKSELALSKQ RRSRRKKAND RERNRMHNLN 100
SALDALRGVL PTFPDDAKLT KIETLRFAHN YIWALTQTLR IADHSFYGPE 150
PPVPCGELGS PGGGSNGDWG SIYSPVSQAG NLSPTASLEE FPGLQVPSSP 200
SYLLPGALVF SDFL 214
Length:214
Mass (Da):23,267
Last modified:February 1, 1997 - v1
Checksum:i1AB31183291FB98B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09167 Genomic DNA. Translation: CAA70366.1.
U76208 Genomic DNA. Translation: AAC53029.1.
CCDSiCCDS23887.1.
RefSeqiNP_033849.3. NM_009719.6.
UniGeneiMm.57236.

Genome annotation databases

EnsembliENSMUST00000050103; ENSMUSP00000054054; ENSMUSG00000044312.
GeneIDi11925.
KEGGimmu:11925.
UCSCiuc007fgu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09167 Genomic DNA. Translation: CAA70366.1 .
U76208 Genomic DNA. Translation: AAC53029.1 .
CCDSi CCDS23887.1.
RefSeqi NP_033849.3. NM_009719.6.
UniGenei Mm.57236.

3D structure databases

ProteinModelPortali P70661.
SMRi P70661. Positions 83-140.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P70661.

Proteomic databases

PRIDEi P70661.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050103 ; ENSMUSP00000054054 ; ENSMUSG00000044312 .
GeneIDi 11925.
KEGGi mmu:11925.
UCSCi uc007fgu.1. mouse.

Organism-specific databases

CTDi 50674.
MGIi MGI:893591. Neurog3.

Phylogenomic databases

eggNOGi NOG327835.
HOGENOMi HOG000063655.
HOVERGENi HBG031743.
InParanoidi P70661.
KOi K08028.
OMAi RKKANDR.
OrthoDBi EOG7TTQB1.
PhylomeDBi P70661.
TreeFami TF315153.

Enzyme and pathway databases

Reactomei REACT_221082. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.
REACT_222486. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.

Miscellaneous databases

NextBioi 280005.
PROi P70661.
SOURCEi Search...

Gene expression databases

Bgeei P70661.
CleanExi MM_NEUROG3.
Genevestigatori P70661.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors."
    Cau E., Gradwohl G., Fode C., Guillemot F.
    Development 124:1611-1621(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS."
    Sommer L., Ma Q., Anderson D.J.
    Mol. Cell. Neurosci. 8:221-241(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas."
    Gradwohl G., Dierich A., LeMeur M., Guillemot F.
    Proc. Natl. Acad. Sci. U.S.A. 97:1607-1611(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3."
    Anderson K.R., Torres C.A., Solomon K., Becker T.C., Newgard C.B., Wright C.V., Hagman J., Sussel L.
    J. Biol. Chem. 284:31236-31248(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNGN3_MOUSE
AccessioniPrimary (citable) accession number: P70661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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