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P70661

- NGN3_MOUSE

UniProt

P70661 - NGN3_MOUSE

Protein

Neurogenin-3

Gene

Neurog3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.2 Publications

    GO - Molecular functioni

    1. chromatin DNA binding Source: UniProtKB
    2. core promoter binding Source: UniProtKB
    3. double-stranded DNA binding Source: Ensembl
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    5. sequence-specific DNA binding transcription factor activity Source: MGI
    6. transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    1. endocrine pancreas development Source: Reactome
    2. epithelial cell differentiation Source: MGI
    3. forebrain development Source: Ensembl
    4. hindbrain development Source: Ensembl
    5. multicellular organismal development Source: MGI
    6. positive regulation of neuron differentiation Source: Ensembl
    7. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    9. regulation of dendrite morphogenesis Source: MGI
    10. spinal cord development Source: Ensembl
    11. transdifferentiation Source: UniProtKB

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_221082. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.
    REACT_222486. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurogenin-3
    Short name:
    NGN-3
    Alternative name(s):
    Helix-loop-helix protein mATH-4B
    Short name:
    mATH4B
    Protein atonal homolog 5
    Gene namesi
    Name:Neurog3
    Synonyms:Ath4b, Atoh5, Ngn3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:893591. Neurog3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. intracellular Source: MGI
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 214214Neurogenin-3PRO_0000127403Add
    BLAST

    Proteomic databases

    PRIDEiP70661.

    PTM databases

    PhosphoSiteiP70661.

    Expressioni

    Gene expression databases

    BgeeiP70661.
    CleanExiMM_NEUROG3.
    GenevestigatoriP70661.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein.

    Structurei

    3D structure databases

    ProteinModelPortaliP70661.
    SMRiP70661. Positions 83-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini83 – 13553bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327835.
    HOGENOMiHOG000063655.
    HOVERGENiHBG031743.
    InParanoidiP70661.
    KOiK08028.
    OMAiRKKANDR.
    OrthoDBiEOG7TTQB1.
    PhylomeDBiP70661.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70661-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPHPLDALT IQVSPETQQP FPGASDHEVL SSNSTPPSPT LIPRDCSEAE    50
    VGDCRGTSRK LRARRGGRNR PKSELALSKQ RRSRRKKAND RERNRMHNLN 100
    SALDALRGVL PTFPDDAKLT KIETLRFAHN YIWALTQTLR IADHSFYGPE 150
    PPVPCGELGS PGGGSNGDWG SIYSPVSQAG NLSPTASLEE FPGLQVPSSP 200
    SYLLPGALVF SDFL 214
    Length:214
    Mass (Da):23,267
    Last modified:February 1, 1997 - v1
    Checksum:i1AB31183291FB98B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09167 Genomic DNA. Translation: CAA70366.1.
    U76208 Genomic DNA. Translation: AAC53029.1.
    CCDSiCCDS23887.1.
    RefSeqiNP_033849.3. NM_009719.6.
    UniGeneiMm.57236.

    Genome annotation databases

    EnsembliENSMUST00000050103; ENSMUSP00000054054; ENSMUSG00000044312.
    GeneIDi11925.
    KEGGimmu:11925.
    UCSCiuc007fgu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09167 Genomic DNA. Translation: CAA70366.1 .
    U76208 Genomic DNA. Translation: AAC53029.1 .
    CCDSi CCDS23887.1.
    RefSeqi NP_033849.3. NM_009719.6.
    UniGenei Mm.57236.

    3D structure databases

    ProteinModelPortali P70661.
    SMRi P70661. Positions 83-140.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P70661.

    Proteomic databases

    PRIDEi P70661.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050103 ; ENSMUSP00000054054 ; ENSMUSG00000044312 .
    GeneIDi 11925.
    KEGGi mmu:11925.
    UCSCi uc007fgu.1. mouse.

    Organism-specific databases

    CTDi 50674.
    MGIi MGI:893591. Neurog3.

    Phylogenomic databases

    eggNOGi NOG327835.
    HOGENOMi HOG000063655.
    HOVERGENi HBG031743.
    InParanoidi P70661.
    KOi K08028.
    OMAi RKKANDR.
    OrthoDBi EOG7TTQB1.
    PhylomeDBi P70661.
    TreeFami TF315153.

    Enzyme and pathway databases

    Reactomei REACT_221082. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.
    REACT_222486. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.

    Miscellaneous databases

    NextBioi 280005.
    PROi P70661.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70661.
    CleanExi MM_NEUROG3.
    Genevestigatori P70661.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors."
      Cau E., Gradwohl G., Fode C., Guillemot F.
      Development 124:1611-1621(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS."
      Sommer L., Ma Q., Anderson D.J.
      Mol. Cell. Neurosci. 8:221-241(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas."
      Gradwohl G., Dierich A., LeMeur M., Guillemot F.
      Proc. Natl. Acad. Sci. U.S.A. 97:1607-1611(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3."
      Anderson K.R., Torres C.A., Solomon K., Becker T.C., Newgard C.B., Wright C.V., Hagman J., Sussel L.
      J. Biol. Chem. 284:31236-31248(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiNGN3_MOUSE
    AccessioniPrimary (citable) accession number: P70661
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3