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P70660

- NGN1_MOUSE

UniProt

P70660 - NGN1_MOUSE

Protein

Neurogenin-1

Gene

Neurog1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.3 Publications

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. E-box binding Source: UniProtKB
    3. protein binding Source: MGI
    4. transcription factor binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. cell fate commitment Source: MGI
    2. inner ear morphogenesis Source: MGI
    3. neurogenesis Source: MGI
    4. neuron differentiation Source: MGI
    5. positive regulation of exit from mitosis Source: MGI
    6. positive regulation of neuron differentiation Source: UniProtKB
    7. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    9. regulation of neuron differentiation Source: MGI
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurogenin-1
    Short name:
    NGN-1
    Alternative name(s):
    Helix-loop-helix protein mATH-4C
    Short name:
    mATH4C
    Neurogenic basic-helix-loop-helix protein
    Neurogenic differentiation factor 3
    Short name:
    NeuroD3
    Gene namesi
    Name:Neurog1
    Synonyms:Ath4c, Neurod3, Ngn, Ngn1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:107754. Neurog1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. neuronal cell body Source: MGI
    2. nucleus Source: UniProtKB-SubCell
    3. perikaryon Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244Neurogenin-1PRO_0000127397Add
    BLAST

    Proteomic databases

    PRIDEiP70660.

    PTM databases

    PhosphoSiteiP70660.

    Expressioni

    Tissue specificityi

    Expression restricted to the embryonic nervous system.

    Developmental stagei

    Highest expression in the embryo between days 10 and 12. Declines to undetectable levels by embryonic day 16.

    Gene expression databases

    BgeeiP70660.
    CleanExiMM_NEUROG1.
    GenevestigatoriP70660.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein.

    Protein-protein interaction databases

    BioGridi201735. 3 interactions.
    STRINGi10090.ENSMUSP00000050484.

    Structurei

    3D structure databases

    ProteinModelPortaliP70660.
    SMRiP70660. Positions 93-150.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini93 – 14553bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG275082.
    GeneTreeiENSGT00680000099860.
    HOGENOMiHOG000063655.
    HOVERGENiHBG101129.
    InParanoidiP70660.
    KOiK09081.
    OMAiYIWALAE.
    OrthoDBiEOG7TTQB1.
    PhylomeDBiP70660.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70660-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAPLETCIS DLDCSSSNSS SDLSSFLTDE EDCARLQPLA STSGLSVPAR    50
    RSAPALSGAS NVPGAQDEEQ ERRRRRGRAR VRSEALLHSL RRSRRVKAND 100
    RERNRMHNLN AALDALRSVL PSFPDDTKLT KIETLRFAYN YIWALAETLR 150
    LADQGLPGGS ARERLLPPQC VPCLPGPPSP ASDTESWGSG AAASPCATVA 200
    SPLSDPSSPS ASEDFTYGPG DPLFSFPGLP KDLLHTTPCF IPYH 244
    Length:244
    Mass (Da):26,300
    Last modified:February 1, 1997 - v1
    Checksum:i3C9C0E1A08AB074B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63841 Genomic DNA. Translation: AAB37576.1.
    U67776 Genomic DNA. Translation: AAC52856.1.
    Y09166 Genomic DNA. Translation: CAA70365.1.
    BC062148 mRNA. Translation: AAH62148.1.
    CCDSiCCDS26559.1.
    RefSeqiNP_035026.1. NM_010896.2.
    UniGeneiMm.266665.

    Genome annotation databases

    EnsembliENSMUST00000058475; ENSMUSP00000050484; ENSMUSG00000048904.
    GeneIDi18014.
    KEGGimmu:18014.
    UCSCiuc007qsl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63841 Genomic DNA. Translation: AAB37576.1 .
    U67776 Genomic DNA. Translation: AAC52856.1 .
    Y09166 Genomic DNA. Translation: CAA70365.1 .
    BC062148 mRNA. Translation: AAH62148.1 .
    CCDSi CCDS26559.1.
    RefSeqi NP_035026.1. NM_010896.2.
    UniGenei Mm.266665.

    3D structure databases

    ProteinModelPortali P70660.
    SMRi P70660. Positions 93-150.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201735. 3 interactions.
    STRINGi 10090.ENSMUSP00000050484.

    PTM databases

    PhosphoSitei P70660.

    Proteomic databases

    PRIDEi P70660.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000058475 ; ENSMUSP00000050484 ; ENSMUSG00000048904 .
    GeneIDi 18014.
    KEGGi mmu:18014.
    UCSCi uc007qsl.2. mouse.

    Organism-specific databases

    CTDi 4762.
    MGIi MGI:107754. Neurog1.

    Phylogenomic databases

    eggNOGi NOG275082.
    GeneTreei ENSGT00680000099860.
    HOGENOMi HOG000063655.
    HOVERGENi HBG101129.
    InParanoidi P70660.
    KOi K09081.
    OMAi YIWALAE.
    OrthoDBi EOG7TTQB1.
    PhylomeDBi P70660.
    TreeFami TF315153.

    Miscellaneous databases

    NextBioi 293045.
    PROi P70660.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70660.
    CleanExi MM_NEUROG1.
    Genevestigatori P70660.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family."
      McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D., Tapscott S.J.
      Mol. Cell. Biol. 16:5792-5800(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "Identification of neurogenin, a vertebrate neuronal determination gene."
      Ma Q., Kintner C., Anderson D.J.
      Cell 87:43-52(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors."
      Cau E., Gradwohl G., Fode C., Guillemot F.
      Development 124:1611-1621(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone.
    5. "Generation of neurons by transient expression of neural bHLH proteins in mammalian cells."
      Farah M.H., Olson J.M., Sucic H.B., Hume R.I., Tapscott S.J., Turner D.L.
      Development 127:693-702(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING.
    6. Cited for: FUNCTION, DNA-BINDING.
    7. "Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers."
      Seo S., Lim J.W., Yellajoshyula D., Chang L.W., Kroll K.L.
      EMBO J. 26:5093-5108(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ASSOCIATION WITH CHROMATIN.

    Entry informationi

    Entry nameiNGN1_MOUSE
    AccessioniPrimary (citable) accession number: P70660
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3