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Protein

Neurogenin-1

Gene

Neurog1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.3 Publications

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • E-box binding Source: UniProtKB
  • protein homodimerization activity Source: MGI
  • sequence-specific double-stranded DNA binding Source: MGI
  • transcription factor activity, transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-1
Short name:
NGN-1
Alternative name(s):
Helix-loop-helix protein mATH-4C
Short name:
mATH4C
Neurogenic basic-helix-loop-helix protein
Neurogenic differentiation factor 3
Short name:
NeuroD3
Gene namesi
Name:Neurog1
Synonyms:Ath4c, Neurod3, Ngn, Ngn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:107754. Neurog1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273971 – 244Neurogenin-1Add BLAST244

Proteomic databases

PaxDbiP70660.
PRIDEiP70660.

PTM databases

iPTMnetiP70660.
PhosphoSitePlusiP70660.

Expressioni

Tissue specificityi

Expression restricted to the embryonic nervous system.

Developmental stagei

Highest expression in the embryo between days 10 and 12. Declines to undetectable levels by embryonic day 16.

Gene expression databases

BgeeiENSMUSG00000048904.
CleanExiMM_NEUROG1.
GenevisibleiP70660. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201735. 3 interactors.
STRINGi10090.ENSMUSP00000050484.

Structurei

3D structure databases

ProteinModelPortaliP70660.
SMRiP70660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 145bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG3898. Eukaryota.
ENOG4111U26. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiP70660.
KOiK09081.
OMAiYIWALAE.
OrthoDBiEOG091G0PNH.
PhylomeDBiP70660.
TreeFamiTF315153.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR036638. HLH_DNA-bd_sf.
IPR032653. Ngn1.
PANTHERiPTHR19290:SF130. PTHR19290:SF130. 1 hit.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

P70660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPLETCIS DLDCSSSNSS SDLSSFLTDE EDCARLQPLA STSGLSVPAR
60 70 80 90 100
RSAPALSGAS NVPGAQDEEQ ERRRRRGRAR VRSEALLHSL RRSRRVKAND
110 120 130 140 150
RERNRMHNLN AALDALRSVL PSFPDDTKLT KIETLRFAYN YIWALAETLR
160 170 180 190 200
LADQGLPGGS ARERLLPPQC VPCLPGPPSP ASDTESWGSG AAASPCATVA
210 220 230 240
SPLSDPSSPS ASEDFTYGPG DPLFSFPGLP KDLLHTTPCF IPYH
Length:244
Mass (Da):26,300
Last modified:February 1, 1997 - v1
Checksum:i3C9C0E1A08AB074B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63841 Genomic DNA. Translation: AAB37576.1.
U67776 Genomic DNA. Translation: AAC52856.1.
Y09166 Genomic DNA. Translation: CAA70365.1.
BC062148 mRNA. Translation: AAH62148.1.
CCDSiCCDS26559.1.
RefSeqiNP_035026.1. NM_010896.2.
UniGeneiMm.266665.

Genome annotation databases

EnsembliENSMUST00000058475; ENSMUSP00000050484; ENSMUSG00000048904.
GeneIDi18014.
KEGGimmu:18014.
UCSCiuc007qsl.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiNGN1_MOUSE
AccessioniPrimary (citable) accession number: P70660
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: October 25, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot