Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neurogenin-1

Gene

Neurog1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.3 Publications

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. E-box binding Source: UniProtKB
  3. transcription factor binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. cell fate commitment Source: MGI
  2. inner ear morphogenesis Source: MGI
  3. neurogenesis Source: MGI
  4. neuron differentiation Source: MGI
  5. positive regulation of exit from mitosis Source: MGI
  6. positive regulation of neuron differentiation Source: UniProtKB
  7. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  9. regulation of neuron differentiation Source: MGI
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-1
Short name:
NGN-1
Alternative name(s):
Helix-loop-helix protein mATH-4C
Short name:
mATH4C
Neurogenic basic-helix-loop-helix protein
Neurogenic differentiation factor 3
Short name:
NeuroD3
Gene namesi
Name:Neurog1
Synonyms:Ath4c, Neurod3, Ngn, Ngn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:107754. Neurog1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. neuronal cell body Source: MGI
  2. nucleus Source: UniProtKB-SubCell
  3. perikaryon Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Neurogenin-1PRO_0000127397Add
BLAST

Proteomic databases

PRIDEiP70660.

PTM databases

PhosphoSiteiP70660.

Expressioni

Tissue specificityi

Expression restricted to the embryonic nervous system.

Developmental stagei

Highest expression in the embryo between days 10 and 12. Declines to undetectable levels by embryonic day 16.

Gene expression databases

BgeeiP70660.
CleanExiMM_NEUROG1.
GenevestigatoriP70660.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

BioGridi201735. 3 interactions.
STRINGi10090.ENSMUSP00000050484.

Structurei

3D structure databases

ProteinModelPortaliP70660.
SMRiP70660. Positions 93-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 14553bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG275082.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiP70660.
KOiK09081.
OMAiYIWALAE.
OrthoDBiEOG7TTQB1.
PhylomeDBiP70660.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPLETCIS DLDCSSSNSS SDLSSFLTDE EDCARLQPLA STSGLSVPAR
60 70 80 90 100
RSAPALSGAS NVPGAQDEEQ ERRRRRGRAR VRSEALLHSL RRSRRVKAND
110 120 130 140 150
RERNRMHNLN AALDALRSVL PSFPDDTKLT KIETLRFAYN YIWALAETLR
160 170 180 190 200
LADQGLPGGS ARERLLPPQC VPCLPGPPSP ASDTESWGSG AAASPCATVA
210 220 230 240
SPLSDPSSPS ASEDFTYGPG DPLFSFPGLP KDLLHTTPCF IPYH
Length:244
Mass (Da):26,300
Last modified:January 31, 1997 - v1
Checksum:i3C9C0E1A08AB074B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63841 Genomic DNA. Translation: AAB37576.1.
U67776 Genomic DNA. Translation: AAC52856.1.
Y09166 Genomic DNA. Translation: CAA70365.1.
BC062148 mRNA. Translation: AAH62148.1.
CCDSiCCDS26559.1.
RefSeqiNP_035026.1. NM_010896.2.
UniGeneiMm.266665.

Genome annotation databases

EnsembliENSMUST00000058475; ENSMUSP00000050484; ENSMUSG00000048904.
GeneIDi18014.
KEGGimmu:18014.
UCSCiuc007qsl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63841 Genomic DNA. Translation: AAB37576.1.
U67776 Genomic DNA. Translation: AAC52856.1.
Y09166 Genomic DNA. Translation: CAA70365.1.
BC062148 mRNA. Translation: AAH62148.1.
CCDSiCCDS26559.1.
RefSeqiNP_035026.1. NM_010896.2.
UniGeneiMm.266665.

3D structure databases

ProteinModelPortaliP70660.
SMRiP70660. Positions 93-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201735. 3 interactions.
STRINGi10090.ENSMUSP00000050484.

PTM databases

PhosphoSiteiP70660.

Proteomic databases

PRIDEiP70660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058475; ENSMUSP00000050484; ENSMUSG00000048904.
GeneIDi18014.
KEGGimmu:18014.
UCSCiuc007qsl.2. mouse.

Organism-specific databases

CTDi4762.
MGIiMGI:107754. Neurog1.

Phylogenomic databases

eggNOGiNOG275082.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiP70660.
KOiK09081.
OMAiYIWALAE.
OrthoDBiEOG7TTQB1.
PhylomeDBiP70660.
TreeFamiTF315153.

Miscellaneous databases

NextBioi293045.
PROiP70660.
SOURCEiSearch...

Gene expression databases

BgeeiP70660.
CleanExiMM_NEUROG1.
GenevestigatoriP70660.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family."
    McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D., Tapscott S.J.
    Mol. Cell. Biol. 16:5792-5800(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Identification of neurogenin, a vertebrate neuronal determination gene."
    Ma Q., Kintner C., Anderson D.J.
    Cell 87:43-52(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors."
    Cau E., Gradwohl G., Fode C., Guillemot F.
    Development 124:1611-1621(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone.
  5. "Generation of neurons by transient expression of neural bHLH proteins in mammalian cells."
    Farah M.H., Olson J.M., Sucic H.B., Hume R.I., Tapscott S.J., Turner D.L.
    Development 127:693-702(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  6. Cited for: FUNCTION, DNA-BINDING.
  7. "Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers."
    Seo S., Lim J.W., Yellajoshyula D., Chang L.W., Kroll K.L.
    EMBO J. 26:5093-5108(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ASSOCIATION WITH CHROMATIN.

Entry informationi

Entry nameiNGN1_MOUSE
AccessioniPrimary (citable) accession number: P70660
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: January 31, 1997
Last modified: January 6, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.