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P70658 (CXCR4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C chemokine receptor type 4

Short name=CXC-R4
Short name=CXCR-4
Alternative name(s):
Fusin
Leukocyte-derived seven transmembrane domain receptor
Short name=LESTR
Pre-B-cell-derived chemokine receptor
Short name=PB-CKR
Stromal cell-derived factor 1 receptor
Short name=SDF-1 receptor
CD_antigen=CD184
Gene names
Name:Cxcr4
Synonyms:Cmkar4, Lestr, Sdf1r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes By similarity. Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

Subunit structure

Monomer By similarity. Can form dimers By similarity. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin; the interaction enhances intracellular calcium ions and reduces cellular cAMP levels By similarity. Interacts with CD164. Interacts with DBN1; this interaction is enhanced by antigenic stimulation By similarity. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8 By similarity. Ref.13

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Cell junction By similarity. Early endosome By similarity. Late endosome By similarity. Lysosome By similarity. Note: In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated By similarity. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) By similarity.

Tissue specificity

Lymphocytes, macrophages, neutrophils, microglial cells and astrocytes. Found in spleen, thymus, bone marrow, lymph nodes and, at lower levels in brain, small intestine, stomach and kidney. CXCR4-A is predominant in all tissues tested. During embryonic development, high levels are detected in the endothelium of developing blood vessels and in many regions of the developing brain including the olfactory epithelium, olfactory bulb, hippocampus, cerebellum and spinal cord. Ref.9 Ref.10

Developmental stage

High expression during embryonic development does not seem to be associated with the differentiation of any particular cell type, but is widely utilized when there is a requirement for cell movement. Frequently associated with less differentiated cell types and down-regulated with subsequent differentiation. Detected in sites with hemopoietic potential: the yolk sac (7.5, 8.5 and 12.5 dpc) and fetal liver (12.5 dpc). During gastrulation, at 7.2 to 7.8 dpc, expressed in the mesoderm and the definitive endoderm. As gastrulation pattern fades (8.5 dpc), expression in the mesoderm is down-regulated, while it becomes predominant in neural ectoderm. Endodermal expression is retained in the foregut and later in a subset of foregut derivatives, including the stomach (10.5 dpc), the cystic ducts of the gall bladder and the lung epithelium (12.5 dpc). In neuronal tissue: at 10.5 and 12.5 dpc, expressed in the dorsal root ganglia, in the ventral mantle layer of the spinal cord (or basal plates), in the hindbrain. At 14.5 dpc, expression more tightly confined to the neural epithelium lining the ventricular space and to the external granular layer of the ventral rhombic lip (the developing cerebellum). Expressed in the outpocketing of the diencephalic floor at 10.5 dpc and in the developing thalamus and, to a lesser extent, the developing hypothalamus. At 14.5 dpc, restricted to the region where thalamus and hypothalamus meet. Detected in a discrete band of cells at the edge of the olfactory bulb. In the vascular system: expressed in the endothelium of numerous blood vessels, but not all, at 10.5, 11.5 and 12.5 dpc, such as vitelline/umbilical vessels, cardiac ventricular wall capillaries, facial vessels and, at 14.5 dpc, in the vasculature of the herniated gut. Expression seems to be associated with expanding vascular networks. In the heart development, expressed at 10.5 dpc in the precursor to the aortopulmonary (AP) septum. At 12.5 dpc, detected in the AP septum at the base of the outflow tract and in the atrioventricular valves. Detected in cranofacial ectoderm from 10.5 to 14.5 dpc. At 10.5 and 11.5 dpc, expressed in the Rathke pouch. Ref.12

Post-translational modification

Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-331 and Ser-332 leads to recruitment of ITCH, ubiquitination and protein degradation By similarity.

Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S By similarity.

Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization By similarity.

O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity By similarity.

Disruption phenotype

Half of the embryos die by E17.5-E18.5 and neonates die within a few hours. Mutants display defective vascular development, cerebellar development, B-lymphopoiesis, myelopoiesis, and cardiogenesis with defective formation of the large vessels supplying the gastrointestinal tract. Ref.9 Ref.10 Ref.11

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell junction
Cell membrane
Endosome
Lysosome
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
Proteoglycan
Sulfation
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell proliferation

Inferred from mutant phenotype PubMed 12707343. Source: MGI

ameboidal cell migration

Inferred from mutant phenotype PubMed 15626744. Source: MGI

brain development

Inferred from mutant phenotype PubMed 12183377. Source: MGI

calcium-mediated signaling

Inferred from sequence orthology PubMed 19064997. Source: MGI

cellular response to cytokine stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

generation of neurons

Inferred from expression pattern PubMed 20882566. Source: DFLAT

germ cell development

Inferred from mutant phenotype PubMed 12900445. Source: MGI

germ cell migration

Inferred from mutant phenotype PubMed 12900445. Source: MGI

motor neuron axon guidance

Inferred from mutant phenotype PubMed 16129397PubMed 18031680. Source: MGI

myelin maintenance

Inferred from mutant phenotype PubMed 20534485. Source: BHF-UCL

nervous system development

Traceable author statement Ref.10. Source: ProtInc

neural precursor cell proliferation

Inferred from expression pattern PubMed 20882566. Source: DFLAT

neuron migration

Inferred from direct assay PubMed 12900445. Source: MGI

neutrophil activation

Inferred from electronic annotation. Source: InterPro

organ morphogenesis

Traceable author statement Ref.9. Source: ProtInc

patterning of blood vessels

Inferred from mutant phenotype PubMed 15626744. Source: MGI

positive regulation of oligodendrocyte differentiation

Inferred from mutant phenotype PubMed 20534485. Source: BHF-UCL

regulation of cell migration

Inferred from mutant phenotype PubMed 12183377PubMed 12900445. Source: MGI

regulation of chemotaxis

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-SubCell

cell leading edge

Inferred from electronic annotation. Source: Ensembl

cell surface

Inferred from direct assay PubMed 22265737. Source: BHF-UCL

cytoplasmic membrane-bounded vesicle

Inferred from electronic annotation. Source: Ensembl

early endosome

Inferred from sequence or structural similarity. Source: UniProtKB

external side of plasma membrane

Inferred from direct assay PubMed 19008373. Source: MGI

growth cone

Inferred from direct assay PubMed 16129397. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

late endosome

Inferred from sequence or structural similarity. Source: UniProtKB

lysosome

Inferred from sequence or structural similarity. Source: UniProtKB

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionC-X-C chemokine receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform CXCR4-B (identifier: P70658-1)

Also known as: LESTR-B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform CXCR4-A (identifier: P70658-2)

Also known as: LESTR-A;

The sequence of this isoform differs from the canonical sequence as follows:
     6-7: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359C-X-C chemokine receptor type 4
PRO_0000069355

Regions

Topological domain1 – 4040Extracellular By similarity
Transmembrane41 – 6525Helical; Name=1; By similarity
Topological domain66 – 7914Cytoplasmic By similarity
Transmembrane80 – 10122Helical; Name=2; By similarity
Topological domain102 – 11211Extracellular By similarity
Transmembrane113 – 13220Helical; Name=3; By similarity
Topological domain133 – 15624Cytoplasmic By similarity
Transmembrane157 – 17620Helical; Name=4; By similarity
Topological domain177 – 20226Extracellular By similarity
Transmembrane203 – 22321Helical; Name=5; By similarity
Topological domain224 – 24825Cytoplasmic By similarity
Transmembrane249 – 26820Helical; Name=6; By similarity
Topological domain269 – 28921Extracellular By similarity
Transmembrane290 – 30920Helical; Name=7; By similarity
Topological domain310 – 35950Cytoplasmic By similarity
Region1 – 2323Important for chemokine binding and signaling By similarity
Region96 – 994Chemokine binding By similarity
Region115 – 1195Chemokine binding By similarity
Region137 – 14913Involved in dimerization; when bound to chemokine By similarity
Region193 – 1975Chemokine binding, important for signaling By similarity
Region198 – 21720Involved in dimerization By similarity
Region273 – 2753Involved in dimerization By similarity
Motif135 – 1373Important for signaling By similarity

Sites

Binding site1731Chemokine By similarity
Binding site2951Chemokine By similarity

Amino acid modifications

Modified residue91Sulfotyrosine By similarity
Modified residue141Sulfotyrosine By similarity
Modified residue231Sulfotyrosine By similarity
Modified residue3261Phosphoserine By similarity
Modified residue3281Phosphoserine By similarity
Modified residue3311Phosphoserine; by PKC and GRK6 By similarity
Modified residue3321Phosphoserine; by PKC and GRK6 By similarity
Modified residue3371Phosphoserine; by GRK6 By similarity
Modified residue3461Phosphoserine; by GRK6 By similarity
Modified residue3551Phosphoserine By similarity
Modified residue3581Phosphoserine By similarity
Glycosylation131N-linked (GlcNAc...) By similarity
Glycosylation201O-linked (Xyl...) (chondroitin sulfate) By similarity
Disulfide bond30 ↔ 281 By similarity
Disulfide bond111 ↔ 193 By similarity

Natural variations

Alternative sequence6 – 72Missing in isoform CXCR4-A.
VSP_001891

Experimental info

Sequence conflict2161I → V in CAA67893. Ref.4
Sequence conflict2161I → V in BAA19187. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform CXCR4-B (LESTR-B) [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 33D1B5552A31595B

FASTA35940,426
        10         20         30         40         50         60 
MEPISVSIYT SDNYSEEVGS GDYDSNKEPC FRDENVHFNR IFLPTIYFII FLTGIVGNGL 

        70         80         90        100        110        120 
VILVMGYQKK LRSMTDKYRL HLSVADLLFV ITLPFWAVDA MADWYFGKFL CKAVHIIYTV 

       130        140        150        160        170        180 
NLYSSVLILA FISLDRYLAI VHATNSQRPR KLLAEKAVYV GVWIPALLLT IPDFIFADVS 

       190        200        210        220        230        240 
QGDISQGDDR YICDRLYPDS LWMVVFQFQH IMVGLILPGI VILSCYCIII SKLSHSKGHQ 

       250        260        270        280        290        300 
KRKALKTTVI LILAFFACWL PYYVGISIDS FILLGVIKQG CDFESIVHKW ISITEALAFF 

       310        320        330        340        350 
HCCLNPILYA FLGAKFKSSA QHALNSMSRG SSLKILSKGK RGGHSSVSTE SESSSFHSS 

« Hide

Isoform CXCR4-A (LESTR-A) [UniParc].

Checksum: 648C8835307AD5EC
Show »

FASTA35740,240

References

« Hide 'large scale' references
[1]"Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor."
Heesen M., Berman M.A., Benson J.D., Gerard C., Dorf M.E.
J. Immunol. 157:5455-5460(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM CXCR4-B).
Strain: 129/Sv and C57BL/6J.
Tissue: Peritoneal exudate.
[2]"Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin."
Nagasawa T., Nakajima T., Tachibana K., Iizasa H., Bleul C.C., Yoshie O., Matsushima K., Yoshida N., Springer T.A., Kishimoto T.
Proc. Natl. Acad. Sci. U.S.A. 93:14726-14729(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CXCR4-B).
Tissue: Pre-B cell.
[3]Schubel A., Burgstahler R., Lipp M.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CXCR4-B).
Strain: 129/Sv.
Tissue: Thymus.
[4]"Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1alpha activation of Gi2 are differentially expressed in vivo."
Moepps B., Frodl R., Rodewald H.-R., Baggiolini M., Gierschik P.
Eur. J. Immunol. 27:2102-2112(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS CXCR4-A AND CXCR4-B).
Strain: C57BL/6J X CBA/J.
Tissue: Thymus.
[5]"Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms."
Heesen M., Berman M.A., Hoepken U.E., Gerard N.P., Dorf M.E.
J. Immunol. 158:3561-3564(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS CXCR4-A AND CXCR4-B).
[6]Suzuki G., Nakata Y., Uzawa A., Shirasawa T., Saito T., Mita K.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CXCR4-B).
Strain: C57BL/6.
Tissue: Thymus.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CXCR4-B).
Strain: FVB/N.
Tissue: Mammary gland.
[8]"Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-B in human tissues."
Frodl R., Gierschik P., Moepps B.
J. Recept. Signal Transduct. 18:321-344(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING.
[9]"The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract."
Tachibana K., Hirota S., Iizasa H., Yoshida H., Kawabata K., Kataoka Y., Kitamura Y., Matsushima K., Yoshida N., Nishikawa S., Kishimoto T., Nagasawa T.
Nature 393:591-594(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[10]"Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development."
Zou Y.-R., Kottmann A.H., Kuroda M., Taniuchi I., Littman D.R.
Nature 393:595-599(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[11]"Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice."
Ma Q., Jones D., Borghesani P.R., Segal R.A., Nagasawa T., Kishimoto T., Bronson R.T., Springer T.A.
Proc. Natl. Acad. Sci. U.S.A. 95:9448-9453(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[12]"Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4."
McGrath K.E., Koniski A.D., Maltby K.M., McGann J.K., Palis J.
Dev. Biol. 213:442-456(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
Strain: ICR.
[13]"Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164."
Bae G.-U., Gaio U., Yang Y.-J., Lee H.-J., Kang J.-S., Krauss R.S.
J. Biol. Chem. 283:8301-8309(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CD164.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59760 mRNA. Translation: AAB07725.1.
U65580 Genomic DNA. Translation: AAC52953.1.
D87747 mRNA. Translation: BAA13451.1.
Z80111 mRNA. Translation: CAB02201.1.
Z80112 mRNA. Translation: CAB02202.1.
X99581 Genomic DNA. Translation: CAA67893.1.
X99582 mRNA. Translation: CAA67894.1.
AB000803 mRNA. Translation: BAA19187.1.
BC031665 mRNA. Translation: AAH31665.1.
BC098322 mRNA. Translation: AAH98322.1.
RefSeqNP_034041.2. NM_009911.3.
UniGeneMm.1401.

3D structure databases

ProteinModelPortalP70658.
SMRP70658. Positions 29-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP70658. 1 interaction.

Chemistry

BindingDBP70658.
ChEMBLCHEMBL1250365.
GuidetoPHARMACOLOGY71.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP70658.

Proteomic databases

PRIDEP70658.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052172; ENSMUSP00000053489; ENSMUSG00000045382.
GeneID12767.
KEGGmmu:12767.
UCSCuc007cls.1. mouse. [P70658-2]
uc007clt.1. mouse. [P70658-1]

Organism-specific databases

CTD7852.
MGIMGI:109563. Cxcr4.

Phylogenomic databases

eggNOGNOG328039.
GeneTreeENSGT00730000110292.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidP70658.
KOK04189.
OrthoDBEOG73Z2TB.
PhylomeDBP70658.
TreeFamTF330966.

Gene expression databases

ArrayExpressP70658.
BgeeP70658.
CleanExMM_CXCR4.
GenevestigatorP70658.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001277. Chemokine_CXCR4.
IPR022726. Chemokine_CXCR4_N_dom.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF7. PTHR24227:SF7. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
PF12109. CXCR4_N. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR00645. CXCCHMKINER4.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCXCR4. mouse.
NextBio282130.
PROP70658.
SOURCESearch...

Entry information

Entry nameCXCR4_MOUSE
AccessionPrimary (citable) accession number: P70658
Secondary accession number(s): O09059 expand/collapse secondary AC list , O09062, P70233, P70346, Q4KMW1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries