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P70658

- CXCR4_MOUSE

UniProt

P70658 - CXCR4_MOUSE

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Protein

C-X-C chemokine receptor type 4

Gene

Cxcr4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.By similarity3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei173 – 1731ChemokineBy similarity
Binding sitei295 – 2951ChemokineBy similarity

GO - Molecular functioni

  1. C-X-C chemokine receptor activity Source: InterPro

GO - Biological processi

  1. ameboidal cell migration Source: MGI
  2. brain development Source: MGI
  3. calcium-mediated signaling Source: MGI
  4. cellular response to cytokine stimulus Source: UniProtKB
  5. generation of neurons Source: DFLAT
  6. germ cell development Source: MGI
  7. germ cell migration Source: MGI
  8. motor neuron axon guidance Source: MGI
  9. myelin maintenance Source: BHF-UCL
  10. nervous system development Source: ProtInc
  11. neural precursor cell proliferation Source: DFLAT
  12. neuron migration Source: MGI
  13. neutrophil activation Source: InterPro
  14. organ morphogenesis Source: ProtInc
  15. patterning of blood vessels Source: MGI
  16. positive regulation of oligodendrocyte differentiation Source: BHF-UCL
  17. regulation of cell migration Source: MGI
  18. regulation of chemotaxis Source: Ensembl
  19. response to hypoxia Source: Ensembl
  20. T cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 4
Short name:
CXC-R4
Short name:
CXCR-4
Alternative name(s):
Fusin
Leukocyte-derived seven transmembrane domain receptor
Short name:
LESTR
Pre-B-cell-derived chemokine receptor
Short name:
PB-CKR
Stromal cell-derived factor 1 receptor
Short name:
SDF-1 receptor
CD_antigen: CD184
Gene namesi
Name:Cxcr4
Synonyms:Cmkar4, Lestr, Sdf1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:109563. Cxcr4.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junction By similarity. Early endosome By similarity. Late endosome By similarity. Lysosome By similarity
Note: In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated (By similarity). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) (By similarity).By similarity

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. cell leading edge Source: Ensembl
  3. cell surface Source: BHF-UCL
  4. cytoplasmic membrane-bounded vesicle Source: Ensembl
  5. early endosome Source: UniProtKB
  6. external side of plasma membrane Source: MGI
  7. extracellular vesicular exosome Source: Ensembl
  8. growth cone Source: MGI
  9. integral component of membrane Source: UniProtKB-KW
  10. late endosome Source: UniProtKB
  11. lysosome Source: UniProtKB
  12. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Half of the embryos die by E17.5-E18.5 and neonates die within a few hours. Mutants display defective vascular development, cerebellar development, B-lymphopoiesis, myelopoiesis, and cardiogenesis with defective formation of the large vessels supplying the gastrointestinal tract.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359C-X-C chemokine receptor type 4PRO_0000069355Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91SulfotyrosineBy similarity
Glycosylationi13 – 131N-linked (GlcNAc...)By similarity
Modified residuei14 – 141SulfotyrosineBy similarity
Glycosylationi20 – 201O-linked (Xyl...) (chondroitin sulfate)By similarity
Modified residuei23 – 231SulfotyrosineBy similarity
Disulfide bondi30 ↔ 281PROSITE-ProRule annotation
Disulfide bondi111 ↔ 193PROSITE-ProRule annotation
Modified residuei326 – 3261PhosphoserineBy similarity
Modified residuei328 – 3281PhosphoserineBy similarity
Modified residuei331 – 3311Phosphoserine; by PKC and GRK6By similarity
Modified residuei332 – 3321Phosphoserine; by PKC and GRK6By similarity
Modified residuei337 – 3371Phosphoserine; by GRK6By similarity
Modified residuei346 – 3461Phosphoserine; by GRK6By similarity
Modified residuei355 – 3551PhosphoserineBy similarity
Modified residuei358 – 3581PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-331 and Ser-332 leads to recruitment of ITCH, ubiquitination and protein degradation (By similarity).By similarity
Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S (By similarity).By similarity
Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.By similarity
O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Sulfation, Ubl conjugation

Proteomic databases

MaxQBiP70658.
PRIDEiP70658.

PTM databases

PhosphoSiteiP70658.

Expressioni

Tissue specificityi

Lymphocytes, macrophages, neutrophils, microglial cells and astrocytes. Found in spleen, thymus, bone marrow, lymph nodes and, at lower levels in brain, small intestine, stomach and kidney. CXCR4-A is predominant in all tissues tested. During embryonic development, high levels are detected in the endothelium of developing blood vessels and in many regions of the developing brain including the olfactory epithelium, olfactory bulb, hippocampus, cerebellum and spinal cord.2 Publications

Developmental stagei

High expression during embryonic development does not seem to be associated with the differentiation of any particular cell type, but is widely utilized when there is a requirement for cell movement. Frequently associated with less differentiated cell types and down-regulated with subsequent differentiation. Detected in sites with hemopoietic potential: the yolk sac (7.5, 8.5 and 12.5 dpc) and fetal liver (12.5 dpc). During gastrulation, at 7.2 to 7.8 dpc, expressed in the mesoderm and the definitive endoderm. As gastrulation pattern fades (8.5 dpc), expression in the mesoderm is down-regulated, while it becomes predominant in neural ectoderm. Endodermal expression is retained in the foregut and later in a subset of foregut derivatives, including the stomach (10.5 dpc), the cystic ducts of the gall bladder and the lung epithelium (12.5 dpc). In neuronal tissue: at 10.5 and 12.5 dpc, expressed in the dorsal root ganglia, in the ventral mantle layer of the spinal cord (or basal plates), in the hindbrain. At 14.5 dpc, expression more tightly confined to the neural epithelium lining the ventricular space and to the external granular layer of the ventral rhombic lip (the developing cerebellum). Expressed in the outpocketing of the diencephalic floor at 10.5 dpc and in the developing thalamus and, to a lesser extent, the developing hypothalamus. At 14.5 dpc, restricted to the region where thalamus and hypothalamus meet. Detected in a discrete band of cells at the edge of the olfactory bulb. In the vascular system: expressed in the endothelium of numerous blood vessels, but not all, at 10.5, 11.5 and 12.5 dpc, such as vitelline/umbilical vessels, cardiac ventricular wall capillaries, facial vessels and, at 14.5 dpc, in the vasculature of the herniated gut. Expression seems to be associated with expanding vascular networks. In the heart development, expressed at 10.5 dpc in the precursor to the aortopulmonary (AP) septum. At 12.5 dpc, detected in the AP septum at the base of the outflow tract and in the atrioventricular valves. Detected in cranofacial ectoderm from 10.5 to 14.5 dpc. At 10.5 and 11.5 dpc, expressed in the Rathke pouch.1 Publication

Gene expression databases

BgeeiP70658.
CleanExiMM_CXCR4.
ExpressionAtlasiP70658. baseline and differential.
GenevestigatoriP70658.

Interactioni

Subunit structurei

Monomer (By similarity). Can form dimers (By similarity). Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin; the interaction enhances intracellular calcium ions and reduces cellular cAMP levels (By similarity). Interacts with CD164. Interacts with DBN1; this interaction is enhanced by antigenic stimulation (By similarity). Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8 (By similarity).By similarity

Protein-protein interaction databases

IntActiP70658. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP70658.
SMRiP70658. Positions 29-324.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularBy similarityAdd
BLAST
Topological domaini66 – 7914CytoplasmicBy similarityAdd
BLAST
Topological domaini102 – 11211ExtracellularBy similarityAdd
BLAST
Topological domaini133 – 15624CytoplasmicBy similarityAdd
BLAST
Topological domaini177 – 20226ExtracellularBy similarityAdd
BLAST
Topological domaini224 – 24825CytoplasmicBy similarityAdd
BLAST
Topological domaini269 – 28921ExtracellularBy similarityAdd
BLAST
Topological domaini310 – 35950CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6525Helical; Name=1By similarityAdd
BLAST
Transmembranei80 – 10122Helical; Name=2By similarityAdd
BLAST
Transmembranei113 – 13220Helical; Name=3By similarityAdd
BLAST
Transmembranei157 – 17620Helical; Name=4By similarityAdd
BLAST
Transmembranei203 – 22321Helical; Name=5By similarityAdd
BLAST
Transmembranei249 – 26820Helical; Name=6By similarityAdd
BLAST
Transmembranei290 – 30920Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2323Important for chemokine binding and signalingBy similarityAdd
BLAST
Regioni96 – 994Chemokine bindingBy similarity
Regioni115 – 1195Chemokine bindingBy similarity
Regioni137 – 14913Involved in dimerization; when bound to chemokineBy similarityAdd
BLAST
Regioni193 – 1975Chemokine binding, important for signalingBy similarity
Regioni198 – 21720Involved in dimerizationBy similarityAdd
BLAST
Regioni273 – 2753Involved in dimerizationBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi135 – 1373Important for signalingBy similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG328039.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP70658.
KOiK04189.
OrthoDBiEOG73Z2TB.
PhylomeDBiP70658.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001277. Chemokine_CXCR4.
IPR022726. Chemokine_CXCR4_N_dom.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF7. PTHR24227:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF12109. CXCR4_N. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00645. CXCCHMKINER4.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform CXCR4-B (identifier: P70658-1) [UniParc]FASTAAdd to Basket

Also known as: LESTR-B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPISVSIYT SDNYSEEVGS GDYDSNKEPC FRDENVHFNR IFLPTIYFII
60 70 80 90 100
FLTGIVGNGL VILVMGYQKK LRSMTDKYRL HLSVADLLFV ITLPFWAVDA
110 120 130 140 150
MADWYFGKFL CKAVHIIYTV NLYSSVLILA FISLDRYLAI VHATNSQRPR
160 170 180 190 200
KLLAEKAVYV GVWIPALLLT IPDFIFADVS QGDISQGDDR YICDRLYPDS
210 220 230 240 250
LWMVVFQFQH IMVGLILPGI VILSCYCIII SKLSHSKGHQ KRKALKTTVI
260 270 280 290 300
LILAFFACWL PYYVGISIDS FILLGVIKQG CDFESIVHKW ISITEALAFF
310 320 330 340 350
HCCLNPILYA FLGAKFKSSA QHALNSMSRG SSLKILSKGK RGGHSSVSTE

SESSSFHSS
Length:359
Mass (Da):40,426
Last modified:November 1, 1997 - v2
Checksum:i33D1B5552A31595B
GO
Isoform CXCR4-A (identifier: P70658-2) [UniParc]FASTAAdd to Basket

Also known as: LESTR-A

The sequence of this isoform differs from the canonical sequence as follows:
     6-7: Missing.

Show »
Length:357
Mass (Da):40,240
Checksum:i648C8835307AD5EC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161I → V in CAA67893. (PubMed:9295051)Curated
Sequence conflicti216 – 2161I → V in BAA19187. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei6 – 72Missing in isoform CXCR4-A. 1 PublicationVSP_001891

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59760 mRNA. Translation: AAB07725.1.
U65580 Genomic DNA. Translation: AAC52953.1.
D87747 mRNA. Translation: BAA13451.1.
Z80111 mRNA. Translation: CAB02201.1.
Z80112 mRNA. Translation: CAB02202.1.
X99581 Genomic DNA. Translation: CAA67893.1.
X99582 mRNA. Translation: CAA67894.1.
AB000803 mRNA. Translation: BAA19187.1.
BC031665 mRNA. Translation: AAH31665.1.
BC098322 mRNA. Translation: AAH98322.1.
CCDSiCCDS15254.1. [P70658-1]
RefSeqiNP_034041.2. NM_009911.3.
UniGeneiMm.1401.

Genome annotation databases

EnsembliENSMUST00000052172; ENSMUSP00000053489; ENSMUSG00000045382.
GeneIDi12767.
KEGGimmu:12767.
UCSCiuc007cls.1. mouse. [P70658-2]
uc007clt.1. mouse. [P70658-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59760 mRNA. Translation: AAB07725.1 .
U65580 Genomic DNA. Translation: AAC52953.1 .
D87747 mRNA. Translation: BAA13451.1 .
Z80111 mRNA. Translation: CAB02201.1 .
Z80112 mRNA. Translation: CAB02202.1 .
X99581 Genomic DNA. Translation: CAA67893.1 .
X99582 mRNA. Translation: CAA67894.1 .
AB000803 mRNA. Translation: BAA19187.1 .
BC031665 mRNA. Translation: AAH31665.1 .
BC098322 mRNA. Translation: AAH98322.1 .
CCDSi CCDS15254.1. [P70658-1 ]
RefSeqi NP_034041.2. NM_009911.3.
UniGenei Mm.1401.

3D structure databases

ProteinModelPortali P70658.
SMRi P70658. Positions 29-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P70658. 1 interaction.

Chemistry

BindingDBi P70658.
ChEMBLi CHEMBL1250365.
GuidetoPHARMACOLOGYi 71.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P70658.

Proteomic databases

MaxQBi P70658.
PRIDEi P70658.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052172 ; ENSMUSP00000053489 ; ENSMUSG00000045382 .
GeneIDi 12767.
KEGGi mmu:12767.
UCSCi uc007cls.1. mouse. [P70658-2 ]
uc007clt.1. mouse. [P70658-1 ]

Organism-specific databases

CTDi 7852.
MGIi MGI:109563. Cxcr4.

Phylogenomic databases

eggNOGi NOG328039.
GeneTreei ENSGT00760000118785.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P70658.
KOi K04189.
OrthoDBi EOG73Z2TB.
PhylomeDBi P70658.
TreeFami TF330966.

Miscellaneous databases

ChiTaRSi CXCR4. mouse.
NextBioi 282130.
PROi P70658.
SOURCEi Search...

Gene expression databases

Bgeei P70658.
CleanExi MM_CXCR4.
ExpressionAtlasi P70658. baseline and differential.
Genevestigatori P70658.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001277. Chemokine_CXCR4.
IPR022726. Chemokine_CXCR4_N_dom.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF7. PTHR24227:SF7. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
PF12109. CXCR4_N. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR00645. CXCCHMKINER4.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor."
    Heesen M., Berman M.A., Benson J.D., Gerard C., Dorf M.E.
    J. Immunol. 157:5455-5460(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM CXCR4-B).
    Strain: 129/Sv and C57BL/6J.
    Tissue: Peritoneal exudate.
  2. "Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin."
    Nagasawa T., Nakajima T., Tachibana K., Iizasa H., Bleul C.C., Yoshie O., Matsushima K., Yoshida N., Springer T.A., Kishimoto T.
    Proc. Natl. Acad. Sci. U.S.A. 93:14726-14729(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CXCR4-B).
    Tissue: Pre-B cell.
  3. Schubel A., Burgstahler R., Lipp M.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CXCR4-B).
    Strain: 129/Sv.
    Tissue: Thymus.
  4. "Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1alpha activation of Gi2 are differentially expressed in vivo."
    Moepps B., Frodl R., Rodewald H.-R., Baggiolini M., Gierschik P.
    Eur. J. Immunol. 27:2102-2112(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS CXCR4-A AND CXCR4-B).
    Strain: C57BL/6J X CBA/J.
    Tissue: Thymus.
  5. "Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms."
    Heesen M., Berman M.A., Hoepken U.E., Gerard N.P., Dorf M.E.
    J. Immunol. 158:3561-3564(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS CXCR4-A AND CXCR4-B).
  6. Suzuki G., Nakata Y., Uzawa A., Shirasawa T., Saito T., Mita K.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CXCR4-B).
    Strain: C57BL/6.
    Tissue: Thymus.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CXCR4-B).
    Strain: FVB/N.
    Tissue: Mammary gland.
  8. "Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-B in human tissues."
    Frodl R., Gierschik P., Moepps B.
    J. Recept. Signal Transduct. 18:321-344(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  9. "The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract."
    Tachibana K., Hirota S., Iizasa H., Yoshida H., Kawabata K., Kataoka Y., Kitamura Y., Matsushima K., Yoshida N., Nishikawa S., Kishimoto T., Nagasawa T.
    Nature 393:591-594(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  10. "Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development."
    Zou Y.-R., Kottmann A.H., Kuroda M., Taniuchi I., Littman D.R.
    Nature 393:595-599(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  11. "Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice."
    Ma Q., Jones D., Borghesani P.R., Segal R.A., Nagasawa T., Kishimoto T., Bronson R.T., Springer T.A.
    Proc. Natl. Acad. Sci. U.S.A. 95:9448-9453(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  12. "Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4."
    McGrath K.E., Koniski A.D., Maltby K.M., McGann J.K., Palis J.
    Dev. Biol. 213:442-456(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
    Strain: ICR.
  13. "Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164."
    Bae G.-U., Gaio U., Yang Y.-J., Lee H.-J., Kang J.-S., Krauss R.S.
    J. Biol. Chem. 283:8301-8309(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD164.

Entry informationi

Entry nameiCXCR4_MOUSE
AccessioniPrimary (citable) accession number: P70658
Secondary accession number(s): O09059
, O09062, P70233, P70346, Q4KMW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3