Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P70658

- CXCR4_MOUSE

UniProt

P70658 - CXCR4_MOUSE

Protein

C-X-C chemokine receptor type 4

Gene

Cxcr4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes By similarity. Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.By similarity3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei173 – 1731ChemokineBy similarity
    Binding sitei295 – 2951ChemokineBy similarity

    GO - Molecular functioni

    1. C-X-C chemokine receptor activity Source: InterPro
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. ameboidal cell migration Source: MGI
    2. brain development Source: MGI
    3. calcium-mediated signaling Source: MGI
    4. cellular response to cytokine stimulus Source: UniProtKB
    5. generation of neurons Source: DFLAT
    6. germ cell development Source: MGI
    7. germ cell migration Source: MGI
    8. motor neuron axon guidance Source: MGI
    9. myelin maintenance Source: BHF-UCL
    10. nervous system development Source: ProtInc
    11. neural precursor cell proliferation Source: DFLAT
    12. neuron migration Source: MGI
    13. neutrophil activation Source: InterPro
    14. organ morphogenesis Source: ProtInc
    15. patterning of blood vessels Source: MGI
    16. positive regulation of oligodendrocyte differentiation Source: BHF-UCL
    17. regulation of cell migration Source: MGI
    18. regulation of chemotaxis Source: Ensembl
    19. response to hypoxia Source: Ensembl
    20. T cell proliferation Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 4
    Short name:
    CXC-R4
    Short name:
    CXCR-4
    Alternative name(s):
    Fusin
    Leukocyte-derived seven transmembrane domain receptor
    Short name:
    LESTR
    Pre-B-cell-derived chemokine receptor
    Short name:
    PB-CKR
    Stromal cell-derived factor 1 receptor
    Short name:
    SDF-1 receptor
    CD_antigen: CD184
    Gene namesi
    Name:Cxcr4
    Synonyms:Cmkar4, Lestr, Sdf1r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:109563. Cxcr4.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junction By similarity. Early endosome By similarity. Late endosome By similarity. Lysosome By similarity
    Note: In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated By similarity. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) By similarity.By similarity

    GO - Cellular componenti

    1. cell-cell junction Source: MGI
    2. cell leading edge Source: Ensembl
    3. cell surface Source: BHF-UCL
    4. cytoplasmic membrane-bounded vesicle Source: Ensembl
    5. early endosome Source: UniProtKB
    6. external side of plasma membrane Source: MGI
    7. growth cone Source: MGI
    8. integral component of membrane Source: UniProtKB-KW
    9. late endosome Source: UniProtKB
    10. lysosome Source: UniProtKB
    11. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Half of the embryos die by E17.5-E18.5 and neonates die within a few hours. Mutants display defective vascular development, cerebellar development, B-lymphopoiesis, myelopoiesis, and cardiogenesis with defective formation of the large vessels supplying the gastrointestinal tract.3 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359C-X-C chemokine receptor type 4PRO_0000069355Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91SulfotyrosineBy similarity
    Glycosylationi13 – 131N-linked (GlcNAc...)By similarity
    Modified residuei14 – 141SulfotyrosineBy similarity
    Glycosylationi20 – 201O-linked (Xyl...) (chondroitin sulfate)By similarity
    Modified residuei23 – 231SulfotyrosineBy similarity
    Disulfide bondi30 ↔ 281PROSITE-ProRule annotation
    Disulfide bondi111 ↔ 193PROSITE-ProRule annotation
    Modified residuei326 – 3261PhosphoserineBy similarity
    Modified residuei328 – 3281PhosphoserineBy similarity
    Modified residuei331 – 3311Phosphoserine; by PKC and GRK6By similarity
    Modified residuei332 – 3321Phosphoserine; by PKC and GRK6By similarity
    Modified residuei337 – 3371Phosphoserine; by GRK6By similarity
    Modified residuei346 – 3461Phosphoserine; by GRK6By similarity
    Modified residuei355 – 3551PhosphoserineBy similarity
    Modified residuei358 – 3581PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-331 and Ser-332 leads to recruitment of ITCH, ubiquitination and protein degradation By similarity.By similarity
    Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S By similarity.By similarity
    Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.By similarity
    O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Sulfation, Ubl conjugation

    Proteomic databases

    PRIDEiP70658.

    PTM databases

    PhosphoSiteiP70658.

    Expressioni

    Tissue specificityi

    Lymphocytes, macrophages, neutrophils, microglial cells and astrocytes. Found in spleen, thymus, bone marrow, lymph nodes and, at lower levels in brain, small intestine, stomach and kidney. CXCR4-A is predominant in all tissues tested. During embryonic development, high levels are detected in the endothelium of developing blood vessels and in many regions of the developing brain including the olfactory epithelium, olfactory bulb, hippocampus, cerebellum and spinal cord.2 Publications

    Developmental stagei

    High expression during embryonic development does not seem to be associated with the differentiation of any particular cell type, but is widely utilized when there is a requirement for cell movement. Frequently associated with less differentiated cell types and down-regulated with subsequent differentiation. Detected in sites with hemopoietic potential: the yolk sac (7.5, 8.5 and 12.5 dpc) and fetal liver (12.5 dpc). During gastrulation, at 7.2 to 7.8 dpc, expressed in the mesoderm and the definitive endoderm. As gastrulation pattern fades (8.5 dpc), expression in the mesoderm is down-regulated, while it becomes predominant in neural ectoderm. Endodermal expression is retained in the foregut and later in a subset of foregut derivatives, including the stomach (10.5 dpc), the cystic ducts of the gall bladder and the lung epithelium (12.5 dpc). In neuronal tissue: at 10.5 and 12.5 dpc, expressed in the dorsal root ganglia, in the ventral mantle layer of the spinal cord (or basal plates), in the hindbrain. At 14.5 dpc, expression more tightly confined to the neural epithelium lining the ventricular space and to the external granular layer of the ventral rhombic lip (the developing cerebellum). Expressed in the outpocketing of the diencephalic floor at 10.5 dpc and in the developing thalamus and, to a lesser extent, the developing hypothalamus. At 14.5 dpc, restricted to the region where thalamus and hypothalamus meet. Detected in a discrete band of cells at the edge of the olfactory bulb. In the vascular system: expressed in the endothelium of numerous blood vessels, but not all, at 10.5, 11.5 and 12.5 dpc, such as vitelline/umbilical vessels, cardiac ventricular wall capillaries, facial vessels and, at 14.5 dpc, in the vasculature of the herniated gut. Expression seems to be associated with expanding vascular networks. In the heart development, expressed at 10.5 dpc in the precursor to the aortopulmonary (AP) septum. At 12.5 dpc, detected in the AP septum at the base of the outflow tract and in the atrioventricular valves. Detected in cranofacial ectoderm from 10.5 to 14.5 dpc. At 10.5 and 11.5 dpc, expressed in the Rathke pouch.1 Publication

    Gene expression databases

    ArrayExpressiP70658.
    BgeeiP70658.
    CleanExiMM_CXCR4.
    GenevestigatoriP70658.

    Interactioni

    Subunit structurei

    Monomer By similarity. Can form dimers By similarity. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin; the interaction enhances intracellular calcium ions and reduces cellular cAMP levels By similarity. Interacts with CD164. Interacts with DBN1; this interaction is enhanced by antigenic stimulation By similarity. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8 By similarity.By similarity

    Protein-protein interaction databases

    IntActiP70658. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP70658.
    SMRiP70658. Positions 29-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040ExtracellularBy similarityAdd
    BLAST
    Topological domaini66 – 7914CytoplasmicBy similarityAdd
    BLAST
    Topological domaini102 – 11211ExtracellularBy similarityAdd
    BLAST
    Topological domaini133 – 15624CytoplasmicBy similarityAdd
    BLAST
    Topological domaini177 – 20226ExtracellularBy similarityAdd
    BLAST
    Topological domaini224 – 24825CytoplasmicBy similarityAdd
    BLAST
    Topological domaini269 – 28921ExtracellularBy similarityAdd
    BLAST
    Topological domaini310 – 35950CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6525Helical; Name=1By similarityAdd
    BLAST
    Transmembranei80 – 10122Helical; Name=2By similarityAdd
    BLAST
    Transmembranei113 – 13220Helical; Name=3By similarityAdd
    BLAST
    Transmembranei157 – 17620Helical; Name=4By similarityAdd
    BLAST
    Transmembranei203 – 22321Helical; Name=5By similarityAdd
    BLAST
    Transmembranei249 – 26820Helical; Name=6By similarityAdd
    BLAST
    Transmembranei290 – 30920Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2323Important for chemokine binding and signalingBy similarityAdd
    BLAST
    Regioni96 – 994Chemokine bindingBy similarity
    Regioni115 – 1195Chemokine bindingBy similarity
    Regioni137 – 14913Involved in dimerization; when bound to chemokineBy similarityAdd
    BLAST
    Regioni193 – 1975Chemokine binding, important for signalingBy similarity
    Regioni198 – 21720Involved in dimerizationBy similarityAdd
    BLAST
    Regioni273 – 2753Involved in dimerizationBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi135 – 1373Important for signalingBy similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG328039.
    GeneTreeiENSGT00730000110292.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP70658.
    KOiK04189.
    OrthoDBiEOG73Z2TB.
    PhylomeDBiP70658.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001277. Chemokine_CXCR4.
    IPR022726. Chemokine_CXCR4_N_dom.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF7. PTHR24227:SF7. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    PF12109. CXCR4_N. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR00645. CXCCHMKINER4.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform CXCR4-B (identifier: P70658-1) [UniParc]FASTAAdd to Basket

    Also known as: LESTR-B

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPISVSIYT SDNYSEEVGS GDYDSNKEPC FRDENVHFNR IFLPTIYFII    50
    FLTGIVGNGL VILVMGYQKK LRSMTDKYRL HLSVADLLFV ITLPFWAVDA 100
    MADWYFGKFL CKAVHIIYTV NLYSSVLILA FISLDRYLAI VHATNSQRPR 150
    KLLAEKAVYV GVWIPALLLT IPDFIFADVS QGDISQGDDR YICDRLYPDS 200
    LWMVVFQFQH IMVGLILPGI VILSCYCIII SKLSHSKGHQ KRKALKTTVI 250
    LILAFFACWL PYYVGISIDS FILLGVIKQG CDFESIVHKW ISITEALAFF 300
    HCCLNPILYA FLGAKFKSSA QHALNSMSRG SSLKILSKGK RGGHSSVSTE 350
    SESSSFHSS 359
    Length:359
    Mass (Da):40,426
    Last modified:November 1, 1997 - v2
    Checksum:i33D1B5552A31595B
    GO
    Isoform CXCR4-A (identifier: P70658-2) [UniParc]FASTAAdd to Basket

    Also known as: LESTR-A

    The sequence of this isoform differs from the canonical sequence as follows:
         6-7: Missing.

    Show »
    Length:357
    Mass (Da):40,240
    Checksum:i648C8835307AD5EC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti216 – 2161I → V in CAA67893. (PubMed:9295051)Curated
    Sequence conflicti216 – 2161I → V in BAA19187. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei6 – 72Missing in isoform CXCR4-A. 1 PublicationVSP_001891

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59760 mRNA. Translation: AAB07725.1.
    U65580 Genomic DNA. Translation: AAC52953.1.
    D87747 mRNA. Translation: BAA13451.1.
    Z80111 mRNA. Translation: CAB02201.1.
    Z80112 mRNA. Translation: CAB02202.1.
    X99581 Genomic DNA. Translation: CAA67893.1.
    X99582 mRNA. Translation: CAA67894.1.
    AB000803 mRNA. Translation: BAA19187.1.
    BC031665 mRNA. Translation: AAH31665.1.
    BC098322 mRNA. Translation: AAH98322.1.
    CCDSiCCDS15254.1. [P70658-1]
    RefSeqiNP_034041.2. NM_009911.3.
    UniGeneiMm.1401.

    Genome annotation databases

    EnsembliENSMUST00000052172; ENSMUSP00000053489; ENSMUSG00000045382.
    GeneIDi12767.
    KEGGimmu:12767.
    UCSCiuc007cls.1. mouse. [P70658-2]
    uc007clt.1. mouse. [P70658-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59760 mRNA. Translation: AAB07725.1 .
    U65580 Genomic DNA. Translation: AAC52953.1 .
    D87747 mRNA. Translation: BAA13451.1 .
    Z80111 mRNA. Translation: CAB02201.1 .
    Z80112 mRNA. Translation: CAB02202.1 .
    X99581 Genomic DNA. Translation: CAA67893.1 .
    X99582 mRNA. Translation: CAA67894.1 .
    AB000803 mRNA. Translation: BAA19187.1 .
    BC031665 mRNA. Translation: AAH31665.1 .
    BC098322 mRNA. Translation: AAH98322.1 .
    CCDSi CCDS15254.1. [P70658-1 ]
    RefSeqi NP_034041.2. NM_009911.3.
    UniGenei Mm.1401.

    3D structure databases

    ProteinModelPortali P70658.
    SMRi P70658. Positions 29-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P70658. 1 interaction.

    Chemistry

    BindingDBi P70658.
    ChEMBLi CHEMBL1250365.
    GuidetoPHARMACOLOGYi 71.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P70658.

    Proteomic databases

    PRIDEi P70658.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052172 ; ENSMUSP00000053489 ; ENSMUSG00000045382 .
    GeneIDi 12767.
    KEGGi mmu:12767.
    UCSCi uc007cls.1. mouse. [P70658-2 ]
    uc007clt.1. mouse. [P70658-1 ]

    Organism-specific databases

    CTDi 7852.
    MGIi MGI:109563. Cxcr4.

    Phylogenomic databases

    eggNOGi NOG328039.
    GeneTreei ENSGT00730000110292.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P70658.
    KOi K04189.
    OrthoDBi EOG73Z2TB.
    PhylomeDBi P70658.
    TreeFami TF330966.

    Miscellaneous databases

    ChiTaRSi CXCR4. mouse.
    NextBioi 282130.
    PROi P70658.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70658.
    Bgeei P70658.
    CleanExi MM_CXCR4.
    Genevestigatori P70658.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001277. Chemokine_CXCR4.
    IPR022726. Chemokine_CXCR4_N_dom.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF7. PTHR24227:SF7. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    PF12109. CXCR4_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR00645. CXCCHMKINER4.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor."
      Heesen M., Berman M.A., Benson J.D., Gerard C., Dorf M.E.
      J. Immunol. 157:5455-5460(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM CXCR4-B).
      Strain: 129/Sv and C57BL/6J.
      Tissue: Peritoneal exudate.
    2. "Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin."
      Nagasawa T., Nakajima T., Tachibana K., Iizasa H., Bleul C.C., Yoshie O., Matsushima K., Yoshida N., Springer T.A., Kishimoto T.
      Proc. Natl. Acad. Sci. U.S.A. 93:14726-14729(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CXCR4-B).
      Tissue: Pre-B cell.
    3. Schubel A., Burgstahler R., Lipp M.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CXCR4-B).
      Strain: 129/Sv.
      Tissue: Thymus.
    4. "Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1alpha activation of Gi2 are differentially expressed in vivo."
      Moepps B., Frodl R., Rodewald H.-R., Baggiolini M., Gierschik P.
      Eur. J. Immunol. 27:2102-2112(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS CXCR4-A AND CXCR4-B).
      Strain: C57BL/6J X CBA/J.
      Tissue: Thymus.
    5. "Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms."
      Heesen M., Berman M.A., Hoepken U.E., Gerard N.P., Dorf M.E.
      J. Immunol. 158:3561-3564(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS CXCR4-A AND CXCR4-B).
    6. Suzuki G., Nakata Y., Uzawa A., Shirasawa T., Saito T., Mita K.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CXCR4-B).
      Strain: C57BL/6.
      Tissue: Thymus.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CXCR4-B).
      Strain: FVB/N.
      Tissue: Mammary gland.
    8. "Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-B in human tissues."
      Frodl R., Gierschik P., Moepps B.
      J. Recept. Signal Transduct. 18:321-344(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
    9. "The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract."
      Tachibana K., Hirota S., Iizasa H., Yoshida H., Kawabata K., Kataoka Y., Kitamura Y., Matsushima K., Yoshida N., Nishikawa S., Kishimoto T., Nagasawa T.
      Nature 393:591-594(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    10. "Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development."
      Zou Y.-R., Kottmann A.H., Kuroda M., Taniuchi I., Littman D.R.
      Nature 393:595-599(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    11. "Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice."
      Ma Q., Jones D., Borghesani P.R., Segal R.A., Nagasawa T., Kishimoto T., Bronson R.T., Springer T.A.
      Proc. Natl. Acad. Sci. U.S.A. 95:9448-9453(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    12. "Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4."
      McGrath K.E., Koniski A.D., Maltby K.M., McGann J.K., Palis J.
      Dev. Biol. 213:442-456(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
      Strain: ICR.
    13. "Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164."
      Bae G.-U., Gaio U., Yang Y.-J., Lee H.-J., Kang J.-S., Krauss R.S.
      J. Biol. Chem. 283:8301-8309(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CD164.

    Entry informationi

    Entry nameiCXCR4_MOUSE
    AccessioniPrimary (citable) accession number: P70658
    Secondary accession number(s): O09059
    , O09062, P70233, P70346, Q4KMW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3