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P70619

- GSHR_RAT

UniProt

P70619 - GSHR_RAT

Protein

Glutathione reductase

Gene

Gsr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Maintains high levels of reduced glutathione in the cytosol.By similarity

    Catalytic activityi

    2 glutathione + NADP+ = glutathione disulfide + NADPH.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei413 – 4131Proton acceptorBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: RGD
    2. glutathione binding Source: RGD
    3. glutathione-disulfide reductase activity Source: RGD
    4. NADP binding Source: RGD
    5. protein homodimerization activity Source: RGD

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. glutathione metabolic process Source: RGD
    3. response to ethanol Source: RGD
    4. response to nicotine Source: RGD
    5. response to vitamin A Source: RGD
    6. spermatogenesis Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    SABIO-RKP70619.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione reductase (EC:1.8.1.7)
    Short name:
    GR
    Short name:
    GRase
    Gene namesi
    Name:Gsr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621747. Gsr.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. mitochondrion Source: RGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 424›424Glutathione reductasePRO_0000067957Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 – 32InterchainBy similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP70619.
    PRIDEiP70619.

    Expressioni

    Gene expression databases

    GenevestigatoriP70619.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020252.

    Structurei

    3D structure databases

    ProteinModelPortaliP70619.
    SMRiP70619. Positions 1-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG1249.
    HOGENOMiHOG000276712.
    HOVERGENiHBG004959.
    InParanoidiP70619.
    PhylomeDBiP70619.

    Family and domain databases

    Gene3Di3.30.390.30. 1 hit.
    InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
    IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR006322. Glutathione_Rdtase_euk/bac.
    IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    [Graphical view]
    PfamiPF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF02852. Pyr_redox_dim. 1 hit.
    [Graphical view]
    PRINTSiPR00368. FADPNR.
    SUPFAMiSSF55424. SSF55424. 1 hit.
    TIGRFAMsiTIGR01421. gluta_reduc_1. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    P70619-1 [UniParc]FASTAAdd to Basket

    « Hide

    VNVGCVPKKV MWNTAVHSEF IHDHVDYGFQ NCKSKFNWHV IKEKRDAYVS    50
    RLNNIYQNNL TKSHIEVIHG YATFRDGPQP TAEVNGKKFT APHILIATGG 100
    VPTVPHENQI PGASLGITSD GFFQLEDLPS RSVIVGAGYI AVEIAGILSA 150
    LGSKTSLMIR HDKVLRSFDS LISSNCTEEL ENAGGVEVLT VKKFSQVKEV 200
    KKTSSGLELH VVTALPGRKP TVTTIPDVDC LLWAIGRDPN SKGLNLNKLG 250
    IQTDDKGHIL VDEFQNTNVK GVYAVGDVCG KALLTPVAIA AGRKLAHRLF 300
    EGKEDSRLDY DNIPTVVFSH PPIGTVGLTE DEAVHKYGKD NVKIYSTAFT 350
    PMYHAVTTRK TKCVMKMVCA NKEEKVVGIH MQGIGCDEML QGFAVAVKMG 400
    ATKADFDNRV AIHPTSSEEL VTLR 424
    Length:424
    Mass (Da):46,301
    Last modified:July 5, 2004 - v2
    Checksum:i0714FF531F90BEBA
    GO

    Sequence cautioni

    The sequence AAB18132.1 differs from that shown. Reason: Frameshift at position 7.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73174 mRNA. Translation: AAB18132.1. Frameshift.
    UniGeneiRn.19721.

    Genome annotation databases

    UCSCiRGD:621747. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73174 mRNA. Translation: AAB18132.1 . Frameshift.
    UniGenei Rn.19721.

    3D structure databases

    ProteinModelPortali P70619.
    SMRi P70619. Positions 1-424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020252.

    Proteomic databases

    PaxDbi P70619.
    PRIDEi P70619.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:621747. rat.

    Organism-specific databases

    RGDi 621747. Gsr.

    Phylogenomic databases

    eggNOGi COG1249.
    HOGENOMi HOG000276712.
    HOVERGENi HBG004959.
    InParanoidi P70619.
    PhylomeDBi P70619.

    Enzyme and pathway databases

    SABIO-RK P70619.

    Miscellaneous databases

    NextBioi 13950447.
    PROi P70619.

    Gene expression databases

    Genevestigatori P70619.

    Family and domain databases

    Gene3Di 3.30.390.30. 1 hit.
    InterProi IPR016156. FAD/NAD-linked_Rdtase_dimer.
    IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR006322. Glutathione_Rdtase_euk/bac.
    IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    [Graphical view ]
    Pfami PF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF02852. Pyr_redox_dim. 1 hit.
    [Graphical view ]
    PRINTSi PR00368. FADPNR.
    SUPFAMi SSF55424. SSF55424. 1 hit.
    TIGRFAMsi TIGR01421. gluta_reduc_1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Hou W.M., Cheplinsky A.B.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGSHR_RAT
    AccessioniPrimary (citable) accession number: P70619
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3