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P70619 (GSHR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutathione reductase
Short name=GR
Short name=GRase
EC=1.8.1.7
Gene names
Name:Gsr
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length424 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Maintains high levels of reduced glutathione in the cytosol By similarity.

Catalytic activity

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Sequence caution

The sequence AAB18132.1 differs from that shown. Reason: Frameshift at position 7.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 424›424Glutathione reductase
PRO_0000067957

Sites

Active site4131Proton acceptor By similarity

Amino acid modifications

Disulfide bond32Interchain By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P70619 [UniParc].

Last modified July 5, 2004. Version 2.
Checksum: 0714FF531F90BEBA

FASTA42446,301
        10         20         30         40         50         60 
VNVGCVPKKV MWNTAVHSEF IHDHVDYGFQ NCKSKFNWHV IKEKRDAYVS RLNNIYQNNL 

        70         80         90        100        110        120 
TKSHIEVIHG YATFRDGPQP TAEVNGKKFT APHILIATGG VPTVPHENQI PGASLGITSD 

       130        140        150        160        170        180 
GFFQLEDLPS RSVIVGAGYI AVEIAGILSA LGSKTSLMIR HDKVLRSFDS LISSNCTEEL 

       190        200        210        220        230        240 
ENAGGVEVLT VKKFSQVKEV KKTSSGLELH VVTALPGRKP TVTTIPDVDC LLWAIGRDPN 

       250        260        270        280        290        300 
SKGLNLNKLG IQTDDKGHIL VDEFQNTNVK GVYAVGDVCG KALLTPVAIA AGRKLAHRLF 

       310        320        330        340        350        360 
EGKEDSRLDY DNIPTVVFSH PPIGTVGLTE DEAVHKYGKD NVKIYSTAFT PMYHAVTTRK 

       370        380        390        400        410        420 
TKCVMKMVCA NKEEKVVGIH MQGIGCDEML QGFAVAVKMG ATKADFDNRV AIHPTSSEEL 


VTLR

« Hide

References

[1]Hou W.M., Cheplinsky A.B.
Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U73174 mRNA. Translation: AAB18132.1. Frameshift.
IPIIPI01016454.
UniGeneRn.19721.

3D structure databases

ProteinModelPortalP70619.
SMRP70619. Positions 1-424.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000020252.

Proteomic databases

PaxDbP70619.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:621747. rat.

Organism-specific databases

RGD621747. Gsr.

Phylogenomic databases

eggNOGCOG1249.
HOGENOMHOG000276712.
HOVERGENHBG004959.
InParanoidP70619.
OrthoDBEOG42BX8H.

Enzyme and pathway databases

SABIO-RKP70619.

Gene expression databases

ArrayExpressP70619.
GenevestigatorP70619.
GermOnlineENSRNOG00000014915. Rattus norvegicus.

Family and domain databases

Gene3D3.30.390.30. 1 hit.
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
TIGRFAMsTIGR01421. gluta_reduc_1. 1 hit.
PROSITEPS00076. PYRIDINE_REDOX_1. Partial match.
[Graphical view]
ProtoNetSearch...

Other

NextBio13950447.

Entry information

Entry nameGSHR_RAT
AccessionPrimary (citable) accession number: P70619
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 3, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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