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P70619

- GSHR_RAT

UniProt

P70619 - GSHR_RAT

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Protein

Glutathione reductase

Gene
Gsr
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Maintains high levels of reduced glutathione in the cytosol By similarity.

Catalytic activityi

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactori

Binds 1 FAD per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei413 – 4131Proton acceptor By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: RGD
  2. glutathione binding Source: RGD
  3. glutathione-disulfide reductase activity Source: RGD
  4. NADP binding Source: RGD
  5. protein homodimerization activity Source: RGD

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. glutathione metabolic process Source: RGD
  3. response to ethanol Source: RGD
  4. response to nicotine Source: RGD
  5. response to vitamin A Source: RGD
  6. spermatogenesis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

SABIO-RKP70619.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione reductase (EC:1.8.1.7)
Short name:
GR
Short name:
GRase
Gene namesi
Name:Gsr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621747. Gsr.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
  2. mitochondrion Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 424›424Glutathione reductasePRO_0000067957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 – 32Interchain By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP70619.
PRIDEiP70619.

Expressioni

Gene expression databases

GenevestigatoriP70619.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020252.

Structurei

3D structure databases

ProteinModelPortaliP70619.
SMRiP70619. Positions 1-424.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG1249.
HOGENOMiHOG000276712.
HOVERGENiHBG004959.
InParanoidiP70619.
PhylomeDBiP70619.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
SUPFAMiSSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01421. gluta_reduc_1. 1 hit.

Sequencei

Sequence statusi: Fragment.

P70619-1 [UniParc]FASTAAdd to Basket

« Hide

VNVGCVPKKV MWNTAVHSEF IHDHVDYGFQ NCKSKFNWHV IKEKRDAYVS    50
RLNNIYQNNL TKSHIEVIHG YATFRDGPQP TAEVNGKKFT APHILIATGG 100
VPTVPHENQI PGASLGITSD GFFQLEDLPS RSVIVGAGYI AVEIAGILSA 150
LGSKTSLMIR HDKVLRSFDS LISSNCTEEL ENAGGVEVLT VKKFSQVKEV 200
KKTSSGLELH VVTALPGRKP TVTTIPDVDC LLWAIGRDPN SKGLNLNKLG 250
IQTDDKGHIL VDEFQNTNVK GVYAVGDVCG KALLTPVAIA AGRKLAHRLF 300
EGKEDSRLDY DNIPTVVFSH PPIGTVGLTE DEAVHKYGKD NVKIYSTAFT 350
PMYHAVTTRK TKCVMKMVCA NKEEKVVGIH MQGIGCDEML QGFAVAVKMG 400
ATKADFDNRV AIHPTSSEEL VTLR 424
Length:424
Mass (Da):46,301
Last modified:July 5, 2004 - v2
Checksum:i0714FF531F90BEBA
GO

Sequence cautioni

The sequence AAB18132.1 differs from that shown. Reason: Frameshift at position 7.

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73174 mRNA. Translation: AAB18132.1. Frameshift.
UniGeneiRn.19721.

Genome annotation databases

UCSCiRGD:621747. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73174 mRNA. Translation: AAB18132.1 . Frameshift.
UniGenei Rn.19721.

3D structure databases

ProteinModelPortali P70619.
SMRi P70619. Positions 1-424.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000020252.

Proteomic databases

PaxDbi P70619.
PRIDEi P70619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:621747. rat.

Organism-specific databases

RGDi 621747. Gsr.

Phylogenomic databases

eggNOGi COG1249.
HOGENOMi HOG000276712.
HOVERGENi HBG004959.
InParanoidi P70619.
PhylomeDBi P70619.

Enzyme and pathway databases

SABIO-RK P70619.

Miscellaneous databases

NextBioi 13950447.
PROi P70619.

Gene expression databases

Genevestigatori P70619.

Family and domain databases

Gene3Di 3.30.390.30. 1 hit.
InterProi IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view ]
Pfami PF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view ]
PRINTSi PR00368. FADPNR.
SUPFAMi SSF55424. SSF55424. 1 hit.
TIGRFAMsi TIGR01421. gluta_reduc_1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Hou W.M., Cheplinsky A.B.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGSHR_RAT
AccessioniPrimary (citable) accession number: P70619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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