Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione reductase

Gene

Gsr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Maintains high levels of reduced glutathione in the cytosol.By similarity

Catalytic activityi

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei413Proton acceptorBy similarity1

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: RGD
  • glutathione binding Source: RGD
  • glutathione-disulfide reductase activity Source: CACAO
  • NADP binding Source: RGD
  • protein homodimerization activity Source: RGD
  • selenodiglutathione-disulfide reductase activity Source: Reactome

GO - Biological processi

  • aging Source: RGD
  • cell redox homeostasis Source: InterPro
  • glutathione metabolic process Source: RGD
  • response to activity Source: RGD
  • response to cadmium ion Source: RGD
  • response to ethanol Source: RGD
  • response to iron(III) ion Source: RGD
  • response to ischemia Source: RGD
  • response to nicotine Source: RGD
  • response to oxidative stress Source: RGD
  • response to vitamin A Source: RGD
  • spermatogenesis Source: RGD

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

SABIO-RKiP70619

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione reductase (EC:1.8.1.7)
Short name:
GR
Short name:
GRase
Gene namesi
Name:Gsr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621747 Gsr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3286088

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000067957‹1 – 424Glutathione reductaseAdd BLAST›424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP70619
PRIDEiP70619

PTM databases

iPTMnetiP70619
PhosphoSitePlusiP70619

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020252

Chemistry databases

BindingDBiP70619

Structurei

3D structure databases

ProteinModelPortaliP70619
SMRiP70619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0405 Eukaryota
COG1249 LUCA
HOGENOMiHOG000276712
HOVERGENiHBG004959
InParanoidiP70619
PhylomeDBiP70619

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006322 Glutathione_Rdtase_euk/bac
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
PANTHERiPTHR42737 PTHR42737, 1 hit
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01421 gluta_reduc_1, 1 hit

Sequencei

Sequence statusi: Fragment.

P70619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VNVGCVPKKV MWNTAVHSEF IHDHVDYGFQ NCKSKFNWHV IKEKRDAYVS
60 70 80 90 100
RLNNIYQNNL TKSHIEVIHG YATFRDGPQP TAEVNGKKFT APHILIATGG
110 120 130 140 150
VPTVPHENQI PGASLGITSD GFFQLEDLPS RSVIVGAGYI AVEIAGILSA
160 170 180 190 200
LGSKTSLMIR HDKVLRSFDS LISSNCTEEL ENAGGVEVLT VKKFSQVKEV
210 220 230 240 250
KKTSSGLELH VVTALPGRKP TVTTIPDVDC LLWAIGRDPN SKGLNLNKLG
260 270 280 290 300
IQTDDKGHIL VDEFQNTNVK GVYAVGDVCG KALLTPVAIA AGRKLAHRLF
310 320 330 340 350
EGKEDSRLDY DNIPTVVFSH PPIGTVGLTE DEAVHKYGKD NVKIYSTAFT
360 370 380 390 400
PMYHAVTTRK TKCVMKMVCA NKEEKVVGIH MQGIGCDEML QGFAVAVKMG
410 420
ATKADFDNRV AIHPTSSEEL VTLR
Length:424
Mass (Da):46,301
Last modified:July 5, 2004 - v2
Checksum:i0714FF531F90BEBA
GO

Sequence cautioni

The sequence AAB18132 differs from that shown. Reason: Frameshift at position 7.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73174 mRNA Translation: AAB18132.1 Frameshift.
UniGeneiRn.19721

Genome annotation databases

UCSCiRGD:621747 rat

Similar proteinsi

Entry informationi

Entry nameiGSHR_RAT
AccessioniPrimary (citable) accession number: P70619
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health